Canal TRP/TRPV
Os canais TRP (Potencial do Receptor Transitório), incluindo a subfamília TRPV, são um grupo de canais iônicos envolvidos em vários processos sensoriais, como sensação de temperatura, percepção da dor e osmorregulação. Os canais TRP são amplamente expressos em diferentes tecidos e desempenham um papel nas respostas fisiológicas aos estímulos ambientais. Os canais TRPV, em particular, estão envolvidos na detecção de mudanças de temperatura e estão implicados em condições como dor crônica, inflamação e câncer. Na CymitQuimica, oferecemos uma gama abrangente de moduladores de canais TRP/TRPV para apoiar sua pesquisa em biologia sensorial, manejo da dor e transdução de sinais.
Foram encontrados 92 produtos de "Canal TRP/TRPV"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
(Z)-Capsaicin
CAS:<p>(Z)-Capsaicin (Zucapsaicin) is a medication used to treat osteoarthritis of the knee and Others neuropathic pain.(Z)-Capsaicin is a synthetic cis isomer of</p>Fórmula:C18H27NO3Pureza:97.33% - 98.91%Cor e Forma:SolidPeso molecular:305.41Vocacapsaicin hydrochloride
CAS:<p>Vocacapsaicin hydrochloride (CA-008 hydrochloride) is a non-opioid TRPV1 agonist, a raw material for capsaicin, and is used for pain relief.</p>Fórmula:C26H42ClN3O4Pureza:99.66% - 99.80%Cor e Forma:SolidPeso molecular:496.08TRPV4 agonist-1 free base
CAS:<p>TRPV4 agonist-1 free base (OUN67600) is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).</p>Fórmula:C25H22F2N4O2Pureza:99.79%Cor e Forma:SolidPeso molecular:448.46BI-749327
CAS:<p>BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).</p>Fórmula:C23H21F3N4O2Pureza:99.68%Cor e Forma:SolidPeso molecular:442.43IA-Alkyne
CAS:<p>IA-Alkyne: TRPC agonist, cysteine-reactivity probe, potential in respiratory infection study.</p>Fórmula:C8H12INOPureza:99.76%Cor e Forma:SolidPeso molecular:265.09GFB-8438
CAS:<p>GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).</p>Fórmula:C16H14ClF3N4O2Pureza:99.58%Cor e Forma:SolidPeso molecular:386.76PF-04745637
CAS:<p>PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].</p>Fórmula:C27H32ClF3N2O2Pureza:98.88% - 99.3%Cor e Forma:SolidPeso molecular:509Oleoyl Serotonin
CAS:<p>Oleoyl Serotonin is an antagonist of hTRPV1 with an IC50 of 2.57 μM.</p>Fórmula:C28H44N2O2Pureza:99.88%Cor e Forma:SolidPeso molecular:440.66L-R4W2
CAS:<p>Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM); blocks Ca2+ currents in dorsal root ganglion neurons. Analgesic in vivo.</p>Fórmula:C46H71N21O6Pureza:98%Cor e Forma:SolidPeso molecular:1014.2TRPA1-IN-2
CAS:<p>TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 µM.TRPA1-IN-2 has anti-inflammatory activity.</p>Fórmula:C24H25F3N4OPureza:98.05%Cor e Forma:SoildPeso molecular:442.48RN-1665
CAS:<p>RN-1665 is a potent and selective TRPV4 receptor antagonist.</p>Fórmula:C20H24F5N3O3S2Pureza:>99.99%Cor e Forma:SoildPeso molecular:513.54CBP-1008
<p>CBP-1008 is a dual-ligand peptide-drug conjugate (PDC) with MMAE, targeting folate receptor (FRα) and TRPV6. It exhibits high binding affinity to FRα and low affinity to TRPV6. CBP-1008 shows antitumor activity and can be utilized for research in advanced solid tumors such as colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma, and follicular dendritic cell sarcoma.</p>Cor e Forma:Odour SolidAP 18
