Canal TRP/TRPV
Os canais TRP (Potencial do Receptor Transitório), incluindo a subfamília TRPV, são um grupo de canais iônicos envolvidos em vários processos sensoriais, como sensação de temperatura, percepção da dor e osmorregulação. Os canais TRP são amplamente expressos em diferentes tecidos e desempenham um papel nas respostas fisiológicas aos estímulos ambientais. Os canais TRPV, em particular, estão envolvidos na detecção de mudanças de temperatura e estão implicados em condições como dor crônica, inflamação e câncer. Na CymitQuimica, oferecemos uma gama abrangente de moduladores de canais TRP/TRPV para apoiar sua pesquisa em biologia sensorial, manejo da dor e transdução de sinais.
Foram encontrados 96 produtos de "Canal TRP/TRPV"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
BI-749327
CAS:BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).Fórmula:C23H21F3N4O2Pureza:99.68% - 99.84%Cor e Forma:SolidPeso molecular:442.43Ref: TM-T10537
1mg126,00€2mg168,00€5mg260,00€1mL*10mM (DMSO)285,00€10mg409,00€25mg597,00€50mg782,00€100mg1.044,00€500mg2.088,00€GFB-8438
CAS:GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).Fórmula:C16H14ClF3N4O2Pureza:99.58%Cor e Forma:SolidPeso molecular:386.76Ref: TM-T11394
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg77,00€25mg111,00€50mg166,00€100mg236,00€200mg349,00€TRPV4 agonist-1 free base
CAS:TRPV4 agonist-1 free base (OUN67600) is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).Fórmula:C25H22F2N4O2Pureza:99.79%Cor e Forma:SolidPeso molecular:448.46IA-Alkyne
CAS:IA-Alkyne: TRPC agonist, cysteine-reactivity probe, potential in respiratory infection study.Fórmula:C8H12INOPureza:99.76%Cor e Forma:SolidPeso molecular:265.09Ref: TM-T15543
1mg56,00€1mL*10mM (DMSO)114,00€5mg119,00€10mg177,00€25mg250,00€50mg313,00€100mg432,00€Vocacapsaicin hydrochloride
CAS:Vocacapsaicin hydrochloride (CA-008 hydrochloride) is a non-opioid TRPV1 agonist, a raw material for capsaicin, and is used for pain relief.Fórmula:C26H42ClN3O4Pureza:99.66% - 99.80%Cor e Forma:SolidPeso molecular:496.08(S)-ABT 102
CAS:N-[(1S)-1H-inden-1-yl]-N'-indazol-4-ylurea is a strong TRPV1 blocker with a 123 nM IC50 against capsaicin.Fórmula:C21H24N4OPureza:99.65% - 99.77%Cor e Forma:SoildPeso molecular:348.44Ref: TM-T29522L
1mg73,00€5mg149,00€1mL*10mM (DMSO)154,00€10mg212,00€25mg319,00€50mg447,00€100mg610,00€200mg822,00€RN-1665
CAS:RN-1665 is a potent and selective TRPV4 receptor antagonist.Fórmula:C20H24F5N3O3S2Pureza:99.96%Cor e Forma:SoildPeso molecular:513.54AP 18
CAS:AP-18 is a potent and selective TRPA1 inhibitor.Fórmula:C11H12ClNOPureza:99.85% - 99.96%Cor e Forma:SolidPeso molecular:209.67Ref: TM-T21543
5mg46,00€1mL*10mM (DMSO)48,00€10mg66,00€25mg114,00€50mg177,00€100mg286,00€200mg425,00€GSK2798745
CAS:GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4).Fórmula:C25H28N6O3Cor e Forma:SolidPeso molecular:460.53TRPM8 antagonist 3
CAS:TRPM8 antagonist 3 is a blocker of TRPM8 (IC50 = 11 nM).Fórmula:C13H12N2O4SPureza:99.74%Cor e Forma:SolidPeso molecular:292.31GSK2798745 derivative
CAS:GSK2798745 derivatives are solid-form derivatives of GSK2798745, selective TRPV4 blockers and antagonists for cardiac and respiratory disorders.Fórmula:C25H27PN6O3Pureza:98.80% - 99.40%Peso molecular:478.53CBP-1008
