IκB/IKK
O complexo IκB/IKK é um regulador chave da via de sinalização NF-κB, que controla a expressão de genes envolvidos em respostas imunes, inflamação e sobrevivência celular. As proteínas IκB inibem a atividade do NF-κB sequestrando-o no citoplasma, enquanto as IKKs fosforilam a IκB, levando à sua degradação e à ativação do NF-κB. A desregulação da via IκB/IKK está associada à inflamação crônica, câncer e doenças autoimunes. Na CymitQuimica, oferecemos uma seleção de moduladores IκB/IKK de alta qualidade para apoiar sua pesquisa em transdução de sinal, inflamação e desenvolvimento terapêutico.
Foram encontrados 58 produtos de "IκB/IKK"
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SC-514
CAS:SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
Fórmula:C9H8N2OS2Pureza:99.88% - >99.99%Cor e Forma:SolidPeso molecular:224.3BMS-345541
CAS:BMS-345541 (IKK Inhibitor III) is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.Fórmula:C14H17N5Pureza:99.36% - 99.74%Cor e Forma:SolidPeso molecular:255.32TBK1/IKKε-IN-5
CAS:TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM, respectively).Fórmula:C28H31N7O3Pureza:98.77%Cor e Forma:SolidPeso molecular:513.59Ref: TM-T7951
1mg88,00€5mg182,00€1mL*10mM (DMSO)224,00€10mg269,00€25mg429,00€50mg587,00€100mg837,00€200mg1.125,00€JTP 0819958 - HOIPIN-1
JTP-0819958: LUBAC inhibitor, IC50 2.8 μM; blocks NF-kB activation in vitro.Fórmula:C17H13NaO4Pureza:99.95%Cor e Forma:SolidPeso molecular:304.27Ref: TM-T8951
1mg37,00€2mg50,00€5mg65,00€1mL*10mM (DMSO)77,00€10mg95,00€25mg210,00€50mg339,00€100mg495,00€500mg1.099,00€2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC
CAS:2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.
Fórmula:C11H10N2OSPureza:99.48%Cor e Forma:SolidPeso molecular:218.27BMS-345541 hydrochloride
CAS:BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).Fórmula:C14H18ClN5Pureza:99.13%Cor e Forma:SolidPeso molecular:291.78Ref: TM-T8542
1mg38,00€2mg50,00€1mL*10mM (DMSO)52,00€5mg82,00€10mg119,00€25mg212,00€50mg356,00€100mg533,00€BOT-64
CAS:BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathioleFórmula:C15H15NO2SPureza:99.73%Cor e Forma:SolidPeso molecular:273.35Ref: TM-T8705
1mg50,00€1mL*10mM (DMSO)102,00€5mg110,00€10mg170,00€25mg323,00€50mg494,00€100mg665,00€200mg893,00€IMD-0354
CAS:IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.Fórmula:C15H8ClF6NO2Pureza:99.65% - 99.98%Cor e Forma:SolidPeso molecular:383.67Ref: TM-T6141
2mg46,00€5mg63,00€1mL*10mM (DMSO)65,00€10mg87,00€25mg155,00€50mg210,00€100mg294,00€500mg713,00€NF-κB-IN-1
CAS:NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathwayFórmula:C31H30O8Pureza:99.03%Cor e Forma:SolidPeso molecular:530.57Ref: TM-T9105
1mg166,00€5mg341,00€1mL*10mM (DMSO)398,00€10mg550,00€25mg898,00€50mg1.216,00€100mg1.644,00€INH14
CAS:INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).Fórmula:C15H16N2OPureza:95.41%Cor e Forma:SolidPeso molecular:240.3GSK319347A
CAS:GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.Fórmula:C22H19N3O5S2Pureza:98.42%Cor e Forma:SolidPeso molecular:469.53BAY32-5915
CAS:BAY32-5915 is a selective inhibitor of IKKalpha.Fórmula:C10H7NO3Pureza:96.48% - 97%Cor e Forma:Yellow Crystalline PowderPeso molecular:189.17Bay 65-1942 free base
CAS:Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.Fórmula:C22H25N3O4Pureza:98%Cor e Forma:SolidPeso molecular:395.45Ertiprotafib
CAS:Ertiprotafib (PTP 112), a PTP1B and IKK-β inhibitor, is a novel insulin sensitizer for the study of type 2 diabetes and breast cancer.Fórmula:C31H27BrO3SPureza:98.70%Cor e Forma:SolidPeso molecular:559.51TBK1/IKKε-IN-4
CAS:TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nMFórmula:C28H35N7O4Cor e Forma:SolidPeso molecular:533.62PHA-408
CAS:PHA-408 is a novel potent, highly selective and ATP-competitive inhibitor of IKB kinase-2.Fórmula:C29H27ClFN7O2Pureza:98%Cor e Forma:SolidPeso molecular:560.02DMX-129
CAS:DMX-129 is a chemical compound acting as an inhibitor for both ΙΚΚε and TBK-1, demonstrating efficacy with IC50 values of below 30 nM for each [1].Fórmula:C19H17FN8Cor e Forma:SolidPeso molecular:376.39IKK2-IN-4
CAS:IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.Fórmula:C12H11N3O2SPureza:99.83%Cor e Forma:SolidPeso molecular:261.3Ref: TM-T36524
500µg82,00€1mg108,00€5mg261,00€10mg401,00€25mg622,00€50mg837,00€100mg1.125,00€200mg1.504,00€1-Dehydro-[10]-gingerdione
CAS:1-Dehydro-[10]-gingerdione blocks IKKβ, curbs IκBα phosphorylation, halts NF-κB activity, and aids inflammation research.Fórmula:C21H30O4Cor e Forma:SolidPeso molecular:346.46CS12192
CAS:CS12192 enhances survival, boosts weight, and shows promise in GVHD research per patent CN112773802A.Fórmula:C25H23ClFN7O2Cor e Forma:SolidPeso molecular:507.95
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