Canal TRP/TRPV
Os canais TRP (Potencial do Receptor Transitório), incluindo a subfamília TRPV, são um grupo de canais iônicos envolvidos em vários processos sensoriais, como sensação de temperatura, percepção da dor e osmorregulação. Os canais TRP são amplamente expressos em diferentes tecidos e desempenham um papel nas respostas fisiológicas aos estímulos ambientais. Os canais TRPV, em particular, estão envolvidos na detecção de mudanças de temperatura e estão implicados em condições como dor crônica, inflamação e câncer. Na CymitQuimica, oferecemos uma gama abrangente de moduladores de canais TRP/TRPV para apoiar sua pesquisa em biologia sensorial, manejo da dor e transdução de sinais.
Foram encontrados 92 produtos de "Canal TRP/TRPV"
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AMG9810
CAS:<p>AMG 9810 blocks capsaicin's action on TRPV1; human IC50=24.5 nM, rat IC50=85.6 nM.</p>Fórmula:C21H23NO3Pureza:99.79% - 99.95%Cor e Forma:SolidPeso molecular:337.41Optovin
CAS:<p>Optovin is a TRPA1 activator, which is reversibly photoactivated.</p>Fórmula:C15H13N3OS2Pureza:99.47% - 99.67%Cor e Forma:SolidPeso molecular:315.41MDR-652
CAS:<p>MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM for</p>Fórmula:C22H23ClFN3O2SPureza:99.96%Cor e Forma:SolidPeso molecular:447.95RN-1747
CAS:<p>RN-1747: TRPV4 agonist (EC50: human 0.77 μM, mouse 4.0 μM, rat 4.1 μM), TRPM8 antagonist (IC50: 4 μM).</p>Fórmula:C17H18ClN3O4SPureza:99.29%Cor e Forma:SolidPeso molecular:395.86AMTB hydrochloride
CAS:<p>AMTB HCl: Novel TRPM8 blocker, relieves pain, treats urinary issues, moderates bladder reflexes in rats.</p>Fórmula:C23H27ClN2O2SPureza:99.08%Cor e Forma:SolidPeso molecular:430.99TRPM8 antagonist 2
CAS:<p>TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM. TRPM8 antagonist 2 is used in the research of neuropathic pain syndromes.</p>Fórmula:C26H26N2O2Pureza:98.1%Cor e Forma:SolidPeso molecular:398.5AC1903
CAS:<p>AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.</p>Fórmula:C19H17N3OPureza:98.45%Cor e Forma:SolidPeso molecular:303.36cim0216
CAS:<p>CIM0216 is a synthetic TRPM3 activator whose potency and apparent affinity greatly exceeds that of the canonical TRPM3 agonist.</p>Fórmula:C21H21N3O2Pureza:99.87%Cor e Forma:SolidPeso molecular:347.41AMG 517
CAS:<p>AMG 517 is an effective and specific TRPV1 antagonist, antagonizes proton (IC50: 0.76 nM), capsaicin (IC50: 0.62 nM) and heat activation (IC50: 1.3 nM) of TRPV1</p>Fórmula:C20H13F3N4O2SPureza:99.77% - 99.85%Cor e Forma:SolidPeso molecular:430.4JNJ-28583113
CAS:<p>JNJ-28583113 is a TRPM2 antagonist, inducing phosphorylation of GSK3α and β subunits, protecting cells from oxidative stress-induced cell death.</p>Fórmula:C19H21F3N2O2Pureza:98.57%Cor e Forma:SolidPeso molecular:366.38SAR7334
CAS:<p>SAR7334 (TRCP6-IN-1) is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).</p>Fórmula:C21H22ClN3OPureza:99.62% - 99.71%Cor e Forma:SolidPeso molecular:367.87JYL 1421