CBP-1008 is a dual-ligand peptide-drug conjugate (PDC) with MMAE, targeting folate receptor (FRα) and TRPV6. It exhibits high binding affinity to FRα and low affinity to TRPV6. CBP-1008 shows antitumor activity and can be utilized for research in advanced solid tumors such as colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma, and follicular dendritic cell sarcoma.Cor e Forma:Odour SolidOleoyl Serotonin
CAS:Oleoyl Serotonin is an antagonist of hTRPV1 with an IC50 of 2.57 μM.Fórmula:C28H44N2O2Pureza:99.88%Cor e Forma:SolidPeso molecular:440.66Ref: TM-T22124
5mg62,00€10mg87,00€1mL*10mM (DMSO)90,00€25mg173,00€50mg299,00€100mg520,00€500mg1.134,00€NGD-8243
CAS:NGD-8243 (N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amine) is a TRPV1 inhibitor and can be used in studies for preventionFórmula:C21H12F6N4Pureza:95.26%Cor e Forma:SolidPeso molecular:434.34L-R4W2
CAS:Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM); blocks Ca2+ currents in dorsal root ganglion neurons. Analgesic in vivo.Fórmula:C46H71N21O6Pureza:98%Cor e Forma:SolidPeso molecular:1014.2TRPA1-IN-2
CAS:TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 µM.TRPA1-IN-2 has anti-inflammatory activity.Fórmula:C24H25F3N4OPureza:98.93%Cor e Forma:SoildPeso molecular:442.48Ref: TM-T77511
1mg56,00€5mg129,00€1mL*10mM (DMSO)142,00€10mg188,00€25mg319,00€50mg447,00€100mg600,00€200mg807,00€PF-04745637
CAS:PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].Fórmula:C27H32ClF3N2O2Pureza:98.88% - 99.3%Cor e Forma:SolidPeso molecular:509Ref: TM-T64337
1mg70,00€5mg138,00€1mL*10mM (DMSO)155,00€10mg187,00€25mg315,00€50mg450,00€100mg622,00€200mg835,00€Resolvin D2
CAS:Resolvin D2 (RvD2) is a TRPV1 inhibitor and pro-ablative mediator with anti-inflammatory, anti-infective and pro-ablative effects.Fórmula:C22H32O5Pureza:98%Cor e Forma:SolidPeso molecular:376.49N-Oleoyl Valine Ammonium salt
N-Oleoyl Valine Ammonium salt is an N-acyl amide compound that is a TRPV3 antagonist and can be used to study inflammation.Fórmula:C23H46N2O3Pureza:99.72%Cor e Forma:SolidPeso molecular:398.62Cyclic ADP-Ribose (ammonium salt)
Cyclic ADP-Ribose (ammonium salt) (cADPR) is an NAD⁺ metabolite that triggers Ca²⁺ release from ER stores via ryanodine receptors, relevant to inflammation research.Fórmula:C15H21N5O13P2·xNH3Cor e Forma:SolidBTD
CAS:BTD is a TRPC5 activator that activates heteromeric channel complexes composed of TRPC5 and its closest relatives TRPC1 or TRPC4.Fórmula:C24H33N3O4SCor e Forma:SolidPeso molecular:459.6Phenazopyridine
CAS:Phenazopyridine is an orally administered azo dye with local analgesic effects on urinary tract infections,. against SARM1 and TRPM8.Fórmula:C11H11N5Pureza:99.98%Cor e Forma:SolidPeso molecular:213.24Pico145
CAS:Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels.Fórmula:C23H20ClF3N4O5Pureza:99.06%Cor e Forma:SolidPeso molecular:524.88Ref: TM-T16532
1mg70,00€5mg150,00€1mL*10mM (DMSO)167,00€10mg215,00€25mg358,00€50mg517,00€100mg707,00€200mg1.009,00€TRPM4-IN-1
CAS:TRPM4-IN-1 (4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid) is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 μM.Fórmula:C15H11Cl2NO4Pureza:97.22%Cor e Forma:SolidPeso molecular:340.16MK6-83
CAS:MK6-83 is the transient receptor potential channel ML3 agonist.Fórmula:C16H20N2O2S2Pureza:99.5%Cor e Forma:SolidPeso molecular:336.479-Phenanthrol
