Canal de Potássio
Os canais de potássio são um grupo diversificado de proteínas de membrana que facilitam o fluxo de íons de potássio (K+) através da membrana celular. Esses canais desempenham um papel crucial na manutenção do potencial de membrana em repouso, na regulação do volume celular e no controle da excitabilidade de neurônios e células musculares. Os canais de potássio estão envolvidos em vários processos fisiológicos, incluindo a regulação do ritmo cardíaco, a secreção de insulina e a liberação de neurotransmissores. A desregulação dos canais de potássio está associada a condições como arritmias, epilepsia e hipertensão. Na CymitQuimica, oferecemos uma ampla gama de moduladores de canais de potássio para apoiar sua pesquisa em eletrofisiologia, saúde cardiovascular e neurobiologia.
Foram encontrados 283 produtos de "Canal de Potássio"
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RL648_81
CAS:RL648_81 is a selective activator of KCNQ2/3 channels (EC50 = 190 nM). RL648_81 can be used in studies about neuronal hyperexcitability neurologic disorders.Fórmula:C17H17F4N3O2Pureza:99.82%Cor e Forma:SolidPeso molecular:371.33XE991
CAS:XE991 is a Kv7 (KCNQ) channel blocker.XE 991 dihydrochloride inhibits Kv7.1 (KCNQ1) and M-current and can be used in the study of neurological disorders.Fórmula:C26H20N2OPureza:98.87%Cor e Forma:SolidPeso molecular:376.45JNJ-26489112
CAS:JNJ-26489112 is a CNS-active agent and an inhibitor of voltage-gated Na+ channels and N-type Ca2+ channels.Fórmula:C9H11ClN2O4SPureza:99.31%Cor e Forma:SolidPeso molecular:278.71CyPPA
CAS:<p>CyPPA enhances SK channels, reducing firing rate and extending apamin-sensitive afterhyperpolarization.</p>Fórmula:C16H23N5Pureza:99.88%Cor e Forma:SolidPeso molecular:285.39SKA-111
CAS:SKA-111 activates KCa3.1 potassium channels, modulates membrane potential in endothelial cells, and dilates rat coronary arteries.Fórmula:C12H10N2SPureza:99.9%Cor e Forma:SolidPeso molecular:214.29Ref: TM-T24799
1mg70,00€5mg153,00€10mg250,00€25mg504,00€50mg727,00€100mg1.017,00€500mg2.043,00€1mL*10mM (DMSO)167,00€IKs124
CAS:IKs124 is a KCNE2/KCNQ1 potassium channel blocker, for hKCNE1 and hKCNE3, and can be used to study peptic ulcers.Fórmula:C18H26N2O3SPureza:99.53%Cor e Forma:SolidPeso molecular:350.48TWIK-1/TREK-1-IN-3
CAS:TWIK-1/TREK-1-IN-3 is a potassium channel TREK-1 inhibitor TWIK-1/TREK-1-IN-3 has antidepressant activity and can be used to study depression.Fórmula:C19H27F3N2O2Pureza:99.04%Cor e Forma:SolidPeso molecular:372.43KT-362 fumarate
CAS:<p>KT-362 fumarate, a novel antagonist of Ca, K, and Na channels, induces vasodilation and relaxes rabbit arterial strips.</p>Fórmula:C26H32N2O7SPureza:99.75% - 99.98%Cor e Forma:SolidPeso molecular:516.61GW 542573X
CAS:GW 542573X is a potent and selective small molecule Ca2+-activated K+ 2 (SK2) channel activator.GW 542573X induces a leftward shift in the Ca2+ response curveFórmula:C19H28N2O5Pureza:99.99%Cor e Forma:SolidPeso molecular:364.44DMP-543
