Nrf2
Nrf2 é um fator de transcrição que regula a expressão de proteínas antioxidantes e enzimas de desintoxicação, desempenhando um papel fundamental na defesa celular contra o estresse oxidativo e a inflamação. A ativação da sinalização Nrf2 oferece proteção contra várias doenças, incluindo câncer, neurodegeneração e distúrbios cardiovasculares. Os moduladores de Nrf2 estão sendo explorados por suas potenciais aplicações terapêuticas na redução de danos oxidativos e inflamação. Na CymitQuimica, oferecemos uma gama de moduladores da via Nrf2 de alta qualidade para apoiar sua pesquisa em estresse oxidativo, inflamação e prevenção de doenças.
Foram encontrados 78 produtos de "Nrf2"
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NK-252
CAS:<p>NK-252 is a potential activator of Nrf2. It has great Nrf2-activating potential.</p>Fórmula:C13H11N5O3Pureza:98.32%Cor e Forma:SolidPeso molecular:285.26AA147
CAS:<p>AA147 is an ER proteostasis regulator that selectively activates the ATF6 arm of UPR as a prodrug.</p>Fórmula:C16H17NO2Pureza:99.24%Cor e Forma:SolidPeso molecular:255.31(E/Z)-BCI
CAS:<p>(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS</p>Fórmula:C22H23NOPureza:99.94%Cor e Forma:SolidPeso molecular:317.42BPK-29 hydrochloride
CAS:<p>"BPK-29 hydrochloride targets NR0B1, altering C274 and hinders KEAP1-mutant cancer cell growth."</p>Fórmula:C26H33Cl2N3O3Pureza:99.06%Cor e Forma:SolidPeso molecular:506.46Ezetimibe
CAS:<p>Ezetimibe (SCH 58235) is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption.</p>Fórmula:C24H21F2NO3Pureza:97.28% - 99.77%Cor e Forma:SolidPeso molecular:409.43Fraxinellone analog 1
<p>Fraxinellone analog 1 (compound 2) is an effective and rapid activator of the Nrf2-mediated antioxidative defense system, providing protection against glutamate-mediated excitotoxicity. It induces the expression of antioxidative genes Gpx4, Sod1, and Nqo1. Additionally, Fraxinellone analog 1 exerts neuroprotective effects and modulates oxidative stress and inflammation, making it suitable for research on neurodegenerative diseases.</p>Cor e Forma:Odour SolidNrf2 activator 18
<p>Nrf2 activator 18 (Compound 11a) is an orally active activator of the Keap1/Nrf2/HO-1 signaling pathway, promoting Nrf2 nuclear translocation and enhancing antioxidant effects. It inhibits IL-6 release with an IC50 of 4.816 μM. In a mouse model of PM2.5-induced lung injury, Nrf2 activator 18 demonstrates anti-inflammatory activity.</p>Fórmula:C23H24FN3OCor e Forma:SolidPeso molecular:377.45TPNA10168
CAS:<p>Compound Fr13590, with CAS No. 957942-34-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr13590 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Fórmula:C9H9ClO2S2Cor e Forma:SolidPeso molecular:248.75His-Pro
CAS:<p>His-Pro is a dipeptide consisting of histidyl and proline.</p>Fórmula:C11H16N4O3Pureza:98%Cor e Forma:SolidPeso molecular:252.27Nrf2 activator-1
CAS:<p>Nrf2 activator-1 activates Nrf2; used for COPD, asthma, ALI, ARDS, pulmonary fibrosis research.</p>Fórmula:C30H34N4O6SPureza:97.8%Cor e Forma:SolidPeso molecular:578.68Nrf2/HO-1 activator 3
