CXCR
Os CXCRs são uma subclasse de GPCRs que se ligam a quimiocinas, pequenas proteínas sinalizadoras que guiam o movimento de células imunológicas em direção a locais de inflamação, infecção ou lesão. Os CXCRs desempenham papéis cruciais nas respostas imunológicas, metástase do câncer e doenças inflamatórias. Moduladores de CXCRs estão sendo investigados por seu potencial no tratamento de doenças autoimunes, câncer e condições inflamatórias crônicas. Na CymitQuimica, oferecemos uma gama de moduladores de CXCRs de alta qualidade para apoiar sua pesquisa em imunologia, oncologia e inflamação.
Foram encontrados 148 produtos de "CXCR"
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CXCR2 antagonist 3
CAS:<p>Compound 11h, a CXCR2 antagonist, inhibits neutrophil/MDSCs and boosts CD3+ T cells in Pan02 tumors.</p>Fórmula:C17H15FN2O4SCor e Forma:SolidPeso molecular:362.38CXCR4 antagonist 6
CAS:<p>CXCR4 antagonist 6 blocks CXCR4 (IC50: 79 nM), hinders calcium flux (IC50: 0.25 nM), reduces cell migration, and is effective in cancer metastasis mice.</p>Fórmula:C21H30N6Cor e Forma:SolidPeso molecular:366.5Ladarixin Sodium
CAS:<p>Ladarixin Sodium, an Chemokine CXCR antagonist, is used potentially for the treatment of type I diabetes.</p>Fórmula:C11H12F3NNaO6S2Cor e Forma:SolidPeso molecular:398.32E6130
CAS:<p>E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.</p>Fórmula:C28H37ClF3N3O3Cor e Forma:SolidPeso molecular:556.06Pentixafor
CAS:<p>Pentixafor is a peptide that selectively targets the CXCR4 receptor and can be labeled with Gallium-68 (68Ga) for visualization using positron emission</p>Fórmula:C60H80N14O14Pureza:98%Cor e Forma:SolidPeso molecular:1221.36NUCC-390 dihydrochloride (1060524-97-1 free base)
<p>NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.</p>Fórmula:C23H35Cl2N5OPureza:98%Cor e Forma:SolidPeso molecular:468.46(±)-AMG 487
<p>AMG 487 is an effective and selective antagonist of chemokine receptor 3.</p>Fórmula:C32H28F3N5O4Pureza:98%Cor e Forma:SolidPeso molecular:603.59CXCR2 antagonist 2
CAS:<p>CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC 50 value of 95 nM.</p>Fórmula:C17H17FN2O4SCor e Forma:SolidPeso molecular:364.39CXCR2-IN-1
CAS:<p>CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.</p>Fórmula:C19H20Cl2FN3O4SPureza:99.89%Cor e Forma:SolidPeso molecular:476.35CXCR4 antagonist 10
CAS:<p>CXCR4 antagonist10 (compound 21) is an effective CXCR4 inhibitor with an IC50 value of 7.8 nM. It plays a significant role in cancer research.</p>Fórmula:C18H18N4O4Cor e Forma:SolidPeso molecular:354.36(R)-SCH 546738
CAS:<p>(R)-SCH 546738, the R-isomer of SCH 546738, is a non-competitive, orally active antagonist targeting the CXCR3 receptor, exhibiting a K_i of 0.4 nM for the human CXCR3 receptor.</p>Fórmula:C23H31Cl2N7OCor e Forma:SolidPeso molecular:492.45EMU-116
CAS:<p>EMU-116 is an orally active antagonist of CXCR4, utilized in cancer research.</p>Fórmula:C25H35N5Cor e Forma:SolidPeso molecular:405.58Paeoniflorin-6′-O-benzene sulfonate
CAS:<p>Paeoniflorin-6′-O-benzene sulfonate (CP-25) acts as an inhibitor of G protein-coupled receptor kinase 2 (GRK2), preventing its translocation to the cell membrane and inhibiting the JAK1/STAT3 signaling pathway. It suppresses HaCaT cell proliferation induced by IL-17A/CXCL2. In mouse models, CP-25 reduces the levels of inflammatory cytokines and chemokines such as IL-17A, IL-17F, IFN-γ, TNF-α, IL-22, IL-23, CXCL2, CXCL3, and CXCL9, thereby alleviating psoriasis induced by Imiquimod.</p>Fórmula:C29H32O13SCor e Forma:SolidPeso molecular:620.622CCX662
CAS:<p>CCX662 is a CXCR7 antagonist. It inhibits the binding of 125I-CXCL12 to CXCR7 with an IC50 of 9 nM. This compound is suitable for use in cancer research.</p>Fórmula:C28H37N5O4SCor e Forma:SolidPeso molecular:539.69CXCR2 antagonist 5
<p>CXCR2 antagonist 5 (compound 25) binds strongly (IC50=0.013μM) and mobilizes calcium (IC50=0.1μM).</p>Fórmula:C15H14F2N4O2SCor e Forma:SolidPeso molecular:352.36SCH 563705
CAS:<p>SCH 563705 is a CXCR2 and CXCR1 antagonist used in the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.</p>Fórmula:C23H27N3O5Pureza:98.03%Cor e Forma:SolidPeso molecular:425.48SLW131
CAS:<p>SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.</p>Fórmula:C21H27N5O5SCor e Forma:SolidPeso molecular:461.535CXCR2 antagonist 4
<p>CXCR2 antagonist 4 inhibits CXCR2 (IC50: 0.13 μM) and CXCL8-induced calcium rise (IC50: 27 μM), promising for cancer research.</p>Fórmula:C15H14F2N4OS2Cor e Forma:SolidPeso molecular:368.42CXCR2 antagonist 6
<p>CXCR2 antagonist 6: strong CXCR2 affinity (IC50=0.044 μM), hinders calcium mobilization (IC50=0.66 μM).</p>Fórmula:C17H16F2N4OSCor e Forma:SolidPeso molecular:362.4CXCR7 antagonist-1 hydrochloride
CAS:<p>CXCR7 antagonist-1 hydrochloride blocks SDF-1 and I-TAC from CXCR7; may prevent cancer and inflammation.</p>Fórmula:C21H20ClFN6OCor e Forma:SolidPeso molecular:426.87
