TGF-beta/Smad
Os inibidores da via TGF-beta/Smad são compostos que interferem na via de sinalização do TGF-beta (Transforming Growth Factor-beta), mediada por proteínas Smad. Esta via está envolvida na regulação do crescimento celular, diferenciação, apoptose e função das células-tronco. A desregulação da sinalização TGF-beta/Smad está associada ao câncer, fibrose e outras doenças. Os inibidores desta via são ferramentas importantes para estudar estas condições e desenvolver potenciais terapias. Na CymitQuimica, oferecemos inibidores de TGF-beta/Smad para apoiar sua pesquisa em sinalização celular, oncologia e reparação de tecidos.
Foram encontrados 60 produtos de "TGF-beta/Smad"
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Oxymatrine
CAS:<p>Oxymatrine (Oxysophoridine) is an alkaloid isolated from Sophora flavescens, used as the antibiotic.</p>Fórmula:C15H24N2O2Pureza:98.72% - 99.72%Cor e Forma:SolidPeso molecular:264.36Ponsegromab
CAS:<p>Ponsegromab (PF 06946860), a humanized anti-GDF15 antibody, may treat cancer cachexia by blocking GDF15/GFRAL signaling.</p>Pureza:100% (SEC-HPLC) - > 95%Cor e Forma:LiquidPeso molecular:146.08 kDaHydrochlorothiazide
CAS:<p>Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药，可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能，减少纤维化并具有降压作用。</p>Fórmula:C7H8ClN3O4S2Pureza:99.43% - 99.50%Cor e Forma:Crystals Physical Description Crystals Or White Powder (Ntp 1992)Peso molecular:297.74Garetosmab
CAS:<p>Garetosmab (REGN 2477), a human IgG4 monoclonal antibody, inhibits activin A for potential cancer treatment and FOP study.</p>Pureza:> 95% - > 95%Cor e Forma:LiquidPeso molecular:146 kDaIsoviolanthin
CAS:Isoviolanthin, a flavonoid from Dendrobium Officinale, inhibits migration of TGF-β1-treated HCC cells, non-toxic to normal cells, potential HCC therapy.Fórmula:C27H30O14Pureza:99.25% - 99.66%Cor e Forma:SolidPeso molecular:578.52Emugrobart
Emugrobart is a humanized IgG1κ antibody targeted at GDF8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Cor e Forma:Odour LiquidCBT-295
<p>CBT-295, an orally active autotaxin (ATX) inhibitor, effectively decreases inflammatory cytokines including TGF-β, TNF-α, and IL-6, along with the bile duct proliferation marker CK-19, and ameliorates liver fibrosis. The compound's ability to reverse liver fibrosis contributes to lowered ammonia levels in the blood and brain, which in turn reduces ammonia-induced neuroinflammation. CBT-295 shows potential for the study of liver cirrhosis and related encephalopathy.</p>Fórmula:C18H20ClN3OCor e Forma:SolidPeso molecular:329.82Linavonkibart
CAS:Linavonkibart (SRK181) is a humanized antibody targeting TGFβ1 that blocks the release of TGF-β1 protein by specifically binding latent TGF-β1.Pureza:97.4% (SDS-PAGE); 99.4% (SEC-HPLC) - 97.4% (SDS-PAGE); 99.4% (SEC-HPLC)Cor e Forma:LiquidSotatercept
CAS:<p>Sotatercept (ACE-011) is an ActRIIA-Fc fusion protein and an inhibitor of activin signaling.</p>Pureza:97% (SDS-PAGE); 97.8% (SEC-HPLC) - 97% (SDS-PAGE); 97.8% (SEC-HPLC)Cor e Forma:LiquidSLLK, Control Peptide for TSP1 Inhibitor(TFA)
CAS:<p>SLLK is a control peptide for LSKL.</p>Fórmula:C21H41N5O6Pureza:98%Cor e Forma:SolidPeso molecular:459.58Fresolimumab
CAS:Fresolimumab (GC1008) is a human monoclonal antibody targeting active TGFβ1, TGFβ2, TGFβ3, studied for cancer and focal segmental glomerulosclerosis.Pureza:> 95% - > 95%Cor e Forma:LiquidPeso molecular:144.4 kDaLerdelimumab
