CXCR
Os CXCRs são uma subclasse de GPCRs que se ligam a quimiocinas, pequenas proteínas sinalizadoras que guiam o movimento de células imunológicas em direção a locais de inflamação, infecção ou lesão. Os CXCRs desempenham papéis cruciais nas respostas imunológicas, metástase do câncer e doenças inflamatórias. Moduladores de CXCRs estão sendo investigados por seu potencial no tratamento de doenças autoimunes, câncer e condições inflamatórias crônicas. Na CymitQuimica, oferecemos uma gama de moduladores de CXCRs de alta qualidade para apoiar sua pesquisa em imunologia, oncologia e inflamação.
Foram encontrados 159 produtos para "CXCR".
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LY2510924
CAS:LY2510924 is an effective and selective CXCR4 antagonist. It blocks SDF-1 binding to CXCR4 (IC50: 0.079 nM).Fórmula:C62H88N14O10Cor e Forma:SolidPeso molecular:1189.45CXCR2 antagonist 8
CAS:CXCR2 antagonist 8 is a selective CXCR2 antagonist, which can be used for the treatment and prevention of insulin resistance.Fórmula:C14H13N3O5Cor e Forma:Yellow SolidPeso molecular:303.27Peptide R TFA
Peptide R (TFA) is a synthetic and specific CXCR4 antagonist. It demonstrates excellent tumor stroma remodeling capabilities and is applicable in research on solid tumors, such as glioblastoma.Fórmula:C39H57N13O8S2·xC2HF3O2Cor e Forma:SolidPeso molecular:900.08 (free base)ACT-1004-1239
CAS:ACT-1004-1239 is a CXCR7 antagonist with immunomodulatory and myelination-promoting effects, used for research on inflammatory demyelinating diseases.Fórmula:C27H28F2N6O3Pureza:98.31%Cor e Forma:SolidPeso molecular:522.55ATI-2341
CAS:ATI-2341, pepducin targeting the CXCR4, is an allosteric agonist activating the Gi to promote inhibition of cAMP production and induce calcium mobilization.Fórmula:C104H178N26O25S2Cor e Forma:SolidPeso molecular:2256.82USL311
CAS:USL311 blocks CXCR4/SDF-1 interaction, inhibits tumor cell growth and migration.Fórmula:C24H34N6OPureza:98.46% - 99.56%Cor e Forma:SolidPeso molecular:422.57Navarixin
CAS:Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophilFórmula:C21H23N3O5Pureza:98% - 99.51%Cor e Forma:SolidPeso molecular:397.42Ref: TM-T7130
1mg38,00€5mg80,00€1mL*10mM (DMSO)88,00€10mg114,00€25mg200,00€50mg299,00€100mg442,00€500mg973,00€Plerixafor
CAS:Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.Fórmula:C28H54N8Pureza:99.17% - >99.99%Cor e Forma:SolidPeso molecular:502.78MSX-130
CAS:MSX-130 is CXCR4 Antagonist.Fórmula:C36H26N4Pureza:99.19%Cor e Forma:SolidPeso molecular:514.62Alirocumab
CAS:Alirocumab is a human monoclonal antibody that inhibits PCSK9. It is produced by recombinant DNA technology in Chinese hamster ovary cell suspension culture.Pureza:95% - 97.1% (SDS-PAGE); 96.1% (SEC-HPLC)Cor e Forma:Transparent LiquidPeso molecular:146.2 kDaFC131 TFA (606968-52-9 free base)
CAS:FC131 TFA (606968-52-9 free base) (FC131 TFA) is an antagonist of CXCR4 that inhibits the binding of [125I] -sdf-1 to CXCR4(IC50 : 4.5 nM ), and has anti-hivFórmula:C38H48F3N11O8Pureza:99.67% - 99.94%Cor e Forma:White SolidPeso molecular:843.85ATI-2341 acetate(1337878-62-2 free base)
ATI-2341 acetate is an effective allosteric agonist of CXCR4, it activates Gα1 instead of Gα13.Fórmula:C106H182N26O27S2Pureza:97.14%Cor e Forma:White SolidPeso molecular:2316.87WZ811
CAS:WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM).Fórmula:C18H18N4Pureza:99.42% - ≥95%Cor e Forma:SolidPeso molecular:290.36NUCC-390 dihydrochloride
CAS:NUCC-390, a selective CXCR4 agonist, promotes nerve repair by inducing CXCR4 internalization, opposite to AMD3100.Fórmula:C23H35Cl2N5OCor e Forma:SolidPeso molecular:468.46Decursin
