ERK
ERK é uma proteína chave na via de sinalização MAPK (Mitogen-Activated Protein Kinase), que está envolvida na transmissão de sinais dos receptores de superfície celular para o DNA no núcleo da célula. ERK desempenha um papel crucial na regulação de vários processos celulares, incluindo proliferação, diferenciação e sobrevivência. A desregulação da sinalização ERK está associada ao desenvolvimento de câncer e outras doenças, tornando-a um alvo importante para intervenções terapêuticas. Na CymitQuimica, oferecemos uma seleção de inibidores e moduladores de ERK de alta qualidade para apoiar sua pesquisa em sinalização celular, oncologia e desenvolvimento terapêutico.
Foram encontrados 204 produtos de "ERK"
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Firazorexton
CAS:Firazorexton is a potent orexin type 2 receptor (OX2R) agonist.Fórmula:C22H25F3N2O4SCor e Forma:SolidPeso molecular:470.51PROTAC HPK1 Degrader-5
PROTACHPK1 Degrader-5 is a potent, orally active HPK1 PROTAC degrader with a DC50 of 5.0 nM and a Dmax of at least 99%. It significantly inhibits HPK1 by degrading it, reducing SLP76 phosphorylation, and enhancing ERK pathway activation, which in turn stimulates the release of IL-2 and IFN-γ. This compound effectively counteracts immune suppression induced by PGE2, NECA, or TGF-β. Alone, PROTACHPK1 Degrader-5 is capable of suppressing tumor growth in MC38 syngeneic mouse models. It is used in research for immunotherapy applications in cancers such as colorectal cancer.Cor e Forma:Odour SolidROCK-IN-5
CAS:<p>ROCK-IN-5 (I-B-37) inhibits kinases like ROCK/ERK/GSK; may aid in cardiac and neuro disease studies.</p>Fórmula:C16H11ClFN3OSPureza:99.72% - 99.83%Cor e Forma:SolidPeso molecular:347.79PD 198306
CAS:PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.Fórmula:C18H16F3IN2O2Pureza:99.66%Cor e Forma:SolidPeso molecular:476.23Anti-inflammatory agent 35
CAS:Anti-inflammatory agent 35 is a potent anti-inflammatory agent.Fórmula:C27H29NO8Pureza:99.98%Cor e Forma:SoildPeso molecular:495.52Olomoucine
CAS:<p>Olomoucine hinders Cdk2, Cdc2, CDK5, ERK1, regulates the cell cycle, and fights melanoma; IC50s: 3-25 µM.</p>Fórmula:C15H18N6OPureza:99.77%Cor e Forma:White Crystalline PowderPeso molecular:298.34VSLRGDTRG acetate
<p>VSLRGDTRG acetate is a synthetic peptide of the RGD motif from cadherin17 (CDH17), capable of binding to α2β1 integrin and activating its signaling pathways. It facilitates the high-affinity conformational change of β1 integrin via the RGD motif, enhancing cell adhesion and phosphorylation of FAK and ERK1/2, thereby promoting tumor proliferation and metastasis. VSLRGDTRG acetate is applicable in research on cancers expressing CDH17, such as colon and pancreatic cancers.</p>Cor e Forma:Odour SolidGSK143
CAS:GSK143: Oral SYK inhibitor, pIC50=7.5, curbs pErk, anti-inflammatory, hinders immune cells in mice.Fórmula:C17H22N6O2Cor e Forma:SolidPeso molecular:342.403Fulipiftide
CAS:<p>Fulipiftide is a short peptide derived from pigment epithelium-derived factor (PEDF). It stimulates the amplification of nuclear stem cell factor+TSPC by activating the ERK2 and STAT3 signaling pathways. Fulipiftide also exhibits anti-inflammatory properties and is applicable in research on acute tendon injuries.</p>Fórmula:C144H227N41O47Cor e Forma:SolidPeso molecular:3284.59Anti-inflammatory agent 31
Andrographolide derivative 31 is an anti-inflammatory that blocks NF-κB, PI3K/Akt, and ERK1/2 MAPK, and restores GSH levels to protect the liver.Fórmula:C19H30O3Cor e Forma:SolidPeso molecular:306.44Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Cor e Forma:Odour SolidERK1/2 inhibitor 3
CAS:ERK1/2 inhibitor 3, a strong ERK1/2 blocker, may aid in cancer and inflammation research.Fórmula:C28H31ClFN5O6SCor e Forma:SolidPeso molecular:620.09VSLRGDTRG
CAS:VSLRGDTRG is a synthetic peptide derived from the RGD motif in cadherin17 (CDH17) that binds to the α2β1 integrin, activating its signaling pathways. By promoting high-affinity conformational changes in β1 integrins through the RGD motif, VSLRGDTRG enhances cell adhesion and the phosphorylation of FAK and ERK1/2, thereby driving tumor proliferation and metastasis. This peptide is useful for research on cancers expressing CDH17, such as colorectal and pancreatic cancer.Fórmula:C38H69N15O14Cor e Forma:SolidPeso molecular:960.047ERα degrader-2
CAS:ERα degrader-2 is an estrogen receptor (SERD) degrader with anticancer activity that inhibits ERα for the prevention and treatment of HER-positive breast cancFórmula:C29H27F3N2O2Pureza:99.71%Cor e Forma:SolidPeso molecular:492.53TRPM4 inhibitor 8
CAS:TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.Fórmula:C11H17BrN2Pureza:99.84%Cor e Forma:SolidPeso molecular:257.17PERK-IN-2
CAS:PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).Fórmula:C23H18F3N5OPureza:98%Cor e Forma:SolidPeso molecular:437.42SBI-810 hydrochloride
CAS:SBI-810 hydrochloride is a β-arrestin-2 (βarr2)-biased allosteric modulator of NTSR1 (neurotensin receptor 1), exerting analgesic effects.Fórmula:C27H35ClN4O2Pureza:99.42%Peso molecular:483.05Pamoic acid disodium
CAS:Pamoic acid disodium is a GPR35 agonist.Fórmula:C23H16NaO6Pureza:99.73%Cor e Forma:Yellow PowderPeso molecular:411.36EM127
CAS:EM127: covalent SMYD3 inhibitor, KD 13μM, impedes ERK1/2, hinders SMYD3 gene regulation, long-term methyltransferase reduction, potential in cancer study.Fórmula:C14H18ClN3O3Pureza:97.55%Cor e Forma:SolidPeso molecular:311.76EphB2 Protein, Human, Recombinant (His)
EphB2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Cor e Forma:Lyophilized PowderPeso molecular:59.2 kDa (predicted); 65-75 kDa (reducing condition, due to glycosylation)
