CCR
Os receptores de quimiocinas C-C (CCRs) são um grupo de GPCRs que respondem às quimiocinas, moléculas de sinalização que orientam a migração de células imunológicas para locais de inflamação ou infecção. Os CCRs desempenham papéis cruciais nas respostas imunológicas, inflamação e no desenvolvimento de várias doenças, incluindo distúrbios autoimunes e câncer. A modulação da atividade dos CCRs está sendo explorada como uma estratégia terapêutica para condições como artrite reumatoide, esclerose múltipla e infecção pelo HIV. Na CymitQuimica, oferecemos uma gama de moduladores de CCR de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Foram encontrados 140 produtos de "CCR"
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J-113863
CAS:J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM).Fórmula:C30H37Cl2IN2O2Pureza:95.11%Cor e Forma:SolidPeso molecular:655.44Ref: TM-T11699
1mg56,00€2mg82,00€5mg119,00€10mg160,00€25mg288,00€50mg500,00€100mg718,00€1mL*10mM (DMSO)170,00€Mogamulizumab
CAS:Mogamulizumab is a monoclonal antibody targeting CC chemokine receptor 4 with anticancer effects, used in ATLL and CTCL studies.Pureza:SDS-PAGE:97.3%;SEC-HPLC:99.4%Cor e Forma:LiquidPeso molecular:146.43 kDaCCR2-RA-[R]
CAS:CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).Fórmula:C18H19ClFNO3Pureza:99.7%Cor e Forma:SolidPeso molecular:351.8RS102895 hydrochloride
CAS:RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).Fórmula:C21H22ClF3N2O2Pureza:98.95%Cor e Forma:SolidPeso molecular:426.86CCX140
CAS:CCX140 (CCX140-B) (CCX140-B) is an antagonist of CCR2.Fórmula:C20H13ClF3N5O3SPureza:99.66% - 99.95%Cor e Forma:SolidPeso molecular:495.86INCB-9471
CAS:INCB-9471 is a CCR5 antagonist with anti-HIV activity and inhibits the interaction between HIV-1 gp120.Fórmula:C30H40F3N5O2Pureza:98.80%Cor e Forma:SolidPeso molecular:559.666AZ084
CAS:AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.Fórmula:C26H34N4O2Pureza:97.12%Cor e Forma:SolidPeso molecular:434.57Ref: TM-T10425
1mg84,00€5mg161,00€10mg245,00€25mg406,00€50mg572,00€100mg772,00€200mg1.035,00€1mL*10mM (DMSO)172,00€MK-0812 Succinate
CAS:MK-0812 Succinate is an effective and selective CCR2 antagonist.Fórmula:C28H40F3N3O7Pureza:98.62% - 99.93%Cor e Forma:SolidPeso molecular:587.63Leronlimab
CAS:Leronlimab (PRO 140), a humanized IgG4 monoclonal antibody, targets CCR5 to combat HIV and cancer.Pureza:SDS-PAGE:95.0%;SEC-HPLC:99.6%Cor e Forma:LiquidPeso molecular:146.66 kDaML604086
CAS:ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations.Fórmula:C27H32N4O4SPureza:99.91%Cor e Forma:SolidPeso molecular:508.63INCB 3284 dimesylate
CAS:INCB 3284 dimesylate: oral CCR2 antagonist, blocks MCP-1/hCCR2 binding (IC50: 3.7 nM), potential in acute liver failure research.Fórmula:C28H39F3N4O10S2Pureza:98%Cor e Forma:SolidPeso molecular:712.76CCR4 antagonist 3 hydrochloride
CAS:Orally active CCR4 antagonist 3 hydrochloride with potent selectivity, IC50s: 22/50 nM; has antitumor properties.Fórmula:C24H27Cl2N7O·xHClCor e Forma:SolidCHS-114
CHS-114 (SRF-114) is a fully human IgG1 antibody targeting the (CCR8) receptor. It shows potential for research in head and neck squamous cell carcinoma (HNSCC). The isotype control for CHS-114 can be referred to as HumanIgG1kappa, Isotype Control.Cor e Forma:Odour LiquidCCR4 antagonist 3
CAS:Orally active CCR4 antagonist with piperidinyl-azetidine; IC50: 22 nM (calcium flux), 50 nM (CTX); antitumor effects.Fórmula:C24H27Cl2N7OCor e Forma:SolidPeso molecular:500.43HGS101