CAS:Decursin: potential antiepileptic, hepatoprotective, anti-cancer, anti-amnesic; affects NOX activation, PKCα/MAPK/NF-κB pathways, AChE.Fórmula:C19H20O5Pureza:97.22% - 99.91%Cor e Forma:SolidPeso molecular:328.36Ref: TM-T3S1416
1mg40,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg113,00€25mg245,00€50mg439,00€100mg627,00€500mg1.288,00€CTCE 9908 acetate
CTCE 9908 acetate is an antagonist of CXCR4 and inhibits migration in CXCR4-expressing ovarian cancer cells.Fórmula:C88H151N27O25Pureza:98.47%Cor e Forma:SolidPeso molecular:1987.31SB-265610
CAS:SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist.Fórmula:C14H9BrN6OPureza:99.5%Cor e Forma:SolidPeso molecular:357.16Ref: TM-T16850
1mg52,00€5mg113,00€1mL*10mM (DMSO)124,00€10mg177,00€25mg356,00€50mg530,00€100mg758,00€500mg1.558,00€Danirixin
CAS:Danirixin (GSK1325756) is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM).Fórmula:C19H21ClFN3O4SPureza:99.78% - >99.99%Cor e Forma:SolidPeso molecular:441.9Ref: TM-T5193
1mg58,00€1mL*10mM (DMSO)102,00€5mg105,00€10mg170,00€25mg318,00€50mg505,00€100mg713,00€200mg982,00€Nicotinamide N-oxide
CAS:Nicotinamide N-oxide, a metabolite of nicotinamide and precursor to NAD+, is reduced by liver enzyme xanthine oxidase.Fórmula:C6H6N2O2Pureza:99.66% - 99.9%Cor e Forma:SolidPeso molecular:138.12MSX-127
CAS:MSX-127 elicites positive response in peptide CXCR4.Fórmula:C16H24N2O4Pureza:98.43%Cor e Forma:SolidPeso molecular:308.37JMS-17-2 hydrochloride
CAS:JMS-17-2 hydrochloride: potent CX3CR1 blocker, IC50 of 0.32 nM, hinders breast cancer metastasis.Fórmula:C25H27Cl2N3OCor e Forma:SolidPeso molecular:456.41JMS-17-2
CAS:JMS-17-2 is a potent and selective antagonist of CX3CR1( IC50 : 0.32 nM).Fórmula:C25H26ClN3OPureza:98.7% - 99.44%Cor e Forma:White SolidPeso molecular:419.95Ref: TM-T5849
1mg35,00€5mg78,00€1mL*10mM (DMSO)87,00€10mg117,00€25mg198,00€50mg310,00€100mg460,00€200mg665,00€SX-682
CAS:SX-682 is an orally available allosteric inhibitor of CXCR1 and CXCR2.Cost-effective and quality-assured.Fórmula:C19H14BF4N3O4SPureza:98.19% - 99.61%Cor e Forma:SolidPeso molecular:467.2SRT3109
CAS:SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.Fórmula:C18H23F2N5O4S2Pureza:99.65% - 99.92%Cor e Forma:SolidPeso molecular:475.53Baohuoside I
CAS:Baohuoside I (Icariside-II) is a component of Epimedium koreanum, exhibits anti-inflammatory activity and anti-osteoporosis activities.Fórmula:C27H30O10Pureza:97.64% - 98.14%Cor e Forma:Yellow SolidPeso molecular:514.52Ref: TM-T3396
2mg43,00€5mg63,00€10mg92,00€1mL*10mM (DMSO)123,00€25mg170,00€50mg268,00€100mg447,00€200mg623,00€SB225002
CAS:SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2.Fórmula:C13H10BrN3O4Pureza:98.16% - 99.85%Cor e Forma:SolidPeso molecular:352.14Ref: TM-T1955
5mg48,00€1mL*10mM (DMSO)50,00€10mg63,00€25mg120,00€50mg213,00€100mg383,00€200mg585,00€500mg888,00€MSX-122
CAS:MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).Fórmula:C16H16N6Pureza:98.31% - 99.15%Cor e Forma:SolidPeso molecular:292.34AMD 3465 hexahydrobromide
CAS:AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.Fórmula:C24H44Br6N6Pureza:99.39%Cor e Forma:SolidPeso molecular:896.07Elubrixin HCl
CAS:Elubrixin is a interleukin 8 inhibitor and CXCR2 selective antagonist.Fórmula:C17H18Cl3FN4O4SCor e Forma:SolidPeso molecular:499.77Reparixin
CAS:Reparixin inhibits CXCR1 (IC50=1 nM) strongly, CXCR2 weakly (IC50=100 nM), and it's a CXCL8 receptor blocker.Fórmula:C14H21NO3SPureza:98% - 99.89%Cor e Forma:SolidPeso molecular:283.39Ref: TM-T4163
5mg46,00€10mg58,00€1mL*10mM (DMSO)105,00€25mg114,00€50mg177,00€100mg285,00€200mg424,00€ML339
CAS:ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.Fórmula:C26H32ClN3O5Pureza:99.9%Cor e Forma:White SolidPeso molecular:502Mavorixafor trihydrochloride