CAS:9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel.Fórmula:C14H10OPureza:98.48%Cor e Forma:SolidPeso molecular:194.23TC-I2000
CAS:TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50 of 53 nM.Fórmula:C23H18F4N2OPureza:99.778%Cor e Forma:SolidPeso molecular:414.4Ref: TM-T8449
1mL*10mM (DMSO)A consultar5mg35,00€10mg50,00€25mg88,00€50mg119,00€100mg173,00€200mg259,00€ML204 hydrochloride
CAS:ML204 hydrochloride (ML204 HCl) is a TRPC4/TRPC5 channel antagonist.Fórmula:C15H19ClN2Cor e Forma:SolidPeso molecular:262.78WS-12
CAS:WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM)Fórmula:C18H27NO2Pureza:99.99%Cor e Forma:Whitish To White Solid CrystallinePeso molecular:289.41HC-067047
CAS:HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .Fórmula:C26H28F3N3O2Pureza:99.45% - 99.97%Cor e Forma:SolidPeso molecular:471.51cim0216
CAS:CIM0216 is a synthetic TRPM3 activator whose potency and apparent affinity greatly exceeds that of the canonical TRPM3 agonist.Fórmula:C21H21N3O2Pureza:99.87%Cor e Forma:SolidPeso molecular:347.41Ref: TM-T9263
1mg44,00€2mg56,00€5mg87,00€1mL*10mM (DMSO)96,00€10mg138,00€25mg281,00€50mg442,00€100mg665,00€500mg1.378,00€AMG 517
CAS:AMG 517 is an effective and specific TRPV1 antagonist, antagonizes proton (IC50: 0.76 nM), capsaicin (IC50: 0.62 nM) and heat activation (IC50: 1.3 nM) of TRPV1Fórmula:C20H13F3N4O2SPureza:99.77% - 99.85%Cor e Forma:SolidPeso molecular:430.4GSK2193874
CAS:GSK2193874 was identified as a selective, orally active TRPV4 blocker.Fórmula:C37H38BrF3N4OPureza:99.99% - ≥95%Cor e Forma:SolidPeso molecular:691.62Ref: TM-T5640
1mg40,00€2mg54,00€5mg77,00€1mL*10mM (DMSO)105,00€10mg120,00€25mg234,00€50mg384,00€100mg570,00€JNJ-17203212
CAS:JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).Fórmula:C17H15F6N5OPureza:99.18%Cor e Forma:SolidPeso molecular:419.32M8-B Hydrochloride
CAS:M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.Fórmula:C22H25ClN2O3SPureza:99.33%Cor e Forma:SolidPeso molecular:432.96Ref: TM-T8442
2mg34,00€5mg50,00€1mL*10mM (DMSO)60,00€10mg71,00€25mg138,00€50mg215,00€100mg318,00€200mg444,00€SB-366791
CAS:SB-366791 is a new and selective cinnamide TRPV1 antagonist.Fórmula:C16H14ClNO2Pureza:99.51%Cor e Forma:SolidPeso molecular:287.74Ononetin
CAS:Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM).Fórmula:C15H14O4Pureza:98.06%Cor e Forma:SolidPeso molecular:258.27Evifacotrep
CAS:Evifacotrep: TRPC5 antagonist for neurological disease research (WO2020061162, compound 100).Fórmula:C18H12ClF4N5O2Pureza:98.6%Cor e Forma:SolidPeso molecular:441.77Ref: TM-T40042
1mg92,00€1mL*10mM (DMSO)152,00€5mg178,00€10mg286,00€25mg440,00€50mg655,00€100mg973,00€200mg1.468,00€HC067047 Hydrochloride(883031-03-6 free base)
CAS:HC-067047 hydrochloride, a TRPV4 antagonist, selectively inhibits human, rat, and mouse currents with IC50s: 486 nM, 133 nM, and 17 nM.Fórmula:C26H29ClF3N3O2Pureza:99.95%Cor e Forma:SolidPeso molecular:507.98Ref: TM-T4680L
1mg88,00€5mg172,00€1mL*10mM (DMSO)217,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€HC-030031
CAS:HC-030031 (TOSLAB 829227) is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2 and 5.3 μM, respectively.Fórmula:C18H21N5O3Pureza:99.69% - ≥95%Cor e Forma:SolidPeso molecular:355.39ML204
