MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 893 produtos de "MAPK"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
pan-KRAS-IN-2
CAS:Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12DFórmula:C34H34F2N4O3Pureza:98%Cor e Forma:SolidPeso molecular:584.66SB-682330A
CAS:SB-682330A is a Raf kinase inhibitor.Fórmula:C28H27N3O3Cor e Forma:SolidPeso molecular:453.53TC13172
CAS:TC13172 is a potent, covalent MLKL inhibitor, selective over RIPK1/RIPK3. It blocks TSZ-induced necroptosis (EC50=2nM) and MLKL oligomerization at 100nM.Fórmula:C17H16N4O5SPureza:98%Cor e Forma:SolidPeso molecular:388.4KRAS G12C inhibitor 1R
CAS:KRAS G12C inhibitor 1R can be used in studies about Ras.Fórmula:C31H36ClFN6O2Cor e Forma:SoildPeso molecular:579.11Cobimetinib racemate
CAS:Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as a mitogen-activatedFórmula:C21H21F3IN3O2Pureza:98.00% - 99.71%Cor e Forma:SolidPeso molecular:531.31KRAS inhibitor-14
CAS:KRAS inhibitor-14 targets G12C (IC50: 0.249 μM) and inhibits p-ERK in cancer cells; promising for pancreatic, colorectal, lung cancers.Fórmula:C20H15Cl3FN3O2SCor e Forma:SolidPeso molecular:486.77ARS-1323-alkyne
CAS:ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.Fórmula:C28H27ClF2N6O3Pureza:98.00% - 99%Cor e Forma:SolidPeso molecular:569Ilaprazole sodium hydrate
CAS:Ilaprazole sodium hydrate (IY-81149 sodium hydrate) is a proton pump inhibitor that blocks the transport of HSV particles.Fórmula:C19H21N4NaO4SPureza:99.2%Cor e Forma:SolidPeso molecular:424.45KRAS G12C inhibitor 53
CAS:KRAS G12C inhibitor 53 (Compound 1) is a KRAS G12C inhibitor.Fórmula:C21H14ClF2N5O2Cor e Forma:SolidPeso molecular:441.82KRAS inhibitor FB9
CAS:KRAS inhibitor FB9 can be used in studies about Ras.Fórmula:C23H21ClF4N2O5Cor e Forma:SolidPeso molecular:516.87KRAS G12D mutation regulator 4
CAS:KRAS G12D mutation regulator 4 can be used in studies about Ras.Fórmula:C33H33FN6O2Cor e Forma:SolidPeso molecular:564.65JNK3 inhibitor-1
CAS:JNK3 inhibitor-1: potent, selective, IC50 of 0.005 μM, orally bioavailable, brain-penetrant.Fórmula:C21H17ClFN5O2SCor e Forma:SolidPeso molecular:457.91Org OD 02-0
CAS:10-Ethenyl-19-norprogesterone (Org OD 02-0) is a selective agonist for the membrane progesterone receptor α (mPRα) with an IC50 of 33.9 nM, known to activateFórmula:C22H30O2Pureza:98%Cor e Forma:SolidPeso molecular:326.47KRAS G12C inhibitor 17
CAS:KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor.Fórmula:C24H20ClF2N3O3Pureza:98%Cor e Forma:SolidPeso molecular:471.88KRAS degrader-1
CAS:KRAS degrader-1 (compound 1) is a potent agent that selectively targets KRAS proteins for destruction via the autophagy-lysosomal degradation pathway [1].Fórmula:C55H57Br2ClFIN8O7Cor e Forma:SolidPeso molecular:1283.25SOS1-IN-7
CAS:SOS1-IN-7 (compound 18-p1) is a potent inhibitor of SOS1 and acts on SOS1-G12D (IC50: 20 nM) and SOS1-G12V (IC50: 67 nM).Fórmula:C23H25F3N4O3Cor e Forma:SolidPeso molecular:462.46HPK1-IN-27
CAS:HPK1-IN-27 inhibits HPK1 (MAP4K1), a kinase with potential for cancer treatment, per patent WO2019016071A1, compound 38.Fórmula:C26H23F3N4O4Cor e Forma:SolidPeso molecular:512.48HPK1-IN-11
CAS:HPK1-IN-11 is a potent HPK1 inhibitor. HPK1-IN-11 has potential for the study of HPK1-related diseases.Fórmula:C27H25N5O2Cor e Forma:SolidPeso molecular:451.52ERK1/2 inhibitor 5
CAS:ERK1/2 inhibitor 5: potent against ERK1/2, may combat cancer and inflammation.Fórmula:C28H32ClFN6O5Cor e Forma:SolidPeso molecular:587.04ZG1077
CAS:ZG1077, a covalent KRAS G12C inhibitor, is utilized in non-small cell lung cancer (NSCLC) research.Fórmula:C33H33F2N5O5SCor e Forma:SolidPeso molecular:649.71