<p>Nrf2/HO-1 Activator 3 (Compound C3a) is an activator of the Nrf2 signaling pathway that facilitates the translocation of Nrf2 into the nucleus and enhances the expression of heme oxygenase-1 (HO-1). In H9c2 cardiomyocytes subjected to H2O2 or high glucose stimulation, Nrf2/HO-1 Activator 3 inhibits the excessive expression of ROS and MDA, suppressing cell viability and colony formation, thereby exhibiting antioxidant activity.</p>Fórmula:C27H26N2O6Cor e Forma:SolidPeso molecular:474.51Butan-1-amine hydrochloride
CAS:<p>1-Butylamine hydrochloride,butylamine, a potential agonist of Nrf2/ARE (Nuclear Factor Erythroid 2 Associated Factor 2/Antioxidant Response Element).</p>Fórmula:C4H12ClNCor e Forma:SolidPeso molecular:109.6Keap1/Nrf2/ARE activator 1
<p>Keap1/Nrf2/ARE activator 1 (compound HT-3) functions as an activator of the Keap1/Nrf2/ARE pathway. This compound has antioxidant properties and offers neuroprotective effects.</p>Fórmula:C19H20O6Cor e Forma:SolidPeso molecular:344.12599Eriodictyol-7-O-glucoside
CAS:<p>Eriodictyol-7-O-glucoside, a flavonoid in pistachio skin, activates Nrf2 and protects against Cisplatin toxicity.</p>Fórmula:C21H22O11Pureza:99.53%Cor e Forma:SolidPeso molecular:450.39Nrf2 activator-8
<p>Nrf2 Activator-8 (Compound 10e), with an EC50 of 37.9 nM, is a potent Nrf2 activator that demonstrates significant antioxidant and anti-inflammatory properties</p>Fórmula:C13H11ClN2O3SCor e Forma:SolidPeso molecular:310.76Nrf2 degrader 1
CAS:<p>Nrf2 degrader 1 (compound 1), a PROTAC Nrf2 degrader, exhibits anticancer properties by inhibiting the growth of cancer cells. It demonstrates IC 50 values of 100 nM for A549 cells and 40 nM for LK-2 cells, indicating potent efficacy [1].</p>Fórmula:C45H42N6O8SCor e Forma:SolidPeso molecular:826.92Ac-LDEETGEFL-NH2
CAS:<p>Ac-LDEETGEFL-NH2 is a fluorescent molecule designed to target the interaction between the Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor</p>Fórmula:C48H72N10O19Cor e Forma:SolidPeso molecular:1093.144-P-PDOT
CAS:<p>4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.</p>Fórmula:C19H21NOPureza:99.91%Cor e Forma:SolidPeso molecular:279.3817-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
CAS:<p>Aspirin-enhanced COX-2 metabolite of DHA, activates Nrf2 and PPARγ, inhibits inflammation, with EC50 ~200 nM, effective at 5-25 μM.</p>Fórmula:C22H30O3Cor e Forma:SolidPeso molecular:342.479Pterisolic acid B
<p>Pterisolic acid B is a useful organic compound for research related to life sciences and the catalog number is T125924.</p>Fórmula:C20H26O4Cor e Forma:SolidPeso molecular:330.424TAT 14
CAS:<p>TAT 14: a 14-mer peptide Nrf2 activator, anti-inflammatory, boosts Nrf2 protein, targets Keap1, no effect on mRNA.</p>Fórmula:C137H230N48O39Pureza:98%Cor e Forma:SolidPeso molecular:3173.59S217879
<p>S217879 is a potent and selective activator of NRF2 that disrupts the KEAP1-NRF2 interaction, resulting in significant activation of the NRF2 pathway.</p>Fórmula:C29H30N4O7SCor e Forma:SolidPeso molecular:578.64Keap1-Nrf2-IN-9
