MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 881 produtos de "MAPK"
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NK7-902
<p>NK7-902 is a CRBN molecular glue degrader of NEK7. It fully degrades NEK7 in human primary monocytes and whole blood, yet only partially inhibits NLRP3-dependent IL-1β production. NK7-902 results in profound and lasting degradation of NEK7, but only temporarily blocks NLRP3 inflammasome activation in non-human primates via oral administration. The compound demonstrates activity in mouse systems.</p>Cor e Forma:Odour SolidPROTAC K-Ras Degrader-2
CAS:<p>PROTAC K-Ras degrader-2 (compound 48) is a broad-spectrum KRAS mutant PROTAC degrader that demonstrates an IC50 of ≤200 nM for KRAS G12V/RAF1. Additionally, PROTAC K-Ras degrader-2 achieves a DC50 of ≤200 nM in degrading SW620 KRAS G12D and inhibits the growth of SW620 3D cells with an IC50 of ≤20 nM.</p>Fórmula:C52H60F4N8O5Cor e Forma:SolidPeso molecular:953.077Antimicrobial agent-21
CAS:<p>Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment of</p>Fórmula:C18H13N3OSPureza:99.82%Cor e Forma:SolidPeso molecular:319.38HPK1-IN-20
CAS:<p>HPK1-IN-19 is a potent inhibitor of hematopoietic progenitor kinase 1 (HPK1).</p>Fórmula:C26H28N6O2Cor e Forma:SolidPeso molecular:456.55KRAS inhibitor-33
<p>KRAS inhibitor-33 (compound 115a) is a pyrido[2,3-d]pyrimidine derivative that serves as an effective inhibitor of KRAS, exhibiting an IC50 value of ≤ 100nM.</p>Fórmula:C33H39ClF2N6O3Cor e Forma:SolidPeso molecular:641.15SAH-SOS1A
CAS:<p>KRas/SOS1 inhibitor; binds KRas pocket, Kd 106-176 nM; blocks nucleotide binding; cytotoxic to KRas-driven cancers; disrupts ERK-MAPK pathway; cell-permeable.</p>Fórmula:C100H159N27O28Pureza:98%Cor e Forma:SolidPeso molecular:2187.53RTIL 13
CAS:<p>RTIL 13 inhibits dynamin GTPase (IC50: 2.3 μM), targets its lipid binding domain, and suppresses endocytosis (IC50: 9.3 & 7.1 μM).</p>Fórmula:C30H55BrN2O3Cor e Forma:SolidPeso molecular:571.685YN14
<p>YN14 is a highly potent and selective KRASG12C proteolysis targeting chimera (PROTAC) capable of forming a stable KRASG12C: YN14: VHL ternary complex with low</p>Pureza:98%Cor e Forma:Odour SolidPROTAC MEK1 Degrader-1
CAS:<p>PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2</p>Fórmula:C53H66FIN8O11S2Pureza:98%Cor e Forma:SolidPeso molecular:1201.174′-Demethylnobiletin
CAS:<p>4′-Demethylnobiletin, a bioactive metabolite, activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and</p>Fórmula:C20H20O8Cor e Forma:SolidPeso molecular:388.37MRTF-A-IN-2
<p>MRTF-A-IN-2 (compound 16) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.</p>Cor e Forma:Odour SolidS6 Kinase Substrate Peptide 32
S6 Kinase Substrate Peptide 32 is a peptide that measures the activity of kinases that phosphorylate ribosomal protein S6. It can also be used as a substrate.Fórmula:C149H270N56O49Pureza:98%Cor e Forma:SolidPeso molecular:3630.1JNK3 inhibitor-7
<p>Potent, oral JNK3 inhibitor-7 crosses blood-brain barrier, IC50: 53 nM (JNK3), offers neuroprotection, potential in AD research.</p>Fórmula:C32H31N7O3Cor e Forma:SolidPeso molecular:561.63ZZ151
<p>ZZ151 is an effective and selective SOS1 PROTAC with in vivo anti-tumor efficacy against KRAS-mutant cancers. This compound induces rapid and specific degradation of SOS1 and exhibits strong anti-proliferative activity against a wide range of KRAS mutation-driven cancer cells. In murine xenograft models with KRASG12D and G12V mutations, ZZ151 demonstrates superior anticancer activity. It represents a promising lead compound for developing new chemotherapeutic agents targeting KRAS mutations.</p>Fórmula:C54H68F3N9O6SCor e Forma:SolidPeso molecular:1028.23HRX-0233
CAS:<p>HRX-0233 is a small molecule inhibitor targeting MAP2K4. In vivo, HRX-0233 effectively reduces tumors in H358 KRASG12C mutant non-small cell lung cancer (NSCLC) without significant toxicity. This compound also prevents feedback activation of receptor tyrosine kinases (RTKs) when used as a monotherapy with the KRAS inhibitor Sotorasib, leading to more sustained and comprehensive inhibition of the MAPK signaling pathway. HRX-0233 holds potential for research in AR-negative prostate cancer, lung cancer, and colon cancer.</p>Fórmula:C24H21F2N5O3SCor e Forma:SolidPeso molecular:497.52NG 25 (hydrochloride hydrate)
<p>NG 25 is a type II kinase inhibitor targeting multiple kinases with various IC50 values and reduces colorectal cancer cell viability and tumors.</p>Cor e Forma:SolidPROTAC SOS1 degrader-2
CAS:<p>PROTAC SOS1 degrader-2 reduces pERK & RAS-GTP, inhibiting tumor growth dose-dependently in vivo.</p>Fórmula:C57H76ClFN10O4SCor e Forma:SolidPeso molecular:1051.79MRTX1133 formic
<p>MRTX1133: Selective inhibitor of KRAS G12D, effective in all protein states, targeting mutant cells.</p>Fórmula:C34H33F3N6O4Cor e Forma:SoildPeso molecular:646.67Ibetazol
<p>Ibetazol is an inhibitor of importin β1 (KPNB1), which functions by binding to Cys585 of importin β1, thus preventing importin β1-mediated nuclear import with an EC50 of 6.1 µM.</p>Fórmula:C13H11F3N2OSCor e Forma:SolidPeso molecular:300.3MORINDONE
CAS:<p>MORINDONE, an anthraquinone compound, exhibits significant binding affinity towards multiple targets including β-catenin, MDM2-p53, and KRAS. It displays notable cytotoxicity and selective activity against colorectal cancer cell lines, and effectively downregulates the expression of mutated TP53 and KRAS genes.</p>Fórmula:C15H10O5Cor e Forma:SolidPeso molecular:270.24
