MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 886 produtos de "MAPK"
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GAGGVGKSAL
CAS:<p>GAGGVGKSAL, a wild-type KRAS G12D 10mer peptide, serves as an immunogenic neoantigen in cancer immunotherapy research [1].</p>Fórmula:C34H61N11O12Cor e Forma:SolidPeso molecular:815.91IPS-06061
<p>IPS-06061 is an orally active molecular glue that forms a ternary complex with CRBN and KRASG12D, capable of degrading KRAS G12D, with a DC50 of less than 500 nM.</p>Fórmula:C22H26O3Cor e Forma:SolidPeso molecular:338.44SW083688
CAS:<p>SW083688 is a potent and highly selective inhibitor of Thousand-And-One Kinase 2 (TAOK2) with an IC 50 value of 1.3 µmol/L.</p>Fórmula:C23H25N3O5SCor e Forma:SolidPeso molecular:455.53Vem-L-Cy5
<p>Vem-L-Cy5 (compound 3), a Vemurafenib-based BRAF inhibitor conjugated with the near-infrared (NIR) fluorophore cyanine-5 (Cy5), selectively targets the BRAF</p>Fórmula:C63H68F5N7O9SPureza:98%Cor e Forma:SolidPeso molecular:1194.31MEK4 inhibitor-1
CAS:<p>MEK4 inhibitor-1 targets MEK4 enzyme in pancreatic cancer, IC50=61 nM.</p>Fórmula:C13H10FN3O2SCor e Forma:SolidPeso molecular:291.3Anti-inflammatory agent 7
<p>Anti-inflammatory Agent 7 suppresses proinflammatory cytokines by hindering the NF-κB/MAPK signaling pathway in both LPS-treated RAW 264.7 cells and mice.</p>Fórmula:C36H40N4O9Cor e Forma:SolidPeso molecular:672.72StRIP16
<p>Rab8a GTPase-binding stapled peptide (Kd = 12.7 μM). Cell permeable; localizes to the endomembrane system.</p>Cor e Forma:SolidPROTAC JNK1-targeted-1
<p>PROTAC JNK1-targeted-1 (PA2) is a JNK1 PROTAC degrader with a DC50 of 10 nM. It effectively reduces fibronectin levels and is useful in lung fibrosis research. [Pink: JNK1 inhibitor; Black: linker; Blue: CRBN Ligand]</p>Fórmula:C35H32BrN9O6Cor e Forma:SolidPeso molecular:754.589KRASG12C IN-2
<p>KRASG12C IN-2 (compound 17) is an orally active inhibitor of KRAS G12C, which effectively suppresses tumor growth in mice [1].</p>Cor e Forma:SolidMRTF-A-IN-1
<p>MRTF-A-IN-1 (compound 14) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.</p>Fórmula:C22H21N3Cor e Forma:SolidPeso molecular:327.42MEK/RAF-IN-1
<p>MEK/RAF-IN-1 (Compound 16b) serves as an inhibitor targeting both MEK and RAF, demonstrating potent efficacy with IC 50 values reported at 28 nM for MEK1, and 3 nM for both BRAF and BRAFV600E. This compound exhibits significant antitumor capabilities, effectively curbing cell proliferation in vitro in MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Furthermore, MEK/RAF-IN-1 significantly restricts tumor growth in xenograft mouse models employed in the study of colorectal cancer.</p>Fórmula:C28H29F3N6O5SCor e Forma:SolidPeso molecular:618.63PPM-3
<p>PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM.</p>Fórmula:C54H69N11O6SPureza:98%Cor e Forma:SolidPeso molecular:1000.26JNK3 inhibitor-9
<p>JNK3inhibitor-9 (Compound 24a) is a potent, selective JNK3 inhibitor capable of crossing the blood-brain barrier (BBB), demonstrating an IC50 value of 12 nM. It effectively inhibits GSK3α/β, which is involved in Tau phosphorylation, with IC50 values of 14 nM and 35 nM, respectively. JNK3inhibitor-9 also reduces the phosphorylation of c-Jun and APP and protects neurons from Aβ1-42 toxicity.</p>Fórmula:C25H27N7O2Cor e Forma:SolidPeso molecular:457.528BSc5367
