Canal de Potássio

Os canais de potássio são um grupo diversificado de proteínas de membrana que facilitam o fluxo de íons de potássio (K+) através da membrana celular. Esses canais desempenham um papel crucial na manutenção do potencial de membrana em repouso, na regulação do volume celular e no controle da excitabilidade de neurônios e células musculares. Os canais de potássio estão envolvidos em vários processos fisiológicos, incluindo a regulação do ritmo cardíaco, a secreção de insulina e a liberação de neurotransmissores. A desregulação dos canais de potássio está associada a condições como arritmias, epilepsia e hipertensão. Na CymitQuimica, oferecemos uma ampla gama de moduladores de canais de potássio para apoiar sua pesquisa em eletrofisiologia, saúde cardiovascular e neurobiologia.

Foram encontrados 280 produtos de "Canal de Potássio"

Pureza (%)

100

produtos por página.

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Guanfu base A
CAS:
- 1394-48-5
Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.
Fórmula:C₂₄H₃₁NO₆
Pureza:99.71% - 99.85%
Cor e Forma:Solid
Peso molecular:429.5
Ref: TM-T8182
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Aekatperone
Aekatperone, a reversible KATP channel inhibitor, exhibits an IC50 of 9 μM. It is utilized in research related to congenital hyperinsulinism (CHI).
Fórmula:C₂₀H₂₅N₅O₂S
Cor e Forma:Solid
Peso molecular:399.51
Ref: TM-T201230
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Agitoxin-2
CAS:
- 168147-41-9
Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).
Fórmula:C₁₆₉H₂₇₈N₅₄O₄₈S₈
Pureza:98%
Cor e Forma:Solid
Peso molecular:4090.87
Ref: TM-TP2089
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Ebio2
Ebio2 is an effective activator of KCNQ2.
Fórmula:C₁₇H₁₉F₂N₃O₂
Cor e Forma:Solid
Peso molecular:335.349
Ref: TM-T204914
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Apamin
CAS:
- 24345-16-2
Apamin: 18-amino acid bee venom peptide, blocks SK channels, anti-inflammatory, anti-fibrotic, strongly basic.
Fórmula:C₇₉H₁₃₁N₃₁O₂₄S₄
Pureza:98%
Cor e Forma:Solid
Peso molecular:2027.34
Ref: TM-TP1223
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Charybdotoxin
CAS:
- 95751-30-7
Specific inhibitor of the big conductance Ca2+-activated K+ channel.
Fórmula:C₁₇₆H₂₇₇N₅₇O₅₅S₇
Pureza:98%
Cor e Forma:Solid
Peso molecular:4295.95
Ref: TM-TP2059
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Margatoxin
CAS:
- 145808-47-5
KV1.3 channel blocker, IC50 36 pM, no effect on calcium-activated channels, hinders VEGF-induced Ca++ influx & NO in endothelial cells.
Fórmula:C₁₇₈H₂₈₆N₅₂O₅₀S₇
Pureza:98%
Cor e Forma:Solid
Peso molecular:4178.96
Ref: TM-TP2004
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MASP-2-IN-1
MASP-2-IN-1 (Compound 77) is an inhibitor of mannan-binding lectin-associated serine proteases (MASP), specifically targeting MASP2 and MASP3, with IC50 values of 11.4 nM and 13.2 µM, respectively. It shows weak inhibitory activity on hERG with an IC50 of 175 µM. This compound exhibits poor stability in mouse plasma, with a half-life of 4.4 hours.
Fórmula:C₂₂H₂₁N₇O₃S
Cor e Forma:Solid
Peso molecular:463.512
Ref: TM-T204802
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Apamin acetate
Apamin acetate: Selective Ca2+-activated K+ channel blocker, 18-amino acid bee venom peptide, promotes synapse repair, anti-inflammatory.
Pureza:96.97%
Cor e Forma:Solid
Ref: TM-TP1223L
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Cromakalim
CAS:
- 94470-67-4
Cromakalim (BRL 34915) is an ATP-dependent K(+) channel opener, a smooth muscle relaxant with antiepileptic activity.
Fórmula:C₁₆H₁₈N₂O₃
Pureza:99.39%
Cor e Forma:Solid
Peso molecular:286.33
Ref: TM-T21478
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KCNQ1 activator-1
CAS:
- 1008671-38-2
N-[4-(4-Methoxyphenyl)-2-thiazolyl]-2-piperidinecarboxamide is a potent KCNQ1 activator for LQTS research.
Fórmula:C₂₂H₂₃N₃O₄S₂
Pureza:99.71%
Cor e Forma:Solid
Peso molecular:457.57
Ref: TM-T9778
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Neosolaniol
CAS:
- 36519-25-2
Neosolaniol, a type A trichothecene mycotoxin produced by Fusarium species, strongly induces an anorectic (loss of appetite) response.
Fórmula:C₁₉H₂₆O₈
Pureza:98%
Cor e Forma:Solid
Peso molecular:382.4
Ref: TM-T16285
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Endoxifen Z-isomer hydrochloride
CAS:
- 1032008-74-4
Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
Fórmula:C₂₅H₂₈ClNO₂
Cor e Forma:Solid
Peso molecular:409.95
Ref: TM-T6827
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Nateglinide D5
CAS:
- 1227666-13-8
Nateglinide D5 is a deuterium labeled Nateglinide.
Fórmula:C₁₉H₂₇NO₃
Pureza:98%
Cor e Forma:Solid
Peso molecular:322.45
Ref: TM-T12178
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QO-58
CAS:
- 1259536-62-3
QO-58 is a novel Kv7 activator (opener) that activates neuronal Kv7/KCNQ/M channels, danti-nociceptive effects on inflammatory pain
Fórmula:C₁₈H₈Cl₂F₄N₄O
Pureza:99.17%
Cor e Forma:Solid
Peso molecular:443.18
Ref: TM-T28483
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Flecainide
CAS:
- 54143-55-4
Flecainide is an orally administered antiarrhythmic agent acting as a sodium channel blocker and IKr inhibitor,PSVT.
Fórmula:C₁₇H₂₀F₆N₂O₃
Pureza:99.896%
Cor e Forma:Solid
Peso molecular:414.34
Ref: TM-T21391
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Clamikalant sodium
CAS:
- 261717-22-0
Clamikalant sodium (HMR 1098) is an ATP-dependent potassium channel (KATP) cardiac-selective blocker, used in the study of arrhythmias.
Fórmula:C₁₉H₂₁ClN₃NaO₅S₂
Pureza:99.95%
Cor e Forma:Solid
Peso molecular:493.96
Ref: TM-T63330
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ML365
CAS:
- 947914-18-3
ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3).
Fórmula:C₂₂H₂₀N₂O₃
Pureza:98.78%
Cor e Forma:Solid
Peso molecular:360.41
Ref: TM-T4316
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Azimilide Dihydrochloride
CAS:
- 149888-94-8
Azimilide Dihydrochloride (NE-10064 Dihydrochloride), a novel class III antiarrhythmic agent, blocks both the IKs and IKr with antiarrhythmic activity.
Fórmula:C₂₃H₃₀Cl₃N₅O₃
Pureza:97.59% - ≥95%
Cor e Forma:Solid
Peso molecular:530.88
Ref: TM-T7505
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ICA-069673
CAS:
- 582323-16-8
ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).
Fórmula:C₁₁H₆ClF₂N₃O
Pureza:99.04% - 99.68%
Cor e Forma:Solid
Peso molecular:269.63
Ref: TM-T3959