MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 893 produtos de "MAPK"
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MNK1 ligand 1
CAS:MNK1ligand 1 (Compound 5) is an MNK1 ligand used in the synthesis of PROTACMNK1 degrader-1.Fórmula:C15H17N3OSCor e Forma:SolidPeso molecular:287.38MK2-IN-4
CAS:MK2-IN-4 is a MAPKAPK2 (MK2) inhibitor (IC50: 45 nM). MK2-IN-4 can be used in cancer, inflammation and immunology studies.Fórmula:C25H24N4O2Cor e Forma:SolidPeso molecular:412.48HPK1-IN-14
CAS:HPK1-IN-14 is a potent inhibitor of HPK1. HPK1-IN-14 has potential for the study of HPK1-related diseases.Fórmula:C24H23FN6O2Cor e Forma:SolidPeso molecular:446.48AM-001
CAS:AM-001 is a non-competitive inhibitor of Epac1, preventing the activation of its downstream effector Rap1 in cultured cells. This compound is utilized in research related to cardiac diseases.Fórmula:C24H16FN3OS2Cor e Forma:SolidPeso molecular:445.53KRAS inhibitor-36
CAS:KRAS inhibitor-36 (compound Abd2) directly inhibits KRAS Q61H.Fórmula:C14H13NO4Cor e Forma:SolidPeso molecular:259.26AZD4625
AZD4625 (Compound 21) is a selective, potent, orally active, covalent and mutagenic mutant GTPaseKRASG12C inhibitor.Fórmula:C24H21ClF2N4O3Cor e Forma:SolidPeso molecular:486.9ABS-752
CAS:ABS-752 is an effective and orally active molecular glue degrader targeting GSPT1 and NEK7. It exhibits cytotoxic properties and reduces the protein expression of GSPT1, SALL4, and NEK7. ABS-752 possesses anticancer activity and shows potential for research in hepatocellular carcinoma.Fórmula:C14H14FN3O3Cor e Forma:SolidPeso molecular:291.28SOS1-IN-10
SOS1-IN-10 is a potent inhibitor of SOS1 that acts on KRAS G12C-SOS1 (IC50: 13 nM).Fórmula:C22H19F5N4OCor e Forma:SolidPeso molecular:450.4pan-KRAS-IN-17
CAS:pan-KRAS-IN-17 (Example 34) is an inhibitor that targets multiple forms of the KRAS protein.Fórmula:C34H33F3N5O8PCor e Forma:SolidPeso molecular:727.623KRAS G12C inhibitor 46
CAS:KRAS G12C inhibitor 46 is a potent inhibitor of KRAS G12C.Fórmula:C32H33F2N7O2Cor e Forma:SolidPeso molecular:585.65KRAS inhibitor-35
CAS:KRAS inhibitor-35 (compound 72) is a KRAS inhibitor with an IC50 of 2 nM, utilized in tumor research.Fórmula:C38H32F4N6O3SCor e Forma:SolidPeso molecular:728.76KRAS inhibitor-21
CAS:KRAS inhibitor-21 (22b) is a KRAS G12C inhibitor (IC50<0.01 μM) that can be used in cancer research.Fórmula:C33H41N5O3Cor e Forma:SolidPeso molecular:555.71Everafenib
Everafenib: potent BRAF inhibitor, crosses blood-brain barrier, hinders MAPK, effective on V600EBRAF cells, outperforms other drugs in trials.Fórmula:C20H23ClFN5O2S2Cor e Forma:SolidPeso molecular:484.01G12Si-1
G12Si-1 selectively binds and inhibits K-Ras(G12S) to block oncogenic signaling and nucleotide exchange.Fórmula:C29H32ClN5O3Cor e Forma:SolidPeso molecular:534.05MAP855
CAS:MAP855: potent, selective, oral MEK1/2 inhibitor; IC50=3 nM, pERKEC50=5 nM; effective on wild-type/mutant MEK1/2.Fórmula:C28H23ClF2N6O3Cor e Forma:SolidPeso molecular:564.97ZCL279
CAS:ZCL279 is a small molecule modulator (SMM) that inhibits the interaction between CDC42 and intersectin (ITSN). At lower concentrations (<10 μM), ZCL279 activates Cdc42, a cytoplasmic small GTPase in the Ras superfamily, while at higher concentrations (<10 μM) it significantly inhibits it.Fórmula:C24H18N2O7S2Cor e Forma:SolidPeso molecular:510.539Dioleyl phosphatidylserine
CAS:Dioleyl phosphatidylserine is a phospholipid that can activate PKC-γ (Protein Kinase C-gamma) when the Ca2+ concentration is below 0.5 μM, specifically at a concentration of 100 μM.Fórmula:C42H78NO10PCor e Forma:SolidPeso molecular:788.04KRas G12C inhibitor 2
CAS:KRas G12C inhibitor 2 is a compound that inhibits KRas G12C.Fórmula:C32H37N7O3Pureza:98%Cor e Forma:SolidPeso molecular:567.68Luvometinib
CAS:Luvometinib is an inhibitor of the mitogen-activated protein kinase (MEK) with antitumor activity.Fórmula:C26H22F2IN5O4SCor e Forma:SolidPeso molecular:665.45Nek2/Hec1-IN-3
CAS:Nek2/Hec1-IN-3 (Compound 11-28) is an inhibitor of the Hec1/Nek2 interaction. It disrupts the binding between Nek2 and Hec1 and is applicable for research in tumor diseases.Fórmula:C16H13N3OSCor e Forma:SolidPeso molecular:295.36
