Canal de Potássio
Os canais de potássio são um grupo diversificado de proteínas de membrana que facilitam o fluxo de íons de potássio (K+) através da membrana celular. Esses canais desempenham um papel crucial na manutenção do potencial de membrana em repouso, na regulação do volume celular e no controle da excitabilidade de neurônios e células musculares. Os canais de potássio estão envolvidos em vários processos fisiológicos, incluindo a regulação do ritmo cardíaco, a secreção de insulina e a liberação de neurotransmissores. A desregulação dos canais de potássio está associada a condições como arritmias, epilepsia e hipertensão. Na CymitQuimica, oferecemos uma ampla gama de moduladores de canais de potássio para apoiar sua pesquisa em eletrofisiologia, saúde cardiovascular e neurobiologia.
Foram encontrados 280 produtos de "Canal de Potássio"
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SCH-23390 hydrochloride
CAS:SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) is an effective dopamine receptor antagonist, and for the D1(Ki=0.2 nM) and D5(Ki=0.3 nM).Fórmula:C17H19Cl2NOPureza:98% - 99.83%Cor e Forma:SolidPeso molecular:324.24ICA-105574
CAS:ICA-105574 activates hERG, enhancing peak current and shortening action potential, while modulating activation kinetics.Fórmula:C19H14N2O4Pureza:98.89%Cor e Forma:SolidPeso molecular:334.33Branaplam
CAS:<p>Branaplam (LMI 070) is a highly potent, selective and orally active small molecule SMN2 splicing modulator.</p>Fórmula:C22H27N5O2Pureza:98.28% - 99.72%Cor e Forma:SolidPeso molecular:393.48Rosuvastatin
CAS:<p>Rosuvastatin (ZD4522) is an inhibitor of HMG-CoA reductase (HMGCR). Rosuvastatin has hypolipidemic and antiatherosclerotic effects. Cost-effective and quality-assured.</p>Fórmula:C22H28FN3O6SPureza:95.24% - 99.8%Cor e Forma:SolidPeso molecular:481.54Levosimendan
CAS:<p>Levosimendan (OR1259) is a calcium sensitizer for acute heart failure, enhancing cardiac contractility without raising calcium levels.</p>Fórmula:C14H12N6OPureza:99.37% - 99.91%Cor e Forma:Yellow Crystalline PowderPeso molecular:280.28H3B-120
CAS:H3B-120: selective, competitive CPS1 inhibitor with anti-cancer properties. IC50: 1.5 μM, Ki: 1.4 μM.Fórmula:C19H24N4O2SPureza:99.03% - 99.2%Cor e Forma:SolidPeso molecular:372.48CLP290
CAS:CLP290 is an activator of the neuron-specific K+-Cl cotransporter KCC2 and displays potential for the treatment of a wide range of neurological and psychiatricFórmula:C19H21FN4O3SPureza:99.93% - >99.99%Cor e Forma:SolidPeso molecular:404.46BMS-191011
CAS:<p>BMS-191011 (BMS-A) is an activator of large-conductance calcium-activated potassium (BKCa) channels ,effective in stroke models</p>Fórmula:C16H10ClF3N2O3Pureza:97.43%Cor e Forma:SolidPeso molecular:370.71Tetrandrine
CAS:Tetrandrine (Sinomenine A) is a naturally occurring biphenylisoquinoline alkaloid, a calcium channel inhibitor. Cost-effective and quality-assured.Fórmula:C38H42N2O6Pureza:99.61% - 99.94%Cor e Forma:White SolidPeso molecular:622.75Doxapram
CAS:Doxapram (Dopram) is a respiratory stimulant that inhibits TASK-1, TASK-3, and TASK-1/TASK-3 heterodimer channels.Fórmula:C24H30N2O2Pureza:99.42%Cor e Forma:SolidPeso molecular:378.51VU590
CAS:VU590 is an inhibitor of extrarenal medullary potassium ROMK.VU590 inhibits Kir7.1 and modulates uterine myometrial contractility and melanocortin signalling.Fórmula:C24H32N4O7Pureza:98.06%Cor e Forma:SolidPeso molecular:488.53BL-1249
CAS:BL-1249 is a selective and potent non-steroidal potassium channel activator with anti-inflammatory activity that activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2).Fórmula:C17H17N5Pureza:98% - 98.25%Cor e Forma:SolidPeso molecular:291.35HUP30