CAS:ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.Fórmula:C15H18N2Pureza:98.1% - 99.72%Cor e Forma:SolidPeso molecular:226.32RN-1734
CAS:RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM,5.9 μM,3.2 μM for hTRPV4, mTRPV4 and rTRPV4,respectively)Fórmula:C14H22Cl2N2O2SPureza:99.1% - 99.3%Cor e Forma:SolidPeso molecular:353.31AMG 333
CAS:AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.Fórmula:C20H12F5N3O4Pureza:99.95%Cor e Forma:SolidPeso molecular:453.32Chembridge-5861528
CAS:Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM.Fórmula:C19H23N5O3Pureza:99.97%Cor e Forma:SolidPeso molecular:369.42RQ-00203078
CAS:RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist.Fórmula:C21H13ClF6N2O5SPureza:98% - 99.6%Cor e Forma:SolidPeso molecular:554.85A-967079
CAS:A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively
Fórmula:C12H14FNOPureza:98.34% - 99.75%Cor e Forma:SolidPeso molecular:207.24ICILIN
CAS:ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.Fórmula:C16H13N3O4Pureza:98.45% - ≥95%Cor e Forma:Light Yellow SolidPeso molecular:311.29ASP7663
CAS:ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.Fórmula:C14H14FNO3Pureza:98.61%Cor e Forma:SolidPeso molecular:263.26AM-0902
CAS:AM-0902 is a potent and specific TRPA1 antagonist (IC50s: 71/131 nM for rTRPA1 and hTRPA1).Fórmula:C17H15ClN6O2Pureza:>99.99%Cor e Forma:SolidPeso molecular:370.79SB 452533
CAS:SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).Fórmula:C18H22BrN3OPureza:99.87%Cor e Forma:SolidPeso molecular:376.29Ref: TM-T23322
2mg39,00€5mg60,00€1mL*10mM (DMSO)73,00€10mg92,00€25mg173,00€50mg269,00€100mg389,00€200mg555,00€PF-4840154
CAS:PF-4840154: potent TrpA1 agonist; EC50 of 97 nM (rat) & 23 nM (human); triggers nociception in mice.
Fórmula:C26H38N6O2Pureza:>99.99%Cor e Forma:SolidPeso molecular:466.62Pyr10
CAS:Pyr10, a pyrazole derivative, selectively inhibits TRPC3, not STIM1/Orai1, with IC50 of 0.72 μM in TRPC3-HEK293, and 13.08 μM in BRL-2H3 cells.Fórmula:C18H13F6N3O2SPureza:99.69% - 99.7%Cor e Forma:SolidPeso molecular:449.37SB-705498
CAS:SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis.Fórmula:C17H16BrF3N4OPureza:99.57% - ≥95%Cor e Forma:SolidPeso molecular:429.23Vanilloid receptor antagonist 1
CAS:Vanilloid receptor antagonist 1 (4-(7-Hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile) is a potent vanilloid receptor TRPV1 antagonist.Fórmula:C18H15N3O2Pureza:98.14%Cor e Forma:SolidPeso molecular:305.33AMG9810
CAS:AMG 9810 blocks capsaicin's action on TRPV1; human IC50=24.5 nM, rat IC50=85.6 nM.Fórmula:C21H23NO3Pureza:99.79% - 99.95%Cor e Forma:SolidPeso molecular:337.41Ref: TM-T7189
2mg34,00€5mg48,00€1mL*10mM (DMSO)50,00€10mg58,00€25mg110,00€50mg177,00€100mg286,00€200mg425,00€Optovin
CAS:Optovin is a TRPA1 activator, which is reversibly photoactivated.Fórmula:C15H13N3OS2Pureza:99.47% - 99.67%Cor e Forma:SolidPeso molecular:315.41Ref: TM-T6617
2mg37,00€5mg54,00€1mL*10mM (DMSO)60,00€10mg88,00€25mg152,00€50mg236,00€100mg385,00€200mg560,00€MDR-652
CAS:MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM forFórmula:C22H23ClFN3O2SPureza:99.96%Cor e Forma:SolidPeso molecular:447.95Ref: TM-T22360
1mg60,00€2mg87,00€5mg130,00€1mL*10mM (DMSO)142,00€10mg178,00€25mg331,00€50mg512,00€100mg707,00€200mg973,00€RN-1747