CAS:<p>BSc5367 is a potent inhibitor of the structural domain of Nek1 kinase.cell cycle regulation, DNA repair, and microtubule regulation. ALS, PKD.</p>Fórmula:C20H15N3O2Pureza:98.72%Cor e Forma:SoildPeso molecular:329.35R18
CAS:<p>14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.</p>Fórmula:C101H157N27O29S3Pureza:98%Cor e Forma:SolidPeso molecular:2309.69Anti-inflammatory agent 31
<p>Andrographolide derivative 31 is an anti-inflammatory that blocks NF-κB, PI3K/Akt, and ERK1/2 MAPK, and restores GSH levels to protect the liver.</p>Fórmula:C19H30O3Cor e Forma:SolidPeso molecular:306.44Pan-RAS-IN-6
Pan-RAS-IN-6 (compound 24) serves as a DUSP6 inhibitor, effectively reducing MAPK activation in the NCI-H1373-Luc model (DUSP6). It concurrently exhibits notable tumor growth inhibition and regression in the NSCLC brain metastasis mouse model. The compound displays high selectivity and potent inhibitory effects, particularly on KRAS mutation-associated signaling pathways. It demonstrates varied inhibitory activities against distinct KRAS mutants and their interacting proteins. The IC 50 values for KRAS G12C, G12D, and G12V are 1.3 nM, 4.7 nM, and 0.3 nM, respectively.Fórmula:C46H60N8O5SCor e Forma:SolidPeso molecular:837.08Cyclotraxin B
CAS:<p>TrkB receptor antagonist; inhibits BDNF-TrkB signaling (IC50 = 0.30 nM); alters receptor shape; may reduce anxiety in mice.</p>Fórmula:C48H73N13O17S3Pureza:98%Cor e Forma:SolidPeso molecular:1200.36SAH-SOS1A TFA
<p>SAH-SOS1A TFA inhibits SOS1/KRAS interaction, binding wild/mutant KRAS with 106-175 nM affinity and blocks ERK-MAPK signaling, reducing cancer cell viability.</p>Fórmula:C102H160N27F3O30Cor e Forma:SolidPeso molecular:2301.55NK7-902
<p>NK7-902 is a CRBN molecular glue degrader of NEK7. It fully degrades NEK7 in human primary monocytes and whole blood, yet only partially inhibits NLRP3-dependent IL-1β production. NK7-902 results in profound and lasting degradation of NEK7, but only temporarily blocks NLRP3 inflammasome activation in non-human primates via oral administration. The compound demonstrates activity in mouse systems.</p>Cor e Forma:Odour SolidNUCC-0200808
<p>NUCC-0200808 (Compound 12g) is an MNK1 inhibitor with an IC50 of 42 nM. It reduces eIF4E phosphorylation and cell viability in AML cells and induces apoptosis. NUCC-0200808 shows potential for research in the field of leukemia.</p>Cor e Forma:Odour SolidRP03707
CAS:<p>RP03707 is a PROTAC degrader of KRASG12D.</p>Fórmula:C55H58F3N11O4Cor e Forma:SolidPeso molecular:994.12SP 600125, negative control
CAS:<p>SP 600125, negative control is a methylated analog of SP 600125 and can be used as a negative control for SP 600125.</p>Fórmula:C15H10N2OPureza:≥98%Cor e Forma:SolidPeso molecular:234.25RTIL 13
CAS:<p>RTIL 13 inhibits dynamin GTPase (IC50: 2.3 μM), targets its lipid binding domain, and suppresses endocytosis (IC50: 9.3 & 7.1 μM).</p>Fórmula:C30H55BrN2O3Cor e Forma:SolidPeso molecular:571.685PROTAC SOS1 degrader-1
CAS:<p>PROTAC SOS1 degrader-1: potent, DC50 98.4 nM, inhibits KRAS mutant cancer cells, low-toxic antitumor.</p>Fórmula:C57H76O4ClFN10SCor e Forma:SoildPeso molecular:1050.54443KRAS inhibitor-33
<p>KRAS inhibitor-33 (compound 115a) is a pyrido[2,3-d]pyrimidine derivative that serves as an effective inhibitor of KRAS, exhibiting an IC50 value of ≤ 100nM.</p>Fórmula:C33H39ClF2N6O3Cor e Forma:SolidPeso molecular:641.15Cyclorasin 9A5 TFA
