MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 891 produtos de "MAPK"
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DT-061
CAS:DT-061 is an orally bioavailable protein phosphatase 2A (PP2A) activator. It could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.Fórmula:C25H23F3N2O5SPureza:98%Cor e Forma:SolidPeso molecular:520.52KRAS G12C inhibitor 16
CAS:KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor.Fórmula:C24H21ClFN3O3Pureza:97.84%Cor e Forma:SolidPeso molecular:453.89KRAS G12C inhibitor 58
CAS:KRAS G12C inhibitor 58 is utilized in cancer research as an inhibitor of the KRAS G12C mutation [1].Fórmula:C51H64ClF4N9O8SPureza:98%Cor e Forma:SolidPeso molecular:1074.62KRAS G12D modulator-1
CAS:KRAS G12D modulator-1 (compound 6), a potent modulator of KRAS G12D, exhibits IC50 values ranging from 1-10 μM against NEA-G12D, PPI-G12D, and p ERK-AGS, and isFórmula:C30H36FN5O4Pureza:98%Cor e Forma:SolidPeso molecular:549.64pan-KRAS-IN-2
CAS:Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12DFórmula:C34H34F2N4O3Pureza:98%Cor e Forma:SolidPeso molecular:584.66SB-682330A
CAS:SB-682330A is a Raf kinase inhibitor.Fórmula:C28H27N3O3Cor e Forma:SolidPeso molecular:453.53TC13172
CAS:TC13172 is a potent, covalent MLKL inhibitor, selective over RIPK1/RIPK3. It blocks TSZ-induced necroptosis (EC50=2nM) and MLKL oligomerization at 100nM.Fórmula:C17H16N4O5SPureza:98%Cor e Forma:SolidPeso molecular:388.4Cobimetinib racemate
CAS:Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as a mitogen-activatedFórmula:C21H21F3IN3O2Pureza:98.00% - 99.71%Cor e Forma:SolidPeso molecular:531.31KRAS G12C inhibitor 17
CAS:KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor.Fórmula:C24H20ClF2N3O3Pureza:98%Cor e Forma:SolidPeso molecular:471.88KRAS inhibitor FB9
CAS:KRAS inhibitor FB9 can be used in studies about Ras.Fórmula:C23H21ClF4N2O5Cor e Forma:SolidPeso molecular:516.87KRAS degrader-1
CAS:KRAS degrader-1 (compound 1) is a potent agent that selectively targets KRAS proteins for destruction via the autophagy-lysosomal degradation pathway [1].Fórmula:C55H57Br2ClFIN8O7Cor e Forma:SolidPeso molecular:1283.25KRAS G12D mutation regulator 4
CAS:KRAS G12D mutation regulator 4 can be used in studies about Ras.Fórmula:C33H33FN6O2Cor e Forma:SolidPeso molecular:564.65JNK3 inhibitor-1
CAS:JNK3 inhibitor-1: potent, selective, IC50 of 0.005 μM, orally bioavailable, brain-penetrant.Fórmula:C21H17ClFN5O2SCor e Forma:SolidPeso molecular:457.91ARS-1323-alkyne
CAS:ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.Fórmula:C28H27ClF2N6O3Pureza:98.00% - 99%Cor e Forma:SolidPeso molecular:569Kras binder 12
CAS:Kras binder 12 can be used in studies about Ras.Fórmula:C29H47N9O6Cor e Forma:SoildPeso molecular:617.74SOS1-IN-7
CAS:SOS1-IN-7 (compound 18-p1) is a potent inhibitor of SOS1 and acts on SOS1-G12D (IC50: 20 nM) and SOS1-G12V (IC50: 67 nM).Fórmula:C23H25F3N4O3Cor e Forma:SolidPeso molecular:462.46KRAS inhibitor-14
CAS:KRAS inhibitor-14 targets G12C (IC50: 0.249 μM) and inhibits p-ERK in cancer cells; promising for pancreatic, colorectal, lung cancers.Fórmula:C20H15Cl3FN3O2SCor e Forma:SolidPeso molecular:486.77KRAS G12C inhibitor 1R
CAS:KRAS G12C inhibitor 1R can be used in studies about Ras.Fórmula:C31H36ClFN6O2Cor e Forma:SoildPeso molecular:579.11SOS1-IN-13
CAS:SOS1-IN-13 inhibits SOS1 (IC50: 6.5 nM) and pERK (327 nM); potential in cancer research.Fórmula:C21H22F3N3O2Cor e Forma:SolidPeso molecular:405.41ARS-1323
CAS:ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor.Fórmula:C21H17ClF2N4O2Pureza:99.53%Cor e Forma:SolidPeso molecular:430.84Ref: TM-T10375
2mg38,00€5mg56,00€10mg94,00€25mg129,00€50mg168,00€100mg235,00€200mg350,00€1mL*10mM (DMSO)63,00€