CAS:Lerdelimumab (CAT-152) is an IgG4 monoclonal antibody targeting TGF-β2, used in glaucoma scarring research.Cor e Forma:LiquidCirevetmab
CAS:Cirevetmab (ZTS-00521426), a caninized monoclonal antibody targeting Canis lupus familiaris TGFB1, is classified as an immunoglobulin G2-kappa.Cor e Forma:LiquidPrafnosbart
CAS:Prafnosbart (DS-6016A) is a humanized IgG1-kappa monoclonal antibody targeting ACVR1 (activin A receptor type 1, ACVRLK2, ALK2, ACVR1A, SKR1), utilized inCor e Forma:LiquidRilogrotug
CAS:Rilogrotug is a humanized IgG1κ monoclonal antibody targeting GDF15, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.Cor e Forma:Odour LiquidTubastatin
CAS:<p>Tubastatin inhibits TGF-β1-induced S6K phosphorylation, HIF-1α expression and VEG F expression.</p>Fórmula:C21H22N2O2Pureza:98.23%Cor e Forma:SolidPeso molecular:334.41TGFβRI-IN-7
<p>TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGFβRI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.</p>Fórmula:C27H32N6O2Cor e Forma:SolidPeso molecular:472.582ALK5-IN-83
ALK5-IN-83 (compound 13b) is an ALK5 inhibitor with an IC50 of 0.13 μM. It suppresses TGF-β1-induced Smad2 phosphorylation and cell motility in A549 cells.Fórmula:C20H23N7O2SCor e Forma:SolidPeso molecular:425.51Bintrafusp alfa
CAS:Bintrafusp alfa (M7824) is a protein consisting of the extracellular structural domain of TGF-βRII with a monoclonal antibody to human immunoglobulin G1.Pureza:96.1% (SDS-PAGE); 99.2% (SEC-HPLC) - 96.1% (SDS-PAGE); 99.2% (SEC-HPLC)Cor e Forma:LiquidSD-208
CAS:<p>SD-208 (ALK5 Inhibitor V), a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.</p>Fórmula:C17H10ClFN6Pureza:98.72% - 99.65%Cor e Forma:SolidPeso molecular:352.75SRI-011381 hydrochloride
CAS:SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.Fórmula:C20H32ClN3OPureza:99.32% - 99.41%Cor e Forma:SolidPeso molecular:365.94Asiaticoside
CAS:<p>Asiaticoside, in Centella asiatica, may treat wounds/burns.</p>Fórmula:C48H78O19Pureza:98% - 99.96%Cor e Forma:PowderPeso molecular:959.12Chebulinic acid
CAS:Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.Fórmula:C41H32O27Pureza:98.91% - 99.71%Cor e Forma:SolidPeso molecular:956.68(E)-SIS3
CAS:(E)-SIS3 (SIS3) is a Smad3 inhibitor (IC50=3 μM) selective.inhibits the differentiation of fibroblasts into myofibroblasts via TGF-β1. High-Quality, Low-Cost!Fórmula:C28H27N3O3·HClPureza:95.64% - 98%Cor e Forma:SolidPeso molecular:489.99R-268712
CAS:R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.Fórmula:C20H18FN5OPureza:99.61%Cor e Forma:SolidPeso molecular:363.39SJ000291942
CAS:SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.Fórmula:C16H15FN2O4Pureza:99.66%Cor e Forma:SolidPeso molecular:318.3LSKL, Inhibitor of Thrombospondin TSP-1 2TFA
LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .Fórmula:C25H44F6N6O9Pureza:99.75%Cor e Forma:SolidPeso molecular:686.64Kartogenin
CAS:Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.Fórmula:C20H15NO3Pureza:96.25% - 97.79%Cor e Forma:SolidPeso molecular:317.34ITD-1
CAS:ITD-1 is a potent and highly selective TGFβ pathway inhibitor.Fórmula:C27H29NO3Pureza:99.89% - >99.99%Cor e Forma:SolidPeso molecular:415.52Galunisertib
CAS:Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. Cost-effective and quality-assured.Fórmula:C22H19N5OPureza:97.09% - 99.98%Cor e Forma:SolidPeso molecular:369.42Alantolactone