CAS:HUP30 is a potent vasodilating agent. HUP30 can stimulate soluble guanylyl cyclase, activate K+ channels, and block extracellular Ca2+ influx.Fórmula:C14H15N3O3SPureza:99.96%Cor e Forma:SolidPeso molecular:305.35Eleclazine
CAS:Eleclazine (GS-6615) is a novel and selective voltage-gated sodium channel inhibitor with antiarrhythmic properties that reduces peak sodium current (INaP).Fórmula:C21H16F3N3O3Pureza:98.67%Cor e Forma:SolidPeso molecular:415.37Repaglinide D5
CAS:<p>Repaglinide D5 is deuterium labeled Repaglinide. Repaglinide is an insulin secretagogue for treatment type-2 diabetes mellitus.</p>Fórmula:C27H36N2O4Pureza:98%Cor e Forma:SolidPeso molecular:457.62Dofetilide D4
CAS:Dofetilide D4 (UK 68789 D4), a deuterium-labeled version of Dofetilide, is categorized as a Class III antiarrhythmic medication.Fórmula:C19H27N3O5S2Pureza:98%Cor e Forma:SolidPeso molecular:445.59Meclofenamic acid
CAS:Meclofenamic acid: non-selective gap-junction blocker, FTO inhibitor, anti-inflammatory.Fórmula:C14H11Cl2NO2Pureza:99.98%Cor e Forma:SolidPeso molecular:296.15LY 303511
CAS:<p>LY303511, an inactive analogue of LY294002, is a mTOR inhibitor and no inhibition for PI3-K.</p>Fórmula:C19H18N2O2Pureza:98%Cor e Forma:SolidPeso molecular:306.36CPK20
CAS:CPK20 is a potent and selective inhibitor of the KCNT1 channel, useful for epilepsy research.Fórmula:C23H24F6N2O2SCor e Forma:SolidPeso molecular:506.50Nifekalant hydrochloride
CAS:Nifekalant hydrochloride is an IKr potassium channel blocker with an IC50 of 10 µM.Fórmula:C19H28ClN5O5Pureza:99.91%Cor e Forma:SolidPeso molecular:441.91Vernakalant Hydrochloride
CAS:Vernakalant Hydrochloride (RSD1235 hydrochloride) is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker.Fórmula:C20H32ClNO4Pureza:99.89%Cor e Forma:SolidPeso molecular:385.93Pinacidil
CAS:Pinacidil (P 1134) is a guanidine that opens potassium channels and directly dilates peripheral blood vessels in small arteries, lowering blood pressure andFórmula:C13H19N5Pureza:99.9%Cor e Forma:SolidPeso molecular:245.32AVE-0118
CAS:AVE-0118 is a potassium channel blocker and suppresses persistent atrial fibrillation.Fórmula:C30H29N3O3Pureza:97.04% - 98.93%Cor e Forma:SolidPeso molecular:479.57Amsacrine
CAS:<p>Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.</p>Fórmula:C21H19N3O3SPureza:99.2%Cor e Forma:Yellow Crystalline Powder SolidPeso molecular:393.46SCH-23390 maleate
CAS:SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective antagonist of dopamine D1-like receptor (1 and D5 receptor with Kis of 0.2 nM and 0.3 nM,Fórmula:C21H22ClNO5Pureza:98%Cor e Forma:SolidPeso molecular:403.86Psora 4
CAS:<p>Psora 4 (5-(4-Phenylbutoxy)psoralen) is a Kv1.3 blocker and a caloric restriction mimetic.</p>Fórmula:C21H18O4Cor e Forma:SolidPeso molecular:334.37HN37
CAS:<p>HN37, KCNQ2 activator (EC50=37 nM). Affordable Excellence: Reliable Quality You Can Trust</p>Fórmula:C20H21FN2O2Pureza:99.27%Cor e Forma:SolidPeso molecular:340.39VU0405601
CAS:VU0405601 is a hERG channel activator that protects against drug-induced cardiac arrhythmias.Fórmula:C17H13BrN2O2Pureza:99.16%Cor e Forma:SolidPeso molecular:357.2ML402
CAS:<p>ML402 (ZINC3671497) is an activator of TREK-1 and TREK-2 with EC50s of 13.7 μM and 5.9 μM.</p>Fórmula:C14H14ClNO2SPureza:99.71%Cor e Forma:SolidPeso molecular:295.78Aprikalim
CAS:Aprikalim opens KATP channels, protects the heart, and at high doses, dilates blood vessels.Fórmula:C12H16N2OS2Pureza:99.42% - 99.90%Cor e Forma:SolidPeso molecular:268.4AVE1231
CAS:AVE1231 is a TASK-1 channel blocker that inhibits TASK-1 and can be used in the study of atrial fibrillation.Fórmula:C20H27N3O4SPureza:98.03%Cor e Forma:SolidPeso molecular:405.51UK 78282 hydrochloride
CAS:UK-78282 hydrochloride, a Kv1.3 blocker.UK-78282 hydrochloride inhibits Kv1.3 voltage-gated potassium channels and suppresses human T cell activation.Fórmula:C29H36ClNO2Pureza:99.89%Cor e Forma:SolidPeso molecular:466.05GAL-021 sulfate