HGS101 is a fully humanized CCR5 monoclonal antibody that exhibits high affinity for CCR5. It binds to the second extracellular loop (ECL-2) and functions as a signaling antagonist. HGS101 restores the inhibitory effect of Maraviroc in Maraviroc-resistant HIV-1 infected PBMCs. In an uninfected simian immunodeficiency virus model of rhesus monkeys, HGS101 shows anti-HIV activity by inhibiting CCR5 signaling.Cor e Forma:Odour LiquidTagmokitug
CAS:Tagmokitug is a humanized IgG1κ monoclonal antibody inhibitor targeting CCR8. It exhibits anti-tumor activity and is applicable in cancer immunotherapy research, including studies on breast cancer, colon cancer, and lung cancer.INCB3344 R-isomer
INCB3344 is a potent CCR2 antagonist. INCB3344 R-isomer is the R-isomer of INCB3344.Fórmula:C29H34F3N3O6Pureza:98%Cor e Forma:SolidPeso molecular:577.59NI-0701
NI-0701 is a humanized antibody targeting CCL5/RANTES.Pureza:95.4% (SDS-PAGE); 99.4% (SEC-HPLC) - 95.4% (SDS-PAGE); 99.4% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:144.83 kDaNebokitug
Nebokitug is a humanized IgG1κ antibody targeting CCL24, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Cor e Forma:Odour LiquidCMKLR1 antagonist 1
CMKLR1 antagonist 1 (compound S-26d) is a potent, orally active antagonist of the chemokine-like receptor 1 (CMKLR1), exhibiting a pIC50 of 7.44 in hCMKLR1-Cor e Forma:Odour SolidSQA1
CAS:SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.Fórmula:C22H26N4O5Cor e Forma:SolidPeso molecular:426.47CCR2 antagonist 1
CAS:CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).Fórmula:C28H32BrF3N2OCor e Forma:SolidPeso molecular:549.47Denikitug
Denikitug is a chimeric antibody of the IgG1κ type that targets CCR8, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.Cor e Forma:Odour LiquidCH-0076989
CAS:CH-0076989 is a chemokine receptor CCR3 agonist.Fórmula:C24H22Br2N2O2Cor e Forma:SolidPeso molecular:530.25CCR8 agonist 1
CCR8 agonist1 (Compound 2) is an activator of CCR8 and is applicable in studies related to autoimmune diseases.Fórmula:C22H29NO3Cor e Forma:SolidPeso molecular:355.472-Methoxyhydroquinone
CAS:2-Methoxyhydroquinone inhibits MAO-A and MAO-B and reduces TNF-α-induced CCL2 production, a precursor for synthesising the Hsp90 inhibitor Geldanamycin.Fórmula:C7H8O3Pureza:98.25%Cor e Forma:SolidPeso molecular:140.14PF-232798
CAS:PF-232798 is a second generation oral CCR5 antagonist with potent broad-spectrum anti-HIV-1 activity.Fórmula:C29H40FN5O2Cor e Forma:SolidPeso molecular:509.66Met-RANTES,human,acetate
Met-RANTES (human) acetate is the acetate salt form of Met-RANTES (human). It acts as an antagonist for CCR1 and CCR5 receptors. This compound inhibits the human chemokines MIP-1α and MIP-1β, with respective IC50 values of 5 and 2 nM. Additionally, Met-RANTES (human) acetate reduces bone destruction and alleviates adjuvant-induced arthritis (AIA) in rats.Cor e Forma:Odour SolidCCR6 antagonist 1
CAS:CCR6 antagonist 1 blocks CCL20/CCR6, aiding autoimmune and IBD research.
Fórmula:C17H12F3NO2Pureza:99.83%Cor e Forma:SoildPeso molecular:319.28CCR8 antagonist 1
CAS:CCR8 antagonist 1 is an antagonist of C-C Motif Chemokine Receptor 8 (CCR8) with a Ki value of 1.6 nM.Fórmula:C26H29N3O5SPureza:99.51%Cor e Forma:SolidPeso molecular:495.59Bertilimumab
CAS:Bertilimumab (CAT 213; iCo-008), a human monoclonal antibody that targets eotaxin-1 (CCL11), shows promise in the research of allergic disorders [1].
