MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 894 produtos de "MAPK"
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6-T-GDP
CAS:<p>6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of thiopurine. It inhibits the activity of Rac1, thereby reducing the transcription of inflammatory factors and the expression of cell adhesion molecules, which ultimately suppresses leukocyte migration and the occurrence of tissue inflammation.</p>Fórmula:C10H15N5O10P2SCor e Forma:SolidPeso molecular:459.27MTBT
CAS:MTBT is the proliferation of cancer cells inhibitor. It induces cell cycle arrest and activates p38 MAPK.Fórmula:C14H11NO2S2Cor e Forma:SolidPeso molecular:289.37CK1-IN-2
CAS:<p>CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor p38a, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.</p>Fórmula:C17H12FN3O2Pureza:99.31%Cor e Forma:SolidPeso molecular:309.29PAF (C16)
CAS:<p>PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability.</p>Fórmula:C26H54NO7PPureza:98%Cor e Forma:SolidPeso molecular:523.68B-Raf IN 13
CAS:<p>B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.</p>Fórmula:C19H19ClFN3O4SPureza:99.41% - >99.99%Cor e Forma:SoildPeso molecular:439.89ZINC09659342
CAS:<p>ZINC09659342 (compound 13) is an inhibitor of Lbc-RhoA interaction (IC50: 3.6 μM).</p>Fórmula:C23H15F3N2O4Cor e Forma:SolidPeso molecular:440.37BSJ-04-122
CAS:BSJ-04-122: MKK4/7 inhibitor with IC50s of 4 nM & 181 nM, used in cancer research.Fórmula:C15H12ClN5OPureza:98.09%Cor e Forma:SolidPeso molecular:313.74HPK1-IN-24
CAS:<p>HPK1-IN-24 (example 51) has potential to be used in the cancer research which is an inhibitor of hematopoietic progenitor kinase 1 (HPK1) (Ki = 100 nM) [1].</p>Fórmula:C19H14FN5Cor e Forma:SolidPeso molecular:331.35SW-034538
CAS:SW-034538 is a TAO2 inhibitor (IC 50= 300 nM).Fórmula:C18H20N4O3S2Cor e Forma:SolidPeso molecular:404.51GDC-0879
CAS:GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.Fórmula:C19H18N4O2Pureza:99.62%Cor e Forma:SolidPeso molecular:334.37Antifungal agent 46
CAS:Compound 2f (Antifungal Agent 46) is a potent antifungal that inhibits Ras signaling by targeting protein farnesyltransferase [1].Fórmula:C26H28BrF3N4O2Pureza:98%Cor e Forma:SolidPeso molecular:565.43ARS-2102
CAS:ARS-2102 is a potent covalent KRAS G12C inhibitor for use in cancer research .Fórmula:C28H31ClF2N6O2Cor e Forma:SolidPeso molecular:557.03HPK1-IN-26
CAS:<p>HPK1-IN-26, from WO2021254118A1, is a potent dual HPK1/GLK inhibitor for studying animal infections.</p>Fórmula:C19H21N5OSCor e Forma:SolidPeso molecular:367.47D-87503
CAS:D-87503 is a dual extracellular signaling-related kinase (ERK)/PI3K inhibitor.Fórmula:C17H15N5OSCor e Forma:SolidPeso molecular:337.4Quazinone
CAS:Quazinone: PDE3 inhibitor, enhances heart muscle contractility, lowers blood pressure, and inhibits DNA synthesis in muscle cells. IC50 = 4.2 μM.Fórmula:C11H10ClN3OCor e Forma:SolidPeso molecular:235.67KYA1797
CAS:KYA1797 inhibits Wnt/ß-catenin, targeting axin, and promotes ß-catenin/Ras decay, halting APC/KRAS mutant CRC growth.Fórmula:C17H12N2O6S2Pureza:98%Cor e Forma:SolidPeso molecular:404.42KRAS G12C inhibitor 22
CAS:<p>KRAS G12C inhibitor 22 is a KRAS G12C inhibitor.</p>Fórmula:C32H41N7O2Cor e Forma:SolidPeso molecular:555.71MNK1/2-IN-5
CAS:MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor with anticancer activity and can be used to study solid tumors and hematological malignancies.Fórmula:C17H16N4O2Pureza:98.04%Cor e Forma:SolidPeso molecular:308.33RSK2-IN-2
CAS:<p>RSK2-IN-2 (Compound 25) is a reversible covalent inhibitor of the RPS6KA3 ( RSK2 ) kinase which also inhibits MSK1, MSK2, and RSK3 [1].</p>Fórmula:C16H11N5OCor e Forma:SolidPeso molecular:289.29SOS1-IN-12
CAS:SOS1-IN-12 is a potent inhibitor of SOS1, acting on SOS1 (Ki: 0.11 nM) and on pERK (IC50: 47 nM).Fórmula:C23H26F3N5Cor e Forma:SolidPeso molecular:429.48
