MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 881 produtos de "MAPK"
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PLX7904
CAS:<p>PLX7904 (PB04), a selective RAF inhibitor, blocks ERK1/2 in mutant BRAF melanoma without activating it in RAS mutants.</p>Fórmula:C24H22F2N6O3SPureza:99.51% - 99.66%Cor e Forma:SolidPeso molecular:512.53Sulindac sulfide
CAS:<p>Sulindac sulfide: NSAID targeting COX-1, inhibits Ras-Raf-1 and gamma-secretase (IC50: 20.2 μM), active sulinic acid metabolite.</p>Fórmula:C20H17FO2SPureza:99.35%Cor e Forma:SolidPeso molecular:340.41HCI-2184
CAS:<p>HCI-2184 is an inhibitor of AXL kinase and Nek2 that acts by successfully mitigating drug resistance in bortezomib-resistant multiple myeloma.</p>Fórmula:C23H28ClN7O2SPureza:98%Cor e Forma:SolidPeso molecular:502.03BRAF inhibitor
CAS:<p>BRAF inhibitor is an inhibitor of B-Raf.</p>Fórmula:C22H18F2N4O3SPureza:98.2% - 98.41%Cor e Forma:SolidPeso molecular:456.47ERK1/2 inhibitor 1
CAS:<p>ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.</p>Fórmula:C29H32ClN5O4Pureza:98.81%Cor e Forma:SolidPeso molecular:550.05PF-05381941
CAS:<p>PF-05381941 is a selective and potent dual inhibitor of TAK1 and p38α that inhibits the kinase activity of TAK1 by binding to its active site.</p>Fórmula:C27H26N6O2Pureza:98.04%Cor e Forma:SolidPeso molecular:466.53MEK-IN-1
CAS:<p>MEK-IN-1 is a MEK inhibitor.</p>Fórmula:C24H20N4O4Pureza:98%Cor e Forma:SolidPeso molecular:428.44PAF (C16)
CAS:<p>PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability.</p>Fórmula:C26H54NO7PPureza:98%Cor e Forma:SolidPeso molecular:523.68B-Raf IN 13
CAS:<p>B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.</p>Fórmula:C19H19ClFN3O4SPureza:99.41% - >99.99%Cor e Forma:SoildPeso molecular:439.89KRAS G12D inhibitor 10
CAS:<p>KRAS G12D inhibitor 10 targets KRAS G12D in cancer research (WO2021108683A1, compound 34).</p>Fórmula:C33H41ClN8O2Cor e Forma:SolidPeso molecular:617.18GGTI-286
CAS:<p>GGTI-286: GGTase I inhibitor, cell-permeable, IC50=2μM. Strongly blocks Rap1A geranylation; less effective on H-Ras, Ras4B IC50=1μM.</p>Fórmula:C23H31N3O3SCor e Forma:SolidPeso molecular:429.58MCP110
CAS:<p>MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.</p>Fórmula:C33H36N2O3Pureza:97.23%Cor e Forma:OilPeso molecular:508.65KYA1797
CAS:<p>KYA1797 inhibits Wnt/ß-catenin, targeting axin, and promotes ß-catenin/Ras decay, halting APC/KRAS mutant CRC growth.</p>Fórmula:C17H12N2O6S2Pureza:98%Cor e Forma:SolidPeso molecular:404.42RSK2-IN-2
CAS:<p>RSK2-IN-2 (Compound 25) is a reversible covalent inhibitor of the RPS6KA3 ( RSK2 ) kinase which also inhibits MSK1, MSK2, and RSK3 [1].</p>Fórmula:C16H11N5OCor e Forma:SolidPeso molecular:289.29GABAB receptor antagonist 1
CAS:(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selectiveFórmula:C18H24O4Pureza:98%Cor e Forma:SolidPeso molecular:304.38B-Raf IN 8
CAS:<p>B-Raf IN 8: strong B-Raf inhibitor (70.65 nM IC50); combats liver, colon, breast & prostate cancer with IC50s from 9.78 to 29.85 μM.</p>Fórmula:C18H17N3O2Cor e Forma:SolidPeso molecular:307.35HPK1-IN-24
CAS:<p>HPK1-IN-24 (example 51) has potential to be used in the cancer research which is an inhibitor of hematopoietic progenitor kinase 1 (HPK1) (Ki = 100 nM) [1].</p>Fórmula:C19H14FN5Cor e Forma:SolidPeso molecular:331.35UC-857993
CAS:<p>UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.</p>Fórmula:C25H22ClNO2Cor e Forma:SolidPeso molecular:403.9JNK3 inhibitor-2
CAS:<p>JNK3 inhibitor-2: selectively inhibits JNK3 (IC50 = 0.25 μM); less effective on JNK1/JNK2 (>100 μM); targets DDR1 and EGFR mutations.</p>Fórmula:C20H14N2O2Cor e Forma:SolidPeso molecular:314.34Tpl2 Kinase Inhibitor 1
CAS:<p>Tpl2 Kinase Inhibitor 1 is an effective and selective Tpl2 inhibitor.</p>Fórmula:C21H14ClFN6Pureza:98%Cor e Forma:SolidPeso molecular:404.83
