MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 890 produtos de "MAPK"
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GNE 220 hydrochloride
CAS:GNE 220 (hydrochloride) is a potent and selective inhibitor of MAP4K4 (IC50: 7 nM).Fórmula:C25H27ClN8Cor e Forma:SolidPeso molecular:474.99FGTI-2734 mesylate (1247018-19-4 free base)
CAS:FGTI-2734 mesylate hinders KRAS, overcoming resistance and targeting pancreatic tumors; inhibits FT and GGT with IC50s of 250 nM, 520 nM.Fórmula:C27H35FN6O5S2Pureza:98%Cor e Forma:SolidPeso molecular:606.73ERK-IN-2 free base
CAS:ERK-IN-2 free base inhibits ERK2 (IC50: 1.8 nM); potential off-target effects at >10 μM.Fórmula:C16H17N5O2Cor e Forma:SolidPeso molecular:311.34CXJ-2
CAS:CXJ-2, a cyclic peptide, binds EDPs, inhibits PI3K/ERK, and reduces hepatic cell growth/migration, offering antifibrotic effects.Fórmula:C55H87N15O22Pureza:98%Cor e Forma:SolidPeso molecular:1310.37(R)-BDP9066
CAS:(R)-BDP9066 blocks MRCK to curb cancer cell spread, aiding research on diseases like cancer.Fórmula:C20H24N6Cor e Forma:SolidPeso molecular:348.44Org OD 02-0
CAS:10-Ethenyl-19-norprogesterone (Org OD 02-0) is a selective agonist for the membrane progesterone receptor α (mPRα) with an IC50 of 33.9 nM, known to activateFórmula:C22H30O2Pureza:98%Cor e Forma:SolidPeso molecular:326.47Ilaprazole sodium hydrate
CAS:Ilaprazole sodium hydrate (IY-81149 sodium hydrate) is a proton pump inhibitor that blocks the transport of HSV particles.Fórmula:C19H21N4NaO4SPureza:99.2%Cor e Forma:SolidPeso molecular:424.45ERK1/2 inhibitor 5
CAS:ERK1/2 inhibitor 5: potent against ERK1/2, may combat cancer and inflammation.Fórmula:C28H32ClFN6O5Cor e Forma:SolidPeso molecular:587.04B-Raf IN 15
CAS:B-Raf IN 15 is a BRAF inhibitor that inhibits BRAFWT and BRAFV600E and can be used to study melanoma and cancer.Fórmula:C19H15N3OSPureza:98%Cor e Forma:SolidPeso molecular:333.41K-Ras G12C-IN-2
CAS:K-Ras G12C-IN-2 is a covalent kras g12c inhibitor.Fórmula:C21H27ClN4O3Pureza:98%Cor e Forma:SolidPeso molecular:418.92KRAS G12C inhibitor 61
CAS:KRAS G12C inhibitor 61 (Example 3) demonstrates potent activity by inhibiting phospho-ERK 1/2 in MIA PaCa-2 cells, reflected in an IC50 value of 9 nM.Fórmula:C31H33ClFN7O2Pureza:98%Cor e Forma:SolidPeso molecular:590.09KRAS G12C inhibitor 40
CAS:KRAS G12C inhibitor 40 targets KRAS G12C in cancer research (WO2021129824A1, compound 70).Fórmula:C34H36ClFN10O2Cor e Forma:SolidPeso molecular:671.17FGTI-2734
CAS:FGTI-2734, a dual FT/GGT-1 inhibitor (IC50: 250/520 nM), blocks KRAS membrane binding and curbs KRAS-driven pancreatic cancer.Fórmula:C26H31FN6O2SPureza:99.69%Cor e Forma:SolidPeso molecular:510.63Ref: TM-T11282
1mg49,00€5mg113,00€10mg178,00€25mg371,00€50mg557,00€100mg792,00€1mL*10mM (DMSO)129,00€BDP8900
CAS:BDP8900: potent, selective MRCK inhibitor; alters cancer cell shape, reduces mobility and invasion.Fórmula:C19H23N5SCor e Forma:SolidPeso molecular:353.48Laxiflorin B
CAS:Laxiflorin B, a novel selective inhibitor of ERK 1/2 derived from herbal sources, exhibits antitumor activity [1].Fórmula:C20H24O5Pureza:98%Cor e Forma:SolidPeso molecular:344.4GNE 220
CAS:GNE-220 is a potent and selective inhibitor of MAP4K4 (IC50: 7 nM).Fórmula:C25H26N8Pureza:98%Cor e Forma:SolidPeso molecular:438.53HPK1-IN-12
CAS:HPK1-IN-12 is a potent inhibitor of HPK1. HPK1-IN-12 has potential for the study of HPK1-related diseases.Fórmula:C25H24FN5O2Cor e Forma:SolidPeso molecular:445.49XRP44X
CAS:XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.Fórmula:C21H21ClN4OPureza:99.67%Cor e Forma:SolidPeso molecular:380.87MNK inhibitor 9
CAS:MNK inhibitor 9 potently blocks MNK1/2 (IC50: 0.003 µM each), is cell-permeable, and useful for tumor research.Fórmula:C25H29N9OCor e Forma:SolidPeso molecular:471.56KRAS inhibitor-11
KRAS inhibitor-11 is a KRAS inhibitor .Fórmula:C29H47N9O6Cor e Forma:SolidPeso molecular:617.74
