CXCR
Os CXCRs são uma subclasse de GPCRs que se ligam a quimiocinas, pequenas proteínas sinalizadoras que guiam o movimento de células imunológicas em direção a locais de inflamação, infecção ou lesão. Os CXCRs desempenham papéis cruciais nas respostas imunológicas, metástase do câncer e doenças inflamatórias. Moduladores de CXCRs estão sendo investigados por seu potencial no tratamento de doenças autoimunes, câncer e condições inflamatórias crônicas. Na CymitQuimica, oferecemos uma gama de moduladores de CXCRs de alta qualidade para apoiar sua pesquisa em imunologia, oncologia e inflamação.
Foram encontrados 157 produtos de "CXCR"
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KRH-1636
CAS:KRH-1636: potent, selective CXCR4 antagonist; orally active; inhibits X4 HIV-1 by blocking viral entry and membrane fusion.Fórmula:C32H37N7O2Cor e Forma:SolidPeso molecular:551.68IT1t
CAS:IT1t inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. is a potent CXCR4 antagonist.Fórmula:C21H34N4S2Pureza:98%Cor e Forma:SolidPeso molecular:406.65SRT3190
CAS:SRT3190 is an antagonist of CXCR2.Fórmula:C18H23F2N5O4S2Pureza:98%Cor e Forma:SolidPeso molecular:475.53Burixafor hydrobromide
CAS:<p>Burixafor hydrobromide is an oral CXCR4 blocker with anti-angiogenic properties, potentially treating choroid neovascularization.</p>Fórmula:C27H52BrN8O3PPureza:98%Cor e Forma:SolidPeso molecular:647.644VUF5834
CAS:VUF5834 is a full inverse agonist of CXCR3 N3.35A.Fórmula:C31H41N5O2Pureza:98%Cor e Forma:SolidPeso molecular:515.69GSK812397
CAS:GSK812397 inhibits X4-tropic HIV-1 with high potency, targeting CXCR4 receptor noncompetitively and showing broad efficacy and good pharmacokinetics.Fórmula:C24H32N6OCor e Forma:SolidPeso molecular:420.55SCH 546738
CAS:SCH 546738 is an orally available, selective and potent CXCR3 antagonist that attenuates the development of autoimmune diseases and delays graft rejection.Fórmula:C23H31Cl2N7OPureza:98.67%Cor e Forma:SolidPeso molecular:492.45PS372424
CAS:PS372424 is a specific agonist of human CXCR3, with anti-inflammatory activity.Fórmula:C33H44N6O4Pureza:98%Cor e Forma:SolidPeso molecular:588.74AZ10397767
CAS:<p>AZ10397767: Potent CXCR2 blocker (IC50=1nM); lowers neutrophil infiltration in tumors in vitro/in vivo.</p>Fórmula:C15H14ClFN4O2S2Cor e Forma:SolidPeso molecular:400.88AMD 3465
CAS:AMD 3465 (GENZ-644494) blocks CXCR4, hinders X4 HIV replication (IC50: 1-10 nM), ineffective against R5 viruses, IC50: 0.75 nM (12G5 mAb), 18 nM (CXCL12AF647).Fórmula:C24H38N6Pureza:98%Cor e Forma:SolidPeso molecular:410.60GPR35 agonist 1
CAS:GPR35 agonist 1 is a highly effective and specific GPR35/CXCR8 agonist (EC50: 5.8 nM).Fórmula:C10H4BrN5O5Pureza:98%Cor e Forma:SolidPeso molecular:354.07SB02024
CAS:SB02024 inhibits VPS34, boosts cGAS-STING, hinders autophagy, and shrinks breast cancer xenografts; enhances Sunitinib/Erlotinib efficacy.Fórmula:C16H22F3N3O2Cor e Forma:SolidPeso molecular:345.36ACT-660602
