CCR
Os receptores de quimiocinas C-C (CCRs) são um grupo de GPCRs que respondem às quimiocinas, moléculas de sinalização que orientam a migração de células imunológicas para locais de inflamação ou infecção. Os CCRs desempenham papéis cruciais nas respostas imunológicas, inflamação e no desenvolvimento de várias doenças, incluindo distúrbios autoimunes e câncer. A modulação da atividade dos CCRs está sendo explorada como uma estratégia terapêutica para condições como artrite reumatoide, esclerose múltipla e infecção pelo HIV. Na CymitQuimica, oferecemos uma gama de moduladores de CCR de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Foram encontrados 140 produtos de "CCR"
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SB297006
CAS:SB297006 is an antagonist of C-C chemokine receptor 3, which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ.Fórmula:C18H18N2O5Pureza:99.59%Cor e Forma:SolidPeso molecular:342.35Vicriviroc
CAS:Vicriviroc, also known as MK4176 is a CCR5 antagonist.Fórmula:C28H38F3N5O2Cor e Forma:SolidPeso molecular:533.63CCR2 antagonist 4 hydrochloride
CAS:CCR2 antagonist 4 hydrochloride is a specific CCR2 antagonist (IC50s: 180 nM for CCR2b). It potently inhibits MCP-1-induced chemotaxis (IC50: 24 nM).Fórmula:C21H22Cl2F3N3O2Cor e Forma:SolidPeso molecular:476.32RS 504393
CAS:RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).Fórmula:C25H27N3O3Pureza:98.64% - 99.62%Cor e Forma:SolidPeso molecular:417.5Vercirnon sodium
CAS:Vercirnon (GSK1605786A) sodium: oral CCR9 antagonist, inhibits Ca2+ mobilization/chemotaxis, IC50 = 2.6-5.4 nM, selective for CCR9 vs. CCR1-12/CX3CR1-7.Fórmula:C22H21ClN2NaO4SCor e Forma:SolidPeso molecular:467.92RE-640
CAS:NSC-5844 (RE-640) (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.Fórmula:C20H16Cl2N4Pureza:99.60% - 99.87%Cor e Forma:SolidPeso molecular:383.27BMS-813160
CAS:BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.Fórmula:C25H40N8O2Pureza:99.66% - 99.79%Cor e Forma:SolidPeso molecular:484.64Ref: TM-T4584
1mg63,00€5mg137,00€10mg187,00€25mg341,00€50mg567,00€100mg810,00€500mg1.644,00€1mL*10mM (DMSO)145,00€DAPTA
CAS:DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.Fórmula:C35H56N10O15Pureza:>99.99%Cor e Forma:SolidPeso molecular:856.887,4'-Dihydroxyflavone
CAS:7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti.Fórmula:C15H10O4Pureza:99.39% - 99.6%Cor e Forma:SolidPeso molecular:254.24PF-4136309
CAS:PF-4136309 (INCB8761) is a specific, effective, and orally bioavailable CCR2 antagonist.Fórmula:C29H31F3N6O3Pureza:98.85% - 99.47%Cor e Forma:SolidPeso molecular:568.59C-021
CAS:C 021 dihydrochloride is a potent CCR4 antagonist.Fórmula:C27H41N5O2Pureza:99.74% - 99.90%Cor e Forma:SolidPeso molecular:467.65Ref: TM-T21870
1mg49,00€2mg67,00€5mg90,00€10mg144,00€25mg286,00€50mg444,00€100mg622,00€1mL*10mM (DMSO)90,00€Maraviroc
CAS:Maraviroc: a CCR5 antagonist blocking HIV-1 entry; IC50s—MIP-1α: 3.3nM, MIP-1β: 7.2nM, RANTES: 5.2nM.Fórmula:C29H41F2N5OPureza:97.13% - 99.59%Cor e Forma:Brown SolidPeso molecular:513.67Ref: TM-T6016
5mg49,00€10mg90,00€25mg152,00€50mg259,00€100mg465,00€200mg600,00€500mg945,00€1mL*10mM (DMSO)56,00€Vercirnon
CAS:Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.Fórmula:C22H21ClN2O4SPureza:99.23%Cor e Forma:SolidPeso molecular:444.93Ref: TM-T17225
1mg105,00€5mg259,00€10mg406,00€25mg680,00€50mg938,00€100mg1.301,00€500mg2.593,00€1mL*10mM (DMSO)363,00€AZD-4818
