MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 887 produtos de "MAPK"
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GS87
CAS:<p>GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.</p>Fórmula:C16H11N5O2SPureza:98.86%Cor e Forma:SolidPeso molecular:337.36ZT-12-037-01
CAS:<p>Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).</p>Fórmula:C21H31N5O2Pureza:99.56%Cor e Forma:SolidPeso molecular:385.5LY-364947
CAS:<p>LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.</p>Fórmula:C17H12N4Pureza:99.41% - 99.96%Cor e Forma:SolidPeso molecular:272.3Regorafenib Hydrochloride
CAS:<p>Regorafenib HCl (BAY73-4506) is an oral inhibitor targeting angiogenic, stromal, and cancer kinases with strong antitumor effects.</p>Fórmula:C21H16Cl2F4N4O3Pureza:99.56%Cor e Forma:SolidPeso molecular:519.28TAK-632
CAS:<p>TAK-632 is a potent pan-Raf inhibitor.</p>Fórmula:C27H18F4N4O3SPureza:98% - 99.5%Cor e Forma:SolidPeso molecular:554.52BI-78D3
CAS:<p>BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.</p>Fórmula:C13H9N5O5S2Pureza:97.89% - >99.99%Cor e Forma:SolidPeso molecular:379.37XMD17-109
CAS:<p>XMD17-109 (ERK5-IN-1) is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).</p>Fórmula:C36H46N8O3Pureza:98.75% - 99.7%Cor e Forma:SolidPeso molecular:638.8BMS582949
CAS:<p>BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.</p>Fórmula:C22H26N6O2Pureza:98.11%Cor e Forma:SolidPeso molecular:406.48Bohemine
CAS:<p>Bohemine is a cyclin-dependent kinase inhibitor.</p>Fórmula:C18H24N6OPureza:99.09% - 99.53%Cor e Forma:SolidPeso molecular:340.42Dabrafenib Mesylate
CAS:<p>Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).</p>Fórmula:C24H24F3N5O5S3Pureza:99.45% - 99.82%Cor e Forma:SolidPeso molecular:615.67Locostatin
CAS:<p>Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.</p>Fórmula:C14H15NO3Pureza:97.13%Cor e Forma:SolidPeso molecular:245.27MW-150
CAS:<p>MW-150 (MW01-18-150SRM) is a unique protein kinase inhibitor, is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM.</p>Fórmula:C24H23N5Pureza:97.35% - 99.27%Cor e Forma:SolidPeso molecular:381.47Deltarasin HCl
CAS:<p>Deltarasin hinders KRAS-PDEδ, impairs cancer cell growth via a PDEδ pocket, disrupting RAS/RAF signaling and autophagy.</p>Fórmula:C40H37N5O·xHClCor e Forma:SolidPeso molecular:713.144(S)-AMG-510
CAS:<p>(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.</p>Fórmula:C30H30F2N6O3Pureza:99.05% - 99.76%Cor e Forma:SolidPeso molecular:560.594APS-2-79 hydrochloride
CAS:<p>APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization.</p>Fórmula:C23H21N3O3·HClPureza:98.64% - 99.55%Cor e Forma:SolidPeso molecular:423.89SB 242235
CAS:<p>SB 242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases.</p>Fórmula:C19H20FN5OPureza:99.13% - 99.68%Cor e Forma:SolidPeso molecular:353.39CC-401 Hydrochloride
CAS:<p>CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.</p>Fórmula:C22H25ClN6OPureza:99.71% - ≥95%Cor e Forma:SolidPeso molecular:424.93Compound 3344 hydrochloride
<p>Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.</p>Fórmula:C24H27ClN2O3Pureza:99.23%Cor e Forma:SolidPeso molecular:426.94ASP2453
CAS:<p>ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.</p>Fórmula:C40H48F3N7O4Pureza:99.71%Cor e Forma:SolidPeso molecular:747.85Maohuoside A
CAS:<p>Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.</p>Fórmula:C27H32O12Pureza:98.91% - 99.57%Cor e Forma:SolidPeso molecular:548.54SKF-86002
CAS:<p>SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).</p>Fórmula:C16H12FN3SPureza:98% - 99.85%Cor e Forma:SolidPeso molecular:297.35Butein
CAS:<p>Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.</p>Fórmula:C15H12O5Pureza:98.76% - >99.99%Cor e Forma:SolidPeso molecular:272.25NVP-BHG712
CAS:<p>NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and</p>Fórmula:C26H20F3N7OPureza:97.32% - 98.63%Cor e Forma:SolidPeso molecular:503.48Vemurafenib
CAS:<p>Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and potently.</p>Fórmula:C23H18ClF2N3O3SPureza:98% - 99.65%Cor e Forma:SolidPeso molecular:489.92Agerafenib
CAS:<p>Agerafenib (CEP32496) is a highly potent inhibitor of BRAF.</p>Fórmula:C24H22F3N5O5Pureza:95.78% - 99.23%Cor e Forma:SolidPeso molecular:517.46SGX-523
CAS:<p>SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, and c-Raf.</p>Fórmula:C18H13N7SPureza:99% - >99.99%Cor e Forma:SolidPeso molecular:359.41APS-2-79
