MEK
MEK é uma quinase de dupla especificidade que desempenha um papel central na via de sinalização MAPK/ERK, ativando ERK por meio de fosforilação. A sinalização de MEK é crucial para a regulação do crescimento, sobrevivência e diferenciação celular. A atividade anômala de MEK tem sido implicada em vários tipos de câncer e distúrbios do desenvolvimento, tornando-a um importante alvo terapêutico. Na CymitQuimica, oferecemos uma variedade de inibidores e moduladores de MEK para apoiar sua pesquisa em oncologia, sinalização celular e desenvolvimento terapêutico.
Foram encontrados 73 produtos de "MEK"
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SL327
CAS:<p>SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.</p>Fórmula:C16H12F3N3SPureza:97.98% - >99.99%Cor e Forma:SolidPeso molecular:335.35PD184161
CAS:PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1].Fórmula:C17H13BrClF2IN2O2Pureza:99.40%Cor e Forma:SolidPeso molecular:557.56BI-847325
CAS:<p>BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.</p>Fórmula:C29H28N4O2Pureza:97.13% - 97.54%Cor e Forma:SolidPeso molecular:464.56U0126-EtOH
CAS:U0126-etoh (U0126 Ethanol) is a non-ATP competitive inhibitor of MEK1 (IC50=72 nM) and MEK2 (IC50=58 nM) with selectivity, inhibit autophagy. Low-Cost!Fórmula:C18H16N6S2·C2H6OPureza:99.72% - 99.88%Cor e Forma:SolidPeso molecular:426.6trans-Zeatin
CAS:<p>trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient</p>Fórmula:C10H13N5OPureza:97.13% - 98.96%Cor e Forma:White To Light Yellow Crystal PowderPeso molecular:219.24Cobimetinib
CAS:Cobimetinib (GDC-0973) is a MEK1 inhibitor with selective and oral activity. Cobimetinib exhibits antitumor activity. Cost-effective and quality-assured.Fórmula:C21H21F3IN3O2Pureza:98% - 99.61%Cor e Forma:SolidPeso molecular:531.31U0126
CAS:<p>U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively.</p>Fórmula:C18H16N6S2Pureza:99.61%Cor e Forma:White SolidPeso molecular:380.49APS-2-79 hydrochloride
CAS:<p>APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization.</p>Fórmula:C23H21N3O3·HClPureza:98.64% - 99.55%Cor e Forma:SolidPeso molecular:423.89Isorhamnetin
CAS:<p>Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin.</p>Fórmula:C16H12O7Pureza:99.20% - >99.99%Cor e Forma:SolidPeso molecular:316.26PD318088
CAS:<p>PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-</p>Fórmula:C16H13BrF3IN2O4Pureza:99.81%Cor e Forma:SolidPeso molecular:561.09Trametinib
CAS:<p>Trametinib (GSK1120212), an ATP-noncompetitive MEK 1/2 inhibitor (IC50: 0.7/0.9 nM), weakly inhibits >180 kinases.</p>Fórmula:C26H23FIN5O4Pureza:98% - 99.96%Cor e Forma:SolidPeso molecular:615.39RO4987655
CAS:<p>RO4987655 (RG7167) is an orally active and highly selective MEK inhibitor (IC50: 5.2 nM for MEK1/MEK2).</p>Fórmula:C20H19F3IN3O5Pureza:98.21%Cor e Forma:SolidPeso molecular:565.28GW284543
CAS:<p>GW284543 (UNC10225170) is a selective inhibitor of MEK5 .</p>Fórmula:C23H20N2O3Pureza:99.75%Cor e Forma:SolidPeso molecular:372.42Trametiglue
CAS:<p>Trametiglue, a potent Trametinib derivative, selectively targets KSR-MEK and RAF-MEK through unique binding.</p>Fórmula:C25H24FIN6O5SCor e Forma:SolidPeso molecular:666.46PD 334581
CAS:<p>MEK1 inhibitor</p>Fórmula:C20H19F3IN5O2Pureza:98%Cor e Forma:SolidPeso molecular:545.3Avutometinib potassium
CAS:<p>Avutometinib potassium, a MEKi, blocks Delta and Omicron infection in airway cells, potentially lessening disease severity.</p>Fórmula:C21H17FKN5O5SCor e Forma:SolidPeso molecular:509.55(R)-PD 0325901CL
CAS:<p>(R)-PD 0325901CL, a PD 0325901CL isomer, is a MEK inhibitor used in cancer research, effective against cancer cells in vitro and in vivo.</p>Fórmula:C16H14ClF2IN2O4Cor e Forma:SolidPeso molecular:498.65MEK inhibitor
CAS:<p>MEK inhibitor is a MEK receptor and cell cycle protein/CDK complex inhibitor with antitumor activity that can be used to study tumor cell proliferation.</p>Fórmula:C26H26N4O2Pureza:97.48%Cor e Forma:SolidPeso molecular:426.51JTP-70902
CAS:<p>JTP-70902 is a protein kinase inhibitor with antineoplastic activity.</p>Fórmula:C24H21BrFN5O5SCor e Forma:SolidPeso molecular:590.42MEK-IN-1
CAS:<p>MEK-IN-1 is a MEK inhibitor.</p>Fórmula:C24H20N4O4Pureza:98%Cor e Forma:SolidPeso molecular:428.44