CAS:<p>AP-18 is a potent and selective TRPA1 inhibitor.</p>Fórmula:C11H12ClNOPureza:99.85% - 99.96%Cor e Forma:SolidPeso molecular:209.67TRPM8 antagonist 3
CAS:<p>TRPM8 antagonist 3 is a blocker of TRPM8 (IC50 = 11 nM).</p>Fórmula:C13H12N2O4SPureza:99.74%Cor e Forma:SolidPeso molecular:292.31GSK2798745
CAS:<p>GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4).</p>Fórmula:C25H28N6O3Cor e Forma:SolidPeso molecular:460.53Resolvin D2
CAS:<p>Resolvin D2 (RvD2) is a TRPV1 inhibitor and pro-ablative mediator with anti-inflammatory, anti-infective and pro-ablative effects.</p>Fórmula:C22H32O5Pureza:98%Cor e Forma:SolidPeso molecular:376.49NGD-8243
CAS:<p>NGD-8243 (N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amine) is a TRPV1 inhibitor and can be used in studies for prevention</p>Fórmula:C21H12F6N4Pureza:95.26%Cor e Forma:SolidPeso molecular:434.34(S)-ABT 102
CAS:<p>N-[(1S)-1H-inden-1-yl]-N'-indazol-4-ylurea is a strong TRPV1 blocker with a 123 nM IC50 against capsaicin.</p>Fórmula:C21H24N4OPureza:99.65% - 99.77%Cor e Forma:SoildPeso molecular:348.44BTD
CAS:<p>BTD is a TRPC5 activator that activates heteromeric channel complexes composed of TRPC5 and its closest relatives TRPC1 or TRPC4.</p>Fórmula:C24H33N3O4SCor e Forma:SolidPeso molecular:459.6Phenazopyridine
CAS:<p>Phenazopyridine is an orally administered azo dye with local analgesic effects on urinary tract infections,. against SARM1 and TRPM8.</p>Fórmula:C11H11N5Pureza:99.98%Cor e Forma:SolidPeso molecular:213.24ASP7663
CAS:<p>ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.</p>Fórmula:C14H14FNO3Pureza:98.61%Cor e Forma:SolidPeso molecular:263.26PF-4840154
CAS:<p>PF-4840154: potent TrpA1 agonist; EC50 of 97 nM (rat) & 23 nM (human); triggers nociception in mice.</p>Fórmula:C26H38N6O2Pureza:>99.99%Cor e Forma:SolidPeso molecular:466.62GSK2193874
CAS:<p>GSK2193874 was identified as a selective, orally active TRPV4 blocker.</p>Fórmula:C37H38BrF3N4OPureza:98.79% - ≥95%Cor e Forma:SolidPeso molecular:691.62JNJ-17203212
CAS:<p>JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).</p>Fórmula:C17H15F6N5OPureza:99.18%Cor e Forma:SolidPeso molecular:419.32M8-B Hydrochloride
CAS:<p>M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.</p>Fórmula:C22H25ClN2O3SPureza:99.33%Cor e Forma:SolidPeso molecular:432.96SB-366791
CAS:<p>SB-366791 is a new and selective cinnamide TRPV1 antagonist.</p>Fórmula:C16H14ClNO2Pureza:99.51%Cor e Forma:SolidPeso molecular:287.74Ononetin
CAS:<p>Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM).</p>Fórmula:C15H14O4Pureza:98.06%Cor e Forma:SolidPeso molecular:258.27Evifacotrep
CAS:<p>Evifacotrep: TRPC5 antagonist for neurological disease research (WO2020061162, compound 100).</p>Fórmula:C18H12ClF4N5O2Pureza:98.6%Cor e Forma:SolidPeso molecular:441.77HC067047 Hydrochloride(883031-03-6 free base)
CAS:<p>HC-067047 hydrochloride, a TRPV4 antagonist, selectively inhibits human, rat, and mouse currents with IC50s: 486 nM, 133 nM, and 17 nM.</p>Fórmula:C26H29ClF3N3O2Pureza:99.95%Cor e Forma:SolidPeso molecular:507.98HC-030031
CAS:<p>HC-030031 (TOSLAB 829227) is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2 and 5.3 μM, respectively.</p>Fórmula:C18H21N5O3Pureza:99.69% - ≥95%Cor e Forma:SolidPeso molecular:355.39ML204
CAS:<p>ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.</p>Fórmula:C15H18N2Pureza:98.1% - 99.72%Cor e Forma:SolidPeso molecular:226.32RN-1734
