MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 893 produtos para "MAPK". São mostrados os primeiros 500.
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
HCI-2184
CAS:HCI-2184 is an inhibitor of AXL kinase and Nek2 that acts by successfully mitigating drug resistance in bortezomib-resistant multiple myeloma.Fórmula:C23H28ClN7O2SPureza:98%Cor e Forma:SolidPeso molecular:502.03GSK649A
CAS:GSK649A is a novel activator of Satellite Cell Proliferation, it could enhance repair of Damaged Muscle.Fórmula:C15H12ClFN6OSPureza:98%Cor e Forma:SolidPeso molecular:378.81CP-281384
CAS:CP-281384 is a potent, p38alpha-selective inhibitor.Fórmula:C18H14F2N4OPureza:98%Cor e Forma:SolidPeso molecular:340.33DDO3711
CAS:"DDO3711, a PHORC, links an ASK1 inhibitor to a PP5 activator, inhibiting ASK1 (IC50=164.1 nM), dephosphorylating p-ASK1, and showing anti-cancer potential."Fórmula:C42H41N9O6Cor e Forma:SolidPeso molecular:767.83JNK3 inhibitor-2
CAS:JNK3 inhibitor-2: selectively inhibits JNK3 (IC50 = 0.25 μM); less effective on JNK1/JNK2 (>100 μM); targets DDR1 and EGFR mutations.Fórmula:C20H14N2O2Cor e Forma:SolidPeso molecular:314.34KRAS G12C inhibitor 31
CAS:KRAS G12C inhibitor 31 is an inhibitor of KRAS G12C that can be used to study cancer.Fórmula:C25H22ClFN6O3Cor e Forma:SolidPeso molecular:508.93RBC6
CAS:RBC6 is an inhibitor of the binding of Ral to its effector RALBP1.Fórmula:C16H14Cl2N4O2Pureza:98%Cor e Forma:SolidPeso molecular:365.21PB1
CAS:PB1, a stable borane-protected TCEP analogue, effectively reduces disulfides intracellularly and aids retinal cell survival post-axotomy.Fórmula:C14H22BO4PCor e Forma:SolidPeso molecular:296.11KRas G12C inhibitor 4
CAS:KRas G12C inhibitor 4 is a compound that inhibits KRas G12C.Fórmula:C33H38ClN7O2Pureza:98%Cor e Forma:SolidPeso molecular:600.15Tpl2 Kinase Inhibitor 1
CAS:Tpl2 Kinase Inhibitor 1 is an effective and selective Tpl2 inhibitor.Fórmula:C21H14ClFN6Pureza:98%Cor e Forma:Yellow SolidPeso molecular:404.83KRAS G12C inhibitor 48
KRAS G12C inhibitor 48: potent with IC50 639.91 nM; hampers H358, H23, A549 cell growth with IC50s of 0.796, 6.33, 16.14 µM, respectively.Fórmula:C36H39ClN8O2Cor e Forma:SolidPeso molecular:651.2TOPK-p38/JNK-IN-1
CAS:TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NOFórmula:C17H15F3N2O4Cor e Forma:SolidPeso molecular:368.31KRAS G12C inhibitor 29
CAS:KRAS G12C inhibitor 29 is an inhibitor of KRAS G12C and can be used to study cancer.Fórmula:C23H21ClFN5O2Cor e Forma:SolidPeso molecular:453.9HPK1-IN-25
CAS:HPK1-IN-25, an HPK1 inhibitor, IC50 129 nM, may aid cancer research.Fórmula:C23H25N5OCor e Forma:SolidPeso molecular:387.48CP-944629
CAS:CP-944629 is a novel, potent, and selective inhibitor of p38alpha.Fórmula:C19H15F3N4OPureza:98%Cor e Forma:SolidPeso molecular:372.34BNC-1
CAS:BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.Fórmula:C16H14N2O3Pureza:98%Cor e Forma:SolidPeso molecular:282.29KRAS inhibitor-7
CAS:KRAS inhibitor-7 is a potent KRAS G12C inhibitor.Fórmula:C26H27ClF2N6O2Pureza:98%Cor e Forma:SolidPeso molecular:528.98Migoprotafib
CAS:Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for advanced solid tumours.Fórmula:C25H26N8OPureza:98.31%Cor e Forma:Yellow SolidPeso molecular:454.53Ref: TM-T62798