CAS:GAL-021 sulfate is a BKCa channel blocker that inhibits the analgesic effects of opioids and is used in the study of respiratory control diseases.Fórmula:C11H24N6O5SPureza:99.92%Cor e Forma:SolidPeso molecular:352.41TRAM 39
CAS:TRAM 39 (2-Chloro-α,α-diphenylbenzeneacetonitrile) is a selective blocker of intermediate-conductance Ca2+-activated K+channels.Fórmula:C20H14ClNPureza:99.97%Cor e Forma:SolidPeso molecular:303.78Almokalant
CAS:<p>Almokalant: Class III antiarrhythmic, K+ channel blocker, inhibits Ikr current.</p>Fórmula:C18H28N2O3SPureza:98%Cor e Forma:SolidPeso molecular:352.49CM-TPMF
CAS:<p>CM-TPMF is a highly efficient and potent activator of the K(Ca)2.1 channel, Ser293 in the transmembrane segment 5, neurological disorders.</p>Fórmula:C16H17ClN6O2Pureza:99.94%Cor e Forma:SolidPeso molecular:360.8Vernakalant
CAS:<p>Vernakalant (RSD-1235) is a mixed ion channel blocker.</p>Fórmula:C20H31NO4Pureza:98%Cor e Forma:SolidPeso molecular:349.46B-TPMF
CAS:B-TPMF is a highly efficient and selective KCa2.1 channel inhibitor with an IC50 of 31 nM, interacting with serine residue at position 293 to inhibit KCa2.1.Fórmula:C19H24N6O2Pureza:99.82%Cor e Forma:SolidPeso molecular:368.43TWIK-1/TREK-1-IN-2
CAS:<p>TWIK-1/TREK-1-IN-2 (Compound 2g) serves as an inhibitor of both TWIK-1 and TREK-1, targeting the TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50 values</p>Fórmula:C20H29F3N2O2Pureza:98%Cor e Forma:SolidPeso molecular:386.45TWIK-1/TREK-1-IN-1
CAS:Compound 2a, identified as TWIK-1/TREK-1-IN-1, acts as an inhibitor of the TREK-1, a two-pore domain potassium channel (K2p) that forms TREK-1 homodimers andFórmula:C21H24F3NO3Pureza:98%Cor e Forma:SolidPeso molecular:395.42ICA
CAS:ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) is a SK channel inhibitor and exhibits antileishmanial activity (IC50: 2.1 µM).Fórmula:C13H10N4SPureza:99.68%Cor e Forma:SolidPeso molecular:254.31RY796
CAS:RY796 is a selective voltage-gated potassium (KV2) channel inhibitor that inhibits KV2.1 and KV2.2, used in research on neurological disorders.Fórmula:C21H27N3O2Pureza:98.59%Cor e Forma:SolidPeso molecular:353.46CyPPA
CAS:<p>CyPPA enhances SK channels, reducing firing rate and extending apamin-sensitive afterhyperpolarization.</p>Fórmula:C16H23N5Pureza:99.88%Cor e Forma:SolidPeso molecular:285.39ZTZ240
CAS:<p>ZTZ240 is a KCNQ2 channel activator used in the study of epilepsy.</p>Fórmula:C12H8ClFN2OPureza:99.89%Cor e Forma:SolidPeso molecular:250.66TASK-1-IN-1
CAS:<p>TASK-1-IN-1: Potent, selective TASK-1 blocker (IC50: 148 nM), weaker on TASK-3 (IC50: 1750 nM), anticancer properties.</p>Fórmula:C22H20N2O2Pureza:99.57%Cor e Forma:SoildPeso molecular:344.41JNJ-26489112
CAS:JNJ-26489112 is a CNS-active agent and an inhibitor of voltage-gated Na+ channels and N-type Ca2+ channels.Fórmula:C9H11ClN2O4SPureza:99.31%Cor e Forma:SolidPeso molecular:278.71PD-118057
CAS:<p>PD-118057, a potent hERG activator, may treat long QT syndrome and heart failure without hERG activity inhibition.</p>Fórmula:C21H17Cl2NO2Pureza:99.16% - 99.97%Cor e Forma:SolidPeso molecular:386.27XE991
CAS:XE991 is a Kv7 (KCNQ) channel blocker.XE 991 dihydrochloride inhibits Kv7.1 (KCNQ1) and M-current and can be used in the study of neurological disorders.Fórmula:C26H20N2OPureza:98.87%Cor e Forma:SolidPeso molecular:376.45SKA-111
CAS:SKA-111 activates KCa3.1 potassium channels, modulates membrane potential in endothelial cells, and dilates rat coronary arteries.Fórmula:C12H10N2SPureza:99.9%Cor e Forma:SolidPeso molecular:214.29TWIK-1/TREK-1-IN-3
CAS:TWIK-1/TREK-1-IN-3 is a potassium channel TREK-1 inhibitor TWIK-1/TREK-1-IN-3 has antidepressant activity and can be used to study depression.Fórmula:C19H27F3N2O2Pureza:99.04%Cor e Forma:SolidPeso molecular:372.43