CAS:<p>RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM,5.9 μM,3.2 μM for hTRPV4, mTRPV4 and rTRPV4,respectively)</p>Fórmula:C14H22Cl2N2O2SPureza:99.1% - 99.3%Cor e Forma:SolidPeso molecular:353.31AMG 333
CAS:<p>AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.</p>Fórmula:C20H12F5N3O4Pureza:99.95%Cor e Forma:SolidPeso molecular:453.32Chembridge-5861528
CAS:<p>Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM.</p>Fórmula:C19H23N5O3Pureza:99.97%Cor e Forma:SolidPeso molecular:369.42RQ-00203078
CAS:<p>RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist.</p>Fórmula:C21H13ClF6N2O5SPureza:98% - 99.6%Cor e Forma:SolidPeso molecular:554.85A-967079
CAS:<p>A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively</p>Fórmula:C12H14FNOPureza:98.34% - 99.75%Cor e Forma:SolidPeso molecular:207.24ICILIN
CAS:<p>ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.</p>Fórmula:C16H13N3O4Pureza:98.45% - ≥95%Cor e Forma:Light Yellow SolidPeso molecular:311.29HC-067047
CAS:<p>HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .</p>Fórmula:C26H28F3N3O2Pureza:99.45% - 99.97%Cor e Forma:SolidPeso molecular:471.51AM-0902
CAS:<p>AM-0902 is a potent and specific TRPA1 antagonist (IC50s: 71/131 nM for rTRPA1 and hTRPA1).</p>Fórmula:C17H15ClN6O2Pureza:>99.99%Cor e Forma:SolidPeso molecular:370.79SB 452533
CAS:<p>SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).</p>Fórmula:C18H22BrN3OPureza:99.87%Cor e Forma:SolidPeso molecular:376.29Pico145
CAS:<p>Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels.</p>Fórmula:C23H20ClF3N4O5Pureza:99.06%Cor e Forma:SolidPeso molecular:524.88TRPM4-IN-1
CAS:<p>TRPM4-IN-1 (4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid) is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 μM.</p>Fórmula:C15H11Cl2NO4Pureza:97.22%Cor e Forma:SolidPeso molecular:340.16MK6-83
CAS:<p>MK6-83 is the transient receptor potential channel ML3 agonist.</p>Fórmula:C16H20N2O2S2Pureza:99.5%Cor e Forma:SolidPeso molecular:336.479-Phenanthrol
CAS:<p>9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel.</p>Fórmula:C14H10OPureza:98.48%Cor e Forma:SolidPeso molecular:194.23TC-I2000
CAS:<p>TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50 of 53 nM.</p>Fórmula:C23H18F4N2OPureza:99.778%Cor e Forma:SolidPeso molecular:414.4ML204 hydrochloride
CAS:<p>ML204 hydrochloride (ML204 HCl) is a TRPC4/TRPC5 channel antagonist.</p>Fórmula:C15H19ClN2Cor e Forma:SolidPeso molecular:262.78WS-12
CAS:<p>WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM)</p>Fórmula:C18H27NO2Pureza:99.99%Cor e Forma:Whitish To White Solid CrystallinePeso molecular:289.41Pyr10
CAS:<p>Pyr10, a pyrazole derivative, selectively inhibits TRPC3, not STIM1/Orai1, with IC50 of 0.72 μM in TRPC3-HEK293, and 13.08 μM in BRL-2H3 cells.</p>Fórmula:C18H13F6N3O2SPureza:99.69% - 99.7%Cor e Forma:SolidPeso molecular:449.37SB-705498
CAS:<p>SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis.</p>Fórmula:C17H16BrF3N4OPureza:99.57% - ≥95%Cor e Forma:SolidPeso molecular:429.23Vanilloid receptor antagonist 1
CAS:<p>Vanilloid receptor antagonist 1 (4-(7-Hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile) is a potent vanilloid receptor TRPV1 antagonist.</p>Fórmula:C18H15N3O2Pureza:98.14%Cor e Forma:SolidPeso molecular:305.33
