MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 881 produtos de "MAPK"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Sotorasib
CAS:<p>Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C.</p>Fórmula:C30H30F2N6O3Pureza:98% - 99.95%Cor e Forma:SolidPeso molecular:560.594BI-78D3
CAS:<p>BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.</p>Fórmula:C13H9N5O5S2Pureza:97.89% - >99.99%Cor e Forma:SolidPeso molecular:379.37Belvarafenib TFA
<p>Belvarafenib TFA (HM95573 TFA) inhibits RAF: B-RAF (56 nM), B-RAFv600E (7 nM), C-RAF (5 nM) effectively.</p>Fórmula:C25H17ClF4N6O3SCor e Forma:SolidPeso molecular:592.95GS87
CAS:<p>GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.</p>Fórmula:C16H11N5O2SPureza:98.86%Cor e Forma:SolidPeso molecular:337.362-(4-methoxyphenyl)-2-oxoethyl 2-hydroxy-5-methylbenzoate
CAS:<p>Pro-neurotropic drug boosts brain acetylcholine synthesis and release, inhibits breakdown.</p>Fórmula:C17H16O5Pureza:98.68%Cor e Forma:SolidPeso molecular:300.31PROTAC BRAF-V600E degrader-1
CAS:<p>PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.</p>Fórmula:C48H54F2N10O10SPureza:99.43%Cor e Forma:SolidPeso molecular:1001.07R1487
CAS:<p>R1487 is an orally bioavailable and highly selective p38α mitogen-activated protein kinase inhibitor.</p>Fórmula:C19H18F2N4O3Pureza:99.77%Cor e Forma:SolidPeso molecular:388.37GNE-495
CAS:<p>GNE-495 is a potent and specific MAP4K4 inhibitor (IC50: 3.7 nM).</p>Fórmula:C22H20FN5O2Pureza:99.22% - 99.57%Cor e Forma:SolidPeso molecular:405.42PF-06260933
CAS:<p>PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively.</p>Fórmula:C16H13ClN4Pureza:99.63% - 99.97%Cor e Forma:SolidPeso molecular:296.75SCH54292
CAS:<p>SCH-54292 is a GDP exchange inhibitor.</p>Fórmula:C24H28N2O9SPureza:95.65%Cor e Forma:SolidPeso molecular:520.55TA-01
CAS:<p>TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.</p>Fórmula:C20H12F3N3Pureza:99.55% - 99.94%Cor e Forma:SolidPeso molecular:351.32IQ-3
CAS:<p>IQ3 inhibits JNK3 (Kd 66 nM), JNK1/2, NF-κB/AP1 in THP1-Blue cells (IC50 1.4 μM), and reduces TNF-α/IL-6 production.</p>Fórmula:C20H11N3O3Pureza:≥98%Cor e Forma:SolidPeso molecular:341.32SL327
CAS:<p>SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.</p>Fórmula:C16H12F3N3SPureza:97.98% - >99.99%Cor e Forma:SolidPeso molecular:335.35B-Raf IN 11
CAS:<p>B-Raf IN 11 is a novel selective inhibitor.</p>Fórmula:C17H14BrF2N3O3SPureza:99.947%Cor e Forma:SolidPeso molecular:458.28Ro 5126766
CAS:RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.Fórmula:C21H18FN5O5SPureza:98.3% - 98.81%Cor e Forma:SolidPeso molecular:471.46PF-06260933 HCl
CAS:<p>PF-06260933 Dihydrochloride, a MAP4K4 inhibitor, hinders HGK, Mink, Tnik (IC50s: 140, 8, 13 nM) and lessens mouse fasting hyperglycemia.</p>Fórmula:C16H15Cl3N4Cor e Forma:SolidPeso molecular:369.68B-Raf IN 1
CAS:<p>B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor.</p>Fórmula:C29H24F3N5OPureza:97.22% - 99.27%Cor e Forma:SolidPeso molecular:515.53Maohuoside A
CAS:<p>Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.</p>Fórmula:C27H32O12Pureza:98.91% - 99.57%Cor e Forma:SolidPeso molecular:548.54p-Cresyl sulfate potassium
CAS:<p>p-Cresyl sulfate potassium (p-Tolyl sulfate potassium salt) is a prototype protein-bound uremic toxin derived from the metabolites of tyrosine and phenylalanine</p>Fórmula:C7H7KO4SPureza:99.38%Cor e Forma:SolidPeso molecular:226.29Rasarfin
CAS:<p>Rasarfin inhibits Ras and ARF6.</p>Fórmula:C23H24ClN3O3Pureza:97.98%Cor e Forma:SolidPeso molecular:425.91
