Canal de cloreto
Os canais de cloreto são proteínas de membrana que controlam o movimento dos íons cloreto através das membranas celulares, desempenhando um papel vital na manutenção do volume celular, excitabilidade elétrica e equilíbrio ácido-base. A desregulação dos canais de cloreto está associada a doenças como fibrose cística, epilepsia e distúrbios renais. Na CymitQuimica, oferecemos uma variedade de moduladores de canais de cloreto para apoiar sua pesquisa em transporte de íons, homeostase celular e mecanismos de doenças.
Foram encontrados 53 produtos para "Canal de cloreto".
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Halothane
CAS:Halothane (Anestan) 可以减弱内皮依赖性舒张作用。Fórmula:C2HBrClF3Pureza:99.80% - >99.99%Cor e Forma:SolidPeso molecular:197.38Endovion
CAS:Endovion (NS3728) is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.Fórmula:C16H9BrF6N6OPureza:98.51%Cor e Forma:SolidPeso molecular:495.18T16Ainh-A01
CAS:T16Ainh-A01 is a potent TMEM16A chloride channel inhibitor with a 1 μM IC50, targeting CaCC.Fórmula:C19H20N4O3S2Pureza:97.18% - 98.15%Cor e Forma:SolidPeso molecular:416.52Niflumic acid
CAS:Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.Fórmula:C13H9F3N2O2Pureza:99.47%Cor e Forma:SolidPeso molecular:282.22DCPIB
CAS:DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μMFórmula:C22H28Cl2O4Pureza:99.79% - 99.87%Cor e Forma:SolidPeso molecular:427.36Ref: TM-T10979
2mg39,00€5mg57,00€1mL*10mM (DMSO)63,00€10mg87,00€25mg177,00€50mg301,00€100mg485,00€200mg690,00€Eact
CAS:Eact is a potent TMEM16A activator that also triggers TRPV1, causing itch, pain, and heat sensitivity.Fórmula:C22H24N2O5SPureza:98.14%Cor e Forma:SolidPeso molecular:428.5Ref: TM-T15192
1mg34,00€2mg48,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg119,00€25mg213,00€50mg356,00€100mg583,00€Meticrane
CAS:Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.Fórmula:C10H13NO4S2Pureza:99.16%Cor e Forma:SolidPeso molecular:275.34Flufenamic acid
CAS:Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties.Fórmula:C14H10F3NO2Pureza:98.68%Cor e Forma:White SolidPeso molecular:281.23NS1652
CAS:NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.Fórmula:C15H11F3N2O3Pureza:99.62%Cor e Forma:SolidPeso molecular:324.25Afoxolaner
CAS:Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs.Fórmula:C26H17ClF9N3O3Pureza:99.1% - 99.38%Cor e Forma:SolidPeso molecular:625.87Umifoxolaner
CAS:Umifoxolaner is an anti-parasitic agent (veterinary).Fórmula:C26H16ClF10N3O3Cor e Forma:SolidPeso molecular:643.87Chlorotoxin
CAS:Chlorotoxin: 36-amino acid peptide from deathstalker scorpion venom; blocks small chloride channels.Fórmula:C158H249N53O47S11Pureza:98%Cor e Forma:SolidPeso molecular:3995.71Chlorotoxin(linear)
Chlorotoxin(linear): 36-amino-acid peptide from Egyptian scorpion venom, used in research as chloride channel blocker.Fórmula:C158H256N52O48S11Pureza:98%Cor e Forma:SolidPeso molecular:4004.76GaTx2
CAS:High-affinity ClC-2 blocker (KD ~50 pM), selective over other ClCs/CFTR/GABAC/CaCC/KV1.2; slows activation, no effect on open channels.Fórmula:C125H199N39O47S6Pureza:98%Cor e Forma:SolidPeso molecular:3192.54Chlorotoxin TFA
Chlorotoxin TFA, a scorpion venom peptide, blocks chloride channels and has anti-cancer properties.Fórmula:C160H250F3N53O49S11Cor e Forma:SolidPeso molecular:4109.74ANO1-IN-4