CAS:<p>Keap1-Nrf2-IN-9 inhibits Keap1-Nrf2 PPI with 0.575 µM IC50, boosts Nrf2 genes, non-toxic in ARPE19 cells.</p>Fórmula:C31H30N2O11S2Cor e Forma:SolidPeso molecular:670.71Deacetylgedunin
CAS:<p>Deacetylgedunin is a limonoid that is the 7-deacetyl derivative of gedunin. It has been isolated from Azadirachta indica.</p>Fórmula:C26H32O6Cor e Forma:SolidPeso molecular:440.53Anticonvulsant agent 10
<p>Anticonvulsant agent 10 (Compound 6d) is an inhibitor targeting the Keap1-Nrf2 interaction, with a strong activity showing an ED50 of 0.04 mmol/kg. By inhibiting the Keap1-Nrf2 binding, it activates the Nrf2/ARE pathway, providing anticonvulsant and neuroprotective effects, making it useful for research in epilepsy and neuroprotection.</p>Cor e Forma:Odour SolidKeap1-IN-1
<p>Keap1-IN-1 (Compound 27) is an inhibitor of Keap1, functioning by covalently modifying the Cys151 residue on the BTB domain of KEAP1, thereby disrupting the interaction between Keap and Nrf. It enhances the mRNA expression of the antioxidant response element (ARE) dependent gene NQO1, with an EC50 of 160 nM, and exhibits cytotoxicity in U2OS cells, with an EC50 of 527 nM.</p>Fórmula:C17H21Cl2N2O5PS3Cor e Forma:SolidPeso molecular:531.434Keap1-Nrf2-IN-3
CAS:<p>Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein protein interaction inhibitor, and with a K d value of 2.5 nM for KEAP1 protein.</p>Fórmula:C31H34N6O3Cor e Forma:SolidPeso molecular:538.652Keap1-Nrf2-IN-27
<p>Keap1-Nrf2-IN-27 is an inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI) with a KD2 value of 0.119 μM. It suppresses the expression of pro-inflammatory cytokines TNF-α and IL-6 in an LPS-induced RAW264.7 cell model.</p>Cor e Forma:Odour SolidMonascin
CAS:<p>Monascin: azaphilonoid in red-mold rice; anti-tumor and anti-inflammatory.</p>Fórmula:C21H26O5Pureza:98%Cor e Forma:SolidPeso molecular:358.43CBR-470-2
CAS:<p>CBR-470-2 activates NRF2 signaling, aiding in glycolysis research.</p>Fórmula:C12H13Cl2NO6S2Cor e Forma:SolidPeso molecular:402.26KI696 isomer
CAS:<p>KI696 isomer is an isomer of KI696, a low affinity probe for the study of immune and metabolic diseases.</p>Fórmula:C28H30N4O6SPureza:99.8%Cor e Forma:SolidPeso molecular:550.63ML334
CAS:<p>ML334 (LH601A) is an NRF2 activator that inhibits cardiac fibroblast activation and proliferation ameliorating myocardial infarction-induced cardiac fibrosis.</p>Fórmula:C26H26N2O5Pureza:98.06% - 98.06%Cor e Forma:SolidPeso molecular:446.49I-152
CAS:<p>Bepranemab (UCB 0107) is a humanized IgG monoclonal antibody against tau for the study of Alzheimer's disease (AD) and tau proteinopathies.</p>Fórmula:C9H16N2O3S2Pureza:98.36%Cor e Forma:SolidPeso molecular:264.37Anti-NFE2L2 Antibody (9K94)
<p>Anti-NFE2L2 Antibody (9K94) is a Mouse antibody targeting NFE2L2. Anti-NFE2L2 Antibody (9K94) can be used in ELISA, WB, IHC, IF, FCM.</p>Pureza:>95%Cor e Forma:Odour LiquidAnti-Phospho-NFE2L2 (Ser40) Antibody (6V851)
<p>Anti-Phospho-NFE2L2 (Ser40) Antibody (6V851) is an antibody targeting Phospho-NFE2L2 (Ser40). Anti-Phospho-NFE2L2 (Ser40) Antibody (6V851) can be used in ELISA, WB, IHC, IF.</p>Cor e Forma:Odour LiquidAnti-NFE2L2 Antibody (6K859)
