Canal de Potássio
Os canais de potássio são um grupo diversificado de proteínas de membrana que facilitam o fluxo de íons de potássio (K+) através da membrana celular. Esses canais desempenham um papel crucial na manutenção do potencial de membrana em repouso, na regulação do volume celular e no controle da excitabilidade de neurônios e células musculares. Os canais de potássio estão envolvidos em vários processos fisiológicos, incluindo a regulação do ritmo cardíaco, a secreção de insulina e a liberação de neurotransmissores. A desregulação dos canais de potássio está associada a condições como arritmias, epilepsia e hipertensão. Na CymitQuimica, oferecemos uma ampla gama de moduladores de canais de potássio para apoiar sua pesquisa em eletrofisiologia, saúde cardiovascular e neurobiologia.
Foram encontrados 280 produtos de "Canal de Potássio"
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AUT1
CAS:AUT1 (AUT-1) is a novel specific modulator of Kv3 channels (EC50: 4.7 and 4.9 uM for Kv3.1b and Kv3.2a).Fórmula:C18H19N3O4Pureza:99.8% - 99.95%Cor e Forma:SolidPeso molecular:341.36Iptakalim Hydrochloride
CAS:Iptakalim, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholineFórmula:C9H22ClNPureza:98%Cor e Forma:SolidPeso molecular:179.731GSK369796 Dihydrochloride
CAS:GSK369796 Dihydrochloride (N-tert-butylisoquine),is an anti-malaria drug candidate.Fórmula:C20H24Cl3N3OPureza:>99.99%Cor e Forma:SolidPeso molecular:428.78PAP-1
CAS:<p>PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a selective, and orally active Kv1.3 blocker (EC50: 2 nM).</p>Fórmula:C21H18O5Pureza:99.35% - 99.75%Cor e Forma:White SolidPeso molecular:350.36Nigericin sodium salt
CAS:Nigericin sodium salt, an antibiotic and NLRP3 activator from S. hygroscopicus, inhibits Golgi and gram-positive bacteria, blocking viral activation.Fórmula:C40H67NaO11Pureza:98.2% - 99.52%Cor e Forma:SolidPeso molecular:746.94Atpenin A5
CAS:<p>Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM).</p>Fórmula:C15H21Cl2NO5Pureza:97.33% - 99.91%Cor e Forma:SolidPeso molecular:366.24LY 303511 hydrochloride
CAS:LY 303511 hydrochloride is a potent mTOR inhibitorFórmula:C19H19ClN2O2Pureza:98.47%Cor e Forma:SolidPeso molecular:342.82Mitiglinide Calcium
CAS:Mitiglinide Calcium (KAD-1229) is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-Fórmula:(C19H24NO3)2·CaPureza:99.83%Cor e Forma:White Crystal PosderPeso molecular:668.88Flupirtine maleate
CAS:<p>Flupirtine maleate (Katadolon maleate), a centrally acting non-opioid analgesia, is the salt form of Flupirtine. Flupirtine is an NMDA receptor antagonist.</p>Fórmula:C15H17FN4O2·C4H4O4Pureza:99.5% - 99.9%Cor e Forma:Off-White Crystalline PowderPeso molecular:420.39Senicapoc
CAS:Senicapoc (ICA-17043) blocks Gardos channel, reduces RBC dehydration, IC50: 11 nM for rubidium flux, 30 nM for dehydration. Used in Sickle Cell therapy.Fórmula:C20H15F2NOPureza:95.7% - 99.47%Cor e Forma:SolidPeso molecular:323.34E-4031 dihydrochloride
CAS:E-4031 dihydrochloride is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)Fórmula:C21H29Cl2N3O3SPureza:99.31% - 99.87%Cor e Forma:SolidPeso molecular:474.44Allocryptopine
CAS:<p>Allocryptopine (Thalictrimine) induces muscle contraction and relaxation in urinary bladder and ileum, respectively.</p>Fórmula:C21H23NO5Pureza:99.41% - ≥95%Cor e Forma:SolidPeso molecular:369.41KS176