CAS:ANO1-IN-4 (Compound 10bm) is a reversible inhibitor of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1), with an IC50 of 0.030 µM. It demonstrates good metabolic stability in rat liver microsomes and can inhibit spontaneous contractions in isolated mouse ileum.Fórmula:C19H19BrF2N2O2SCor e Forma:SolidPeso molecular:457.33Ion Channel Targeted Library
A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;Cor e Forma:Odour SolidRef: TM-L2300
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarLubiprostone hemiketal
CAS:Lubiprostone (hemiketal) (RU-0211 (hemiketal)), a selective activator of the chloride channel 2 (CLCN2), facilitates the treatment of chronic idiopathic constipation and opioid-induced constipation. It functions by enhancing CLCN2 channel activity, which boosts chloride ion secretion in the intestines, subsequently increasing fluid secretion and improving intestinal peristalsis. Additionally, Lubiprostone (hemiketal) may be utilized in research related to chronic constipation and cancer.Fórmula:C20H32F2O5Cor e Forma:SolidPeso molecular:390.46Afoxolaner (Standard)
CAS:Afoxolaner (Standard) is the standard substance of Afoxolaner, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.Fórmula:C26H17ClF9N3O3Cor e Forma:SolidPeso molecular:625.87Lubiprostone
CAS:Lubiprostone (RU-0211), an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation.Fórmula:C20H32F2O5Pureza:97.31% - 98.54%Cor e Forma:SolidPeso molecular:390.46Adjudin
CAS:Adjudin (AF-2364) is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.Fórmula:C15H12Cl2N4OPureza:96.51% - ≥95%Cor e Forma:SolidPeso molecular:335.19Selamectin
CAS:Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening inFórmula:C43H63NO11Pureza:99.84%Cor e Forma:SolidPeso molecular:769.96Irisolidone
CAS:Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.Fórmula:C17H14O6Pureza:99.41% - 99.87%Cor e Forma:SolidPeso molecular:314.29Ref: TM-TN1035
1mg105,00€5mg250,00€1mL*10mM (DMSO)255,00€10mg378,00€25mg618,00€50mg859,00€100mg1.153,00€Fenamic acid
CAS:Fenamic acid (N-Phenylanthranilic acid) is a chloride channel blocker that causes renal papillary necrosis in rats.Fórmula:C13H11NO2Pureza:99.6%Cor e Forma:SolidPeso molecular:213.2319Anthracene-9-carboxylic acid
CAS:Anthracene-9-carboxylic acid is an inhibitor of chloride transport with a moderate to strong inhibitory action on PKA activated cardiac IcI.Fórmula:C15H10O2Pureza:99.05%Cor e Forma:SolidPeso molecular:222.24Phenyl benzoate
CAS:Phenyl benzoate is a benzoate ester obtained by the formal condensation of phenol with benzoic acid.It is an important organic synthesis intermediate.Fórmula:C13H10O2Pureza:99.63%Cor e Forma:White SolidPeso molecular:198.22Talniflumate
CAS:Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cellFórmula:C21H13F3N2O4Pureza:98% - 99.81%Cor e Forma:Yellow SolidPeso molecular:414.33NPPB
CAS:NPPB is a chloride channel blocker with IC50 of 80 nM .Fórmula:C16H16N2O4Pureza:99.95%Cor e Forma:White SolidPeso molecular:300.31MONNA
CAS:MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.Fórmula:C18H14N2O5Pureza:98.29%Cor e Forma:SolidPeso molecular:338.31CaCCinh-A01