CAS:RN-1747: TRPV4 agonist (EC50: human 0.77 μM, mouse 4.0 μM, rat 4.1 μM), TRPM8 antagonist (IC50: 4 μM).Fórmula:C17H18ClN3O4SPureza:99.29%Cor e Forma:SolidPeso molecular:395.86AMTB hydrochloride
CAS:AMTB HCl: Novel TRPM8 blocker, relieves pain, treats urinary issues, moderates bladder reflexes in rats.Fórmula:C23H27ClN2O2SPureza:99.08%Cor e Forma:SolidPeso molecular:430.99Ref: TM-T19723
1mg34,00€5mg74,00€1mL*10mM (DMSO)87,00€10mg119,00€25mg250,00€50mg424,00€100mg627,00€200mg890,00€TRPM8 antagonist 2
CAS:TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM. TRPM8 antagonist 2 is used in the research of neuropathic pain syndromes.Fórmula:C26H26N2O2Pureza:98.1%Cor e Forma:SolidPeso molecular:398.5Ref: TM-T5698
1mg34,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg99,00€25mg167,00€50mg260,00€100mg416,00€200mg600,00€AC1903
CAS:AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.Fórmula:C19H17N3OPureza:98.45%Cor e Forma:SolidPeso molecular:303.36JNJ-28583113
CAS:JNJ-28583113 is a TRPM2 antagonist, inducing phosphorylation of GSK3α and β subunits, protecting cells from oxidative stress-induced cell death.Fórmula:C19H21F3N2O2Pureza:98.57%Cor e Forma:SolidPeso molecular:366.38Ref: TM-T74779
1mg94,00€5mg193,00€1mL*10mM (DMSO)213,00€10mg241,00€25mg387,00€50mg591,00€100mg754,00€200mg1.046,00€SAR7334
CAS:SAR7334 (TRCP6-IN-1) is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).Fórmula:C21H22ClN3OPureza:99.62% - 99.71%Cor e Forma:SolidPeso molecular:367.87Ref: TM-T12849
1mg67,00€2mg88,00€5mg152,00€1mL*10mM (DMSO)166,00€10mg236,00€25mg295,00€50mg349,00€100mg439,00€200mg628,00€GSK1702934A
CAS:GSK1702934A is a TRPC3 agonist with pro-arrhythmic and positive inotropic effects and is used in the study of diabetes mellitus.Fórmula:C22H25N3O2SPureza:98.15%Cor e Forma:SolidPeso molecular:395.52N-Oleoyl Valine
CAS:N-Oleoyl valine, an N-acyl amine, antagonizes TRPV3 for thermoregulation; rises post-cold exposure; elevates in mouse lung injury.Fórmula:C23H43NO3Peso molecular:381.59TRPM4-IN-2
CAS:NBA, or TRPM4-IN-2, is a potent TRPM4 inhibitor with IC50 of 0.16 μM, used in prostate and colorectal cancer research.Fórmula:C19H14ClNO4Pureza:99.21%Cor e Forma:SolidPeso molecular:355.77AM12
CAS:AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).Fórmula:C15H9BrO5Pureza:98%Cor e Forma:SolidPeso molecular:349.13RN9893
CAS:RN9893 is a selective and potent TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for TRPV4 receptors in mouse, human and rat, respectively.Fórmula:C21H23F3N4O5SPureza:99.99%Cor e Forma:SolidPeso molecular:500.49TRPV4 agonist-1
CAS:TRPV4 agonist-1 is an agonist of TRPV4 (EC50: 60 nM in the hTRPV4 Ca2+ assay).Fórmula:C25H23ClF2N4O2Pureza:98%Cor e Forma:SolidPeso molecular:484.93TRPC6-PAM-C20
CAS:TRPC6-PAM-C20, a selective enhancer for TRPC6, boosts calcium in HEK cells and OAG-related platelet clumping, EC50: 2.37μM.Fórmula:C22H21NO4Pureza:98.16%Cor e Forma:SolidPeso molecular:363.41Asivatrep
CAS:Asivatrep (PAC14028) is a selective and potent antagonist of transient receptor potential vanilloid subtype 1 (TRPV1) for the study of atopic dermatitis.Fórmula:C21H22F5N3O3SPureza:95.13%Cor e Forma:SolidPeso molecular:491.48D-3263 hydrochloride
CAS:D-3263 hydrochloride (D3263 HCl salt) is enteric-coated, orally bioavailable transient receptor potential melatonin member 8 (TRPM8) agonist.