CAS:DMP-543 (XR-543) is a potassium channel (KV7 channel) blocker that enhances the release of neurotransmitters.Fórmula:C26H18F2N2OPureza:99.74%Cor e Forma:SolidPeso molecular:412.43MK-0448
CAS:MK-0448 is a novel and selective blocker of the Kv1.5 (KCNA5) channel, a key channel involved in cardiac repolarization current I Kur.Fórmula:C24H21FN4O2SPureza:99.25% - 99.79%Cor e Forma:SolidPeso molecular:448.51ZM 226600
CAS:ZM 226600 is an ATP-sensitive potassium channel opener with an EC50 value of 500 nM. ZM226600 has an inhibitory effect on spontaneous bladder activity.Fórmula:C16H14F3NO4SPureza:99.87%Cor e Forma:SolidPeso molecular:373.35Ref: TM-T23563
2mg35,00€5mg50,00€10mg80,00€25mg145,00€50mg226,00€100mg335,00€200mg469,00€1mL*10mM (DMSO)55,00€PD-118057
CAS:PD-118057, a potent hERG activator, may treat long QT syndrome and heart failure without hERG activity inhibition.Fórmula:C21H17Cl2NO2Pureza:99.95% - 99.97%Cor e Forma:SolidPeso molecular:386.27Ref: TM-T16444
1mg84,00€2mg107,00€5mg175,00€10mg263,00€25mg464,00€50mg692,00€100mg1.035,00€200mg1.396,00€1mL*10mM (DMSO)192,00€Glibornuride
CAS:Glibornuride is a blocker of ATP-sensitive K+ channel(pKi: 5.75).Fórmula:C18H26N2O4SPureza:99.5%Cor e Forma:SolidPeso molecular:366.48Ref: TM-T15385
1mg71,00€5mg152,00€10mg236,00€25mg409,00€50mg580,00€100mg803,00€1mL*10mM (DMSO)167,00€11-deoxy-PGF2a
CAS:11-deoxy-PGF2a is a thromboxane A2 receptor agonist that partially alleviates crowding in Lpar3(−/−) female embryos and induces smooth muscle contractionFórmula:C20H34O4Cor e Forma:SolidPeso molecular:338.48MCHR1 antagonist 2
CAS:MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) and also inhibits hERG.Fórmula:C23H21FN2O5Pureza:98.29%Cor e Forma:SolidPeso molecular:424.42Ref: TM-T11966
2mg43,00€5mg66,00€10mg100,00€25mg210,00€50mg334,00€100mg537,00€200mg710,00€1mL*10mM (DMSO)80,00€VU0463271
CAS:<p>VU0463271: KCC2 antagonist, IC50 61 nM, >100x selective over NKCC1, inactive on other GPCRs, channels, transporters.</p>Fórmula:C19H18N4OS2Pureza:97.84% - 99.55%Cor e Forma:SolidPeso molecular:382.5CLP257
CAS:<p>CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4.</p>Fórmula:C14H14FN3O2SPureza:99.5%Cor e Forma:SolidPeso molecular:307.34Clobutinol hydrochloride
CAS:Clobutinol hydrochloride, an antitussive agent, influences heart rate and blood pressure, and is utilized in cough-related research [1] [2] [3].Fórmula:C14H23Cl2NOPureza:98%Cor e Forma:SolidPeso molecular:292.25Linaprazan
CAS:Linaprazan (AZD0865) inhibits gastric H+,K+-ATPase by K+-competitive binding with an IC50 of 1.0 μM.Fórmula:C21H26N4O2Pureza:99.54%Cor e Forma:SolidPeso molecular:366.46DPO-1
CAS:DPO-1 可以高效抑制电压门控钾离子通道Kv1.5，也可以阻断超快速延迟整流钾电流。它能够预防房性心律失常。Fórmula:C22H29OPPureza:99.78%Cor e Forma:SolidPeso molecular:340.44Ref: TM-T22745
5mg48,00€10mg74,00€25mg150,00€50mg216,00€100mg313,00€200mg437,00€1mL*10mM (DMSO)52,00€Sigma-1 receptor antagonist 3
CAS:Sigma-1 receptor antagonist 3 is a more potent and selective antagonist of Sigma-1 (σ1) receptor (Ki = 1.14 nM) than σ2 receptor(Ki = 1239 nM).Fórmula:C19H23ClFN3OPureza:99.95%Cor e Forma:SolidPeso molecular:363.86P-1075