Cor e Forma:LiquidZn-DPA-maytansinoid conjugate 1
Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.Fórmula:C115H145ClN18O31S2Zn2Cor e Forma:SolidPeso molecular:2505.83Cafelkibart
Cafelkibart is a chimeric IgG1κ monoclonal antibody targeting CCR8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Cor e Forma:Odour LiquidMaceneolignan H
CAS:Maceneolignan H, a neolignane from Myristica fragrans, selectively blocks CCR3 (EC50=1.4μM) with allergy research potential.Fórmula:C24H30O7Cor e Forma:SolidPeso molecular:430.49Lanerkitug
Lanerkitug is a humanized IgG1λ2 antibody that targets CCR8, with HumanIgG1lambda2, Isotype Control serving as its corresponding isotype control.Cor e Forma:Odour LiquidWAY-639418
CAS:WAY-639418 has potential anti-inflammatory and anti-HIV activity and can be used to study CCR5-mediated inflammatory and immunomodulatory diseases.Fórmula:C17H16ClN5Pureza:99.89%Cor e Forma:SolidPeso molecular:325.8BMS-753426
CAS:BMS-753426 is a potent and orally bioavailable antagonist of CCR2 .
Fórmula:C25H33F3N6O2Cor e Forma:SolidPeso molecular:506.574Chemokine Inhibitor Library
A unique collection of xnum chemokines or chemokine receptors targeted compounds for high throughput and high content screening;
Cor e Forma:Odour SolidMLN-3897 TFA
MLN-3897 TFA is a potent CCR1 antagonist that inhibits the binding of 125I-MIP-1α to THP-1 cell membranes.Fórmula:C32H32ClF3N2O6Pureza:98.62%Cor e Forma:SolidPeso molecular:633.05Ref: TM-T28072L
1mg115,00€5mg245,00€10mg363,00€25mg562,00€50mg775,00€100mg1.035,00€200mg1.406,00€1mL*10mM (DMSO)A consultarCCR6 antagonist 2
CCR6 antagonist2 (Compound 20c) acts as a CCR6 antagonist with a Ki of 1.1 nM. It inhibits CCL20-induced calcium influx with an IC50 of 4.9 nM and suppresses the chemotactic migration of CCR6+ T cells with an IC50 of 190 nM.Fórmula:C19H24N4O4Cor e Forma:SolidPeso molecular:372.42CKLF1-C27 TFA
CKLF1-C27 peptide activates ERK1/2 via CCR4, competes with CKLF1, promotes HUVEC growth, and has psoriasis research potential.Fórmula:C153H244F3N39O39Cor e Forma:SolidPeso molecular:3310.8Plozalizumab
CAS:Plozalizumab (MLN-1202) is a humanized selective and potent anti-CCR2 antibody.Plozalizumab has antitumor activity.Plozalizumab is used in the study of
Pureza:96.4%Cor e Forma:LiquidPeso molecular:146.02 kDaCCR6 inhibitor 1
CAS:CCR6 inhibitor 1 selectively blocks CCR6 (0.45 nM in monkeys, 6 nM in humans), aiding in vitro/vivo disease studies.
Fórmula:C24H23F3N4O3SPureza:99.89%Cor e Forma:SolidPeso molecular:504.52Vercirnon
CAS:Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.Fórmula:C22H21ClN2O4SPureza:99.23%Cor e Forma:SolidPeso molecular:444.93Ref: TM-T17225
1mg105,00€5mg259,00€10mg406,00€25mg680,00€50mg938,00€100mg1.301,00€500mg2.593,00€1mL*10mM (DMSO)363,00€AZD-4818
CAS:AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.Fórmula:C27H32Cl2N2O7Pureza:99.01%Cor e Forma:SolidPeso molecular:567.46BX471
CAS:BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist.Fórmula:C21H24ClFN4O3Pureza:98% - 99.98%Cor e Forma:SolidPeso molecular:434.89Ref: TM-T2375
1mg35,00€5mg86,00€10mg117,00€25mg200,00€50mg313,00€100mg489,00€200mg740,00€1mL*10mM (DMSO)95,00€Vicriviroc maleate
CAS:Vicriviroc maleate (SCH-417690 (maleate))(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus.Fórmula:C32H42F3N5O6Pureza:98.16% - 98.37%Cor e Forma:SolidPeso molecular:649.7SB297006
CAS:SB297006 is an antagonist of C-C chemokine receptor 3, which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ.Fórmula:C18H18N2O5Pureza:99.59%Cor e Forma:SolidPeso molecular:342.35RE-640
CAS:NSC-5844 (RE-640) (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.Fórmula:C20H16Cl2N4Pureza:99.60% - 99.87%Cor e Forma:SolidPeso molecular:383.27RS 504393
CAS:RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).Fórmula:C25H27N3O3Pureza:98.64% - 99.62%Cor e Forma:SolidPeso molecular:417.5
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