MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 885 produtos de "MAPK"
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PAF (C16)
CAS:<p>PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability.</p>Fórmula:C26H54NO7PPureza:98%Cor e Forma:SolidPeso molecular:523.68B-Raf IN 13
CAS:<p>B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.</p>Fórmula:C19H19ClFN3O4SPureza:99.41% - >99.99%Cor e Forma:SoildPeso molecular:439.89KRAS G12D inhibitor 10
CAS:<p>KRAS G12D inhibitor 10 targets KRAS G12D in cancer research (WO2021108683A1, compound 34).</p>Fórmula:C33H41ClN8O2Cor e Forma:SolidPeso molecular:617.18GGTI-286
CAS:<p>GGTI-286: GGTase I inhibitor, cell-permeable, IC50=2μM. Strongly blocks Rap1A geranylation; less effective on H-Ras, Ras4B IC50=1μM.</p>Fórmula:C23H31N3O3SCor e Forma:SolidPeso molecular:429.58MCP110
CAS:<p>MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.</p>Fórmula:C33H36N2O3Pureza:97.23%Cor e Forma:OilPeso molecular:508.65KYA1797
CAS:<p>KYA1797 inhibits Wnt/ß-catenin, targeting axin, and promotes ß-catenin/Ras decay, halting APC/KRAS mutant CRC growth.</p>Fórmula:C17H12N2O6S2Pureza:98%Cor e Forma:SolidPeso molecular:404.42RSK2-IN-2
CAS:<p>RSK2-IN-2 (Compound 25) is a reversible covalent inhibitor of the RPS6KA3 ( RSK2 ) kinase which also inhibits MSK1, MSK2, and RSK3 [1].</p>Fórmula:C16H11N5OCor e Forma:SolidPeso molecular:289.29GABAB receptor antagonist 1
CAS:(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selectiveFórmula:C18H24O4Pureza:98%Cor e Forma:SolidPeso molecular:304.38B-Raf IN 8
CAS:<p>B-Raf IN 8: strong B-Raf inhibitor (70.65 nM IC50); combats liver, colon, breast & prostate cancer with IC50s from 9.78 to 29.85 μM.</p>Fórmula:C18H17N3O2Cor e Forma:SolidPeso molecular:307.35HPK1-IN-24
CAS:<p>HPK1-IN-24 (example 51) has potential to be used in the cancer research which is an inhibitor of hematopoietic progenitor kinase 1 (HPK1) (Ki = 100 nM) [1].</p>Fórmula:C19H14FN5Cor e Forma:SolidPeso molecular:331.35UC-857993
CAS:<p>UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.</p>Fórmula:C25H22ClNO2Cor e Forma:SolidPeso molecular:403.9JNK3 inhibitor-2
CAS:<p>JNK3 inhibitor-2: selectively inhibits JNK3 (IC50 = 0.25 μM); less effective on JNK1/JNK2 (>100 μM); targets DDR1 and EGFR mutations.</p>Fórmula:C20H14N2O2Cor e Forma:SolidPeso molecular:314.34Tpl2 Kinase Inhibitor 1
CAS:<p>Tpl2 Kinase Inhibitor 1 is an effective and selective Tpl2 inhibitor.</p>Fórmula:C21H14ClFN6Pureza:98%Cor e Forma:SolidPeso molecular:404.83SX 011
CAS:<p>SX 011 is a p38α inhibitor.</p>Fórmula:C26H27ClFN3O3Pureza:98%Cor e Forma:SolidPeso molecular:483.96KRAS inhibitor-7
CAS:<p>KRAS inhibitor-7 is a potent KRAS G12C inhibitor.</p>Fórmula:C26H27ClF2N6O2Pureza:98%Cor e Forma:SolidPeso molecular:528.98HPK1-IN-25
CAS:<p>HPK1-IN-25, an HPK1 inhibitor, IC50 129 nM, may aid cancer research.</p>Fórmula:C23H25N5OCor e Forma:SolidPeso molecular:387.48KRAS G12C inhibitor 43