CAS:Alantolactone is a selective inhibitor of STAT3 that induces cancer-associated apoptosis and has antitumor activity.Cost-effective and quality-assured.Fórmula:C15H20O2Pureza:99.02% - 99.66%Cor e Forma:Crystalline PowderPeso molecular:232.32BMP signaling agonist sb4
CAS:<p>BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)</p>Fórmula:C14H10BrNOSPureza:99.48% - 99.805%Cor e Forma:SolidPeso molecular:320.2BMS986260
CAS:BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).Fórmula:C18H12ClFN6OPureza:97.67%Cor e Forma:SolidPeso molecular:382.78BIO-013077-01
CAS:BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.Fórmula:C17H13N5Pureza:99.87%Cor e Forma:SolidPeso molecular:287.32Trimethylamine N-oxide dihydrate
CAS:<p>TMANO Dihydrate, from trimethylamine oxidation, stabilizes proteins against sharks' urea.</p>Fórmula:C3H13NO3Pureza:98.75%Cor e Forma:White CrystalPeso molecular:111.14LY3200882
CAS:LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).Fórmula:C24H29N5O3Pureza:99.46% - 99.63%Cor e Forma:SolidPeso molecular:435.52SRI-011381
CAS:SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.Fórmula:C20H31N3OPureza:98.64%Cor e Forma:SolidPeso molecular:329.48Trevogrumab
CAS:Trevogrumab is a human monoclonal antibody that inhibits myostatin (GDF8) to promote muscle growth, and is under research for treating age-related muscle loss (sarcopenia).Pureza:95% - 97.6% (SDS-PAGE); 95.9% (SEC-HPLC)Cor e Forma:LiquidNisevokitug
CAS:Nisevokitug (anti-TGF-β mAb) neutralizes TGF-β and is being studied for its ability to modulate the immunosuppressive tumor microenvironment.Pureza:95%Cor e Forma:LiquidMetelimumab
CAS:Metelimumab (CAT-192) is a humanised monoclonal antibody targeting TGFβ1, which can be used to study diffuse systemic sclerosis (d-SSc).Pureza:95%Cor e Forma:LiquidLivmoniplimab
CAS:Livmoniplimab (ABBV-151; ARGX-115) is a humanised monoclonal antibody targeting LRRC32 (GARP)/TGFβ1, which blocks TGFβ1 release mediated by LRRC32Pureza:95%Cor e Forma:LiquidHalofuginone
CAS:Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.Fórmula:C16H17BrClN3O3Pureza:99.53%Cor e Forma:Off-White SolidPeso molecular:414.68CJJ300
CAS:<p>CJJ300 is a TGF-β inhibitor disrupting TGF-β-TβR complex formation, with an IC50 of 5.3 μM, and halts cell migration.</p>Fórmula:C30H33N3Pureza:99.80%Cor e Forma:SolidPeso molecular:435.6TGFβRI-IN-1
CAS:TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII,Fórmula:C20H14D3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:362.4Chromenone 1
CAS:Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP).Fórmula:C18H10F3N3O2Pureza:99.83% - 99.93%Cor e Forma:SolidPeso molecular:357.29(Rac)-SIS3 free base
CAS:SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.Fórmula:C28H27N3O3Pureza:98%Cor e Forma:SolidPeso molecular:453.53Halofuginone hydrobromide
CAS:<p>Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the suppression of angiogenesis and tumor cell growth.</p>Fórmula:C16H17BrClN3O3·HBrPureza:97.01% - 99.73%Cor e Forma:SolidPeso molecular:495.59SJ000063181
CAS:<p>SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.</p>Fórmula:C14H14ClFN2O2Pureza:99.94%Cor e Forma:SolidPeso molecular:296.723,7-DMF
CAS:3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation.Fórmula:C17H14O4Pureza:98%Cor e Forma:SolidPeso molecular:282.29DT-6
CAS:<p>DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing</p>Fórmula:C89H130N20O29S2Pureza:98%Cor e Forma:SolidPeso molecular:2008.23
