CXCR
Os CXCRs são uma subclasse de GPCRs que se ligam a quimiocinas, pequenas proteínas sinalizadoras que guiam o movimento de células imunológicas em direção a locais de inflamação, infecção ou lesão. Os CXCRs desempenham papéis cruciais nas respostas imunológicas, metástase do câncer e doenças inflamatórias. Moduladores de CXCRs estão sendo investigados por seu potencial no tratamento de doenças autoimunes, câncer e condições inflamatórias crônicas. Na CymitQuimica, oferecemos uma gama de moduladores de CXCRs de alta qualidade para apoiar sua pesquisa em imunologia, oncologia e inflamação.
Foram encontrados 147 produtos de "CXCR"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Quetmolimab
CAS:<p>Quetmolimab is a humanized monoclonal antibody targeting chemokine ligand 1 (CX3CL1) that can be used to study rheumatoid arthritis.</p>Pureza:SDS-PAGE:95% SEC-HPLC:97.59%Cor e Forma:LiquidPeso molecular:150 kDaLY2510924 acetate(1088715-84-7 free base)
<p>Ly2510924 acetate is an potent and selective CXCR4 antagonist. It prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM.</p>Fórmula:C64H91N13O13Pureza:97.32%Cor e Forma:SolidPeso molecular:1250.49VUF11207 fumarate
CAS:<p>VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).</p>Fórmula:C31H39FN2O8Pureza:97.98%Cor e Forma:SolidPeso molecular:586.65Reparixin L-lysine salt
CAS:<p>Reparixin L-lysine salt (Repertaxin L-lysine salt) is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.</p>Fórmula:C20H35N3O5SPureza:99%Cor e Forma:SolidPeso molecular:429.57Motixafortide TFA(664334-36-5,Free)
<p>Motixafortide TFA is a CXCR4 antagonist with ~1 nM IC50, promoting AML apoptosis by modulating miR-15a/16-1 and downregulating ERK and BCL-2.</p>Fórmula:C99H145F4N33O21S2Pureza:>99.99%Cor e Forma:SolidPeso molecular:2273.54Delmetacin
CAS:<p>Delmetacin: a non-steroidal anti-inflammatory drug with analgesic properties, inhibits CXCR1.</p>Fórmula:C18H15NO3Pureza:98.14%Cor e Forma:SolidPeso molecular:293.32AMG 487
CAS:<p>AMG 487: potent CXCR3 antagonist, blocks CXCL10/CXCL11 binding, IC50s: 8.0/8.2 nM.</p>Fórmula:C32H28F3N5O4Pureza:99.82% - 99.89%Cor e Forma:SolidPeso molecular:603.59Eldelumab
CAS:<p>Eldelumab (BMS-936557) is an anti-IP-10 IgG 1 monoclonal antibody.Eldelumab has anti-inflammatory activity and is used to study rheumatoid arthritis.</p>Pureza:95%Cor e Forma:LiquidCTCE-9908
CAS:<p>CXCR4 blocker; triggers cell division failure in ovarian cancer, boosts taxol and docetaxel treatment effects, proven in mice.</p>Fórmula:C86H147N27O23Pureza:98%Cor e Forma:SolidPeso molecular:1927.27CXCR4-IN-3
<p>CXCR4-IN-3 (compound XVI) is an orally active inhibitor targeting the inflammation-related receptor CXCR4, with an IC50 of 3.2 nM. It exhibits potent anti-chemotactic effects, with an inhibition rate of 79.19±2.33%. Additionally, CXCR4-IN-3 possesses anti-inflammatory properties and can be utilized in research on IBD (inflammatory bowel disease).</p>RCP168
<p>RCP168 is a highly selective and potent CXCR4 receptor antagonist with an IC50 of 5 nM. It exhibits superior capacity to inhibit HIV-1 (Human Immunodeficiency Virus type 1) from entering host cells via the CXCR4 receptor compared to natural chemokines. RCP168 suppresses HIV-1 infection by blocking viral binding sites or inducing receptor internalization. It can be utilized in research to study interactions between the CXCR4 receptor and other chemokine receptors.</p>Fórmula:C365H585N105O95S5Peso molecular:8119.27766BVT173187
CAS:<p>BVT173187 is a neutrophil formyl peptide receptors (FPR1) inhibitor.</p>Fórmula:C14H10Cl3NO2Cor e Forma:SolidPeso molecular:330.59CXCL-CXCR1/2-IN-1
CAS:<p>CXCL-CXCR1/2-IN-1 is an ELR+CXCL-CXCR1/2 pathway inhibitor with anticancer activity and can be used in the study of cardiovascular disease.</p>Fórmula:C14H8Cl2N4O3SPureza:99.4%Cor e Forma:SoildPeso molecular:383.21PDE4D inhibitor 1