<p>Cyclorasin 9A5 TFA is a cell-penetrating cyclic peptide consisting of 11 residues that inhibits the interaction between Ras and Raf proteins, with an IC50 of 120 nM.</p>Fórmula:C75H108FN25O13·xC2HF3O2Cor e Forma:SolidPeso molecular:1586.82 (free base)HPK1-IN-39
<p>HPK1-IN-39 (Compound 10n), a selective inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) with an inhibitory concentration (IC50) of 29 nM, impedes the</p>Fórmula:C26H27N7O2Cor e Forma:SolidPeso molecular:469.54YN14
<p>YN14 is a highly potent and selective KRASG12C proteolysis targeting chimera (PROTAC) capable of forming a stable KRASG12C: YN14: VHL ternary complex with low</p>Pureza:98%Cor e Forma:Odour Solidp38 MAP Kinase Inhibitor Ⅵ
CAS:p38 MAP Kinase Inhibitor Ⅵ is a potent p38 MAP Kinase inhibitor with anti-inflammatory activity.Fórmula:C16H13FN2OS2Pureza:98.53%Cor e Forma:SolidPeso molecular:332.42Divarasib adipate
CAS:<p>Divarasib (GDC-6036) adipate is a selective and highly potent KRAS G12C inhibitor with an impressively low IC 50 value of <0.01 μM, designed for oral administration. It covalently attaches to the switch II (SW-II) pocket in KRAS G12C, irreversibly maintaining the protein in its inactive GDP-bound state [1] [2].</p>Fórmula:C35H42ClF4N7O6Cor e Forma:SolidPeso molecular:768.2Rineterkib hydrochloride
CAS:<p>Rineterkib hydrochloride (B) is an oral RAF/ERK1/2 inhibitor for MAPK-driven cancers, including KRAS/BRAF-mutant NSCLC and CRC.</p>Fórmula:C26H28BrClF3N5O2Cor e Forma:SolidPeso molecular:614.89Deltasonamide 1 TFA
CAS:<p>Deltasonamide 1 TFA: PDE6δ-KRas inhibitor, K D 203 pM, used in tumor research.</p>Fórmula:C32H40ClF3N6O6S2Cor e Forma:SolidPeso molecular:761.28PROTAC K-Ras Degrader-5
CAS:<p>Pan-KRAS degrader 4 (compound 69) is a cereblon-based PROTAC KRAS degrader exhibiting anticancer activity with a DC50 value of less than 100 nM.</p>Fórmula:C57H63F3N10O5Cor e Forma:SolidPeso molecular:1025.17BI1701963
<p>BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.</p>Fórmula:C47H62N8O4SCor e Forma:SolidPeso molecular:835.11Natsudaidain
<p>Natsudaidain is a useful organic compound for research related to life sciences and the catalog number is T124974.</p>Fórmula:C21H22O9Cor e Forma:SolidPeso molecular:418.398KRAS inhibitor-42
<p>KRAS inhibitor-42 (compound 8) is an effective USP7 inhibitor that exhibits high affinity for GDP-bound KRASG12D, with a Ki value of 2.7 μM.</p>Fórmula:C34H47ClN8O4S2Cor e Forma:SolidPeso molecular:730.28502Pan-RAS-IN-7
CAS:<p>Pan-RAS-IN-7 (Compound D101) is a broad-spectrum RAS inhibitor used in the synthesis of antibody-drug conjugates (ADCs). It is also applicable in cancer research.</p>Fórmula:C59H76N8O8Cor e Forma:SolidPeso molecular:1025.28AS601245.2TFA (345987-15-7 free base)
CAS:AS601245.2TFA (345987-15-7 free base) (AS601245.2TFA) is a cell-permeable Inhibitor of JNK (IC50s of 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3,Fórmula:C24H18F6N6O4SPureza:98%Cor e Forma:SoildPeso molecular:600.50Ibetazol
<p>Ibetazol is an inhibitor of importin β1 (KPNB1), which functions by binding to Cys585 of importin β1, thus preventing importin β1-mediated nuclear import with an EC50 of 6.1 µM.</p>Fórmula:C13H11F3N2OSCor e Forma:SolidPeso molecular:300.3KRAS G12D inhibitor 6
CAS:<p>KRAS G12D inhibitor 6 is an efficacious compound that effectively inhibits KRAS G12D.</p>Fórmula:C32H37ClN8O2Cor e Forma:SolidPeso molecular:601.15KRas G12R inhibitor 1
