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IκB/IKK

IκB/IKK

O complexo IκB/IKK é um regulador chave da via de sinalização NF-κB, que controla a expressão de genes envolvidos em respostas imunes, inflamação e sobrevivência celular. As proteínas IκB inibem a atividade do NF-κB sequestrando-o no citoplasma, enquanto as IKKs fosforilam a IκB, levando à sua degradação e à ativação do NF-κB. A desregulação da via IκB/IKK está associada à inflamação crônica, câncer e doenças autoimunes. Na CymitQuimica, oferecemos uma seleção de moduladores IκB/IKK de alta qualidade para apoiar sua pesquisa em transdução de sinal, inflamação e desenvolvimento terapêutico.

Foram encontrados 61 produtos de "IκB/IKK"

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  • DMX-129
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    DMX-129

    CAS:
    <p>DMX-129 is a chemical compound acting as an inhibitor for both ΙΚΚε and TBK-1, demonstrating efficacy with IC50 values of below 30 nM for each [1].</p>
    Fórmula:C19H17FN8
    Cor e Forma:Solid
    Peso molecular:376.39

    Ref: TM-T61550

  • IKK2-IN-4
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    IKK2-IN-4

    CAS:
    <p>IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.</p>
    Fórmula:C12H11N3O2S
    Pureza:>99.99%
    Cor e Forma:Solid
    Peso molecular:261.3

    Ref: TM-T36524

  • 1-Dehydro-[10]-gingerdione
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    1-Dehydro-[10]-gingerdione

    CAS:
    <p>1-Dehydro-[10]-gingerdione blocks IKKβ, curbs IκBα phosphorylation, halts NF-κB activity, and aids inflammation research.</p>
    Fórmula:C21H30O4
    Cor e Forma:Solid
    Peso molecular:346.46

    Ref: TM-T72208

  • HPN-01
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    HPN-01

    CAS:
    <p>HPN-01 (IKK inhibitor XII) is an IKK inhibitor that inhibits IKK-α and IKK-ε, prolongs the lifespan of mice, and can be used to study immune disorders.</p>
    Fórmula:C19H16ClN3O3S
    Pureza:98.07% - 98.17%
    Cor e Forma:Solid
    Peso molecular:401.87

    Ref: TM-T11573

  • CAY10575
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    CAY10575

    CAS:
    <p>CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.</p>
    Fórmula:C22H21N3O6S2
    Cor e Forma:Solid
    Peso molecular:487.55

    Ref: TM-T26957

  • Bay 65-1942 hydrochloride
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    Bay 65-1942 hydrochloride

    CAS:
    <p>Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.</p>
    Fórmula:C22H26ClN3O4
    Cor e Forma:Solid
    Peso molecular:431.91

    Ref: TM-T14508

  • GSK319347A
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    GSK319347A

    CAS:
    <p>GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.</p>
    Fórmula:C22H19N3O5S2
    Pureza:98.42%
    Cor e Forma:Solid
    Peso molecular:469.53

    Ref: TM-T15558

  • CGA-JK3
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    CGA-JK3

    CAS:
    <p>CGA-JK3 is an IkappaB kinase inhibitor in innate immune process.</p>
    Fórmula:C15H19NO3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:261.32

    Ref: TM-T26989

  • IKK-IN-1
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    IKK-IN-1

    CAS:
    <p>IKK-IN-1 is an inhibitor of IKK.</p>
    Fórmula:C22H26ClN3O4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:431.91

    Ref: TM-T11633

  • PF 184
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    PF 184

    CAS:
    <p>IKKβ inhibitor</p>
    Fórmula:C32H32ClFN6O4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:619.09

    Ref: TM-T23137

  • (Rac)-BAY-985
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    (Rac)-BAY-985

    CAS:
    <p>(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.</p>
    Fórmula:C27H30F3N9O
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:553.58

    Ref: TM-T12659

  • Bay 65-1942 (R form)
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    Bay 65-1942 (R form)

    CAS:
    <p>Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is a selective and ATP-competitive IKKβ inhibitor.</p>
    Fórmula:C22H25N3O4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:395.45

    Ref: TM-T10472

  • ACHP Hydrochloride
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    ACHP Hydrochloride

    CAS:
    <p>ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.</p>
    Fórmula:C21H25ClN4O2
    Pureza:99.83%
    Cor e Forma:Solid
    Peso molecular:400.9

    Ref: TM-T10237

  • IKK-IN-4
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    IKK-IN-4

    CAS:
    <p>IKK-IN-4 is a potent and selective inhibitor of IkappaB kinase 2 with IC 50 values of 45 and 650 nM against IKKβ and IKKα, respectively [1].</p>
    Fórmula:C18H19N5S
    Cor e Forma:Solid
    Peso molecular:337.44

    Ref: TM-T61059

  • TBK1-IN-1
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    TBK1-IN-1

    CAS:
    <p>TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.</p>
    Fórmula:C27H37N7O2
    Pureza:>99.99%
    Cor e Forma:Solid
    Peso molecular:491.63

    Ref: TM-T73322

  • PF-184
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    PF-184

    <p>PF-184: potent IKK-2 inhibitor, selective over 30+ kinases; useful for asthma &amp; COPD research. IC50: 37 nM.</p>
    Fórmula:C32H32ClFN6O4
    Cor e Forma:Solid
    Peso molecular:619.09

    Ref: TM-T73470

  • Glabrescone C
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    Glabrescone C

    CAS:
    <p>Glabrescone C exhibits strong anti-inflammatory properties through direct binding to IKKα/β.</p>
    Fórmula:C19H22O7
    Cor e Forma:Solid
    Peso molecular:362.37

    Ref: TM-T72899

  • Logotipo do CymitQuimica
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    Anti-inflammatory agent 6

    <p>Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.</p>
    Fórmula:C22H20O12
    Cor e Forma:Solid
    Peso molecular:476.39

    Ref: TM-T63107

  • TBK1/IKKε-IN-1
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    TBK1/IKKε-IN-1

    CAS:
    <p>TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of &lt;100 nM).</p>
    Fórmula:C28H26N4O5
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:498.53

    Ref: TM-T13097

  • GTCpFE
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    GTCpFE

    CAS:
    <p>GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.</p>
    Fórmula:C22H20O8
    Cor e Forma:Solid
    Peso molecular:412.39

    Ref: TM-T200141