Canal de Potássio
Os canais de potássio são um grupo diversificado de proteínas de membrana que facilitam o fluxo de íons de potássio (K+) através da membrana celular. Esses canais desempenham um papel crucial na manutenção do potencial de membrana em repouso, na regulação do volume celular e no controle da excitabilidade de neurônios e células musculares. Os canais de potássio estão envolvidos em vários processos fisiológicos, incluindo a regulação do ritmo cardíaco, a secreção de insulina e a liberação de neurotransmissores. A desregulação dos canais de potássio está associada a condições como arritmias, epilepsia e hipertensão. Na CymitQuimica, oferecemos uma ampla gama de moduladores de canais de potássio para apoiar sua pesquisa em eletrofisiologia, saúde cardiovascular e neurobiologia.
Foram encontrados 289 produtos de "Canal de Potássio"
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C 101248
CAS:C 101248 (KCNK13-IN-1) is a selective and potent tandem pore halogen inhibitor of K+ channel 1 (THIK-1) inhibitor and a human and mouse KCNK13 inhibitor.Fórmula:C15H12N6OPureza:99.14% - 99.31%Cor e Forma:SolidPeso molecular:292.3Kv7.2/Kv7.3 agonist 1
CAS:Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally effective agonist for the KV7.2/7.3 channels (KV7.2/7.3 channel/KCNQ2/3) with an EC50 of 1.03 μM. This compound demonstrates analgesic effects in mouse models of chronic constriction injury (CCI) and Streptozotocin-induced diabetic peripheral neuropathy (DPNP), with ED50 values of 12.02 mg/kg and 9.63 mg/kg, respectively.Fórmula:C14H14FN3O2Cor e Forma:SolidPeso molecular:275.28Kv3 modulator 5
CAS:Kv3 modulator 5 (Example 5), a Kv3 channel modulator, enhances the Kv3.2 current and may be employed in research of hearing disorders [1].Fórmula:C20H20N4O4Cor e Forma:SolidPeso molecular:380.4Kv7.2/Kv7.3 modulator-1
CAS:Kv7.2/Kv7.3 modulator-1 (compound 6a) acts as a modulator for Kv7.2/Kv7.3 channels, with a pEC50 value of 7.96 for opening these channels. Kv7.2/Kv7.3 modulator-1 is applicable in research related to epilepsy, depression, brain injury, and pain.Fórmula:C20H21F4N3O3Cor e Forma:SolidPeso molecular:427.393KV1.3-IN-2
CAS:KV1.3-IN-2 (Compound I) selectively inhibits the kv1.3 potassium channel without affecting the hERG channel. It is applicable in research related to immune-associated diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.Fórmula:C16H23ClN2O4Cor e Forma:SolidPeso molecular:342.818KCC2 Modulator-2
CAS:KCC2 Modulator-2 (example 53) is a regulator of KCC2 with an EC50 of 0.215 μM. It is used in the research of neurological diseases.Fórmula:C35H45N5O3Cor e Forma:SolidPeso molecular:583.76Opakalim
CAS:Opakalim is an activator of potassium channels (potassium channel) and exhibits anticonvulsant activity.Fórmula:C18H22F2N4OCor e Forma:SolidPeso molecular:348.39cis-KV1.3-IN-1
CAS:cis-KV1.3-IN-1, also known as Compound cis-18, is the cis-isomer of KV1.3-IN-1 and functions as an inhibitor of the KV1.3 channel. In Xenopus laevis oocytes expressing human hKV1.3, cis-KV1.3-IN-1 (10 μM) achieves an inhibition rate of 25.53% against KV1.3.Fórmula:C23H30N2O4SCor e Forma:SolidPeso molecular:430.56Kv7.2/Kv7.3 activator-1
CAS:Kv7.2/Kv7.3 Activator-1 (compound 517) serves as a powerful activator of the Kv7.2/Kv7.3 channels, exhibiting an EC50 value of less than 1 µM. It holds potential for use in neurological disease research.Fórmula:C19H22F2N4OCor e Forma:SolidPeso molecular:360.40