<p>KRas G12R inhibitor 1 targets mutant cysteines in K-Ras, binds irreversibly, and is used in cancer research.</p>Fórmula:C39H38ClF7N6O9Cor e Forma:SolidPeso molecular:903.2Talmapimod hydrochloride
CAS:<p>Talmapimod hydrochloride: selective p38α inhibitor, 9 nM IC50, 10x less effective on p38β, >2000-fold selective vs 20+ kinases.</p>Fórmula:C27H31Cl2FN4O3Pureza:98%Cor e Forma:SolidPeso molecular:549.46HPK1-IN-20
CAS:<p>HPK1-IN-19 is a potent inhibitor of hematopoietic progenitor kinase 1 (HPK1).</p>Fórmula:C26H28N6O2Cor e Forma:SolidPeso molecular:456.55Cobimetinib (R-enantiomer)
CAS:<p>Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.</p>Fórmula:C21H21F3IN3O2Pureza:98%Cor e Forma:SolidPeso molecular:531.318PROTAC SOS1 degrader-4
<p>PROTAC SOS1 Degrader-4 (compound 10) is a potent degrader of SOS1 and exhibits antiproliferative activity [1].</p>Fórmula:C53H65ClN8O7SPureza:98%Cor e Forma:SolidPeso molecular:993.65Debromohymenialdisine
CAS:<p>Debromohymenialdisine is a natural product for research related to life sciences. The catalog number is T35596 and the CAS number is 75593-17-8.</p>Fórmula:C11H11N5O2Cor e Forma:SolidPeso molecular:245.242KRAS G12D inhibitor 7
CAS:<p>KRAS G12D inhibitor 7, is a highly potent inhibitor specifically targeting KRAS G12D.</p>Fórmula:C32H38N8O3Cor e Forma:SolidPeso molecular:582.709PD 198306
CAS:<p>PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.</p>Fórmula:C18H16F3IN2O2Pureza:99.66%Cor e Forma:SolidPeso molecular:476.23Enniatin B1
CAS:<p>Enniatin B1, a Fusarium mycotoxin, crosses the blood-brain barrier and modulates ERK, NF-κB, and ACAT with an IC50 of 73 μM.</p>Fórmula:C34H59N3O9Pureza:98%Cor e Forma:SolidPeso molecular:653.858S6K1-IN-DG2
CAS:<p>S6K1-IN-DG2(S6K1InhibitorDG2) is a potent p70S6K inhibitor with an IC50 value of less than 100 nM.</p>Fórmula:C16H17BrN6OPureza:99.25%Cor e Forma:SolidPeso molecular:389.25LC-2
CAS:LC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C with a DC50 between 0.25 and 0.76 μM.LC-2 is aFórmula:C59H71ClFN11O7SPureza:98%Cor e Forma:SolidPeso molecular:1132.78Tunlametinib
CAS:<p>Tunlametinib is a MEK1/2 inhibitor (IC50=1.9 nM) for treating RAS/RAF-driven cancers.</p>Fórmula:C16H12F2IN3O3SPureza:98.72%Cor e Forma:SolidPeso molecular:491.25Anti-ERK2 Antibody (5V598)
<p>Anti-ERK2 Antibody (5V598) is a Rabbit antibody targeting ERK2. Anti-ERK2 Antibody (5V598) can be used in ELISA.</p>Cor e Forma:Odour LiquidAnti-ERK2 Antibody (4F551)
<p>Anti-ERK2 Antibody (4F551) is a Rabbit antibody targeting ERK2. Anti-ERK2 Antibody (4F551) can be used in ELISA,FCM.</p>Cor e Forma:Odour LiquidAnti-ERK2 Antibody (9C922)
<p>Anti-ERK2 Antibody (9C922) is a Mouse antibody targeting ERK2. Anti-ERK2 Antibody (9C922) can be used in WB,ELISA.</p>Cor e Forma:Odour LiquidTAK1-IN-3
CAS:<p>TAK1-IN-3 is a novel ATP-competitive TAK1 inhibitor for the study of cancer.</p>Fórmula:C16H19N3O2SPureza:98.88%Cor e Forma:SolidPeso molecular:317.41Enniatin B
CAS:<p>Enniatins B decreases the activation of ERK (p44/p42).</p>Fórmula:C33H57N3O9Pureza:98%Cor e Forma:SolidPeso molecular:639.831TRPM4 inhibitor 8
CAS:<p>TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.</p>Fórmula:C11H17BrN2Pureza:97%Cor e Forma:SolidPeso molecular:257.17JH295
CAS:<p>JH295: potent, selective Nek2 inhibitor (IC50 = 770 nM), irreversibly targets Cys22, no effect on Cdk1, Aurora B, Plk1, or spindle mechanisms.</p>Fórmula:C18H16N4O2Cor e Forma:SolidPeso molecular:320.352EM127
