Canal de Potássio
Os canais de potássio são um grupo diversificado de proteínas de membrana que facilitam o fluxo de íons de potássio (K+) através da membrana celular. Esses canais desempenham um papel crucial na manutenção do potencial de membrana em repouso, na regulação do volume celular e no controle da excitabilidade de neurônios e células musculares. Os canais de potássio estão envolvidos em vários processos fisiológicos, incluindo a regulação do ritmo cardíaco, a secreção de insulina e a liberação de neurotransmissores. A desregulação dos canais de potássio está associada a condições como arritmias, epilepsia e hipertensão. Na CymitQuimica, oferecemos uma ampla gama de moduladores de canais de potássio para apoiar sua pesquisa em eletrofisiologia, saúde cardiovascular e neurobiologia.
Foram encontrados 280 produtos de "Canal de Potássio"
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Linopirdine
CAS:<p>Linopirdine (DuP 996) is a TRPV1 agonist.</p>Fórmula:C26H21N3OPureza:99.45% - 99.78%Cor e Forma:SolidPeso molecular:391.46Minocycline hydrochloride
CAS:Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.Fórmula:C23H28ClN3O7Pureza:99.28% - >99.99%Cor e Forma:Bright Yellow-Orange Amorphous Solid Crystalline YellowPeso molecular:493.94IK1 inhibitor PA-6
CAS:IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1 (KIR2.x ion-channel-carried inward rectifier current)(IC50 of 12-15 nM for human and mouseFórmula:C31H32N4O2Pureza:98.9%Cor e Forma:SolidPeso molecular:492.61ML418
CAS:<p>ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker (IC50 = 310 nM), and also potently inhibits Kir6.2/SUR1.</p>Fórmula:C19H24ClN3O3Pureza:99.3%Cor e Forma:SolidPeso molecular:377.87Eleclazine hydrochloride
CAS:Eleclazine hydrochloride (GS 6615 hydrochloride) is a novel inhibitor of late Na+ current (IC50: 0.7 uM).Fórmula:C21H17ClF3N3O3Pureza:99.86%Cor e Forma:SolidPeso molecular:451.83Propafenone
CAS:<p>Propafenone: a drug for ventricular arrhythmias with mild beta-blocker activity, prolongs refractory period, and reduces heart automaticity.</p>Fórmula:C21H27NO3Pureza:99.02%Cor e Forma:SolidPeso molecular:341.44Hydroxyhexamide
CAS:Hydroxyhexamide ((±)-Hydroxyhexamid) is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agent.Fórmula:C15H22N2O4SPureza:98.91%Cor e Forma:SolidPeso molecular:326.41Apamin acetate
<p>Apamin acetate: Selective Ca2+-activated K+ channel blocker, 18-amino acid bee venom peptide, promotes synapse repair, anti-inflammatory.</p>Pureza:96.97%Cor e Forma:SolidAekatperone
Aekatperone, a reversible KATP channel inhibitor, exhibits an IC50 of 9 μM. It is utilized in research related to congenital hyperinsulinism (CHI).Fórmula:C20H25N5O2SCor e Forma:SolidPeso molecular:399.51BeKm-1
CAS:Potent, selective hERG (KV11.1) blocker; doesn't affect 14 other K+ channels; extends QTc in rabbit heart dose-dependently.Fórmula:C174H261N51O52S6Pureza:98%Cor e Forma:SolidPeso molecular:4091.65Phe-Met-Arg-Phe, amide
CAS:Phe-Met-Arg-Phe amide activates K+ current in neurons (ED50=23 nM), co-localizes with neuropeptide Y in brain regions.Fórmula:C29H42N8O4SPureza:98%Cor e Forma:SolidPeso molecular:598.76MASP-2-IN-1
<p>MASP-2-IN-1 (Compound 77) is an inhibitor of mannan-binding lectin-associated serine proteases (MASP), specifically targeting MASP2 and MASP3, with IC50 values of 11.4 nM and 13.2 µM, respectively. It shows weak inhibitory activity on hERG with an IC50 of 175 µM. This compound exhibits poor stability in mouse plasma, with a half-life of 4.4 hours.</p>Fórmula:C22H21N7O3SCor e Forma:SolidPeso molecular:463.512Ebio2
<p>Ebio2 is an effective activator of KCNQ2.</p>Fórmula:C17H19F2N3O2Cor e Forma:SolidPeso molecular:335.349Lei-Dab7 TFA
Lei-Dab7 TFA blocks SK2 channels with 3.8 nM affinity, is >200x selective, and enhances LTP in rat hippocampus.Fórmula:C143H237F3N46O41S6Cor e Forma:SolidPeso molecular:3506.08ADWX 1
<p>Potent KV1.3 blocker, IC50: 0.0019 nM; less effective on KV1.1. Curbs CD4+ T cell activation; eases rat multiple sclerosis model.</p>Fórmula:C169H281N57O46S7Pureza:98%Cor e Forma:SolidPeso molecular:4071.86ShK-Dap22
CAS:Potent KV1.3 channel blocker; Kd 23 pM; selective; inhibits T cell activation; IC50 < 500 pM for mKV1.3.Fórmula:C166H268N54O48S7Pureza:98%Cor e Forma:SolidPeso molecular:4012.7Dalazatide HCl
<p>Dalazatide HCl is a peptide and specific Kv1.3 inhibitor that suppresses the activation and proliferation of memory effector T cells,</p>Cor e Forma:SolidPeso molecular:4317.53 (Free base)Tertiapin
CAS:Tertiapin (reduced) is a synthetic bee venom peptide characterized by disulfide bonds between Cys3-Cys14 and Cys5-Cys18. It acts as an inhibitor of inward-rectifying potassium channels (potassium Channel) and can also block the activity of calcium-activated large conductance potassium channels. Tertiapin (reduced) is utilized in research related to diseases such as rheumatoid arthritis and multiple sclerosis.Fórmula:C106H180N34O23S5Cor e Forma:SolidPeso molecular:2459.1Potassium Channel Targeted Library
<p>A unique collection of xnum potassium channel blockers and agonists for high throughput and high content screening;</p>Cor e Forma:Odour SolidPhe-Met-Arg-Phe amide trifluoroacetate
CAS:Phe-met-arg-phe amide trifluoroacetate is an activator of K+ current with an ED50 of 23nm on the fundus nerve.Fórmula:C33H44F6N8O8SPureza:98%Cor e Forma:SolidPeso molecular:826.81