1mg130,00€5mg313,00€1mL*10mM (DMSO)341,00€10mg497,00€25mg982,00€50mg1.603,00€100mg2.592,00€PF-04880594
CAS:PF-04880594 is a potent and selective RAF inhibitor which inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 exhibits antitumor activity [1].Fórmula:C19H16F2N8Cor e Forma:SolidPeso molecular:394.38LY-2584702 hydrochloride
CAS:Ly-2584702 hydrochloride is a p70S6K selective ATP competitive inhibitor with IC50 of 4 nM.In the S6K1 enzyme assay, the IC50 of LY-2584702 was 2 nM.Fórmula:C21H20ClF4N7Pureza:98%Cor e Forma:SolidPeso molecular:481.88SX 011
CAS:SX 011 is a p38α inhibitor.Fórmula:C26H27ClFN3O3Pureza:98%Cor e Forma:SolidPeso molecular:483.96(2Z,3Z)-U0126
CAS:U0126 selectively inhibits MEK1/2, blocks MAPK/ERK signaling, and suppresses Ki-ras-induced cell growth, with IC50s of 72 nM and 58 nM for MEK1/2.Fórmula:C18H16N6S2Cor e Forma:SolidPeso molecular:380.49Antifungal agent 46
CAS:Compound 2f (Antifungal Agent 46) is a potent antifungal that inhibits Ras signaling by targeting protein farnesyltransferase [1].Fórmula:C26H28BrF3N4O2Pureza:98%Cor e Forma:SolidPeso molecular:565.43KRas G12C inhibitor 3
CAS:KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.Fórmula:C32H36ClN7O2Pureza:98%Cor e Forma:SolidPeso molecular:586.13HPK1-IN-29
CAS:"HPK1-IN-29 suppresses HPK1, boosting anti-tumor immunity; potential for immune disease research."Fórmula:C26H18F3N5O2Cor e Forma:SolidPeso molecular:489.45ML 3403
CAS:p38 MAPK inhibitor; IC50: 0.38μM. Reduces IL-1β & TNF-α release in PBMC assay; IC50: 0.039μM & 0.16μM.Fórmula:C23H21FN4SCor e Forma:SolidPeso molecular:404.5Spiclomazine HCl
CAS:Spiclomazine HCl induced apoptosis in pancreatic cancer cells, which was generally related to cell viability, migration, and invasion.Fórmula:C22H25Cl2N3OS2Cor e Forma:SolidPeso molecular:482.49CCG-232601
CAS:CCG-232601 is a inhibitor of the Rho/MRTF/SRF transcriptional pathway.Fórmula:C24H20ClF2N3O2Pureza:98%Cor e Forma:SolidPeso molecular:455.88Tinlorafenib
CAS:Tinlorafenib (PF-07284890), a BRAFV600E/K inhibitor, is oral & CNS-permeable, used for BRAF-linked CNS tumors. IC50: 4.25/2.7 nM.Fórmula:C19H19ClF2N4O3SCor e Forma:SolidPeso molecular:456.89MTBT
CAS:MTBT is the proliferation of cancer cells inhibitor. It induces cell cycle arrest and activates p38 MAPK.Fórmula:C14H11NO2S2Cor e Forma:SolidPeso molecular:289.37p38 MAP Kinase Inhibitor IV
CAS:p38 MAPK inhibitor IV blocks p38α/β/γ/δ with IC50s 0.13-8.63 μM and stops TNF-α/IL-1β at 22/44 nM in human cells.Fórmula:C12H4Cl6O4SCor e Forma:SolidPeso molecular:456.94ARS-2102
CAS:ARS-2102 is a potent covalent KRAS G12C inhibitor for use in cancer research .Fórmula:C28H31ClF2N6O2Cor e Forma:SolidPeso molecular:557.03ERK5-IN-4
CAS:ERK5-IN-4 (34b) is a potent, specific ERK5 inhibitor; IC50: 77 nM full-length, 300 nM ΔTAD in HEK293 cells.Fórmula:C16H11Cl2FN4O2Cor e Forma:SolidPeso molecular:381.19KRAS inhibitor-15
CAS:KRAS inhibitor-15 blocks KRAS G12C and p-ERK in cancer cells; potent against pancreatic and lung cancers. IC50: 0.954 μM (KRAS), 2.03/>33.3 μM (p-ERK).Fórmula:C20H17Cl2FN4OSCor e Forma:SolidPeso molecular:451.34KRAS inhibitor-10