CAS:<p>KRAS G12C inhibitor 43 strongly blocks KRAS G12C, H358 cell growth (IC50: 0.001-1μM), less effective on A549, HCC cells (IC50>1μM).</p>Fórmula:C33H35N7O3Cor e Forma:SolidPeso molecular:577.68GGTI-286 hydrochloride
CAS:<p>GGTI-286 HCl strongly inhibits GGTase I (IC50: 2 μM) and K-Ras4B farnesylation (IC50: 1 μM).</p>Fórmula:C23H32ClN3O3SCor e Forma:SolidPeso molecular:466.04SMAP-2
CAS:<p>SMAP-2: oral PP2A activator, targets Aα subunit, halts KRAS-mutant lung cancer growth.</p>Fórmula:C27H27F3N2O4SPureza:98%Cor e Forma:SolidPeso molecular:532.57HPK1-IN-26
CAS:<p>HPK1-IN-26, from WO2021254118A1, is a potent dual HPK1/GLK inhibitor for studying animal infections.</p>Fórmula:C19H21N5OSCor e Forma:SolidPeso molecular:367.47ZINC09659342
CAS:<p>ZINC09659342 (compound 13) is an inhibitor of Lbc-RhoA interaction (IC50: 3.6 μM).</p>Fórmula:C23H15F3N2O4Cor e Forma:SolidPeso molecular:440.37NSC-658497
CAS:<p>NSC-658497 is a SOS1-Ras interaction inhibitor that acts by dose-dependently inhibiting SOS1 GEF activity.</p>Fórmula:C20H10N2O6S2Pureza:98%Cor e Forma:SolidPeso molecular:438.43SR 3576
CAS:<p>JNK3 inhibitor, potent and selective</p>Fórmula:C27H27N5O5Pureza:98%Cor e Forma:SolidPeso molecular:501.53CAY10561
CAS:<p>CAY10561: potent, selective ERK2 inhibitor (Ki=2nM); blocks cell proliferation; IC50 in COLO 205 cells: 0.54μM.</p>Fórmula:C22H17Cl2FN4O2Cor e Forma:SolidPeso molecular:459.3KRAS G12C inhibitor 22
CAS:<p>KRAS G12C inhibitor 22 is a KRAS G12C inhibitor.</p>Fórmula:C32H41N7O2Cor e Forma:SolidPeso molecular:555.71Quazinone
CAS:<p>Quazinone: PDE3 inhibitor, enhances heart muscle contractility, lowers blood pressure, and inhibits DNA synthesis in muscle cells. IC50 = 4.2 μM.</p>Fórmula:C11H10ClN3OCor e Forma:SolidPeso molecular:235.67SB-747651A
CAS:<p>SB-747651A: ATP-competitive MSK1 inhibitor (IC50=11nM), affects N-terminal domain, also hinders MSK2, PKA, PKB, RSK, p70S6K.</p>Fórmula:C16H22N8OPureza:98%Cor e Forma:SolidPeso molecular:342.4EO 1428
CAS:<p>p38α and p38β2 inhibitor</p>Fórmula:C20H16BrClN2OPureza:98%Cor e Forma:SolidPeso molecular:415.71PD 334581
CAS:<p>MEK1 inhibitor</p>Fórmula:C20H19F3IN5O2Pureza:98%Cor e Forma:SolidPeso molecular:545.3p38α inhibitor 2
CAS:<p>P38α Inhibitor 2, a potent and selective inhibitor of p38α MAPK, exhibits a pIC50 value of 9.6.</p>Fórmula:C27H33N5O3Cor e Forma:SolidPeso molecular:475.58pan-KRAS-IN-16
CAS:<p>3344 is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.</p>Fórmula:C24H26N2O3Pureza:98%Cor e Forma:SolidPeso molecular:390.47B-Raf IN 6
CAS:<p>B-Raf IN 6: potent B-Raf kinase inhibitor, IC50 of 1.7 nM, doesn't target PXR, metabolically stable, potential in cancer research.</p>Fórmula:C24H21F3N6O2S2Cor e Forma:SolidPeso molecular:546.59(R)-CE3F4
CAS:(R)-CE3F4 is a selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1)(IC50 of 4.2 μM),Fórmula:C11H10Br2FNOCor e Forma:SolidPeso molecular:351.01SR-3737