CAS:KS176: selective BCRP inhibitor, potent against breast cancer drug resistance; ineffective on P-gp, MRP1.Fórmula:C22H19N3O5Pureza:99.61% - 99.61%Cor e Forma:SolidPeso molecular:405.45-Hydroxydecanoate sodium
CAS:5-Hydroxydecanoate sodium: KATP channel blocker, IC50 ~30μM; mitochondrial substrate; antioxidant.Fórmula:C10H19NaO3Pureza:99.24% - 99.89%Cor e Forma:SolidPeso molecular:210.25VU0810464
CAS:VU0810464 is a non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator.Fórmula:C18H21ClFN3OPureza:99.62%Cor e Forma:SolidPeso molecular:349.83Loureirin B
CAS:Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.Fórmula:C18H20O5Pureza:99.33% - 99.86%Cor e Forma:SolidPeso molecular:316.35Mitiglinide calcium hydrate
CAS:Mitiglinide calcium hydrate (S-21403 calcium hydrate) is a drug for the treatment of type 2 diabetes.Fórmula:C38H52CaN2O8Pureza:98.97% - 99.96%Cor e Forma:White SolidPeso molecular:704.91A2793
CAS:<p>A2793 is a dual inhibitor of TWIK-associated acid-sensitive K+ channel 1 (TASK-1)/TRESK, with an IC50 for mTRESK of 6.8 μM.</p>Fórmula:C13H12ClNO3Pureza:98.54%Cor e Forma:SolidPeso molecular:265.69O-Nornuciferine
CAS:O-Nornuciferine reveals distinct in vitro hERG blockages measured in HEK293 cells with the IC50 value of 2.89 uM.Fórmula:C18H19NO2Pureza:99.86%Cor e Forma:SolidPeso molecular:281.35ML213
CAS:ML213 (CID-3111211) is a selective activator of Kv7.2 (KCNQ2) and Kv7.4 (KCNQ4) channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM,Fórmula:C17H23NOPureza:>99.99%Cor e Forma:SolidPeso molecular:257.37Levcromakalim
CAS:Levcromakalim (BRL 38227) is an activator of the ATP-sensitive K+ channel.Fórmula:C16H18N2O3Pureza:99.74%Cor e Forma:SolidPeso molecular:286.33NS 11021
CAS:<p>NS 11021 (NS11021) , a novel opener of large-conductance Ca(2+)-activated K(+) channels</p>Fórmula:C16H9BrF6N6SPureza:97.26%Cor e Forma:SolidPeso molecular:511.24Tetraethylammonium bromide
CAS:<p>Tetraethylammonium bromide (TEA bromide) can selectively block potassium channels.</p>Fórmula:C8H20BrNPureza:98%Cor e Forma:White SolidPeso molecular:210.16ML133 hydrochloride
CAS:ML133 hydrochloride (ML133 HCl) is a selective potassium channel inhibitor for Kir2.1, has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.Fórmula:C19H19NO·HClPureza:99.48%Cor e Forma:SolidPeso molecular:313.82SKF-96365 hydrochloride
CAS:SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal YFórmula:C22H27ClN2O3Pureza:99.47% - 99.92%Cor e Forma:SolidPeso molecular:402.91Rimtuzalcap
CAS:Rimtuzalcap (CAD-1883), a selective modulator for SK channels, may treat movement disorders like SCA and ET.Fórmula:C18H24F2N6OPureza:99.64%Cor e Forma:SolidPeso molecular:378.42A2764 dihydrochloride
CAS:A2764 dihydrochloride is a highly selective inhibitor of TRESK.Fórmula:C15H21Cl3N2OPureza:99.05%Cor e Forma:SolidPeso molecular:351.7(±)-Naringenin
CAS:<p>(±)-Naringenin (Naringenine) is a natural product.</p>Fórmula:C15H12O5Pureza:98.06%Cor e Forma:SolidPeso molecular:272.25Dihydroberberine
CAS:Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities.Fórmula:C20H19NO4Pureza:93.77%Cor e Forma:SolidPeso molecular:337.37Nateglinide
CAS:Nateglinide is an oral drug for type 2 diabetes, stimulating insulin release; may cause rare acute liver injury.Fórmula:C19H27NO3Pureza:99.93% - 99.94%Cor e Forma:White Crystalline PowderPeso molecular:317.42Oxypeucedanin
CAS:<p>1.</p>Fórmula:C16H14O5Pureza:98.66% - 98.85%Cor e Forma:SolidPeso molecular:286.28Guanosine 5'-diphosphate