CAS:<p>EM127: covalent SMYD3 inhibitor, KD 13μM, impedes ERK1/2, hinders SMYD3 gene regulation, long-term methyltransferase reduction, potential in cancer study.</p>Fórmula:C14H18ClN3O3Pureza:97.61%Cor e Forma:SolidPeso molecular:311.76RAS GTPase inhibitor 1
CAS:<p>RAS GTPase inhibitor 1 is a RAS GTPase inhibitor with potential antitumor activity.</p>Fórmula:C27H28ClF4N5O2Pureza:98.43%Cor e Forma:SolidPeso molecular:565.99IACS-13909
CAS:<p>IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.</p>Fórmula:C17H18Cl2N6Pureza:98.8%Cor e Forma:SolidPeso molecular:377.27Gypenoside L
CAS:<p>Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.</p>Fórmula:C42H72O14Pureza:99.42% - 99.65%Cor e Forma:SolidPeso molecular:801.01L-779450
CAS:<p>L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively.</p>Fórmula:C20H14ClN3OPureza:≥95%Cor e Forma:SolidPeso molecular:347.8CC-90001
CAS:<p>CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.</p>Fórmula:C16H27N5O2Pureza:99.96%Cor e Forma:SolidPeso molecular:321.42A-674563 2HCl(552325-73-2(fb-2hcl))
<p>A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.</p>Fórmula:C22H24Cl2N4OPureza:94.66%Cor e Forma:SolidPeso molecular:431.36NG25
CAS:NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.Fórmula:C29H30F3N5O2Pureza:98.32% - ≥95%Cor e Forma:SolidPeso molecular:537.58K-Ras(G12C) inhibitor 6
CAS:<p>Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.</p>Fórmula:C17H22Cl2N2O3SPureza:89.07% - 97.09%Cor e Forma:SolidPeso molecular:405.34K-Ras(G12C) inhibitor 9
CAS:<p>K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).</p>Fórmula:C16H21ClIN3O4SPureza:97.33% - 97.45%Cor e Forma:SolidPeso molecular:513.78Cichoric Acid
CAS:<p>Cichoric Acid (Dicaffeoyltartaric acid) is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues.</p>Fórmula:C22H18O12Pureza:97.87% - 98.77%Cor e Forma:SolidPeso molecular:474.37methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate
CAS:<p>methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate is a biochemical.</p>Fórmula:C13H13NO5Pureza:97.69%Cor e Forma:SolidPeso molecular:263.25AZD8330
CAS:<p>AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.</p>Fórmula:C16H17FIN3O4Pureza:98.72%Cor e Forma:SolidPeso molecular:461.23Kobe2602
CAS:<p>Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.</p>Fórmula:C14H9F4N5O4SPureza:98.36% - 99.39%Cor e Forma:SolidPeso molecular:419.31GS87
CAS:<p>GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.</p>Fórmula:C16H11N5O2SPureza:98.86%Cor e Forma:SolidPeso molecular:337.36Belvarafenib
CAS:<p>Belvarafenib (HM95573) is a potent pan-RAF inhibitor with antitumor activity and inhibits B-RAF, B-RAFv600E, and C-RAF.Cost-effective and quality-assured.</p>Fórmula:C23H16ClFN6OSPureza:98% - 99.65%Cor e Forma:SolidPeso molecular:478.93Agerafenib
CAS:<p>Agerafenib (CEP32496) is a highly potent inhibitor of BRAF.</p>Fórmula:C24H22F3N5O5Pureza:95.78% - 99.23%Cor e Forma:SolidPeso molecular:517.46SCH772984
CAS:<p>SCH772984 is an ERK inhibitor and is highly selective and ATP-competitive. SCH772984 exhibits antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C33H33N9O2Pureza:97.565% - 98.75%Cor e Forma:SolidPeso molecular:587.67Deltarasin HCl
CAS:<p>Deltarasin hinders KRAS-PDEδ, impairs cancer cell growth via a PDEδ pocket, disrupting RAS/RAF signaling and autophagy.</p>Fórmula:C40H37N5O·xHClCor e Forma:SolidPeso molecular:713.144RAF709
