MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 881 produtos de "MAPK"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
KRAS4b-PDEδ stabilizer C19
CAS:<p>KRAS4b-PDEδ stabilizer C19 is a stabilizer of the KRAS4b-PDEδ complex which decreases the proliferation of colorectal cancer cells, and increases apoptosis via</p>Fórmula:C18H20Cl2N2O3Cor e Forma:SolidPeso molecular:383.27SCH 51344
CAS:<p>SCH 51344 inhibits Ras induced malignant transformation. SCH 51344 prevents anchorage-independent growth of oncogene transformed fibroblasts [1].</p>Fórmula:C16H20N4O3Cor e Forma:SolidPeso molecular:316.36LX-3
CAS:<p>LX-3 activates p38 MAPK, enabling expression of genes normally silenced by DNA methylation.</p>Fórmula:C20H13BrN4OSCor e Forma:SolidPeso molecular:437.31KRAS G12C inhibitor 47
CAS:<p>KRAS G12C inhibitor 47 strongly blocks KRAS G12C (IC50: 0.172 μM) and p-ERK in cells; promising for pancreatic, colorectal, lung cancers.</p>Fórmula:C30H28ClFN4O3Cor e Forma:SolidPeso molecular:547.02SOS1-IN-3
CAS:<p>SOS1-IN-3 is an effective inhibitor of SOS1 (son of sevenless homolog 1) (IC50=5 nM). SOS1-IN-3 shows antitumor activity.</p>Fórmula:C21H21F3N4OCor e Forma:SolidPeso molecular:402.41SOS1 activator 1
CAS:<p>SOS1 activator 1 enhances SOS1's GDP-GTP exchange on Ras (Kd: 44 nM).</p>Fórmula:C26H32ClFN6Cor e Forma:SolidPeso molecular:483.026-T-GDP
CAS:<p>6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of thiopurine. It inhibits the activity of Rac1, thereby reducing the transcription of inflammatory factors and the expression of cell adhesion molecules, which ultimately suppresses leukocyte migration and the occurrence of tissue inflammation.</p>Fórmula:C10H15N5O10P2SCor e Forma:SolidPeso molecular:459.27GDC-0879
CAS:<p>GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.</p>Fórmula:C19H18N4O2Pureza:99.62%Cor e Forma:SolidPeso molecular:334.37Tpl2-IN-I
CAS:<p>Tpl2-IN-I is an inhibitor of tumour progression locus 2 (Tpl2) kinase.</p>Fórmula:C21H14ClFN6Pureza:98%Cor e Forma:SolidPeso molecular:404.83NSC1011
CAS:NSC1011 is an inhibitor of ras converting enzyme 1 (Rce1).Fórmula:C23H18N2O3Pureza:98%Cor e Forma:SolidPeso molecular:370.4AZD6703 free base
CAS:<p>AZD6703 is a potent, selective and reversible orally bioavailable inhibitor of p38 mitogen-activated protein kinase 14 (MAPK14).</p>Fórmula:C24H27N5O2Cor e Forma:SolidPeso molecular:417.5Kobe2601
CAS:<p>Kobe2601 is a Kobe0065 and Kobe02602 water-soluble analog. It displays inhibitory activity towards Ras-Raf binding.</p>Fórmula:C13H10FN5O4SPureza:98%Cor e Forma:SolidPeso molecular:351.31GSK329
CAS:<p>GSK329 selectively inhibits TNNI3K, showing cardioprotection in ischemic heart models.</p>Fórmula:C19H14Cl2F3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:472.25GSK649A
CAS:<p>GSK649A is a novel activator of Satellite Cell Proliferation, it could enhance repair of Damaged Muscle.</p>Fórmula:C15H12ClFN6OSPureza:98%Cor e Forma:SolidPeso molecular:378.81CP-281384
CAS:<p>CP-281384 is a potent, p38alpha-selective inhibitor.</p>Fórmula:C18H14F2N4OPureza:98%Cor e Forma:SolidPeso molecular:340.33RBC6
CAS:<p>RBC6 is an inhibitor of the binding of Ral to its effector RALBP1.</p>Fórmula:C16H14Cl2N4O2Pureza:98%Cor e Forma:SolidPeso molecular:365.21CP-944629
CAS:<p>CP-944629 is a novel, potent, and selective inhibitor of p38alpha.</p>Fórmula:C19H15F3N4OPureza:98%Cor e Forma:SolidPeso molecular:372.34BNC-1
