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Pim

Pim

As quinases Pim são uma família de quinases serina/treonina que desempenham um papel fundamental na sobrevivência celular, proliferação e apoptose. Estas quinases são efetores a jusante na via de sinalização JAK/STAT e estão envolvidas em vários processos fisiológicos, incluindo respostas imunológicas e hematopoiese. A superexpressão das quinases Pim tem sido associada ao desenvolvimento de câncer, tornando-as alvos importantes para a intervenção terapêutica. Na CymitQuimica, oferecemos uma variedade de inibidores e moduladores de quinases Pim de alta qualidade para apoiar sua pesquisa em oncologia, biologia celular e transdução de sinal.

Foram encontrados 35 produtos para "Pim".

produtos por página.
  • VB1080
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    VB1080

    VB1080 (compound 12) is a potent PIM inhibitor with IC50 values of 69.5 µM for PIM1, 4996 µM for PIM2, and 9.88 µM for PIM3. Additionally, VB1080 exhibits cytotoxic properties and possesses anthelmintic activity.
    Fórmula:C27H27N3O3
    Cor e Forma:Solid
    Peso molecular:441.522

    Ref: TM-T204937

  • PIM-1 Inhibitor 2
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    PIM-1 Inhibitor 2

    CAS:
    PIM-1 Inhibitor 2 (PIM1-IN-2) is a potent Pim-1 inhibitor with potential anti-cancer activity, used in cancer research.
    Fórmula:C17H11ClN4O
    Pureza:98.81%
    Cor e Forma:Solid
    Peso molecular:322.75

    Ref: TM-T23158

  • K00135
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    K00135

    CAS:
    K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.
    Fórmula:C18H18N4O
    Pureza:98.16%
    Cor e Forma:Yellow Solid
    Peso molecular:306.3617

    Ref: TM-T27704

  • AZD-1897
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    AZD-1897

    CAS:
    AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.
    Fórmula:C18H23N3O3S
    Pureza:99.91%
    Cor e Forma:Solid
    Peso molecular:361.46

    Ref: TM-T71242

  • M-110
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    M-110

    CAS:
    M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth (IC50=0.6-0.9μM).
    Fórmula:C22H28ClN5O3
    Pureza:99.55%
    Cor e Forma:Orange Solid
    Peso molecular:445.942

    Ref: TM-T15830

  • CX-6258
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    CX-6258

    CAS:
    CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.
    Fórmula:C26H24ClN3O3
    Pureza:97.46%
    Cor e Forma:Solid
    Peso molecular:461.94

    Ref: TM-T1834

  • PIM1-IN-1
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    PIM1-IN-1

    CAS:
    PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.
    Fórmula:C25H30N8O2
    Pureza:98.59%
    Cor e Forma:Yellow Solid
    Peso molecular:474.5581

    Ref: TM-T12474

  • Pim-1 kinase inhibitor 5
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    Pim-1 kinase inhibitor 5

    CAS:
    Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-
    Fórmula:C22H13Cl2N3O
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:406.26

    Ref: TM-T78980

  • FD1024
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    FD1024

    CAS:
    FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively.
    Fórmula:C21H20F2N4O2S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:430.47

    Ref: TM-T79456

  • PIM-IN-2
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    PIM-IN-2

    CAS:
    PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM .
    Fórmula:C19H22N4O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:338.4

    Ref: TM-T81460

  • PIM1-IN-4
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    PIM1-IN-4

    CAS:
    PIM1-IN-4: strong PIM1 inhibitor, also blocks SGK-1, PKA, CaMK-1, GSK3β, MSK1; promising for cancer studies.
    Fórmula:C27H25BrCl2CuN6O
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:663.88

    Ref: TM-T73247

  • GNE-955
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    GNE-955

    CAS:
    GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).
    Fórmula:C22H24N8O
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:416.48

    Ref: TM-T15406

  • GDC-0339
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    GDC-0339

    CAS:
    GDC-0339: oral Pim kinase inhibitor for multiple myeloma (Kis: Pim1 - 0.03 nM, Pim2 - 0.1 nM, Pim3 - 0.02 nM), well-tolerated.
    Fórmula:C20H22F3N7OS
    Cor e Forma:Solid
    Peso molecular:465.495

    Ref: TM-T15376

  • CRT0066101
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    CRT0066101

    CAS:
    CRT0066101 is a potent and orally active protein kinase D inhibitor with low-nanomolar activity against PKD1, PKD2, and PKD3, while also inhibiting PIM2, CRT0066101 demonstrates significant anti-inflammatory efficacy in lipopolysaccharide-induced lung injury models as well as anticancer activity, supporting its use in inflammation and oncology research.
    Fórmula:C18H22N6O
    Cor e Forma:Solid
    Peso molecular:338.41

    Ref: TM-T86093

  • Pim-1 kinase inhibitor 6
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    Pim-1 kinase inhibitor 6

    CAS:
    Pim-1 kinase inhibitor 6 (Compound 4d) is a robust inhibitor of Pim-1 kinase, demonstrating an IC 50 of 0.46 μM. It significantly exhibits cytotoxic effects on cancer cells [1].
    Fórmula:C21H10BrCl2N3
    Cor e Forma:Solid
    Peso molecular:455.13

    Ref: TM-T87213