Canal de Potássio
Os canais de potássio são um grupo diversificado de proteínas de membrana que facilitam o fluxo de íons de potássio (K+) através da membrana celular. Esses canais desempenham um papel crucial na manutenção do potencial de membrana em repouso, na regulação do volume celular e no controle da excitabilidade de neurônios e células musculares. Os canais de potássio estão envolvidos em vários processos fisiológicos, incluindo a regulação do ritmo cardíaco, a secreção de insulina e a liberação de neurotransmissores. A desregulação dos canais de potássio está associada a condições como arritmias, epilepsia e hipertensão. Na CymitQuimica, oferecemos uma ampla gama de moduladores de canais de potássio para apoiar sua pesquisa em eletrofisiologia, saúde cardiovascular e neurobiologia.
Foram encontrados 280 produtos de "Canal de Potássio"
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BKCa activator-1
<p>BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.</p>Fórmula:C22H23F7N2O3Cor e Forma:SolidPeso molecular:496.418MASP-2-IN-1
<p>MASP-2-IN-1 (Compound 77) is an inhibitor of mannan-binding lectin-associated serine proteases (MASP), specifically targeting MASP2 and MASP3, with IC50 values of 11.4 nM and 13.2 µM, respectively. It shows weak inhibitory activity on hERG with an IC50 of 175 µM. This compound exhibits poor stability in mouse plasma, with a half-life of 4.4 hours.</p>Fórmula:C22H21N7O3SCor e Forma:SolidPeso molecular:463.512Agitoxin-2
CAS:Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).Fórmula:C169H278N54O48S8Pureza:98%Cor e Forma:SolidPeso molecular:4090.874-Hydroxytolbutamide
CAS:4-Hydroxytolbutamide is a drug metabolite derived from the metabolism of Tolbutamide by CYP2C8 and CYP2C9 a sulfonylurea hypoglycemic agent.Fórmula:C12H18N2O4SPureza:98%Cor e Forma:White To Off-WhitePeso molecular:286.35Apamin
CAS:<p>Apamin: 18-amino acid bee venom peptide, blocks SK channels, anti-inflammatory, anti-fibrotic, strongly basic.</p>Fórmula:C79H131N31O24S4Pureza:98%Cor e Forma:SolidPeso molecular:2027.34Margatoxin
CAS:KV1.3 channel blocker, IC50 36 pM, no effect on calcium-activated channels, hinders VEGF-induced Ca++ influx & NO in endothelial cells.Fórmula:C178H286N52O50S7Pureza:98%Cor e Forma:SolidPeso molecular:4178.96Charybdotoxin
CAS:Specific inhibitor of the big conductance Ca2+-activated K+ channel.Fórmula:C176H277N57O55S7Pureza:98%Cor e Forma:SolidPeso molecular:4295.95RU-TRAAK-2
CAS:<p>RU-TRAAK-2 reversibly inhibits TWIK-related K+ channel, inactive on Kv1.2, GIRK2, Slo1.</p>Fórmula:C19H17N3OSPureza:99.81%Cor e Forma:SolidPeso molecular:335.42Ebio2
<p>Ebio2 is an effective activator of KCNQ2.</p>Fórmula:C17H19F2N3O2Cor e Forma:SolidPeso molecular:335.349Cromakalim
CAS:<p>Cromakalim (BRL 34915) is an ATP-dependent K(+) channel opener, a smooth muscle relaxant with antiepileptic activity.</p>Fórmula:C16H18N2O3Pureza:99.39%Cor e Forma:SolidPeso molecular:286.33KCNQ1 activator-1
CAS:<p>N-[4-(4-Methoxyphenyl)-2-thiazolyl]-2-piperidinecarboxamide is a potent KCNQ1 activator for LQTS research.</p>Fórmula:C22H23N3O4S2Pureza:99.71%Cor e Forma:SolidPeso molecular:457.57Neosolaniol
CAS:Neosolaniol, a type A trichothecene mycotoxin produced by Fusarium species, strongly induces an anorectic (loss of appetite) response.Fórmula:C19H26O8Pureza:98%Cor e Forma:SolidPeso molecular:382.4Endoxifen Z-isomer hydrochloride
CAS:Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.Fórmula:C25H28ClNO2Cor e Forma:SolidPeso molecular:409.95Nateglinide D5
CAS:<p>Nateglinide D5 is a deuterium labeled Nateglinide.</p>Fórmula:C19H27NO3Pureza:98%Cor e Forma:SolidPeso molecular:322.45Flecainide
CAS:Flecainide is an orally administered antiarrhythmic agent acting as a sodium channel blocker and IKr inhibitor,PSVT.Fórmula:C17H20F6N2O3Pureza:99.896%Cor e Forma:SolidPeso molecular:414.34QO-58
CAS:QO-58 is a novel Kv7 activator (opener) that activates neuronal Kv7/KCNQ/M channels, danti-nociceptive effects on inflammatory painFórmula:C18H8Cl2F4N4OPureza:99.17%Cor e Forma:SolidPeso molecular:443.18Clamikalant sodium
CAS:Clamikalant sodium (HMR 1098) is an ATP-dependent potassium channel (KATP) cardiac-selective blocker, used in the study of arrhythmias.Fórmula:C19H21ClN3NaO5S2Pureza:99.95%Cor e Forma:SolidPeso molecular:493.96Azimilide Dihydrochloride
CAS:Azimilide Dihydrochloride (NE-10064 Dihydrochloride), a novel class III antiarrhythmic agent, blocks both the IKs and IKr with antiarrhythmic activity.Fórmula:C23H30Cl3N5O3Pureza:97.59% - ≥95%Cor e Forma:SolidPeso molecular:530.88Almitrine mesylate
CAS:Almitrine mesylate targets Ca2+-dependent K+ channels in rat cells, used for chronic lung hypoxemia.Fórmula:C28H37F2N7O6S2Pureza:99.96%Cor e Forma:CoaPeso molecular:669.76TKIM
CAS:<p>TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1.</p>Fórmula:C18H14ClN3O2SPureza:99.47%Cor e Forma:SolidPeso molecular:371.84
