MNK
As MNKs (quinases interativas de MAPK) são um grupo de quinases que interagem com MAPKs, particularmente ERK e p38, para regular a síntese de proteínas através da fosforilação do fator de iniciação eucariótico 4E (eIF4E). A sinalização das MNKs desempenha um papel nas respostas ao estresse celular, inflamação e progressão do câncer. O direcionamento das MNKs é uma estratégia emergente na terapia contra o câncer e tratamentos anti-inflamatórios. Na CymitQuimica, oferecemos uma seleção de inibidores e moduladores de MNK para apoiar sua pesquisa na regulação da síntese de proteínas, oncologia e inflamação.
Foram encontrados 13 produtos de "MNK"
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ETC-206
CAS:ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).
Fórmula:C25H20N4O2Pureza:99.72% - 99.79%Cor e Forma:SolidPeso molecular:408.45HSND80
HSND80 (Compound 1) is an orally active MNK/p70S6K inhibitor, exhibiting a Kd value of 44 nM for MNK1 and 4 nM for MNK2. The residence time of HSND80 on MNK1 and MNK2 is 45 minutes and 58 minutes, respectively. HSND80 effectively inhibits non-small cell lung cancer (NSCLC) both in vitro and in vivo, and suppresses the growth of triple-negative breast cancer (TNBC) cells in vitro.Cor e Forma:Odour SolidMNK-IN-4
MNK-IN-4 (compound D25) is a potent and selective MNK inhibitor used in treating acute spleen injury related to sepsis.Fórmula:C15H17N5Peso molecular:267.1484NUCC-0200808
NUCC-0200808 (Compound 12g) is an MNK1 inhibitor with an IC50 of 42 nM. It reduces eIF4E phosphorylation and cell viability in AML cells and induces apoptosis. NUCC-0200808 shows potential for research in the field of leukemia.Cor e Forma:Odour SolidCGP 57380
CAS:CGP 57380 (MNK1 Inhibitor) is a potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-likeFórmula:C11H9FN6Pureza:98.49%Cor e Forma:SolidPeso molecular:244.23Tomivosertib
CAS:Tomivosertib (eFT508) is a potent, highly selective MNK1 and MNK2 inhibitor with IC50 value of 1-2 nM.Fórmula:C17H20N6O2Pureza:97.34% - 99.72%Cor e Forma:SolidPeso molecular:340.38Tomivosertib HCl
CAS:Tomivosertib (eFT508) is a MNK1/2 inhibitor that blocks eIF4E phosphorylation, hindering tumor growth and immune signaling.Fórmula:C17H21ClN6O2Cor e Forma:SolidPeso molecular:376.845SLV-2436
CAS:SLV-2436 (SEL201-88) is a novel effective and ATP-competitive inhibitor of MNK1 and MNK2 (IC50: 10.8/5.4 nM).Fórmula:C19H15ClN4OPureza:98.56%Cor e Forma:SolidPeso molecular:350.8Ref: TM-T4424
1mg77,00€2mg101,00€5mg166,00€10mg260,00€25mg462,00€50mg677,00€100mg888,00€200mg1.234,00€1mL*10mM (DMSO)178,00€HG-10-102-01
CAS:HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).Fórmula:C17H20ClN5O3Pureza:99.59%Cor e Forma:SolidPeso molecular:377.83Ref: TM-T7196
2mg35,00€5mg55,00€10mg89,00€25mg161,00€50mg250,00€100mg360,00€200mg512,00€1mL*10mM (DMSO)62,00€ETC-168
CAS:ETC-168 is a selective, orally active MNK inhibitor with IC50 values of 23 nM for MNK1 and 43 nM for MNK2. It demonstrates antiproliferative efficacy both in vivo and in vitro [1].Fórmula:C24H19N5O2Cor e Forma:SolidPeso molecular:409.44MNK1/2-IN-5
CAS:MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor with anticancer activity and can be used to study solid tumors and hematological malignancies.Fórmula:C17H16N4O2Pureza:98.04%Cor e Forma:SolidPeso molecular:308.33Ref: TM-T60733
1mg60,00€2mg86,00€5mg130,00€10mg187,00€25mg338,00€50mg497,00€100mg708,00€200mg973,00€1mL*10mM (DMSO)138,00€DS12881479
CAS:DS12881479 can be used in cancer research which is a potent and selective inhibitor of Mnk1(IC 50 =21 nM) [1].Fórmula:C16H19N3OSPureza:99.85%Cor e Forma:SolidPeso molecular:301.41MNK inhibitor 9
CAS:MNK inhibitor 9 potently blocks MNK1/2 (IC50: 0.003 µM each), is cell-permeable, and useful for tumor research.Fórmula:C25H29N9OCor e Forma:SolidPeso molecular:471.56