<p>PDE4-IN-1 is a PDE4 inhibitor characterized by high potency (IC50: 8.6 nM) and superior selectivity over other PDE subtypes. This compound inhibits the release of inflammatory cytokines and chemokines. Additionally, PDE4-IN-1 significantly restores the damaged cAMP-CREB signaling pathway, inhibits proliferation, and promotes differentiation to reverse psoriasis formation.</p>Cor e Forma:Odour SolidCX4338
CAS:<p>CX4338 is a CXCL8-mediated chemotaxis inhibitor.</p>Fórmula:C22H24N2OSCor e Forma:SolidPeso molecular:364.50E70K
<p>E70K, a CXCL8 C-terminal peptide, features a lysine (K) substitution for glutamic acid (E) at position 70 and has demonstrated the ability to attenuate</p>Fórmula:C108H178N34O28Pureza:98%Cor e Forma:SolidPeso molecular:2400.78TC14012
CAS:<p>CXCR4 antagonist and ACKR3 (CXCR7) agonist (EC50 = 350 nM for CXCR7).</p>Fórmula:C90H140N34O19S2Pureza:98%Cor e Forma:SolidPeso molecular:2066.434-Amino-D-phenylalanine
CAS:<p>4-Amino-D-phenylalanine ([D-Phe(4-NH2)]) is a cyclic pentapeptide that inhibits the binding of CXCL12 to CXCR4 in FC131, with an IC50 value of 0.1 μM.</p>Fórmula:C9H12N2O2Cor e Forma:SolidPeso molecular:180.2CCR7 antagonist 1
<p>CCR7 antagonist1 (30c) functions as a dual antagonist, targeting CXCR2 with an IC50 of 11.02 μM and CCR7 with an IC50 of 0.43 μM.</p>Fórmula:C13H22N6OSPeso molecular:310.15758Peptide R
CAS:<p>Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.</p>Fórmula:C39H59N13O8S2Cor e Forma:SolidPeso molecular:902.1CXCR7 modulator 1
CAS:<p>CXCR7 modulator 1 is an effective and orally bioavailable peptoid hybrid CXCR7 modulator with Ki of 9 nM.</p>Fórmula:C48H57F2N7O7SPureza:98%Cor e Forma:SolidPeso molecular:914.07SDF-1α (human)
CAS:<p>SDF-1α (human) serves as a chemotactic agent for mononuclear cells through its interaction with the CXCR4 receptor, facilitating critical biological processes</p>Fórmula:C356H578N106O93S4Pureza:98%Cor e Forma:SolidPeso molecular:7959.34Balixafortide TFA (1051366-32-5 free base)
<p>Balixafortide TFA is a selective CXCR4 antagonist with IC50 < 10nM, over 1000x preference for CXCR4, and blocks β-arrestin and calcium flux.</p>Fórmula:C82H113N22F3O23S2Pureza:98%Cor e Forma:SolidPeso molecular:1896.05CXCL8 (54-72)
<p>CXCL8 (54-72) is a C-terminal peptide segment of the chemokine CXCL8. This peptide features a long, highly positively charged C-terminal region that interacts with the negative charges on glycosaminoglycans (GAG) to facilitate binding. CXCL8 (54-72) inhibits neutrophil adhesion and migration, as well as adhesion to endothelial cells. It is useful in studying the role of chemokines in inflammatory responses.</p>Fórmula:C107H173N33O30Peso molecular:2400.30261vMIP-II (1-21) TFA
<p>vMIP-II (1-21) (NT21MP) TFA (TFA is a potent inhibitor of CXCR4. This compound interacts broadly with CC and CXC chemokine receptors. Furthermore, vMIP-II (1-21) TFA inhibits CXCR4 by competing for binding sites with 125I-SDF-1R, exhibiting an IC50 value of 190 nM.</p>Cor e Forma:Odour SolidDOTA-CXCR4-L
<p>DOTA-CXCR4-L, a peptide targeting the CXCR4 receptor, is utilized in cancer research, notably in the contexts of glioblastoma and triple-negative breast cancer</p>Fórmula:C58H78N16O14Pureza:98%Cor e Forma:SolidPeso molecular:1223.34Chemokine Inhibitor Library
<p>A unique collection of xnum chemokines or chemokine receptors targeted compounds for high throughput and high content screening;</p>Cor e Forma:Odour SolidVUF-11222
CAS:<p>VUF-11222 is an agonist of high affinity non-peptide CXCR3 agonist (pKi = 7.2).</p>Fórmula:C25H31BrINPureza:99.82%Cor e Forma:SolidPeso molecular:552.33Cyclic MKEY
CAS:<p>MKEY peptide inhibits CXCL4-CCL5, reduces atherosclerosis and aneurysm, neuroinflammatory effects unknown.</p>Fórmula:C113H174N28O34S2Pureza:98%Cor e Forma:SolidPeso molecular:2532.89NI-0801
<p>NI-0801 (Anti-CXCL10 / IP-1) is a CHO-expressed humanized monoclonal antibody targeting CXCL10/IP-10 for the study of vitiligo and biliary cirrhosis.</p>Pureza:97.9% (SDS-PAGE); 99.4% (SEC-HPLC) - 97.9% (SDS-PAGE); 99.4% (SEC-HPLC)Cor e Forma:Odour LiquidAZD4721
CAS:<p>AZD4721, an oral CXCR2 antagonist, may be researched for treating inflammation.</p>Fórmula:C19H25FN4O5S2Cor e Forma:SolidPeso molecular:472.55CXCR2 Probe 1