CAS:P-1075 activates SUR2-KIR6 channels at 45 nM; may open mitoKATP channels and protect the heart.Fórmula:C12H17N5Pureza:99.85%Cor e Forma:SolidPeso molecular:231.3Ref: TM-T16420
1mg60,00€5mg126,00€10mg202,00€25mg369,00€50mg560,00€100mg747,00€200mg1.017,00€1mL*10mM (DMSO)96,00€C 101248
CAS:C 101248 (KCNK13-IN-1) is a selective and potent tandem pore halogen inhibitor of K+ channel 1 (THIK-1) inhibitor and a human and mouse KCNK13 inhibitor.Fórmula:C15H12N6OPureza:99.14% - 99.31%Cor e Forma:SolidPeso molecular:292.3Kv3 modulator 1
CAS:Kv3 modulator 1 is a voltage-gated potassium channel Kv3 modulator that can be used to study neurologic-level diseases.Fórmula:C20H20N4O4Pureza:99.41%Cor e Forma:SolidPeso molecular:380.4Kv7.2/Kv7.3 agonist 1
CAS:Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally effective agonist for the KV7.2/7.3 channels (KV7.2/7.3 channel/KCNQ2/3) with an EC50 of 1.03 μM. This compound demonstrates analgesic effects in mouse models of chronic constriction injury (CCI) and Streptozotocin-induced diabetic peripheral neuropathy (DPNP), with ED50 values of 12.02 mg/kg and 9.63 mg/kg, respectively.Fórmula:C14H14FN3O2Cor e Forma:SolidPeso molecular:275.28Opakalim
CAS:Opakalim is an activator of potassium channels (potassium channel) and exhibits anticonvulsant activity.Fórmula:C18H22F2N4OCor e Forma:SolidPeso molecular:348.39cis-KV1.3-IN-1
CAS:cis-KV1.3-IN-1, also known as Compound cis-18, is the cis-isomer of KV1.3-IN-1 and functions as an inhibitor of the KV1.3 channel. In Xenopus laevis oocytes expressing human hKV1.3, cis-KV1.3-IN-1 (10 μM) achieves an inhibition rate of 25.53% against KV1.3.Fórmula:C23H30N2O4SCor e Forma:SolidPeso molecular:430.56KCC2 Modulator-2
CAS:KCC2 Modulator-2 (example 53) is a regulator of KCC2 with an EC50 of 0.215 μM. It is used in the research of neurological diseases.Fórmula:C35H45N5O3Cor e Forma:SolidPeso molecular:583.76KV1.3-IN-2
CAS:<p>KV1.3-IN-2 (Compound I) selectively inhibits the kv1.3 potassium channel without affecting the hERG channel. It is applicable in research related to immune-associated diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.</p>Fórmula:C16H23ClN2O4Cor e Forma:SolidPeso molecular:342.818Kv7.2/Kv7.3 activator-1
CAS:Kv7.2/Kv7.3 Activator-1 (compound 517) serves as a powerful activator of the Kv7.2/Kv7.3 channels, exhibiting an EC50 value of less than 1 µM. It holds potential for use in neurological disease research.Fórmula:C19H22F2N4OCor e Forma:SolidPeso molecular:360.40Kv7.2/Kv7.3 modulator-1
CAS:Kv7.2/Kv7.3 modulator-1 (compound 6a) acts as a modulator for Kv7.2/Kv7.3 channels, with a pEC50 value of 7.96 for opening these channels. Kv7.2/Kv7.3 modulator-1 is applicable in research related to epilepsy, depression, brain injury, and pain.Fórmula:C20H21F4N3O3Cor e Forma:SolidPeso molecular:427.393Kv3 modulator 5
CAS:Kv3 modulator 5 (Example 5), a Kv3 channel modulator, enhances the Kv3.2 current and may be employed in research of hearing disorders [1].Fórmula:C20H20N4O4Cor e Forma:SolidPeso molecular:380.4