CAS:AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.Fórmula:C27H32Cl2N2O7Pureza:99.01%Cor e Forma:SolidPeso molecular:567.46RS102895
CAS:RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.Fórmula:C21H21F3N2O2Pureza:97.64% - 99.80%Cor e Forma:SolidPeso molecular:390.4TAK-779
CAS:TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).Fórmula:C33H39ClN2O2Pureza:99.21%Cor e Forma:SolidPeso molecular:531.13INCB 3284
CAS:INCB 3284, a potent human CCR2 antagonist with an IC50 of 3.7 nM, is researchable for acute liver failure and inhibits MCP-1/hCCR2 binding.Fórmula:C26H31F3N4O4Pureza:97.81% - 99.42%Cor e Forma:SolidPeso molecular:520.54Tivumecirnon
CAS:Tivumecirnon (FLX475) is a selective and oral CCR4 antagonist inhibits the infiltration and migration of Treg into the tumour microenvironment, antitumourFórmula:C24H27Cl2F3N6OPureza:99.88%Cor e Forma:SolidPeso molecular:543.41Ref: TM-T69834
1mg171,00€5mg418,00€10mg666,00€25mg1.334,00€50mg2.071,00€100mg2.879,00€1mL*10mM (DMSO)500,00€CCR1 antagonist 7
CAS:CCR1 antagonist 7 (compound 16r) is an antagonist of chemokine receptor 1 (CCR1) with an IC 50 of 4 nM [1].Fórmula:C21H24ClN5O3SPureza:98%Cor e Forma:SolidPeso molecular:461.96YM022
CAS:YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist.Fórmula:C32H28N4O3Pureza:98%Cor e Forma:SolidPeso molecular:516.59TAK-220
CAS:TAK-220: Oral CCR5 antagonist. IC50: 3.5 nM (RANTES), 1.4 nM (MIP-1α).Fórmula:C31H41ClN4O3Pureza:98%Cor e Forma:SolidPeso molecular:553.14MLN3126
CAS:MLN3126: Oral CCR9 blocker, hinders CCL25-triggered chemotaxis/thymocyte calcium influx, IC50 of 6.3 nM.Fórmula:C21H19ClN2O5SCor e Forma:SolidPeso molecular:446.9AZD-1678
CAS:AZD-1678 is a potent CCR4 receptor antagonist.Fórmula:C11H8Cl2FN3O3SCor e Forma:SolidPeso molecular:352.17CCR1 antagonist 9
CAS:CCR1 antagonist 9 (compound 19e) is a selective CCR1 antagonist based on aziridine. CCR1 inhibition in calcium flux assays.Fórmula:C20H16FN5O3SPureza:99.13%Cor e Forma:SolidPeso molecular:425.44Ref: TM-T10710
1mg101,00€5mg241,00€10mg402,00€25mg727,00€50mg1.046,00€100mg1.525,00€1mL*10mM (DMSO)265,00€ALK4290
CAS:ALK4290 (AKST4290), a potent oral CCR3 inhibitor with a Ki of 3.2 nM, may treat macular degeneration and Parkinsonism.Fórmula:C27H34ClN5O3Cor e Forma:SolidPeso molecular:512.04RPT193
CAS:RPT193 is an oral CCR4 inhibitor reducing Th2 cell migration in atopic dermatitis, asthma, and allergies.Fórmula:C27H34Cl3N5O2Cor e Forma:SolidPeso molecular:566.95CCR8 antagonist 2
CAS:CCR8 antagonist 2 blocks CCR8 activity, mainly on Treg and Th2 cells, for treating related diseases. See WO2022000443A1, compound 220.Fórmula:C23H30ClN3O3SCor e Forma:SolidPeso molecular:464.02BI-6901
CAS:BI-6901 is a CCR10 antagonist. In a mouse model of DNFB exposure hypersensitivity, BI 6901 displays its anti-inflammatory response in a dose-dependent manner.Fórmula:C23H27N5O3SPureza:99.83% - 99.94%Cor e Forma:SolidPeso molecular:453.56CCR2 antagonist 3
CAS:CCR2 antagonist 3 (AZD-2927) is an antagonist of CCR2.Fórmula:C17H25FN2O2Pureza:99.87%Cor e Forma:SolidPeso molecular:308.39Ref: TM-T10712
1mg66,00€5mg147,00€10mg225,00€25mg398,00€50mg532,00€100mg745,00€200mg982,00€1mL*10mM (DMSO)161,00€CCR4 antagonist 3-1
CAS:CCR4 antagonist 3-1 is a weak inhibitor of [125I]TARC binding and CEM cell migration, with IC50 values of 1.7 μM and 6.4 μM, respectively.
Fórmula:C14H12N2SPureza:99.53%Cor e Forma:SolidPeso molecular:240.32PNU-177864 hydrochloride
CAS:PNU-177864 hydrochloride is a potent, selective and orally active antagonist of dopamine D3 receptor.