<p>CXCR2Probe 1 (Compound[18F]16b) is a selective ligand for CXCR2 and serves as a radioactive tracer for PET imaging of neutrophils in inflammatory diseases.</p>Fórmula:C20H24FN3O4Peso molecular:389.17508VB-85247
<p>VB-85247 is a STING agonist that, by activating the STING pathway, induces the upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as the maturation and activation of dendritic cells. It can lead to the regression of tumors within the bladder and is applicable in bladder cancer research.</p>Cor e Forma:Odour SolidCXCR4 antagonist 1
CAS:<p>CXCR4 antagonist 1 is a potent inhibitor of the CXCR4 receptor, with notable anti-HIV activity.</p>Fórmula:C27H43N7Cor e Forma:SolidPeso molecular:465.69TC14012 TFA
<p>TC14012 TFA is a peptide-mimetic CXCR4 antagonist and CXCR7 agonist that promotes the recruitment of β-arrestin by CXCR7 .</p>Fórmula:C92H141F3N34O21S2Pureza:96.31%Cor e Forma:SolidPeso molecular:2180.44PF-06835375
CAS:<p>PF-06835375 is a humanized IgG1 antibody that selectively targets CXCR5 expressed on B cells, Tfh cells, and circulating Tfh-like cells (cTfh). It is applicable for research into systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).</p>Cor e Forma:LiquidITIC-4F
CAS:<p>ITIC-4F: a postfullerene IDTT electron acceptor for high-efficiency PSCs, relevant in binary, ternary, and tandem setups.</p>Fórmula:C94H78F4N4O2S4Pureza:98%Cor e Forma:SolidPeso molecular:1499.92Bam 12P
CAS:<p>Bam 12P is a Pro-Met-enkephalin precursor that is isolated from the bovine adrenal medulla.</p>Fórmula:C62H97N21O16SPureza:98%Cor e Forma:SolidPeso molecular:1424.64CXCR4 antagonist 2
CAS:<p>CXCR4 antagonist 2 is a CXCR4 antagonist with an IC 50 value of 47 nM.</p>Fórmula:C25H36N6Cor e Forma:SolidPeso molecular:420.605KRH-3955 hydrochloride
CAS:<p>KRH-3955 hydrochloride is an orally available CXCR4 blocker with IC50 of 0.61 nM and EC50 of 0.3-1.0 nM against X4 HIV-1.</p>Fórmula:C28H48Cl3N7Cor e Forma:SolidPeso molecular:589.09ITIC
CAS:<p>"ITIC, a non-fullerene acceptor with high Tg of 180°C, shows excellent thermal stability and a low glass-crystal transition, plus unique crystallization."</p>Fórmula:C94H82N4O2S4Pureza:98%Cor e Forma:SolidPeso molecular:1427.96Polyphemusin II-Derived Peptide
CAS:<p>T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.</p>Fórmula:C90H141N33O18S2Cor e Forma:SolidPeso molecular:2037.42ACT-1004-1239
CAS:<p>ACT-1004-1239 is a CXCR7 antagonist with immunomodulatory and myelination-promoting effects, used for research on inflammatory demyelinating diseases.</p>Fórmula:C27H28F2N6O3Pureza:98.31%Cor e Forma:SolidPeso molecular:522.55Peptide R TFA
<p>Peptide R (TFA) is a synthetic and specific CXCR4 antagonist. It demonstrates excellent tumor stroma remodeling capabilities and is applicable in research on solid tumors, such as glioblastoma.</p>Fórmula:C39H57N13O8S2·xC2HF3O2Cor e Forma:SolidPeso molecular:900.08 (free base)PS372424 hydrochloride
CAS:<p>PS372424 hydrochloride,CXCR3 agonist. Anti-inflammatory. Inhibits T-cell migration.</p>Fórmula:C33H45ClN6O4Pureza:95.03%Cor e Forma:SolidPeso molecular:625.2ATI-2341
CAS:<p>ATI-2341, pepducin targeting the CXCR4, is an allosteric agonist activating the Gi to promote inhibition of cAMP production and induce calcium mobilization.</p>Fórmula:C104H178N26O25S2Cor e Forma:SolidPeso molecular:2256.82LY2510924
CAS:<p>LY2510924 is an effective and selective CXCR4 antagonist. It blocks SDF-1 binding to CXCR4 (IC50: 0.079 nM).</p>Fórmula:C62H88N14O10Cor e Forma:SolidPeso molecular:1189.45Motixafortide
CAS:<p>Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).</p>Fórmula:C97H144FN33O19S2Pureza:98%Cor e Forma:SolidPeso molecular:2159.52CXCR2 antagonist 8
CAS:<p>CXCR2 antagonist 8 is a selective CXCR2 antagonist, which can be used for the treatment and prevention of insulin resistance.</p>Fórmula:C14H13N3O5Cor e Forma:SolidPeso molecular:303.27Navarixin
CAS:<p>Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil</p>Fórmula:C21H23N3O5Pureza:98% - 99.51%Cor e Forma:SolidPeso molecular:397.42