CAS:<p>RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.</p>Fórmula:C28H29F3N4O4Pureza:99.28% - 99.8%Cor e Forma:SolidPeso molecular:542.55NVP-BHG712
CAS:<p>NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and</p>Fórmula:C26H20F3N7OPureza:97.32% - 98.63%Cor e Forma:SolidPeso molecular:503.48ASK1-IN-1
CAS:<p>ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.</p>Fórmula:C19H19N9O2Pureza:99.92%Cor e Forma:SolidPeso molecular:405.41PROTAC BRAF-V600E degrader-1
CAS:<p>PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.</p>Fórmula:C48H54F2N10O10SPureza:99.43%Cor e Forma:SolidPeso molecular:1001.07R1487
CAS:<p>R1487 is an orally bioavailable and highly selective p38α mitogen-activated protein kinase inhibitor.</p>Fórmula:C19H18F2N4O3Pureza:99.77%Cor e Forma:SolidPeso molecular:388.37ASP2453
CAS:<p>ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.</p>Fórmula:C40H48F3N7O4Pureza:99.71%Cor e Forma:SolidPeso molecular:747.85PLX-4720
CAS:<p>PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.</p>Fórmula:C17H14ClF2N3O3SPureza:97.78% - 99.83%Cor e Forma:SolidPeso molecular:413.83ERK-IN-3
CAS:<p>ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.</p>Fórmula:C22H25ClFN7O2Pureza:99.55% - 99.76%Cor e Forma:SolidPeso molecular:473.93GNE-495
CAS:<p>GNE-495 is a potent and specific MAP4K4 inhibitor (IC50: 3.7 nM).</p>Fórmula:C22H20FN5O2Pureza:99.22% - 99.57%Cor e Forma:SolidPeso molecular:405.42BAY-293
CAS:<p>BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).</p>Fórmula:C25H28N4O2SPureza:97.16%Cor e Forma:SolidPeso molecular:448.58(S)-AMG-510
CAS:<p>(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.</p>Fórmula:C30H30F2N6O3Pureza:99.05% - 99.76%Cor e Forma:SolidPeso molecular:560.594B-Raf IN 11
CAS:<p>B-Raf IN 11 is a novel selective inhibitor.</p>Fórmula:C17H14BrF2N3O3SPureza:99.947%Cor e Forma:SolidPeso molecular:458.28Compound 3344 hydrochloride
<p>Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.</p>Fórmula:C24H27ClN2O3Pureza:99.23%Cor e Forma:SolidPeso molecular:426.94Locostatin
CAS:<p>Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.</p>Fórmula:C14H15NO3Pureza:97.13%Cor e Forma:SolidPeso molecular:245.27SB 239063
CAS:<p>SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.</p>Fórmula:C20H21FN4O2Pureza:99.42% - 99.81%Cor e Forma:SolidPeso molecular:368.4AZ7550
CAS:<p>AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>Fórmula:C27H31N7O2Pureza:97.07% - 99.75%Cor e Forma:SolidPeso molecular:485.58IQ-3
CAS:<p>IQ3 inhibits JNK3 (Kd 66 nM), JNK1/2, NF-κB/AP1 in THP1-Blue cells (IC50 1.4 μM), and reduces TNF-α/IL-6 production.</p>Fórmula:C20H11N3O3Pureza:≥98%Cor e Forma:SolidPeso molecular:341.32BMS582949
CAS:<p>BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.</p>Fórmula:C22H26N6O2Pureza:98.11%Cor e Forma:SolidPeso molecular:406.48CC-401 Hydrochloride
CAS:<p>CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.</p>Fórmula:C22H25ClN6OPureza:99.71% - ≥95%Cor e Forma:SolidPeso molecular:424.93Maohuoside A
CAS:<p>Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.</p>Fórmula:C27H32O12Pureza:98.91% - 99.57%Cor e Forma:SolidPeso molecular:548.54BI-78D3
CAS:<p>BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.</p>Fórmula:C13H9N5O5S2Pureza:97.89% - >99.99%Cor e Forma:SolidPeso molecular:379.37