Fórmula:C18H22ClF3N2O3SPureza:99.95%Cor e Forma:SolidPeso molecular:438.89PNU-177864
CAS:PNU-177864 is a selective dopamine D3 receptor antagonist.Fórmula:C18H21F3N2O3SPureza:99.92%Cor e Forma:SolidPeso molecular:402.43C-021 dihydrochloride
CAS:C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM.Fórmula:C27H43Cl2N5O2Pureza:98.67%Cor e Forma:SolidPeso molecular:540.57CCX354
CAS:CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis.Fórmula:C22H22ClN7O2Pureza:99.43% - 99.44%Cor e Forma:SolidPeso molecular:451.91APC-3316 tosylate
CAS:APC-3316 tosylate is a vinyl sulfone cysteine protease inhibitor and selective CCR4 antagonist.Fórmula:C39H46N4O7S2Cor e Forma:SolidPeso molecular:746.94GW 766994
CAS:GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.Fórmula:C21H24Cl2N4O3Pureza:98.77%Cor e Forma:SolidPeso molecular:451.35AF-399/42018025
CAS:AF-399/42018025 is a small-molecule CCR4 antagonist applied to investigate chemokine-mediated immune cell trafficking and inflammatory disease mechanisms.Fórmula:C26H16ClN3O4S3Pureza:99.96%Cor e Forma:SolidPeso molecular:566.07BMS-457
CAS:BMS-457 is a potent, CCR1-selective antagonist.Fórmula:C24H35ClN2O4Pureza:98%Cor e Forma:SolidPeso molecular:451JNJ-27141491
CAS:JNJ-27141491 is a potent, noncompetitive antagonist of human CCR2.Fórmula:C17H15F2N3O3SPureza:98%Cor e Forma:SolidPeso molecular:379.38Cosalane
CAS:Cosalane (NSC 658586) is an HIV replication inhibitor and an inhibitor of chemokine receptor 7 (CCR7) signalling in humans and mice.Fórmula:C45H60Cl2O6Pureza:99.53% - 99.78%Cor e Forma:SolidPeso molecular:767.86Ancriviroc
CAS:Ancriviroc (SCH-351125) is an orally bioavailable small molecule chemokine receptor CCR5 antagonist.Cost-effective and quality-assured.Fórmula:C28H37BrN4O3Pureza:99.76% - 99.82%Cor e Forma:SolidPeso molecular:557.533CCR2 antagonist 5
CAS:JNJ-41443532: oral hCCR2 antagonist, IC50=37 nM, anti-chemotaxis, treats inflammation & diabetes.Fórmula:C22H25F3N4O3SPureza:99.98%Cor e Forma:SolidPeso molecular:482.52BMS-817399
CAS:BMS-817399: oral CCR1 antagonist with binding and chemotaxis inhibition IC50s, potential for rheumatoid arthritis research.Fórmula:C23H36ClN3O4Pureza:99.7%Cor e Forma:SolidPeso molecular:454Ref: TM-T26861
1mg152,00€5mg319,00€10mg485,00€25mg770,00€50mg1.035,00€100mg1.395,00€1mL*10mM (DMSO)356,00€SB 328437
CAS:SB 328437 ((S)-methyl 2-(1-naphthamido)-3-(4-nitrophenyl)propanoate) is an effective and selective antagonist of CCR3 (IC50 = 4.5 nM).Fórmula:C21H18N2O5Pureza:99.54%Cor e Forma:SolidPeso molecular:378.38Ref: TM-T23321
1mg39,00€5mg82,00€10mg123,00€25mg250,00€50mg394,00€100mg618,00€200mg874,00€1mL*10mM (DMSO)69,00€BMS CCR2 22
CAS:BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.Fórmula:C28H34F3N5O4SPureza:99.65%Cor e Forma:SolidPeso molecular:593.66Ref: TM-T14688
1mg55,00€5mg110,00€10mg173,00€25mg349,00€50mg532,00€100mg718,00€200mg964,00€1mL*10mM (DMSO)147,00€GSK2239633A
CAS:GSK2239633A is an allosteric antagonist of CC-chemokine receptor 4 (CCR4) with a pIC50 of 7.96 for the binding of [125I]-TARC to human CCR4.Fórmula:C24H25ClN4O5S2Pureza:99.82%Cor e Forma:SolidPeso molecular:549.06Ref: TM-T11481
1mg35,00€5mg79,00€10mg118,00€25mg245,00€50mg355,00€100mg515,00€500mgA consultar1mL*10mM (DMSO)87,00€CCR1 antagonist 6
CAS:CCR1 antagonist 6 is a CCR1 antagonist (IC50: 3 nM).
Fórmula:C21H23ClN4O3SPureza:99.02% - 99.15%Cor e Forma:SolidPeso molecular:446.95Tanimilast
CAS:Tanimilast (CHF-6001) is a potent PDE4 inhibitor with IC50 of 0.026 nM, used topically for obstructive lung disease.Fórmula:C30H30Cl2F2N2O8SPureza:99.18%Cor e Forma:SolidPeso molecular:687.54CCR4 antagonist 4
CAS:CCR4 Antagonist 4 (Compound 22) is a potent and selective antagonist of the CC chemokine receptor-4 (CCR4), displaying an IC50 value of 0.02 μM. It also inhibits MDC-mediated chemotaxis and Ca2+ mobilization, with IC50 values of 0.007 μM and 0.003 μM, respectively. This compound is utilized in research on allergic inflammation [1].Fórmula:C24H27Cl2N7OCor e Forma:SolidPeso molecular:500.42MLN-3897
CAS:MLN-3897 is an oral CCR1 antagonist, Ki 2.3 nM, blocks 125I-MIP-1α binding, and inhibits Akt signaling in MM cells.Fórmula:C30H31ClN2O4Pureza:98.62%Cor e Forma:SolidPeso molecular:519.03