CAS:ACT-660602: Oral CXCR3 blocker, T-cell migration inhibitor, effective in acute lung injury models, potential for autoimmune research. IC50: 204 nM.Fórmula:C20H20F6N8OSCor e Forma:SolidPeso molecular:534.48CXCR4 antagonist 5
CAS:CXCR4 antagonist with IC50 of 8.8 nM, inhibits CXCL12-induced calcium increase and chemotaxis, with good safety and minimal CYP, hERG impact.Fórmula:C21H30N6Cor e Forma:SolidPeso molecular:366.5CXCR3 Antagonist 6c
CAS:CXCR3 antagonist 6c blocks CXCR3 and inhibits Ca2+ movement and T-cell migration (IC50: 0.06 µM & 100 nM) with selectivity over 14 other GPCRs.Fórmula:C30H32Cl3N5O3Cor e Forma:SolidPeso molecular:616.97AZD8309
CAS:<p>AZD8309 is an oral CXCR2 antagonist, curbing neutrophil movement, lowering MPO in lungs/pancreas, and trypsin/elastase activity.</p>Fórmula:C15H14F2N4O2S2Pureza:98.35% - 99.67%Cor e Forma:SolidPeso molecular:384.42IT1t dihydrochloride
CAS:IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.Fórmula:C21H36Cl2N4S2Pureza:99.91%Cor e Forma:SolidPeso molecular:479.57Elubrixin
CAS:<p>Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM).</p>Fórmula:C17H17Cl2FN4O4SPureza:98.65% - 99.78%Cor e Forma:SolidPeso molecular:463.31Mavorixafor
CAS:<p>Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding.</p>Fórmula:C21H27N5Pureza:98.56%Cor e Forma:SolidPeso molecular:349.47AZD8797
CAS:AZD8797 (KAND567) is a CX3CR1 antagonist with potential protective effects against neuronal damage and prevents nociceptive hypersensitivity in rats.Fórmula:C19H25N5OS2Pureza:98.73% - 99.68%Cor e Forma:SolidPeso molecular:403.56NUCC-390
CAS:NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100.Fórmula:C23H33N5OPureza:97.08%Cor e Forma:SolidPeso molecular:395.54Ladarixin Sodium
CAS:Ladarixin Sodium, an Chemokine CXCR antagonist, is used potentially for the treatment of type I diabetes.Fórmula:C11H12F3NNaO6S2Cor e Forma:SolidPeso molecular:398.32AMD-3329 free base
CAS:AMD-3329 is a potent anti-HIV agent that blocks virus replication by targeting CXCR4, a key receptor for X4 viruses' entry.Fórmula:C34H50N8Cor e Forma:SolidPeso molecular:570.81Pentixafor
CAS:<p>Pentixafor is a peptide that selectively targets the CXCR4 receptor and can be labeled with Gallium-68 (68Ga) for visualization using positron emission</p>Fórmula:C60H80N14O14Pureza:98%Cor e Forma:SolidPeso molecular:1221.36CXCR2 antagonist 3
CAS:Compound 11h, a CXCR2 antagonist, inhibits neutrophil/MDSCs and boosts CD3+ T cells in Pan02 tumors.Fórmula:C17H15FN2O4SCor e Forma:SolidPeso molecular:362.38AMD-3329 hydrobromide
CAS:AMD-3329 hydrobromide: strong, selective anti-HIV agent, blocks virus replication by targeting CXCR4 co-receptor.Fórmula:C34H58Br8N8Cor e Forma:SolidPeso molecular:1218.13CXCR2 antagonist 2
CAS:CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC 50 value of 95 nM.Fórmula:C17H17FN2O4SCor e Forma:SolidPeso molecular:364.39(R,R)-CXCR2-IN-2