CAS:<p>APS-2-79: KSR-dependent MEK inhibitor, blocks ATP biotin at KSR2, IC50 of 120 nM, disrupts Ras-MAPK signaling.</p>Fórmula:C23H21N3O3Cor e Forma:SolidPeso molecular:387.43D-JNKI-1 acetate
<p>D-JNKI-1 acetate (AM-111 acetate) is a highly potent and cell-permeable peptide inhibitor of JNK.</p>Fórmula:C166H290N66O42Pureza:99.48%Cor e Forma:SolidPeso molecular:3882.5GW284543
CAS:<p>GW284543 (UNC10225170) is a selective inhibitor of MEK5 .</p>Fórmula:C23H20N2O3Pureza:99.75%Cor e Forma:SolidPeso molecular:372.42ERK-IN-4
CAS:<p>ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.</p>Fórmula:C14H17ClN2O3SPureza:98.92% - 99.84%Cor e Forma:SolidPeso molecular:328.814Raf inhibitor 1
CAS:<p>B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.</p>Fórmula:C26H19ClN8Pureza:98.05%Cor e Forma:SolidPeso molecular:478.94Cerdulatinib hydrochloride
CAS:<p>Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 < 200 nM.</p>Fórmula:C20H28ClN7O3SPureza:99.85%Cor e Forma:SolidPeso molecular:482Ulixertinib hydrochloride
CAS:<p>Ulixertinib hydrochloride (Ulixertinib HCl) is an ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosis</p>Fórmula:C21H23Cl3N4O2Pureza:99.85%Cor e Forma:SolidPeso molecular:469.79NCB-0846
CAS:<p>NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).</p>Fórmula:C21H21N5O2Pureza:97.04% - 99.89%Cor e Forma:SolidPeso molecular:375.42VX-702
CAS:<p>VX-702: selective p38α MAPK inhibitor, potent anti-cytokine for rheumatoid arthritis.</p>Fórmula:C19H12F4N4O2Pureza:99% - >99.99%Cor e Forma:SolidPeso molecular:404.32TBAP-001
CAS:TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.Fórmula:C27H23F2N7O3Pureza:99.58%Cor e Forma:SolidPeso molecular:531.51Trametiglue
CAS:<p>Trametiglue, a potent Trametinib derivative, selectively targets KSR-MEK and RAF-MEK through unique binding.</p>Fórmula:C25H24FIN6O5SCor e Forma:SolidPeso molecular:666.46AMG410
CAS:<p>AMG410 is a non-covalent, dual-modality KRAS inhibitor effective against both GDP (OFF) and GTP (ON) binding independently of the cell cycle and other mutants,</p>Fórmula:C31H32ClF2N7O5Pureza:98.01% - 99.84%Cor e Forma:SoildPeso molecular:656.08AZD0022
CAS:<p>AZD0022 is a selective, reversible, and orally active KRAS G12D inhibitor, exhibits tumour marker inhibition in PDAC and NSCLC models.</p>Fórmula:C34H30F4N6OPureza:98.73%Cor e Forma:SoildPeso molecular:614.64Cephradine monohydrate
CAS:<p>Cephradine monohydrate is a β-lactam cephalosporin antibiotic exhibiting broad-spectrum activity against Gram-positive and Gram-negative pathogens.</p>Fórmula:C16H21N3O5SPureza:99.91%Cor e Forma:SolidPeso molecular:367.42FMK
CAS:<p>FMK 是一种不可逆的 RSK2 抑制剂，能够共价修饰 RSK 的 C 末端区域。</p>Fórmula:C18H19FN4O2Pureza:99.71%Cor e Forma:SolidPeso molecular:342.37ETC-168
CAS:<p>ETC-168 is a selective, orally active MNK inhibitor with IC50 values of 23 nM for MNK1 and 43 nM for MNK2. It demonstrates antiproliferative efficacy both in vivo and in vitro [1].</p>Fórmula:C24H19N5O2Cor e Forma:SolidPeso molecular:409.44SC-68376
CAS:<p>SC-68376 is a potent, reversible, cell-permeable, ATP-competitive, and selective inhibitor of p38 MAP kinase.</p>Fórmula:C15H12N2OPureza:98%Cor e Forma:SolidPeso molecular:236.27Deltarasin
CAS:<p>Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.</p>Fórmula:C40H37N5OPureza:99.4%Cor e Forma:SolidPeso molecular:603.756H05
CAS:<p>6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).</p>Fórmula:C20H30ClN3O2S3Pureza:98%Cor e Forma:SolidPeso molecular:476.12PLX7904
CAS:<p>PLX7904 (PB04), a selective RAF inhibitor, blocks ERK1/2 in mutant BRAF melanoma without activating it in RAS mutants.</p>Fórmula:C24H22F2N6O3SPureza:99.51% - 99.66%Cor e Forma:SolidPeso molecular:512.53Sulindac sulfide
CAS:<p>Sulindac sulfide: NSAID targeting COX-1, inhibits Ras-Raf-1 and gamma-secretase (IC50: 20.2 μM), active sulinic acid metabolite.</p>Fórmula:C20H17FO2SPureza:99.35%Cor e Forma:SolidPeso molecular:340.41KYA1797
CAS:<p>KYA1797 inhibits Wnt/ß-catenin, targeting axin, and promotes ß-catenin/Ras decay, halting APC/KRAS mutant CRC growth.</p>Fórmula:C17H12N2O6S2Pureza:98%Cor e Forma:SolidPeso molecular:404.42BRAF inhibitor
CAS:<p>BRAF inhibitor is an inhibitor of B-Raf.</p>Fórmula:C22H18F2N4O3SPureza:98.2% - 98.41%Cor e Forma:SolidPeso molecular:456.47ERK1/2 inhibitor 1
CAS:<p>ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.</p>Fórmula:C29H32ClN5O4Pureza:98.81%Cor e Forma:SolidPeso molecular:550.05
