MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 890 produtos de "MAPK"
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PROTAC K-Ras Degrader-1
CAS:PROTAC K-Ras Degrader-1 is a PROTAC degrader based on the Cereblon E3 ligase ligand, capable of degrading K-Ras.Fórmula:C53H62N10O10Pureza:98.05%Cor e Forma:SolidPeso molecular:999.12MRTX849 analog 24
CAS:MRTX849 analog 24, a KRAS G12C inhibitor with an alkyne for click probes, aids in studying MRTX849's functionality.Fórmula:C36H39ClFN7O2Cor e Forma:SolidPeso molecular:656.2PROTAC K-Ras Degrader-4
CAS:PROTAC K-Ras Degrader-4 is a molecule designed to selectively degrade oncogenic K-Ras mutants, a novel strategy for cancer research.
Fórmula:C50H60N12O6S2Cor e Forma:SoildPeso molecular:989.22Rapaprutug
CAS:Rapaprutug is a monoclonal antibody that targets human KARS1 (lysyl-tRNA synthetase 1). It can block inflammation-related signaling pathways involving KARS1, thereby reducing the production and release of inflammatory factors. Rapaprutug shows potential for research into inflammatory diseases.Cor e Forma:LiquidSetidegrasib
CAS:KRAS G12D inhibitor 17, a quinazoline-linked prolinamide, degrades mutant KRAS protein; a PROTAC.Fórmula:C60H65FN12O7SCor e Forma:SolidPeso molecular:1117.3SOS1-IN-18
SOS1-IN-18 (Compound 8) is an inhibitor of the Son of Sevenless 1 protein (SOS1) with a dissociation constant (KD) of 2.6 nM. It disrupts the SOS1-KRAS G12C interaction with an IC50 of 3.4 nM, inhibits ERK phosphorylation in H358 cells with an IC50 of 31 nM, and curtails the proliferation of H358 cells with an IC50 of 5 nM.Fórmula:C26H29F3N4O2Cor e Forma:SolidPeso molecular:486.53KRAS G12D inhibitor 5
CAS:KRAS G12D inhibitor 5 is a KRAS G12D inhibitor for the potential treatment of pancreatic cancer.Fórmula:C31H31ClF2N6O2Cor e Forma:SolidPeso molecular:593.08MEK1/2-IN-3
MEK1/2-IN-3 (Compound M15) is an inhibitor of MEK1, with an IC50 value of 10.29 nM. It effectively suppresses tumor cell proliferation and migration, induces apoptosis, and exhibits good liver microsomal stability. MEK1/2-IN-3 is applicable in the study of solid tumors.Fórmula:C28H23F3IN3O4Cor e Forma:SolidPeso molecular:649.4Tagarafdeg
CAS:Tagarafdeg (CFT1946) is a PROTAC degradator targeting mutant BRAF, capable of degrading BRAF V600E, G469A, G466V mutations, anti proliferation.Fórmula:C45H49F2N11O9SPureza:>99.99% - ＞99.99%Cor e Forma:SolidPeso molecular:958(S)-BAY-293
CAS:(S)-BAY-293 is a potent pan-KRAS inhibitor for the study of primary non-small lung and pancreatic cancers.
Fórmula:C25H28N4O2SPureza:98%Cor e Forma:SolidPeso molecular:448.58Pan-RAS-IN-7
CAS:Pan-RAS-IN-7 (Compound D101) is a broad-spectrum RAS inhibitor used in the synthesis of antibody-drug conjugates (ADCs). It is also applicable in cancer research.Fórmula:C59H76N8O8Cor e Forma:SolidPeso molecular:1025.28SOS1-IN-17
SOS1-IN-17 (Compound 8d) is an orally active inhibitor targeting the SOS1-KRASG12C interaction, with an IC50 of 5.1 nM. It suppresses ERK phosphorylation in DLD-1 cells with an IC50 of 18 nM and demonstrates antiproliferative activity in KRASG12C-mutant Mia-Paca-2 cells, with an IC50 of 0.11 μM. In mouse models, SOS1-IN-17 shows antitumor efficacy against pancreatic cancer.Fórmula:C29H34F3N5O2Cor e Forma:SolidPeso molecular:541.61KRASG12C IN-2
KRASG12C IN-2 (compound 17) is an orally active inhibitor of KRAS G12C, which effectively suppresses tumor growth in mice [1].Cor e Forma:SolidBI-2865
CAS:BI-2865 is a non-covalent pan-KRAS inhibitor.Cost-effective and quality-assured.Fórmula:C23H27N7O2SPureza:99.29% - 99.39%Cor e Forma:SoildPeso molecular:465.57Ref: TM-T72062
1mg210,00€5mg455,00€10mg645,00€25mg938,00€50mg1.293,00€100mg1.758,00€1mL*10mM (DMSO)465,00€6-Thio-GTP tetrasodium
6-Thio-GTP (tetrasodium) is an inhibitor of Vav1-Rac. It can suppress TCR-induced T cell proliferation and CD28-mediated T cell survival. In a murine model of allogeneic heart transplantation, 6-Thio-GTP (tetrasodium) demonstrates immunosuppressive effects, which can prolong the survival time of heart transplants.Fórmula:C10H12N5Na4O13P3SCor e Forma:SolidPeso molecular:626.89559Murrayafoline A
CAS:Murrayafoline A is a useful organic compound for research related to life sciences. The catalog number is T124835 and the CAS number is 4532-33-6.Fórmula:C14H13NOCor e Forma:SolidPeso molecular:211.264R18
CAS:14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.Fórmula:C101H157N27O29S3Pureza:98%Cor e Forma:SolidPeso molecular:2309.69PPM-3
PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM.
Fórmula:C54H69N11O6SPureza:98%Cor e Forma:SolidPeso molecular:1000.26RAS/RAS-RAF-IN-1
CAS:RAS/RAS-RAF-IN-1: Potent RAS & RAS-RAF inhibitor, KD 5-15μM for CYPA, antitumor properties.Fórmula:C45H57N7O7Cor e Forma:SolidPeso molecular:807.993HPK1-IN-4
CAS:HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.
Fórmula:C23H26N6O3Pureza:97.2%Cor e Forma:SolidPeso molecular:434.49
