CCR
Os receptores de quimiocinas C-C (CCRs) são um grupo de GPCRs que respondem às quimiocinas, moléculas de sinalização que orientam a migração de células imunológicas para locais de inflamação ou infecção. Os CCRs desempenham papéis cruciais nas respostas imunológicas, inflamação e no desenvolvimento de várias doenças, incluindo distúrbios autoimunes e câncer. A modulação da atividade dos CCRs está sendo explorada como uma estratégia terapêutica para condições como artrite reumatoide, esclerose múltipla e infecção pelo HIV. Na CymitQuimica, oferecemos uma gama de moduladores de CCR de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Foram encontrados 136 produtos de "CCR"
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J-113863
CAS:<p>J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM).</p>Fórmula:C30H37Cl2IN2O2Pureza:95.11%Cor e Forma:SolidPeso molecular:655.44CCR2-RA-[R]
CAS:<p>CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).</p>Fórmula:C18H19ClFNO3Pureza:99.7%Cor e Forma:SolidPeso molecular:351.8RS102895 hydrochloride
CAS:<p>RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).</p>Fórmula:C21H22ClF3N2O2Pureza:98.95%Cor e Forma:SolidPeso molecular:426.86Leronlimab
CAS:<p>Leronlimab (PRO 140), a humanized IgG4 monoclonal antibody, targets CCR5 to combat HIV and cancer.</p>Pureza:SDS-PAGE:95.0%;SEC-HPLC:99.6%Cor e Forma:LiquidPeso molecular:146.66 kDaMogamulizumab
CAS:<p>Mogamulizumab is a monoclonal antibody targeting CC chemokine receptor 4 with anticancer effects, used in ATLL and CTCL studies.</p>Pureza:SDS-PAGE:97.3%;SEC-HPLC:99.4%Cor e Forma:LiquidPeso molecular:146.43 kDaML604086
CAS:<p>ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations.</p>Fórmula:C27H32N4O4SPureza:99.91%Cor e Forma:SolidPeso molecular:508.63INCB-9471
CAS:<p>INCB-9471 is a CCR5 antagonist with anti-HIV activity and inhibits the interaction between HIV-1 gp120.</p>Fórmula:C30H40F3N5O2Pureza:98.80%Cor e Forma:SolidPeso molecular:559.666MK-0812 Succinate
CAS:<p>MK-0812 Succinate is an effective and selective CCR2 antagonist.</p>Fórmula:C28H40F3N3O7Pureza:98.62% - 99.93%Cor e Forma:SolidPeso molecular:587.63CCX140
CAS:<p>CCX140 (CCX140-B) (CCX140-B) is an antagonist of CCR2.</p>Fórmula:C20H13ClF3N5O3SPureza:99.66% - 99.95%Cor e Forma:SolidPeso molecular:495.86AZ084
CAS:<p>AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.</p>Fórmula:C26H34N4O2Pureza:97.12%Cor e Forma:SolidPeso molecular:434.57CKLF1-C27 TFA
<p>CKLF1-C27 peptide activates ERK1/2 via CCR4, competes with CKLF1, promotes HUVEC growth, and has psoriasis research potential.</p>Fórmula:C153H244F3N39O39Cor e Forma:SolidPeso molecular:3310.8BMS-753426
CAS:<p>BMS-753426 is a potent and orally bioavailable antagonist of CCR2 .</p>Fórmula:C25H33F3N6O2Cor e Forma:SolidPeso molecular:506.574SQA1
CAS:<p>SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.</p>Fórmula:C22H26N4O5Cor e Forma:SolidPeso molecular:426.47PF-232798
CAS:<p>PF-232798 is a second generation oral CCR5 antagonist with potent broad-spectrum anti-HIV-1 activity.</p>Fórmula:C29H40FN5O2Cor e Forma:SolidPeso molecular:509.66INCB 3284 dimesylate
CAS:<p>INCB 3284 dimesylate: oral CCR2 antagonist, blocks MCP-1/hCCR2 binding (IC50: 3.7 nM), potential in acute liver failure research.</p>Fórmula:C28H39F3N4O10S2Pureza:98%Cor e Forma:SolidPeso molecular:712.76MLN-3897 TFA
<p>MLN-3897 TFA is a potent CCR1 antagonist that inhibits the binding of 125I-MIP-1α to THP-1 cell membranes.</p>Fórmula:C32H32ClF3N2O6Pureza:98.62%Cor e Forma:SolidPeso molecular:633.05Zn-DPA-maytansinoid conjugate 1
<p>Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.</p>Fórmula:C115H145ClN18O31S2Zn2Cor e Forma:SolidPeso molecular:2505.83Bertilimumab
CAS:<p>Bertilimumab (CAT 213; iCo-008), a human monoclonal antibody that targets eotaxin-1 (CCL11), shows promise in the research of allergic disorders [1].</p>Cor e Forma:LiquidMet-RANTES,human,acetate
<p>Met-RANTES (human) acetate is the acetate salt form of Met-RANTES (human). It acts as an antagonist for CCR1 and CCR5 receptors. This compound inhibits the human chemokines MIP-1α and MIP-1β, with respective IC50 values of 5 and 2 nM. Additionally, Met-RANTES (human) acetate reduces bone destruction and alleviates adjuvant-induced arthritis (AIA) in rats.</p>Cor e Forma:Odour SolidCCR4 antagonist 3
CAS:<p>Orally active CCR4 antagonist with piperidinyl-azetidine; IC50: 22 nM (calcium flux), 50 nM (CTX); antitumor effects.</p>Fórmula:C24H27Cl2N7OCor e Forma:SolidPeso molecular:500.43
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