CAS:<p>BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.</p>Fórmula:C16H14N2O3Pureza:98%Cor e Forma:SolidPeso molecular:282.29(2Z,3Z)-U0126
CAS:U0126 selectively inhibits MEK1/2, blocks MAPK/ERK signaling, and suppresses Ki-ras-induced cell growth, with IC50s of 72 nM and 58 nM for MEK1/2.Fórmula:C18H16N6S2Cor e Forma:SolidPeso molecular:380.49Migoprotafib
CAS:Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for advanced solid tumours.Fórmula:C25H26N8OCor e Forma:SolidPeso molecular:454.53BSJ-04-122
CAS:<p>BSJ-04-122: MKK4/7 inhibitor with IC50s of 4 nM & 181 nM, used in cancer research.</p>Fórmula:C15H12ClN5OPureza:97.61%Cor e Forma:SolidPeso molecular:313.74CK1-IN-2
CAS:<p>CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor p38a, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.</p>Fórmula:C17H12FN3O2Pureza:99.31%Cor e Forma:SolidPeso molecular:309.29SR-3306
CAS:<p>SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM.Cost-effective and quality-assured.</p>Fórmula:C28H26N8OPureza:99.38% - 99.71%Cor e Forma:SolidPeso molecular:490.56GNE-1858
CAS:<p>GNE-1858 inhibits HPK1; IC50: 1.9 nM for wild-type, 1.9 nM (HPK1-TSEE), 4.5 nM (HPK1-SA).</p>Fórmula:C21H26F2N8Pureza:99.36%Cor e Forma:SolidPeso molecular:428.48J30-8
CAS:<p>J30-8 is a JNK3 inhibitor (IC50: 40 nM) with neuroprotective activity and can be used to study neurodegenerative diseases such as Alzheimer's disease.</p>Fórmula:C17H9ClFN3O2SPureza:99.90%Cor e Forma:SolidPeso molecular:373.79TAK1/MAP4K2 inhibitor 1
CAS:<p>TAK1/MAP4K2 inhibitor 1 (compound 5) is a dual kinase inhibitor of TAK1 and MAP4K2 with IC50 values of 41.1 nM and 18.2 nM, respectively.</p>Fórmula:C29H31F3N6O2Pureza:98%Cor e Forma:SolidPeso molecular:552.59RMM-46
CAS:<p>RMM-46 is a reversible covalent inhibitor with high ligand efficiency and selectivity for MSK/RSK family kinases.</p>Fórmula:C24H26N4O5Pureza:98.89%Cor e Forma:SolidPeso molecular:450.49LY-2584702 hydrochloride
CAS:<p>Ly-2584702 hydrochloride is a p70S6K selective ATP competitive inhibitor with IC50 of 4 nM.In the S6K1 enzyme assay, the IC50 of LY-2584702 was 2 nM.</p>Fórmula:C21H20ClF4N7Pureza:98%Cor e Forma:SolidPeso molecular:481.88MEK inhibitor
CAS:<p>MEK inhibitor is a MEK receptor and cell cycle protein/CDK complex inhibitor with antitumor activity that can be used to study tumor cell proliferation.</p>Fórmula:C26H26N4O2Pureza:97.48%Cor e Forma:SolidPeso molecular:426.51NSC-70220
CAS:<p>SOS1-IN-1 is an inhibitor of SOS1.</p>Fórmula:C22H15NO2Pureza:98%Cor e Forma:SolidPeso molecular:325.36MNK1/2-IN-5
CAS:<p>MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor with anticancer activity and can be used to study solid tumors and hematological malignancies.</p>Fórmula:C17H16N4O2Pureza:98.04%Cor e Forma:SolidPeso molecular:308.33MEK-IN-4
CAS:<p>MEK-IN-4 is a MEK inhibitor that can be used to study inflammatory diseases and cancer.</p>Fórmula:C21H18N4OSPureza:98.35% - 99.16%Cor e Forma:SolidPeso molecular:374.46Nek2-IN-5
CAS:<p>Nek2-IN-5 (NCL00017509) is a potent and selective inhibitor of NIMA-related kinase 2 (Nek2).</p>Fórmula:C15H12N6OPureza:98.11%Cor e Forma:SolidPeso molecular:292.3mSIRK
CAS:<p>mSIRK (G-Protein βγ Binding Peptide) is an ERK1 and ERK2 dual activator that promotes alpha-subunit dissociation.</p>Fórmula:C93H150N20O25Pureza:99.26%Cor e Forma:SolidPeso molecular:1948.31AKP-001