CAS:KRAS inhibitor-10: potent, selective KRAS protein blocker; effective in various cancers; oral; tetrahydroisoquinoline class.Fórmula:C30H37N3O5Cor e Forma:SolidPeso molecular:519.63ERK5-IN-3
CAS:ERK5-IN-3 inhibits ERK5 strongly (IC50: 6 nM) and hampers Hela cell growth (IC50: 31 nM).Fórmula:C24H23Cl2FN4O2Cor e Forma:SolidPeso molecular:489.37SR-3737
CAS:SR-3737 is potent both JNK3 and p38 inhibitor.Fórmula:C29H25FN4O4Pureza:98%Cor e Forma:SolidPeso molecular:512.53KRAS G12C inhibitor 45
CAS:KRAS G12C inhibitor 45 is a potent KRAS G12C inhibitor .Fórmula:C32H33F2N5O5SCor e Forma:SolidPeso molecular:637.7JNK3 inhibitor-4
CAS:JNK3 inhibitor-4: potent, selective JNK3 blocker (IC50=1.0nM), neuroprotective, BBB-permeable.Fórmula:C28H27N7OCor e Forma:SolidPeso molecular:477.56HPK1-IN-17
CAS:HPK1-IN-17 selectively inhibits HPK1, a MAP4Ks family kinase from blood progenitor cells; useful against HPK1-related diseases like cancer.Fórmula:C26H28N6OCor e Forma:SolidPeso molecular:440.54(R)-CE3F4
CAS:(R)-CE3F4 is a selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1)(IC50 of 4.2 μM),Fórmula:C11H10Br2FNOCor e Forma:SolidPeso molecular:351.01PHT-7.3
CAS:PHT-7.3 is a selective connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain inhibitorFórmula:C24H23N3O3SPureza:98%Cor e Forma:SolidPeso molecular:433.52KRAS inhibitor-17
CAS:KRAS inhibitor-17 blocks G12C mutation (IC50: 3.37μM) and p-ERK in MIA PaCA-2 (IC50: 9.25μM). Could target pancreatic, colorectal, lung cancers.Fórmula:C21H18Cl2FN3O2SCor e Forma:SolidPeso molecular:466.36BRAF V600E/CRAF-IN-2
CAS:Potent BRAFV600E/CRAF inhibitor, IC50: 0.888/0.229 μM, induces G0/G1 arrest and apoptosis in HCT-116 cells, potential for cancer research.Fórmula:C30H30F3N5O2Cor e Forma:SolidPeso molecular:549.59JNK-1-IN-1
CAS:JNK-1-IN-1 is an inhibitor specifically targeting JNK-1, also exhibiting inhibition of MKK7 with an IC50 value of 7.8μM.Fórmula:C24H22N6SCor e Forma:SolidPeso molecular:426.54BAY-846
CAS:BAY-846: allosteric MEK inhibitor, long-lasting, highly bioavailable, low brain entry, effective in K-Ras A549 model.Fórmula:C19H13F4IN4O4SCor e Forma:SolidPeso molecular:596.29CK1-IN-2
CAS:CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor p38a, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.Fórmula:C17H12FN3O2Pureza:99.31%Cor e Forma:SolidPeso molecular:309.296-T-GDP
CAS:6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of thiopurine. It inhibits the activity of Rac1, thereby reducing the transcription of inflammatory factors and the expression of cell adhesion molecules, which ultimately suppresses leukocyte migration and the occurrence of tissue inflammation.Fórmula:C10H15N5O10P2SCor e Forma:SolidPeso molecular:459.27B-Raf IN 7
CAS:"B-Raf IN 7 inhibits B-Raf (IC50: 110.23 nM); fights colon, breast, liver, cervical, prostate cancers (IC50: 7.50-12.83 μM)."Fórmula:C15H16N6O3Cor e Forma:SolidPeso molecular:328.33BRAF inhibitor
CAS:BRAF inhibitor is an inhibitor of B-Raf.Fórmula:C22H18F2N4O3SPureza:98.2% - 98.41%Cor e Forma:SolidPeso molecular:456.47Ref: TM-T10599
1mg44,00€5mg87,00€1mL*10mM (DMSO)99,00€10mg137,00€25mg236,00€50mg371,00€100mg530,00€200mg770,00€