Fórmula:C21H32ClN3O3Pureza:99.93%Cor e Forma:SolidPeso molecular:409.95TRPV3 antagonist 74a
CAS:TRPV3 antagonist 74a (TRPV3 74a) is a specific TRPV3 antagonist for the study of neurological disorders.Fórmula:C17H17F3N2O2Pureza:≥98.0%Cor e Forma:SolidPeso molecular:338.32JYL 1421
CAS:JYL 1421 (SC 0030) is an antagonist of TRPV1 receptor (IC50 = 8 nM).Fórmula:C20H26FN3O2S2Pureza:98.83%Cor e Forma:SolidPeso molecular:423.57Ref: TM-T15634
1mg66,00€1mL*10mM (DMSO)170,00€5mg177,00€10mg289,00€25mg580,00€50mg888,00€100mg1.414,00€200mg1.882,00€Pyr3
CAS:Pyr3 selectively blocks TRPC3 channels, reducing Ca2+ influx; it's effective at 700 nM.Fórmula:C16H11Cl3F3N3O3Pureza:98.04%Cor e Forma:SolidPeso molecular:456.63Ref: TM-T16687
1mg34,00€2mg49,00€5mg73,00€1mL*10mM (DMSO)81,00€10mg92,00€25mg203,00€50mg344,00€100mg485,00€200mg700,00€500mg1.063,00€ABT 102
CAS:ABT 102 (CHEMBL398338) is a selective antagonist of transient receptor potential vanilloid 1 (TRPV1) receptor.Fórmula:C21H24N4OPureza:98.38% - 99.86%Cor e Forma:SolidPeso molecular:348.44Ref: TM-T29522
1mg109,00€5mg235,00€1mL*10mM (DMSO)245,00€10mg349,00€25mg532,00€50mg745,00€100mg999,00€200mg1.333,00€HC-070
CAS:HC-070 is a TRPC5 and TRPC4 antagonist (IC50 = 9.3 nM and 46 nM).Fórmula:C22H20Cl2N4O4Pureza:98.48%Cor e Forma:SolidPeso molecular:475.32Ref: TM-T15465
1mg84,00€5mg160,00€1mL*10mM (DMSO)165,00€10mg236,00€25mg406,00€50mg572,00€100mg772,00€200mg1.035,00€Olvanil
CAS:Olvanil (N-Vannilyloleoylamide) is a vanilloid receptor agonist with EC50 of 0.7nM.Fórmula:C26H43NO3Pureza:99.58%Cor e Forma:SolidPeso molecular:417.62Ref: TM-T23106
2mg34,00€5mg49,00€1mL*10mM (DMSO)50,00€10mg75,00€25mg145,00€50mg236,00€100mg385,00€200mg560,00€Elismetrep
CAS:Elismetrep (MT-8554) is an orally available TRPM8 inhibitor with potential analgesic activity for the study of vasomotor symptoms in postmenopausal women.Fórmula:C27H21F3N2O5SPureza:99.37% - 99.93%Cor e Forma:SolidPeso molecular:542.53TC-I 2014
CAS:TC-I 2014 shows antiallodynic properties in pain models.Fórmula:C23H19F6N3OPureza:99.07%Cor e Forma:SolidPeso molecular:467.41Ref: TM-T17006
1mg57,00€5mg120,00€1mL*10mM (DMSO)126,00€10mg192,00€25mg385,00€50mg620,00€100mg1.018,00€200mg1.378,00€Mavatrep
CAS:Mavatrep (JNJ-39439335) is a selective antagonist of TRPV1 with Ki of 6.5 nM and can be used for studies about inflammatory pain.Fórmula:C25H21F3N2OPureza:98.51% - 99.31%Cor e Forma:SolidPeso molecular:422.44Ref: TM-T16014
1mg63,00€2mg90,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg215,00€25mg385,00€50mg618,00€100mg888,00€200mg1.243,00€SET 2
CAS:SET 2 is an antagonist of transient receptor potential vanilloid type 2(TRPV2) with an IC50 of 0.46 μM. SET 2 shows selectivity over TRPV1, TRPV3 and TRPV4.Fórmula:C17H21F3N4O2SPureza:99.77%Cor e Forma:SolidPeso molecular:402.43Ref: TM-T37097
500mgA consultar5mg55,00€1mL*10mM (DMSO)67,00€10mg92,00€25mg168,00€50mg284,00€100mg414,00€FEMA-4809
CAS:FEMA-4809 activates TRPM8, the ion channel for cold sensation, and is used as a cooling agent.Fórmula:C17H17N3O2SPureza:99.9%Cor e Forma:SolidPeso molecular:327.4Ref: TM-T27308