CAS:AKP-001 is a selective inhibitor of MAPK of the p38α isoform and is used in the study of immune and digestive disorders.Fórmula:C21H13ClF2N4O2Pureza:99.50% - 99.92%Cor e Forma:SolidPeso molecular:426.8p38 MAPK Inhibitor
CAS:<p>p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). It inhibits senescence induced by the oncogene RAS.</p>Fórmula:C20H13ClFN3OPureza:99.91%Cor e Forma:SolidPeso molecular:365.79BI-2852
CAS:<p>BI-2852: nanomolar affinity KRAS switch I/II pocket inhibitor; blocks signaling, halts KRAS mutant cell growth.</p>Fórmula:C31H28N6O2Pureza:98.98%Cor e Forma:SolidPeso molecular:516.59p38α inhibitor 4
CAS:p38α inhibitor 4 is a selective MAPK p38α inhibitor, which is used to study diabetes, pain and chronic inflammation.Fórmula:C14H7F6N3OPureza:99.69%Cor e Forma:SolidPeso molecular:347.215MKK7-COV-9
CAS:MKK7-COV-9 is an MKK7 inhibitor that inhibits MKK7-induced protein-protein interactions and interrupts the activation of primary B cells in response to LPS.Fórmula:C18H16N4O2Pureza:99.73% - 99.83%Cor e Forma:SolidPeso molecular:320.35RMC-0331
CAS:<p>RMC-0331 (RM-023) is an oral SOS1 inhibitor with potential to block RAS activation and anticancer properties.</p>Fórmula:C22H25ClF3N5O3Pureza:99.81%Cor e Forma:SolidPeso molecular:499.91NMDAR/TRPM4-IN-2
CAS:<p>Potent NMDAR/TRPM4-IN-2 blocks NMDAR/TRPM4, protects brain and retinal neurons, and prevents mitochondrial dysfunction with an IC50 of 2.1 μM.</p>Fórmula:C11H19BrCl2N2Pureza:98.77%Cor e Forma:SolidPeso molecular:330.092EO-1606
CAS:<p>EO-1606 is a p38MAP kinase inhibitor with anti-inflammatory activity and may be used in studies of Alzheimer;s disease and dermatitis.</p>Fórmula:C21H17ClFNOPureza:98.28% - 98.84%Cor e Forma:SolidPeso molecular:353.82ZINC12409120
CAS:<p>ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 μM.ZINC12409120 inhibits ERK activity by interfering with FGF23</p>Fórmula:C20H16N4O2Pureza:99.71% - 99.95%Cor e Forma:SolidPeso molecular:344.37GSK2008607
CAS:<p>GSK2008607 is a potent B-RafV600E inhibitor with anticancer activity and can be used to study breast, colorectal, melanoma, thyroid, and ovarian cancers.</p>Fórmula:C31H28F3N7O3S2Pureza:99.36%Cor e Forma:SolidPeso molecular:667.72JNK-IN-11
CAS:<p>JNK-IN-11 inhibits JNK1/2/3 (IC50: 2.2/21.4/1.8 μM); promising for Alzheimer's/Parkinson's research.</p>Fórmula:C12H11NO3S2Pureza:98.82%Cor e Forma:SolidPeso molecular:281.35DS12881479
CAS:<p>DS12881479 can be used in cancer research which is a potent and selective inhibitor of Mnk1(IC 50 =21 nM) [1].</p>Fórmula:C16H19N3OSPureza:99.85%Cor e Forma:SolidPeso molecular:301.41SOS1-IN-15
CAS:<p>SOS1-IN-15 is an orally active and potent SOS1 inhibitor with potential antitumor activity.SOS1-IN-15 is used in the study of colon cancer.</p>Fórmula:C28H27F3N6O2Pureza:98.32%Cor e Forma:SolidPeso molecular:536.548UR13870
CAS:<p>UR-13870 (Org 48762-0) is a p38 MAPK inhibitor that prevents bone damage in collagen-induced arthritis in mice.</p>Fórmula:C24H16F2N4Pureza:99.18% - >99.99%Cor e Forma:SolidPeso molecular:398.41(E)-GABAB receptor antagonist 1
CAS:<p>(E)-GABAB antagonist 1 inhibits GABA IP3 production, with an IC50 of 37.9 μM and acts as a selective negative modulator.</p>Fórmula:C18H24O4Pureza:98.09%Cor e Forma:SolidPeso molecular:304.38ERK Inhibitor II (Negative control)
CAS:<p>ERK Inhibitor II, a control, blocks ERK and insulin receptor activation, aiding diabetes research.</p>Fórmula:C18H12N6OCor e Forma:SolidPeso molecular:328.33