CAS:'(R,R)-CXCR2-IN-2 is a brain-penetrating diastereoisomer and CXCR2 antagonist with pIC50 of 9 (Tango) and 6.8 (HWB Gro-α/CD11b).'Fórmula:C18H23ClN2O5SCor e Forma:SolidPeso molecular:414.9E6130
CAS:E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.Fórmula:C28H37ClF3N3O3Cor e Forma:SolidPeso molecular:556.06CXCR4 antagonist 7
CAS:Compound PARA-B, a CXCR4 antagonist with IC50 = 9.3 nM, targets HIV, cancer, inflammatory diseases, and WHIM syndrome.Fórmula:C15H17N5O3Cor e Forma:SolidPeso molecular:315.33(±)-AMG 487
AMG 487 is an effective and selective antagonist of chemokine receptor 3.Fórmula:C32H28F3N5O4Pureza:98%Cor e Forma:SolidPeso molecular:603.59AZD0233
CAS:AZD0233 is an orally-active CX3CR1 antagonist. AZD0233 can regulate the CX3CR1/CX3CL1 signaling axis, and has excellent physicochemical properties, metabolic stability, low toxicity and CYP inhibitory characteristics.Fórmula:C19H29FN6O4SPeso molecular:456.54TIQ-15
CAS:TIQ-15 is an effective and selective CXCR4 antagonist. It has good drug-like properties.Fórmula:C23H32N4Pureza:98%Cor e Forma:SolidPeso molecular:364.53CXCR4 antagonist 6
CAS:CXCR4 antagonist 6 blocks CXCR4 (IC50: 79 nM), hinders calcium flux (IC50: 0.25 nM), reduces cell migration, and is effective in cancer metastasis mice.Fórmula:C21H30N6Cor e Forma:SolidPeso molecular:366.5CXCR2-IN-2
CAS:CXCR2-IN-2: A selective, brain-penetrant, oral CXCR2 inhibitor (IC50: 5.2 nM/1 nM). ~730x selectivity vs CXCR1, >1900x vs other chemokine receptors.Fórmula:C18H23ClN2O5SCor e Forma:SolidPeso molecular:414.9NUCC-390 dihydrochloride (1060524-97-1 free base)
NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.Fórmula:C23H35Cl2N5OPureza:98%Cor e Forma:SolidPeso molecular:468.46CXCR2-IN-1
CAS:CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.Fórmula:C19H20Cl2FN3O4SPureza:99.89%Cor e Forma:SolidPeso molecular:476.35SCH 563705
CAS:SCH 563705 is a CXCR2 and CXCR1 antagonist used in the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.Fórmula:C23H27N3O5Pureza:98.03%Cor e Forma:SolidPeso molecular:425.48EMU-116
CAS:EMU-116 is an orally active antagonist of CXCR4, utilized in cancer research.Fórmula:C25H35N5Cor e Forma:SolidPeso molecular:405.58CXCR2 antagonist 7
CXCR2 antagonist 7 is a powerful blocker with IC50s: 0.044 μM for binding, 0.66 μM for calcium mobilization.Fórmula:C14H14F2N6OSCor e Forma:SolidPeso molecular:352.36(R)-SCH 546738
CAS:(R)-SCH 546738, the R-isomer of SCH 546738, is a non-competitive, orally active antagonist targeting the CXCR3 receptor, exhibiting a K_i of 0.4 nM for the human CXCR3 receptor.Fórmula:C23H31Cl2N7OCor e Forma:SolidPeso molecular:492.45ACT-672125
CAS:ACT-672125: Potent CXCR3 blocker, may treat autoimmunity, safe with dose-dependent efficacy in lung inflammation.Fórmula:C25H25F3N10O2SCor e Forma:SolidPeso molecular:586.59CXCR4 antagonist 10
CAS:CXCR4 antagonist10 (compound 21) is an effective CXCR4 inhibitor with an IC50 value of 7.8 nM. It plays a significant role in cancer research.Fórmula:C18H18N4O4Cor e Forma:SolidPeso molecular:354.36CXCR4 antagonist 3
