NF-κB
O fator nuclear kappa-light-chain-enhancer de células B ativadas (NF-κB) é um fator de transcrição que regula a expressão de genes envolvidos em respostas imunes, inflamação, sobrevivência celular e proliferação. O NF-κB é ativado em resposta a vários estímulos, incluindo citocinas, patógenos e sinais de estresse. A desregulação da sinalização do NF-κB está associada a doenças inflamatórias crônicas, câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores da via NF-κB para apoiar sua pesquisa em inflamação, oncologia e regulação imunológica.
Foram encontrados 385 produtos de "NF-κB"
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Guaiacol
CAS:Guaiacol, a flavorant precursor, has medicinal uses and serves as an oxygen indicator turning yellow-brown at 470 nm.Fórmula:C7H8O2Pureza:99.95%Cor e Forma:Colourless To Pale Yellow Solid CrystallinePeso molecular:124.14Lidocaine
CAS:Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.Fórmula:C14H22N2OPureza:99.95% - >99.99%Cor e Forma:Needles From Benzene Or Alcohol SolidPeso molecular:234.34Theophylline monohydrate
CAS:Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calciumFórmula:C7H8N4O2·H2OPureza:99.78%Cor e Forma:SolidPeso molecular:198.18Sinomenine hydrochloride
CAS:Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.Fórmula:C19H24ClNO4Pureza:99.43%Cor e Forma:SolidPeso molecular:365.85Dihydroartemisinin
CAS:Dihydroartemisinin (Artenimol) is an antimalarial drug. High-Quality, Low-Cost!Fórmula:C15H24O5Pureza:98% - 99.41%Cor e Forma:White SolidPeso molecular:284.35Aspirin
CAS:Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.Fórmula:C9H8O4Pureza:99.78% - 99.91%Cor e Forma:White Solid CrystallinePeso molecular:180.16Lidocaine hydrochloride
CAS:Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.Fórmula:C14H23ClN2OPureza:99.81% - 99.92%Cor e Forma:White Crystal PowderPeso molecular:270.798Sulindac
CAS:Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity.Fórmula:C20H17FO3SPureza:99.09% - 99.15%Cor e Forma:Yellow SolidPeso molecular:356.41Lidocaine Hydrochloride hydrate
CAS:Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.Fórmula:C14H22N2O·HCl·H2OPureza:99.95%Cor e Forma:SolidPeso molecular:288.82DCZ0415
CAS:DCZ0415: Potent TRIP13 inhibitor; combats myeloma in vitro, in vivo, and in drug-resistant patients; hinders DNA repair and NF-κB activity.Fórmula:C23H20N2O2Pureza:99.34% - 99.95%Cor e Forma:SolidPeso molecular:356.42Ref: TM-T10981
1mg50,00€5mg110,00€1mL*10mM (DMSO)119,00€10mg178,00€25mg334,00€50mg505,00€100mg707,00€200mg973,00€TBK1/IKKε-IN-2
CAS:TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.Fórmula:C26H27N5O3Pureza:98.89%Cor e Forma:SolidPeso molecular:457.52Ref: TM-T15559
1mg52,00€5mg111,00€1mL*10mM (DMSO)111,00€10mg173,00€25mg278,00€50mg375,00€100mg482,00€Nimbolide
CAS:Nimbolide, from neem, inhibits CDK4/6, NF-κB, Wnt, PI3K-Akt, MAPK, JAK-STAT pathways and induces apoptosis.Fórmula:C27H30O7Pureza:95.84% - 99.4%Cor e Forma:SolidPeso molecular:466.52Ref: TM-T16324
1mg67,00€5mg167,00€1mL*10mM (DMSO)180,00€10mg289,00€25mg595,00€50mg820,00€100mg1.108,00€200mg1.440,00€Baicalin
CAS:Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIVFórmula:C21H18O11Pureza:90.08% - 99.32%Cor e Forma:Yellow PowderPeso molecular:446.36Ref: TM-T2775
50mg34,00€100mg49,00€200mg49,00€1mL*10mM (DMSO)50,00€500mg55,00€1g80,00€2g102,00€5g152,00€Sodium salicylate
CAS:Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.Fórmula:C7H5NaO3Pureza:99.36% - 99.92%Cor e Forma:White Solid AmorphousPeso molecular:160.11CDDO-dhTFEA
CAS:CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor.Fórmula:C33H45F3N2O3Pureza:95.61% - 99.59%Cor e Forma:SolidPeso molecular:574.72Ref: TM-T13604
1mg66,00€2mg96,00€5mg144,00€1mL*10mM (DMSO)177,00€10mg241,00€25mg485,00€50mg700,00€100mg982,00€500mg1.953,00€Theophylline
CAS:Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and centralFórmula:C7H8N4O2Pureza:99.65% - 99.98%Cor e Forma:White Solid PowderPeso molecular:180.16Ergolide
CAS:Ergolide, from Inula Britannica, inhibits iNOS and COX-2 by deactivating NF-κB in macrophages.Fórmula:C17H22O5Pureza:99.64%Cor e Forma:SolidPeso molecular:306.35Ref: TM-T13686
1mg71,00€5mg139,00€1mL*10mM (DMSO)166,00€10mg230,00€25mg374,00€50mg520,00€100mg697,00€DRI-C21045
CAS:Dri-c21045 inhibits NF-kB (IC50=17.1μM) and B cell proliferation (IC50=4.5μM), selectively blocking CD40-CD40L interaction (IC50=0.17μM).Fórmula:C32H24N2O7SPureza:97.20%Cor e Forma:SolidPeso molecular:580.61DMAPT
CAS:DMAPT is a water-soluble PTL analogue, orally active NF-κB inhibitor with 1.7 μM LD50 in acute myeloid leukemia cells.Fórmula:C17H27NO3Pureza:99.91%Cor e Forma:SolidPeso molecular:293.4R1-ICR-5
CAS:R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.Fórmula:C54H70N8O7S2Cor e Forma:SolidPeso molecular:1007.31