CAS:<p>JYL 1421 (SC 0030) is an antagonist of TRPV1 receptor (IC50 = 8 nM).</p>Fórmula:C20H26FN3O2S2Pureza:98.83%Cor e Forma:SolidPeso molecular:423.57TRPC6-PAM-C20
CAS:<p>TRPC6-PAM-C20, a selective enhancer for TRPC6, boosts calcium in HEK cells and OAG-related platelet clumping, EC50: 2.37μM.</p>Fórmula:C22H21NO4Pureza:98.16%Cor e Forma:SolidPeso molecular:363.41AM12
CAS:<p>AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).</p>Fórmula:C15H9BrO5Pureza:98%Cor e Forma:SolidPeso molecular:349.13D-3263 hydrochloride
CAS:<p>D-3263 hydrochloride (D3263 HCl salt) is enteric-coated, orally bioavailable transient receptor potential melatonin member 8 (TRPM8) agonist.</p>Fórmula:C21H32ClN3O3Pureza:99.93%Cor e Forma:SolidPeso molecular:409.95TRPM4-IN-2
CAS:<p>NBA, or TRPM4-IN-2, is a potent TRPM4 inhibitor with IC50 of 0.16 μM, used in prostate and colorectal cancer research.</p>Fórmula:C19H14ClNO4Pureza:99.21%Cor e Forma:SolidPeso molecular:355.77Asivatrep
CAS:<p>Asivatrep (PAC14028) is a selective and potent antagonist of transient receptor potential vanilloid subtype 1 (TRPV1) for the study of atopic dermatitis.</p>Fórmula:C21H22F5N3O3SPureza:95.13%Cor e Forma:SolidPeso molecular:491.48TRPV3 antagonist 74a
CAS:<p>TRPV3 antagonist 74a (TRPV3 74a) is a specific TRPV3 antagonist for the study of neurological disorders.</p>Fórmula:C17H17F3N2O2Pureza:≥98.0%Cor e Forma:SolidPeso molecular:338.32RN9893
CAS:<p>RN9893 is a selective and potent TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for TRPV4 receptors in mouse, human and rat, respectively.</p>Fórmula:C21H23F3N4O5SPureza:99.89%Cor e Forma:SolidPeso molecular:500.49TRPV4 agonist-1
CAS:<p>TRPV4 agonist-1 is an agonist of TRPV4 (EC50: 60 nM in the hTRPV4 Ca2+ assay).</p>Fórmula:C25H23ClF2N4O2Pureza:98%Cor e Forma:SolidPeso molecular:484.93Motugivatrep
CAS:<p>Motugivatrep is a potent and selective TRPV1 antagonist that can be used to study TRPV1-related respiratory diseases.</p>Fórmula:C22H20F3NO3Pureza:99.22%Cor e Forma:SolidPeso molecular:403.39GSK1702934A
CAS:<p>GSK1702934A is a TRPC3 agonist with pro-arrhythmic and positive inotropic effects and is used in the study of diabetes mellitus.</p>Fórmula:C22H25N3O2SPureza:98.15%Cor e Forma:SolidPeso molecular:395.52ABT 102
CAS:<p>ABT 102 (CHEMBL398338) is a selective antagonist of transient receptor potential vanilloid 1 (TRPV1) receptor.</p>Fórmula:C21H24N4OPureza:98.38% - 99.86%Cor e Forma:SolidPeso molecular:348.44Mavatrep
CAS:<p>Mavatrep (JNJ-39439335) is a selective antagonist of TRPV1 with Ki of 6.5 nM and can be used for studies about inflammatory pain.</p>Fórmula:C25H21F3N2OPureza:98.51% - 99.31%Cor e Forma:SolidPeso molecular:422.44SET 2
CAS:<p>SET 2 is an antagonist of transient receptor potential vanilloid type 2(TRPV2) with an IC50 of 0.46 μM. SET 2 shows selectivity over TRPV1, TRPV3 and TRPV4.</p>Fórmula:C17H21F3N4O2SPureza:99.77%Cor e Forma:SolidPeso molecular:402.43Elismetrep
