PGE Sintase

<p>Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.</p>

<p>Bismuth Subsalicylate, Pepto-Bismol's active ingredient, treats nausea, heartburn, indigestion, diarrhea, and stomach upset.</p>

<p>Pranoprofen (Pyranoprofen) (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology.</p>

<p>Zomepirac sodium salt (McN-2783-21-98) is a prostaglandin synthetase inhibitor.</p>

<p>Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.</p>

<p>Benzydamine hydrochloride (AF864), a locally-acting nonsteroidal anti-inflammatory drug, has local anaesthetic and analgesic properties.</p>

<p>Prostaglandin D synthase is a biomarker for meningioma cells and coronary artery disease. Lipocalin-type prostaglandin D synthase (L-PGDS) is found in human coronary atherosclerotic plaques and can be detected in human serum.</p>

<p>ADP-β-S (trisodium) is an analog of ADP and acts as a partial agonist. It can induce human platelet aggregation and inhibit PGE1-stimulated adenylate cyclase.</p>

<p>PF-9184 inhibits human mPGES-1 selectively, with an IC50 of 16.5 nM, and reduces IL-1β-stimulated PGE2 production in vitro.</p>

<p>AGU654 (Compound 44) is a selective mPGES-1 inhibitor with an IC50 value of 2.9 nM against mPGES-1. By inhibiting mPGES-1, AGU654 interrupts the pathway where COX-1/2 converts arachidonic acid to prostaglandin E2 (PGE2), effectively reducing inflammatory responses, pain, and fever symptoms. In models using activated human monocyte-derived macrophages and whole blood, AGU654 selectively inhibits PGE2 production induced by bacterial endotoxins, while preserving the production of other prostaglandins. In guinea pig models, AGU654 significantly alleviates fever, inflammation, and inflammatory pain, demonstrating excellent anti-inflammatory, analgesic, and antipyretic effects. AGU654 holds promise as a new approach for researching inflammatory diseases and pain.</p>

<p>Furprofen, an NSAID, inhibits PGE synthesis, offers analgesic effects, and is orally taken for pain relief.</p>

<p>Suprofen (Suprol) is an IBUPROFEN-type anti-inflammatory analgesic and antipyretic.</p>

<p>HPGDS inhibitor 1 is a novel and selective inhibitor for Hematopoietic Prostaglandin D Synthase (HPGDS) with an IC50 Value of 0.7 nM.</p>

<p>Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro.</p>

<p>CAY10526 (BTH) is a selective mPGES-1 inhibitor that acts as an inhibitor of the NF-κB signaling pathway.</p>

<p>PGS-IN-1 (KME-4) is a potent inhibitor of prostaglandin synthetase (PGS, IC50: 0.28 μM) and 5-lipoxygenase (IC50: 1.05 μM).</p>

<p>AT56, a specific inhibitor of prostaglandin D2 synthase enzymatic activity, blunted adipogenic aldosterone effects.</p>

<p>HPGDS inhibitor 2 (GSK-2894631A) is a potent, selective hematopoietic prostaglandin D synthase (h-pgds) inhibitor, IC50 = 9.9 nm.</p>

<p>Limaprost (17α,20-dimethyl-δ2-PGE1) is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency.It is a</p>

<p>Sinensetin, a citrus flavone, has antiangiogenic, anti-inflammatory properties, and promotes fat formation and breakdown.</p>

<p>hPGDS-IN-1 is a hPGDS inhibitor.</p>

<p>Esflurbiprofen is an inhibitor of COX-1 and COX-2.</p>

<p>Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant</p>

<p>Cafestol, an ERK inhibitor, suppresses PGE2 and COX-2 by blocking NF-kB in LPS-stimulated RAW264.7 cells.</p>

<p>mPGES-1 Inhibitor-1 is an mPGES-1 inhibitor with anti-inflammatory and analgesic activity, which can be used to study acute liver injury.</p>

<p>F092 is a potent inhibitor of hematopoietic prostaglandin D synthetase (H-PGDS), which can be used to study allergic inflammation and vascular-related diseases.</p>

<p>Friluglanstat is an inhibitor of the enzyme prostaglandin E synthase (mPGES-1) and exhibits anti-inflammatory activity [1].</p>

<p>mPGES1-IN-3 is a potent and selective inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) .</p>

<p>mPGES1-IN-9 (compound 1_8) is an mPGES1 inhibitor with an IC50 of 0.5 μM and is utilized in anti-inflammatory research.</p>

<p>α-Gracinoic acid acts as an inhibitor of mPGES-1, exhibiting anti-inflammatory properties.</p>

<p>PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM).</p>