CAS:Mavorixafor trihydrochloride blocks CXCR4 (IC50: 13 nM) and suppresses T-tropic HIV-1 replication (IC50: 1-9 nM). It's orally active.Fórmula:C21H30Cl3N5Pureza:98.00%Cor e Forma:SolidPeso molecular:458.86AMD-070 hydrochloride
CAS:AMD-070 hydrochloride is a CXCR4 antagonist, is useful for Anti HIV.Fórmula:C21H28ClN5Pureza:98.38% - 98.57%Cor e Forma:SolidPeso molecular:385.93Plerixafor octahydrochloride
CAS:Plerixafor octahydrochloride mobilizes HSCs by blocking SDF-1alpha/CXCR4 interaction, facilitating their release into circulation.Fórmula:C28H62Cl8N8Pureza:98.01% - 99.79%Cor e Forma:White SolidPeso molecular:794.46AZD-5069
CAS:AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).Fórmula:C18H22F2N4O5S2Pureza:98.38% - 99.92%Cor e Forma:White SolidPeso molecular:476.52Ref: TM-T7681
1mg34,00€2mg47,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg98,00€25mg190,00€50mg295,00€100mg447,00€200mg623,00€TAK-779
CAS:TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).Fórmula:C33H39ClN2O2Pureza:99.21%Cor e Forma:SolidPeso molecular:531.13ML 145
CAS:ML 145 is a selective antagonist of GPR35/CXCR8 (IC50/EC50 of 20.1 nM)Fórmula:C24H22N2O5S2Pureza:97.74%Cor e Forma:Yellow SolidPeso molecular:482.57Ref: TM-T12074
1mg52,00€5mg100,00€1mL*10mM (DMSO)109,00€10mg149,00€25mg250,00€50mg408,00€100mg572,00€Anti-Human/Mouse/Monkey CXCR3 Antibody (9C5)
Anti-Human/Mouse/Monkey CXCR3 Antibody (9C5) is a monoclonal antibody targeting CXCR3 for immunological research.Cor e Forma:Transparent LiquidPeso molecular:150 kDaLIH383
CAS:LIH383, an agonist of ACKR3 (CXCR7) with an EC50 of 0.61 nM, effectively promotes the recruitment of β-arrestin to ACKR3. However, it does not initiate typical G protein signaling.Fórmula:C45H72N16O8SPeso molecular:997.22GSK812397
CAS:GSK812397 inhibits X4-tropic HIV-1 with high potency, targeting CXCR4 receptor noncompetitively and showing broad efficacy and good pharmacokinetics.Fórmula:C24H32N6OCor e Forma:SolidPeso molecular:420.55CXCR3 Antagonist 6c
CAS:CXCR3 antagonist 6c blocks CXCR3 and inhibits Ca2+ movement and T-cell migration (IC50: 0.06 µM & 100 nM) with selectivity over 14 other GPCRs.Fórmula:C30H32Cl3N5O3Cor e Forma:SolidPeso molecular:616.97CXCR4 antagonist 9
CAS:CXCR4 antagonist 9, with IC50s of 15 nM & 1.3 nM against CXCR4 & Ca²⁺ rise by CXCL12 respectively.Fórmula:C21H27FN6Cor e Forma:SolidPeso molecular:382.48VUF11211
CAS:VUF11211 is an effective antagonist of CXCR3 that acts by extending from the minor pocket into the major pocket of the transmembrane domains.Fórmula:C26H35Cl2N5OPureza:98%Cor e Forma:SolidPeso molecular:504.49AZ10397767
CAS:AZ10397767: Potent CXCR2 blocker (IC50=1nM); lowers neutrophil infiltration in tumors in vitro/in vivo.Fórmula:C15H14ClFN4O2S2Cor e Forma:SolidPeso molecular:400.88CXCR4 modulator-2
CAS:CXCR4 modulator-2 (Z7R) has high potency (IC50: 1.25 nM), stable in mouse serum (t1/2=77.1 min), and anti-inflammatory in mice.Fórmula:C21H32N8O2Cor e Forma:SolidPeso molecular:428.53VUF10132
CAS:VUF10132 is a full inverse CXCR3 N3.35A agonist.Fórmula:C19H13BrCl4N2O2Pureza:98%Cor e Forma:SolidPeso molecular:523.03SCH 546738
CAS:SCH 546738 is an orally available, selective and potent CXCR3 antagonist that attenuates the development of autoimmune diseases and delays graft rejection.Fórmula:C23H31Cl2N7OPureza:98.67%Cor e Forma:Yellow SolidPeso molecular:492.45SB02024
CAS:SB02024 inhibits VPS34, boosts cGAS-STING, hinders autophagy, and shrinks breast cancer xenografts; enhances Sunitinib/Erlotinib efficacy.Fórmula:C16H22F3N3O2Cor e Forma:SolidPeso molecular:345.36rac-NBI-74330
CAS:rac-NBI-74330 is an effective and selective CXCR3 antagonist.Fórmula:C32H27F4N5O3Pureza:99.6%Cor e Forma:SolidPeso molecular:605.58