CAS:<p>SR-3737 is potent both JNK3 and p38 inhibitor.</p>Fórmula:C29H25FN4O4Pureza:98%Cor e Forma:SolidPeso molecular:512.53TOPK-p38/JNK-IN-1
CAS:<p>TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NO</p>Fórmula:C17H15F3N2O4Cor e Forma:SolidPeso molecular:368.31B-Raf IN 7
CAS:<p>"B-Raf IN 7 inhibits B-Raf (IC50: 110.23 nM); fights colon, breast, liver, cervical, prostate cancers (IC50: 7.50-12.83 μM)."</p>Fórmula:C15H16N6O3Cor e Forma:SolidPeso molecular:328.33KB-5246
CAS:<p>KB-5246, displays antibacterial activities.is a tetracyclic quinolone.</p>Fórmula:C18H17ClFN3O4SPureza:98%Cor e Forma:SolidPeso molecular:425.86KRas G12C inhibitor 4
CAS:KRas G12C inhibitor 4 is a compound that inhibits KRas G12C.Fórmula:C33H38ClN7O2Pureza:98%Cor e Forma:SolidPeso molecular:600.15Avutometinib potassium
CAS:<p>Avutometinib potassium, a MEKi, blocks Delta and Omicron infection in airway cells, potentially lessening disease severity.</p>Fórmula:C21H17FKN5O5SCor e Forma:SolidPeso molecular:509.553,4-Dephostatin
CAS:<p>3,4-Dephostatin is an inhibitor of the interactions of CFTR-associated ligand (CAL) and PSD-95/Dlg1/ZO-1 (PDZ) domain.</p>Fórmula:C7H8N2O3Cor e Forma:SolidPeso molecular:168.15ERK5-IN-3
CAS:<p>ERK5-IN-3 inhibits ERK5 strongly (IC50: 6 nM) and hampers Hela cell growth (IC50: 31 nM).</p>Fórmula:C24H23Cl2FN4O2Cor e Forma:SolidPeso molecular:489.37Ras modulator-1
CAS:<p>Ras modulator-1 is a modulator of Ras.</p>Fórmula:C29H21N5O4SCor e Forma:SolidPeso molecular:535.57KRas G12C inhibitor 3
CAS:<p>KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.</p>Fórmula:C32H36ClN7O2Pureza:98%Cor e Forma:SolidPeso molecular:586.13MW108
CAS:<p>MW108 is an active site targeted, CNS-active, p38αMAPK inhibitor.</p>Fórmula:C21H19ClN4Cor e Forma:SolidPeso molecular:362.86(S)-CCG-1423
<p>(S)-CCG-1423, a stereoisomer, inhibits Rho to block myocardin-related transcription factor A & serum response signaling.</p>Fórmula:C18H13ClF6N2O3Pureza:98%Cor e Forma:SolidPeso molecular:454.8K-Ras G12C-IN-3
CAS:<p>K-Ras G12C-IN-3: novel, irreversible inhibitor of K-Ras G12C mutant protein for cancer treatment.</p>Fórmula:C21H19Cl3N2O3Cor e Forma:SolidPeso molecular:453.75ML 3403
CAS:<p>p38 MAPK inhibitor; IC50: 0.38μM. Reduces IL-1β & TNF-α release in PBMC assay; IC50: 0.039μM & 0.16μM.</p>Fórmula:C23H21FN4SCor e Forma:SolidPeso molecular:404.5CCG-232601
CAS:<p>CCG-232601 is a inhibitor of the Rho/MRTF/SRF transcriptional pathway.</p>Fórmula:C24H20ClF2N3O2Pureza:98%Cor e Forma:SolidPeso molecular:455.88Tinlorafenib
CAS:<p>Tinlorafenib (PF-07284890), a BRAFV600E/K inhibitor, is oral & CNS-permeable, used for BRAF-linked CNS tumors. IC50: 4.25/2.7 nM.</p>Fórmula:C19H19ClF2N4O3SCor e Forma:SolidPeso molecular:456.89PHT-7.3
CAS:<p>PHT-7.3 is a selective connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain inhibitor</p>Fórmula:C24H23N3O3SPureza:98%Cor e Forma:SolidPeso molecular:433.52
