Pim
As quinases Pim são uma família de quinases serina/treonina que desempenham um papel fundamental na sobrevivência celular, proliferação e apoptose. Estas quinases são efetores a jusante na via de sinalização JAK/STAT e estão envolvidas em vários processos fisiológicos, incluindo respostas imunológicas e hematopoiese. A superexpressão das quinases Pim tem sido associada ao desenvolvimento de câncer, tornando-as alvos importantes para a intervenção terapêutica. Na CymitQuimica, oferecemos uma variedade de inibidores e moduladores de quinases Pim de alta qualidade para apoiar sua pesquisa em oncologia, biologia celular e transdução de sinal.
Foram encontrados 32 produtos de "Pim"
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AZD-1897
CAS:<p>AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.</p>Fórmula:C18H23N3O3SPureza:99.49%Cor e Forma:SolidPeso molecular:361.46M-110
CAS:<p>M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth (IC50=0.6-0.9μM).</p>Fórmula:C22H28ClN5O3Pureza:99.55%Cor e Forma:SolidPeso molecular:445.94PIM-1 Inhibitor 2
CAS:<p>PIM-1 Inhibitor 2 (PIM1-IN-2) is a potent Pim-1 inhibitor with potential anti-cancer activity, used in cancer research.</p>Fórmula:C17H11ClN4OPureza:98.81%Cor e Forma:SolidPeso molecular:322.75FD1024
CAS:<p>FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively.</p>Fórmula:C21H20F2N4O2SPureza:98%Cor e Forma:SolidPeso molecular:430.47GNE-955
CAS:<p>GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).</p>Fórmula:C22H24N8OPureza:98%Cor e Forma:SolidPeso molecular:416.48PIM1-IN-4
CAS:<p>PIM1-IN-4: strong PIM1 inhibitor, also blocks SGK-1, PKA, CaMK-1, GSK3β, MSK1; promising for cancer studies.</p>Fórmula:C27H25BrCl2CuN6OPureza:98%Cor e Forma:SolidPeso molecular:663.88Pim-1 kinase inhibitor 5
CAS:<p>Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-</p>Fórmula:C22H13Cl2N3OPureza:98%Cor e Forma:SolidPeso molecular:406.26PIM1-IN-1
CAS:<p>PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.</p>Fórmula:C25H30N8O2Pureza:98%Cor e Forma:SolidPeso molecular:474.56PIM-IN-2
CAS:<p>PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM .</p>Fórmula:C19H22N4O2Pureza:98%Cor e Forma:SolidPeso molecular:338.4HS94
CAS:<p>HS94 (DAPK3 inhibitor HS94) is a selective and potent DAPK3 inhibitor with a Ki value of 126 nM for Pim kinase inhibition and can be used to study hypertension.</p>Fórmula:C15H15N5O2SPureza:95.04%Cor e Forma:SolidPeso molecular:329.38GDC-0339
CAS:<p>GDC-0339: oral Pim kinase inhibitor for multiple myeloma (Kis: Pim1 - 0.03 nM, Pim2 - 0.1 nM, Pim3 - 0.02 nM), well-tolerated.</p>Fórmula:C20H22F3N7OSCor e Forma:SolidPeso molecular:465.5Pim-1 kinase inhibitor 6
CAS:<p>Pim-1 kinase inhibitor 6 (Compound 4d) is a robust inhibitor of Pim-1 kinase, demonstrating an IC 50 of 0.46 μM. It significantly exhibits cytotoxic effects on cancer cells [1].</p>Fórmula:C21H10BrCl2N3Cor e Forma:SolidPeso molecular:455.13
