MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 892 produtos para "MAPK". São mostrados os primeiros 500.
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GGDPS-IN-1
GGDPS-IN-1 (Compound 37) is an inhibitor of geranylgeranyl diphosphate synthase (GGDPS) with an IC50 of 49.4 nM, disrupting protein geranylgeranylation in myeloma cells.Fórmula:C15H28N4O6P2Cor e Forma:SolidPeso molecular:422.14841HPK1-IN-8
CAS:HPK1-IN-8 is an allosteric, inactive, conformation-selective triazolopyrimidine ketone HPK1 inhibitor.Fórmula:C19H17FN6O2SPureza:99.68%Cor e Forma:SolidPeso molecular:412.44KRAS G12C inhibitor 18
CAS:KRAS G12C inhibitor 18 is a potent, orally active compound that inhibits KRAS G12C and exhibits anti-tumor activities.Fórmula:C25H20ClFN4O3SCor e Forma:SolidPeso molecular:510.97SOS1-IN-18
SOS1-IN-18 (Compound 8) is an inhibitor of the Son of Sevenless 1 protein (SOS1) with a dissociation constant (KD) of 2.6 nM. It disrupts the SOS1-KRAS G12C interaction with an IC50 of 3.4 nM, inhibits ERK phosphorylation in H358 cells with an IC50 of 31 nM, and curtails the proliferation of H358 cells with an IC50 of 5 nM.Fórmula:C26H29F3N4O2Cor e Forma:SolidPeso molecular:486.53KRAS G12C inhibitor 60
KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, andFórmula:C31H30F5N7O2Pureza:98%Cor e Forma:SolidPeso molecular:627.61GNE-9815
CAS:GNE-9815 (3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide) is a high kinase-selectiveFórmula:C26H22FN5O2Pureza:99.08% - 99.1%Cor e Forma:SolidPeso molecular:455.48Ref: TM-T9585
1mg60,00€5mg138,00€1mL*10mM (DMSO)138,00€10mg215,00€25mg358,00€50mg510,00€100mg692,00€500mg1.386,00€BI-2865
CAS:BI-2865 is a non-covalent pan-KRAS inhibitor.Cost-effective and quality-assured.Fórmula:C23H27N7O2SPureza:99.29% - 99.92%Cor e Forma:SoildPeso molecular:465.57Ref: TM-T72062
1mg200,00€5mg432,00€1mL*10mM (DMSO)440,00€10mg612,00€25mg888,00€50mg1.224,00€100mg1.665,00€AM-001
CAS:AM-001, a non-competitive inhibitor of Epac1, effectively blocks the activation of Rap1, a downstream effector of Epac1, in cultured cells, and is commonly used in heart disease-related research.Fórmula:C24H16FN3OS2Pureza:99.92%Cor e Forma:Yellow SolidPeso molecular:445.53KS-58
CAS:KS-58 is a derivative of KRpep-2d. It acts as an inhibitory peptide for K-Ras(G12D), selectively binding to K-Ras. KS-58 is capable of penetrating cells and interrupts the interaction between intracellular Ras and effector proteins. It inhibits the proliferation of tumor cells and exhibits antitumor activity.Fórmula:C64H89FN12O14S2Cor e Forma:SolidPeso molecular:1333.59TUS-007
CAS:TUS-007, a non-proteasome inhibiting CANDDY, is an oral KRAS G12D/V degrader for cell-free chemical knockdown and tumor suppression.Fórmula:C44H54Cl2N8O5Cor e Forma:SolidPeso molecular:845.86Edaxeterkib
CAS:Edaxeterkib is a potent extracellular signal- regulated kinase (ERK) inhibitor for the research of cancer.Fórmula:C26H27N7O2Cor e Forma:SolidPeso molecular:469.549Rac1 Inhibitor W56
CAS:Peptide (45-60) blocks Rac1 binding with TrioN, GEF-H1, Tiam1 GEFs.Fórmula:C74H117N19O23SPureza:98%Cor e Forma:SolidPeso molecular:1671.93PROTAC MLKL Degrader-1
PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%.Fórmula:C46H55F2N9O9SCor e Forma:SolidPeso molecular:948.05SOS1-IN-17
SOS1-IN-17 (Compound 8d) is an orally active inhibitor targeting the SOS1-KRASG12C interaction, with an IC50 of 5.1 nM. It suppresses ERK phosphorylation in DLD-1 cells with an IC50 of 18 nM and demonstrates antiproliferative activity in KRASG12C-mutant Mia-Paca-2 cells, with an IC50 of 0.11 μM. In mouse models, SOS1-IN-17 shows antitumor efficacy against pancreatic cancer.Fórmula:C29H34F3N5O2Cor e Forma:SolidPeso molecular:541.61KRAS-IN-43
KRAS-IN-43 (Compound 9) is a broad-spectrum KRAS inhibitor with IC50 values of 0.15 μM for KRASG12V, 0.14 μM for KRASG12C, and 0.47 μM for wild-type KRAS. It disrupts the interaction between KRAS and cRAF and suppresses ERK phosphorylation. KRAS-IN-43 shows potential for research in KRAS mutation-associated cancers, including pancreatic, colorectal, and lung cancers.Cor e Forma:Odour Solid6-Thio-GTP tetrasodium
6-Thio-GTP (tetrasodium) is an inhibitor of Vav1-Rac. It can suppress TCR-induced T cell proliferation and CD28-mediated T cell survival. In a murine model of allogeneic heart transplantation, 6-Thio-GTP (tetrasodium) demonstrates immunosuppressive effects, which can prolong the survival time of heart transplants.Fórmula:C10H12N5Na4O13P3SCor e Forma:SolidPeso molecular:626.89559R18
CAS:14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.Fórmula:C101H157N27O29S3Pureza:98%Cor e Forma:SolidPeso molecular:2309.69KRAS inhibitor-38
CAS:KRAS Inhibitor-38 (Example 18) is a potent inhibitor capable of effectively suppressing the activity of KRAS G12C, KRAS G12D, and KRAS G12V in vivo.Fórmula:C53H68ClF2N9O8SCor e Forma:SolidPeso molecular:1064.68NK7-902 TFA
NK7-902 TFA is a CRBN molecular glue degrader of NEK7. It effectively degrades NEK7 in human primary monocytes and whole blood, yet only partially inhibits NLRP3-dependent IL-1β production. While NK7-902 TFA achieves deep and lasting NEK7 degradation, it temporarily blocks NLRP3 inflammasome activation in non-human primates when administered orally. Additionally, NK7-902 TFA demonstrates activity in mouse systems.Cor e Forma:Odour Solid(RS)-G12Di-1
(RS)-G12Di-1 is a selective covalent inhibitor of K-Ras-G12D.Fórmula:C37H35FN6O4Cor e Forma:SolidPeso molecular:646.27038