CXCR4 antagonist 3, aka compound 12a, has 11 nM IC50, shares TIQ15 traits, and is promising in HIV research.Fórmula:C22H31N5Cor e Forma:SolidPeso molecular:365.52CXCR4 modulator-1
CAS:CXCR4 modulator-1 (ZINC72372983) is potent (EC50=100nM) with uses in anti-inflammatory, anticancer, and anti-HIV research.Fórmula:C23H27N5O2Cor e Forma:SolidPeso molecular:405.49ACT-777991
CAS:ACT-777991: oral CXCR3 blocker, stable in microsomes/hepatocytes, inhibits T-cell migration to CXCL11.Fórmula:C20H20F6N8O2SCor e Forma:SolidPeso molecular:550.48CXCR2 antagonist 6
CXCR2 antagonist 6: strong CXCR2 affinity (IC50=0.044 μM), hinders calcium mobilization (IC50=0.66 μM).Fórmula:C17H16F2N4OSCor e Forma:SolidPeso molecular:362.4CXCR7 antagonist-1 hydrochloride
CAS:CXCR7 antagonist-1 hydrochloride blocks SDF-1 and I-TAC from CXCR7; may prevent cancer and inflammation.Fórmula:C21H20ClFN6OCor e Forma:SolidPeso molecular:426.87Paeoniflorin-6′-O-benzene sulfonate
CAS:Paeoniflorin-6′-O-benzene sulfonate (CP-25) acts as an inhibitor of G protein-coupled receptor kinase 2 (GRK2), preventing its translocation to the cell membrane and inhibiting the JAK1/STAT3 signaling pathway. It suppresses HaCaT cell proliferation induced by IL-17A/CXCL2. In mouse models, CP-25 reduces the levels of inflammatory cytokines and chemokines such as IL-17A, IL-17F, IFN-γ, TNF-α, IL-22, IL-23, CXCL2, CXCL3, and CXCL9, thereby alleviating psoriasis induced by Imiquimod.Fórmula:C29H32O13SCor e Forma:SolidPeso molecular:620.622CXCR2 antagonist 5
<p>CXCR2 antagonist 5 (compound 25) binds strongly (IC50=0.013μM) and mobilizes calcium (IC50=0.1μM).</p>Fórmula:C15H14F2N4O2SCor e Forma:SolidPeso molecular:352.36SLW131
CAS:SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.Fórmula:C21H27N5O5SCor e Forma:SolidPeso molecular:461.535CXCR2 antagonist 4
CXCR2 antagonist 4 inhibits CXCR2 (IC50: 0.13 μM) and CXCL8-induced calcium rise (IC50: 27 μM), promising for cancer research.Fórmula:C15H14F2N4OS2Cor e Forma:SolidPeso molecular:368.42CCX662
CAS:CCX662 is a CXCR7 antagonist. It inhibits the binding of 125I-CXCL12 to CXCR7 with an IC50 of 9 nM. This compound is suitable for use in cancer research.Fórmula:C28H37N5O4SCor e Forma:SolidPeso molecular:539.69CXCR7 modulator 2
CAS:CXCR7 modulator 2 is a 7-type C-X-C chemokine receptor (CXCR7) modulator with a Ki of 13 nM.Fórmula:C29H42N6O3Cor e Forma:SolidPeso molecular:522.68VUF11207 trifluoroacetate salt
CAS:VUF11207 trifluoroacetate salt is a useful organic compound for research related to life sciences. The catalog number is T66657 and the CAS number is 1378524-41-4.Fórmula:C29H36F4N2O6Cor e Forma:SolidPeso molecular:584.609CXCR4-IN-1
CAS:<p>CXCR4-IN-1 (Example C5), with an IC50 of 20 nM, is a potent inhibitor of CXCR4, applicable for the research of various conditions such as cancer, HIV, diabetic</p>Fórmula:C23H32N6Pureza:98%Cor e Forma:SolidPeso molecular:392.54Ref: TM-T79059
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