1mg34,00€5mg73,00€1mL*10mM (DMSO)84,00€10mg110,00€25mg180,00€50mg255,00€100mg363,00€200mg497,00€MSP3
CAS:MSP3 is an agonist of TRPV1 (EC50 = 0.87 μM) and shows antinociceptive and neuroprotective effects.Fórmula:C16H19NO3SPureza:99.89%Cor e Forma:SolidPeso molecular:305.39Ref: TM-T28118
2mg33,00€5mg50,00€1mL*10mM (DMSO)71,00€10mg80,00€25mg161,00€50mg243,00€100mg358,00€200mg505,00€MK-2295
CAS:MK-2295 is a potent TRPV1 antagonist. MK-2295 can be used in studies about the treatment of chronic pain.Fórmula:C27H31FN6O2Pureza:98.83% - 99.44%Cor e Forma:SolidPeso molecular:490.57Mesendogen
CAS:Mesendogen is an inhibitor of transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) and acts by inhibiting TRPM6/TRPM7Fórmula:C18H16ClF3N2OSPureza:99.66%Cor e Forma:SolidPeso molecular:400.85GSK3395879
CAS:GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).Fórmula:C20H15F4N3O5SPureza:98%Cor e Forma:SolidPeso molecular:485.41PF-05105679
CAS:PF-05105679 is a selective TRPM8 antagonist (IC50 = 103 nM). PF-05105679 can be used in research on cold-related pain.Fórmula:C26H21FN2O3Pureza:99.84%Cor e Forma:SolidPeso molecular:428.45Ref: TM-T16483
1mg44,00€2mg57,00€1mL*10mM (DMSO)90,00€5mg93,00€10mg138,00€25mg264,00€50mg404,00€100mg610,00€200mg848,00€JT010
CAS:JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM).Fórmula:C16H19ClN2O3SPureza:99.75%Cor e Forma:SolidPeso molecular:354.85A-1165442
CAS:A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.Fórmula:C22H20ClF2N3O2Cor e Forma:SolidPeso molecular:431.86AMG-0347
CAS:AMG-0347 inhibits TRPA1 ion channels in sensory neurons, blocking pain perception.Fórmula:C24H26F3N3O2Pureza:99.93%Cor e Forma:SolidPeso molecular:445.48Ref: TM-T29968
1mg215,00€5mg523,00€1mL*10mM (DMSO)537,00€10mg695,00€25mg1.054,00€50mg1.414,00€100mg1.900,00€200mg2.565,00€AMG2850
CAS:AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).Fórmula:C19H17F6N3OPureza:99.84%Cor e Forma:SolidPeso molecular:417.35Ref: TM-T10300
1mg71,00€5mg161,00€1mL*10mM (DMSO)172,00€10mg235,00€25mg423,00€50mg627,00€100mg803,00€ELP-004
CAS:ELP-004 is a TRPC channel inhibitor that blocks Ca2+ entry mediated by TRPC channels. It serves as an osteoclast inhibitor by preventing osteoclast differentiation. ELP-004 also hinders basal Ca2+ levels and the associated translocation of NFATc1 in inflammatory osteoclastogenesis. Additionally, it reduces bone erosion in mouse models of rheumatoid arthritis.Fórmula:C10H11Cl2NOCor e Forma:SolidPeso molecular:232.106TRPA1 Antagonist 1
CAS:TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.Fórmula:C24H20F6N5Na2O7PSPureza:98%Cor e Forma:SolidPeso molecular:713.45Apcin A HCL
CAS:Apcin A HCL is an Apcin derivative. Apcin A HCL is an anaphase-promoting complex (APC) inhibitor. Apcin-A HCL interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A HCL can be used to synthesize the PROTAC CP5V [1].
Fórmula:C10H15Cl4N5O2Pureza:99.30%Cor e Forma:SolidPeso molecular:379.07Motugivatrep
CAS:Motugivatrep is a potent and selective TRPV1 antagonist that can be used to study TRPV1-related respiratory diseases.
Fórmula:C22H20F3NO3Pureza:99.22%Cor e Forma:SolidPeso molecular:403.39