CAS:<p>Elismetrep (MT-8554) is an orally available TRPM8 inhibitor with potential analgesic activity for the study of vasomotor symptoms in postmenopausal women.</p>Fórmula:C27H21F3N2O5SPureza:99.37% - 99.93%Cor e Forma:SolidPeso molecular:542.53MSP3
CAS:<p>MSP3 is an agonist of TRPV1 (EC50 = 0.87 μM) and shows antinociceptive and neuroprotective effects.</p>Fórmula:C16H19NO3SPureza:99.89%Cor e Forma:SolidPeso molecular:305.39HC-070
CAS:<p>HC-070 is a TRPC5 and TRPC4 antagonist (IC50 = 9.3 nM and 46 nM).</p>Fórmula:C22H20Cl2N4O4Pureza:98.48%Cor e Forma:SolidPeso molecular:475.32Pyr3
CAS:<p>Pyr3 selectively blocks TRPC3 channels, reducing Ca2+ influx; it's effective at 700 nM.</p>Fórmula:C16H11Cl3F3N3O3Pureza:98.04%Cor e Forma:SolidPeso molecular:456.63TC-I 2014
CAS:<p>TC-I 2014 shows antiallodynic properties in pain models.</p>Fórmula:C23H19F6N3OPureza:99.07%Cor e Forma:SolidPeso molecular:467.41Olvanil
CAS:<p>Olvanil (N-Vannilyloleoylamide) is a vanilloid receptor agonist with EC50 of 0.7nM.</p>Fórmula:C26H43NO3Pureza:99.58%Cor e Forma:SolidPeso molecular:417.62FEMA-4809
CAS:<p>FEMA-4809 activates TRPM8, the ion channel for cold sensation, and is used as a cooling agent.</p>Fórmula:C17H17N3O2SPureza:99.9%Cor e Forma:SolidPeso molecular:327.4Mesendogen
CAS:<p>Mesendogen is an inhibitor of transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) and acts by inhibiting TRPM6/TRPM7</p>Fórmula:C18H16ClF3N2OSPureza:99.66%Cor e Forma:SolidPeso molecular:400.85MK-2295
CAS:<p>MK-2295 is a potent TRPV1 antagonist. MK-2295 can be used in studies about the treatment of chronic pain.</p>Fórmula:C27H31FN6O2Pureza:98.83% - 99.44%Cor e Forma:SolidPeso molecular:490.57A-1165442
CAS:<p>A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.</p>Fórmula:C22H20ClF2N3O2Cor e Forma:SolidPeso molecular:431.86GSK3395879
CAS:<p>GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).</p>Fórmula:C20H15F4N3O5SPureza:98%Cor e Forma:SolidPeso molecular:485.41PF-05105679
CAS:<p>PF-05105679 is a selective TRPM8 antagonist (IC50 = 103 nM). PF-05105679 can be used in research on cold-related pain.</p>Fórmula:C26H21FN2O3Pureza:99.84%Cor e Forma:SolidPeso molecular:428.45JT010
CAS:<p>JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM).</p>Fórmula:C16H19ClN2O3SPureza:99.75%Cor e Forma:SolidPeso molecular:354.85AMG-0347
CAS:<p>AMG-0347 inhibits TRPA1 ion channels in sensory neurons, blocking pain perception.</p>Fórmula:C24H26F3N3O2Pureza:99.93%Cor e Forma:SolidPeso molecular:445.48AMG2850
CAS:<p>AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).</p>Fórmula:C19H17F6N3OPureza:99.84%Cor e Forma:SolidPeso molecular:417.35TRPA1 Antagonist 1
CAS:<p>TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.</p>Fórmula:C24H20F6N5Na2O7PSPureza:98%Cor e Forma:SolidPeso molecular:713.45Apcin A HCL
CAS:<p>Apcin A HCL is an Apcin derivative. Apcin A HCL is an anaphase-promoting complex (APC) inhibitor. Apcin-A HCL interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A HCL can be used to synthesize the PROTAC CP5V [1].</p>Fórmula:C10H15Cl4N5O2Pureza:99.30%Cor e Forma:SolidPeso molecular:379.07