CAS:<p>Guanosine 5'-diphosphate (GDP) as Potential Iron Mobilizer, Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway.</p>Fórmula:C10H15N5O11P2Pureza:98.46% - 99.52%Cor e Forma:SolidPeso molecular:443.2ML 297
CAS:ML 297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively).Fórmula:C17H14F2N4OPureza:97.85%Cor e Forma:SolidPeso molecular:328.32NS1643
CAS:NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 μM.Fórmula:C15H10F6N2O3Pureza:98.37% - 99.31%Cor e Forma:SolidPeso molecular:380.24GAL-021
CAS:<p>GAL-021 an intravenous BKCa-channel blocker.</p>Fórmula:C11H22N6OPureza:97.71% - 99.66%Cor e Forma:SolidPeso molecular:254.33Daurisoline
CAS:<p>Daurisoline ((R,R)-Daurisoline) is a hERG inhibitor. Daurisoline is also an autophagy blocker.</p>Fórmula:C37H42N2O6Pureza:98% - 99.96%Cor e Forma:Light Yellow PowderPeso molecular:610.74NS-1619
CAS:NS1619 have cardio-protective effects after ischemia-reperfusion injury.Fórmula:C15H8F6N2O2Pureza:97.66% - 98%Cor e Forma:SolidPeso molecular:362.23GW9508
CAS:<p>GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner.</p>Fórmula:C22H21NO3Pureza:97.89% - 99.19%Cor e Forma:SolidPeso molecular:347.41JNJ 303
CAS:<p>JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).</p>Fórmula:C21H29ClN2O4SPureza:99.28%Cor e Forma:SolidPeso molecular:440.98TRAM-34
CAS:<p>TRAM-34 (Triarylmethane-34), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel, does not block cytochrome P450.</p>Fórmula:C22H17ClN2Pureza:99.01% - 99.91%Cor e Forma:SolidPeso molecular:344.84ML335
CAS:ML335 is a selective activator of TREK-1 and TREK-2.Fórmula:C15H14Cl2N2O3SPureza:99.73% - 99.79%Cor e Forma:SolidPeso molecular:373.25ICA 110381
CAS:ICA 110381 is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsyFórmula:C12H8Cl2N2OPureza:97.72%Cor e Forma:SolidPeso molecular:267.11Flecainide hydrochloride
CAS:Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias.Fórmula:C17H21ClF6N2O3Pureza:97.79%Cor e Forma:SolidPeso molecular:450.81Minoxidil sulfate
CAS:Minoxidil sulfate (U-58838) is the active metabolite required to exert the vasodilatory and hair growing effects of minoxidil.Fórmula:C9H15N5O4SPureza:99.01% - 99.72%Cor e Forma:White Crystalline SolidPeso molecular:289.31ASP2905
CAS:ASP-2905 is a potent and selective inhibitor of potassium channel Kv12.2 encoded by the Kcnh3/BEC1 gene.Fórmula:C20H17FN8Pureza:97.29%Cor e Forma:SolidPeso molecular:388.4AM-92016 hydrochloride
CAS:AM-92016 is a specific blocker of rectifier potassium current.Fórmula:C19H24Cl2N2O4S·HClPureza:98.68%Cor e Forma:SolidPeso molecular:483.84NS6180
CAS:<p>NS6180 is a potent and selective KCa3.1 channel inhibitor(IC50= 9 nM). It prevents T-cell activation and inflammation.</p>Fórmula:C16H12F3NOSPureza:99.83% - ≥95%Cor e Forma:SolidPeso molecular:323.33Tetraethylammonium chloride
CAS:Tetraethylammonium chloride is a quaternary ammonium compound.Fórmula:C8H20ClNPureza:≥95%Cor e Forma:White Solid Solid Particulate/PowderPeso molecular:165.7RY785
CAS:<p>RY785 is a potent and selective inhibitor of voltage-gated potassium channel such as KV2.2 (IC50 = 50 nM). RY785 may be used in pain relief studies.</p>Fórmula:C21H20N4O2SPureza:99.78%Cor e Forma:SolidPeso molecular:392.47Enflurane
CAS:Enflurane (Efrane), a volatile anaesthetic, inhibits Ca2+-activated K+ channels and is used to gauge anesthesia levels in gas chromatography.Fórmula:C3H2ClF5OPureza:99.64%Cor e Forma:Clear Colorless Liquid Ordinary Temperature And Pressure Bp 56 8°C Density 1 50 G Cm-3 At Room Temperature Used As AnPeso molecular:184.49