<p>Anti-NFE2L2 Antibody (6K859) is an antibody targeting NFE2L2. Anti-NFE2L2 Antibody (6K859) can be used in ELISA, IF.</p>Cor e Forma:Odour LiquidDimethyl fumarate-d6
CAS:<p>Dimethyl fumarate D6 is a deuterium labeled Dimethyl fumarate. can induces upregulation of antioxidant gene expression.</p>Fórmula:C6H8O4Pureza:98%Cor e Forma:SolidPeso molecular:150.16Artemisitene
CAS:<p>Artemisitene, an oxidized antimalarial derivative of Artemisinin, stems from precursors like Artemisinin B and Artemisinic acid.</p>Fórmula:C15H20O5Pureza:99.58%Cor e Forma:SolidPeso molecular:280.32AEM1
CAS:<p>AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer.</p>Fórmula:C20H14FN3O2SPureza:98.37% - 99.88%Cor e Forma:SolidPeso molecular:379.41ML162
CAS:<p>ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor that induces ferroptosis. ML162 has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C23H22Cl2N2O3SPureza:98.42% - 99.55%Cor e Forma:SolidPeso molecular:477.4Diroximel fumarate
CAS:<p>Diroximel fumarate (Diroximel Fumarete), a prodrug of monomethyl fumarate in a controlled-release formulation, rapidly and potently converts to MMF in the body.</p>Fórmula:C11H13NO6Pureza:99.8% - 99.88%Cor e Forma:SolidPeso molecular:255.22Trilobatin
CAS:<p>Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially</p>Fórmula:C21H24O10Pureza:97.16%Cor e Forma:SolidPeso molecular:436.414-Octyl itaconate
CAS:<p>4-Octyl Itaconate is a cell-permeable derivative of Itaconate, an anti-inflammatory metabolite.</p>Fórmula:C13H22O4Pureza:99.3% - 99.94%Cor e Forma:SolidPeso molecular:242.31Kinsenoside
CAS:<p>Kinsenoside ((+)-Kinsenoside) shows significant antihepatotoxic, and anti-inflammatory activities.</p>Fórmula:C10H16O8Pureza:99.2% - >99.99%Cor e Forma:SolidPeso molecular:264.23Brusatol
CAS:<p>Brusatol (NSC-172924) is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.</p>Fórmula:C26H32O11Pureza:99.35% - 99.95%Cor e Forma:SolidPeso molecular:520.53CBR-470-1
CAS:<p>CBR-470-1 is a glycolytic phosphoglycerate kinase 1 inhibitor and Nrf2 activator that exhibits neuroprotective activity by activating the Keap1-Nrf2 cascade.</p>Fórmula:C14H20ClNO4S2Pureza:98.87%Cor e Forma:SolidPeso molecular:365.9L-Cystine dihydrochloride
CAS:<p>L-Cystine dihydrochloride, a sulfur-based glutathione precursor, maintains GSH balance, used in cell culture.</p>Fórmula:C6H14Cl2N2O4S2Pureza:99.58%Cor e Forma:SolidPeso molecular:313.22MIND4-17
CAS:<p>MIND4-17 activates NRF2 by binding Keap1 C151, blocking Keap1-Nrf2, stabilizes Nrf2, and promotes its nuclear entry, with strong antioxidant effects.</p>Fórmula:C20H15N5O3SCor e Forma:SolidPeso molecular:405.43Nrf2-Activator-12G
CAS:<p>Nrf2-Activator-12G is a potent Nrf-2 activator.</p>Fórmula:C15H13ClO3SPureza:98%Cor e Forma:SolidPeso molecular:308.78MSU38225
CAS:<p>MSU38225, an Nrf-2 inhibitor, elevates reactive oxygen species (ROS) levels and suppresses the proliferation of human lung cancer cells.</p>Fórmula:C21H19N3Cor e Forma:SolidPeso molecular:313.4
