MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 892 produtos de "MAPK"
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B-Raf IN 15
CAS:B-Raf IN 15 is a BRAF inhibitor that inhibits BRAFWT and BRAFV600E and can be used to study melanoma and cancer.Fórmula:C19H15N3OSPureza:98%Cor e Forma:SolidPeso molecular:333.41K-Ras G12C-IN-2
CAS:K-Ras G12C-IN-2 is a covalent kras g12c inhibitor.Fórmula:C21H27ClN4O3Pureza:98%Cor e Forma:SolidPeso molecular:418.92KRAS G12C inhibitor 40
CAS:KRAS G12C inhibitor 40 targets KRAS G12C in cancer research (WO2021129824A1, compound 70).Fórmula:C34H36ClFN10O2Cor e Forma:SolidPeso molecular:671.17ERK1/2 inhibitor 7
CAS:ERK1/2 inhibitor 7 is a potent inhibitor of ERK, acting on ERK2 (IC50: 0.94 nM).Fórmula:C23H22FN7OSCor e Forma:SolidPeso molecular:463.53Ras inhibitor 134
CAS:Ras inhibitor 134 can be used in studies about Ras.Fórmula:C23H21ClFN5O3Cor e Forma:SoildPeso molecular:469.9SOS1-IN-4
CAS:SOS1-IN-4 is a potent inhibitor of SOS1 (IC50: 56 nM) and can be used in the study of KRAS-C12C/SOS1 interactions.Fórmula:C24H29F2N4O2PCor e Forma:SolidPeso molecular:474.48HPK1-IN-13
CAS:HPK1-IN-13 is a potent inhibitor of HPK1. HPK1-IN-12 has potential for the study of HPK1-related diseases.Fórmula:C25H24FN5O2Cor e Forma:SolidPeso molecular:445.49Exarafenib
CAS:Exarafenib (RAF/KIN_2787) is an oral pan-RAF inhibitor with antitumor properties, targeting MAPK signaling in cancer research.Fórmula:C26H34F3N5O3Pureza:98.36% - 99.84%Cor e Forma:SolidPeso molecular:521.58Ref: TM-T63644
1mg74,00€5mg160,00€10mg216,00€25mg369,00€50mg540,00€100mg747,00€1mL*10mM (DMSO)A consultarZYF0033
CAS:ZYF0033(HPK1-IN-22) is an orally effective inhibitor of HPK1 that inhibits the phosphorylation of MBP proteins and decreases the phosphorylation of SLP76.Fórmula:C26H30N4O2SPureza:99.70%Cor e Forma:SolidPeso molecular:462.61HG6-64-1
CAS:HG6-64-1 (HMSL 10017-101-1, compound 9 (XI-1)) is a potent and selective B-Raf inhibitor with an IC50 = 0.09 μM in B-raf V600E-transformed Ba/F3 cells.Fórmula:C32H34F3N5O2Pureza:99.89%Cor e Forma:SolidPeso molecular:577.64Ref: TM-T15480
1mg69,00€5mg147,00€10mg215,00€25mg371,00€50mg522,00€100mg708,00€1mL*10mM (DMSO)178,00€BI-2493
CAS:BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth.Cost-effective and quality-assured.Fórmula:C24H27N7OSPureza:97.74% - 99.88%Cor e Forma:SoildPeso molecular:461.58Kras4B G12D-IN-1
CAS:Kras4B G12D-IN-1 is an inhibitor of Kras4B G12D with anticancer activity.Kras4B G12D-IN-1 inhibits Kras protein expression.Fórmula:C16H21ClN2O4SPureza:99.75%Cor e Forma:SolidPeso molecular:372.87Ref: TM-T78170
2mg93,00€5mg144,00€10mg230,00€25mg467,00€50mg745,00€100mg1.134,00€500mg2.277,00€1mL*10mM (DMSO)161,00€MK-8353
CAS:MK-8353 (SCH900353) is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively)Fórmula:C37H41N9O3SPureza:96.15% - 97.19%Cor e Forma:SolidPeso molecular:691.84Ref: TM-T12069
1mg77,00€2mg92,00€5mg147,00€10mg258,00€25mg557,00€50mg888,00€100mg1.341,00€1mL*10mM (DMSO)217,00€Pan-RAS-IN-1
CAS:Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.Fórmula:C36H41Cl2F3N6O2Pureza:99.77%Cor e Forma:SolidPeso molecular:717.65Ref: TM-T16432
1mg75,00€2mg92,00€5mg137,00€10mg205,00€25mg416,00€50mg625,00€100mg888,00€500mg1.783,00€1mL*10mM (DMSO)210,00€MK2-IN-4
CAS:MK2-IN-4 is a MAPKAPK2 (MK2) inhibitor (IC50: 45 nM). MK2-IN-4 can be used in cancer, inflammation and immunology studies.Fórmula:C25H24N4O2Cor e Forma:SolidPeso molecular:412.48TH-Z816
CAS:TH-Z816 acts as a reversible inhibitor targeting the KRAS(G12D) mutation, exhibiting an IC50 of 14 µM. This compound is utilized in cancer research [1].Fórmula:C29H38N6OCor e Forma:SolidPeso molecular:486.65KRAS inhibitor-36
CAS:KRAS inhibitor-36 (compound Abd2) directly inhibits KRAS Q61H.Fórmula:C14H13NO4Cor e Forma:SolidPeso molecular:259.26HPK1-IN-41
CAS:HPK1-IN-41 (compound Z389) functions as an HPK1 inhibitor, exhibiting an IC50 value of 0.21 nM [1].Fórmula:C28H33N5O2Cor e Forma:SolidPeso molecular:471.59(+)-Perillyl alcohol
CAS:(+)-Perillyl alcohol (0.25-1 mM) inhibits cell growth in SW480 cells. At a concentration of 1 mM and a duration of 24 hours, (+)-Perillyl alcohol increases the number of cells in the G0/G1 phase and reduces the number in the S phase in SW480 cells.Fórmula:C10H16OCor e Forma:SolidPeso molecular:152.23AZD4625
AZD4625 (Compound 21) is a selective, potent, orally active, covalent and mutagenic mutant GTPaseKRASG12C inhibitor.Fórmula:C24H21ClF2N4O3Cor e Forma:SolidPeso molecular:486.9