CAS:CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).Fórmula:C18H21NO4SPureza:99.36% - >99.99%Cor e Forma:SolidPeso molecular:347.43Org 25543
CAS:Org 25543 is the development of an N-Acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain.Fórmula:C24H32N2O4Pureza:99.31%Cor e Forma:SolidPeso molecular:412.52Ref: TM-T50082
1mg55,00€5mg114,00€1mL*10mM (DMSO)129,00€10mg170,00€25mg274,00€50mg371,00€100mg522,00€200mg687,00€Guanidinoethyl sulfonate
CAS:Guanidinoethyl sulfonate (Taurocyamine) is a competitive glycine receptor antagonist.Fórmula:C3H9N3O3SPureza:99.43% - 99.47%Cor e Forma:White SolidPeso molecular:167.19H100
CAS:H100 inhibits Cl- transport, mildly affects NaK2Cl cotransporter and Band 3 anion exchanger, not KCl cotransporter.Fórmula:C18H16N2O6SPureza:98%Cor e Forma:SolidPeso molecular:388.4Bts 39542
CAS:Bts 39542 is a diuretic that plays a major role in the Henle circulation and increases renal blood flow without affecting glomerular filtration rate.Fórmula:C16H11ClN4O3SCor e Forma:SolidPeso molecular:374.8BTG-1640
CAS:BTG-1640 is used potentially for the treatment of anxiety and panic disorder.Fórmula:C15H19NO2Cor e Forma:SolidPeso molecular:245.32NS-3736
CAS:NS-3736 is a chloride channel inhibitor that has been shown to prevent osteoclastic acidification and resorption.Fórmula:C15H9BrClF3N6OCor e Forma:SolidPeso molecular:461.62ANO1-IN-2
CAS:ANO1-IN-2: potent ANO1 blocker (IC50: 1.75 μM), less effective on ANO2 (IC50: 7.43 μM), inhibits glioblastoma cell growth.Fórmula:C16H14ClN3O2S2Cor e Forma:SolidPeso molecular:379.88IAA-94
CAS:IAA-94 is an inhibitor of chloride channels, it binds channels in bovine kidney cortex microsomes with a Ki value of 1 µM.Fórmula:C17H18Cl2O4Cor e Forma:SolidPeso molecular:357.23Alilusem
CAS:Alilusem is a new diuretic that is beneficial to the clinical treatment of hypertension.Fórmula:C17H15ClKN2O5SCor e Forma:SolidPeso molecular:433.92Stepronin
CAS:Stepronin (TTPG) shows expectorant activities and inhibits airway secretion.Fórmula:C10H11NO4S2Pureza:99.59%Cor e Forma:White Or Off White CrystallinePeso molecular:273.33Ref: TM-T21433
5mg48,00€1mL*10mM (DMSO)48,00€10mg71,00€25mg111,00€50mg187,00€100mg290,00€200mg410,00€R(+)-IAA-94
CAS:R(+)-IAA-94 (Methylindazone) blocks epithelial chloride channels; inhibits Nef-sdAb19 binding.Fórmula:C17H18Cl2O4Pureza:98.95% - 99.17%Cor e Forma:White SolidPeso molecular:357.23Losigamone
CAS:Losigamone (AO-33) is an agonist of GABA receptor and can be used in studies about the treatment of partial seizures.Fórmula:C12H11ClO4Pureza:99.98%Cor e Forma:SolidPeso molecular:254.67ANO1-IN-1
CAS:ANO1-IN-1 blocks ANO1/2 channels (IC50: 2.56/15.43 μM) and hinders glioma cell growth.Fórmula:C18H28N2O2SPureza:99.93%Cor e Forma:SolidPeso molecular:336.49Ani9
CAS:Ani9 selectively blocks ANO1/TMEM16A with a 77 nM IC50, useful for ANO1 research and treating cancer, hypertension, pain, diarrhea, asthma.Fórmula:C17H17ClN2O3Pureza:99.73%Cor e Forma:White SolidPeso molecular:332.78Ref: TM-T26630
1mg37,00€5mg79,00€1mL*10mM (DMSO)87,00€10mg124,00€25mg255,00€50mg430,00€100mg620,00€500mg1.333,00€ARN 11391
CAS:ARN 11391 enhances the function of the IP3-gated calcium channel ITPR1 (Inositol 1,4,5-trisphosphate (IP3) receptor type 1), boosting intracellular calcium ionFórmula:C22H29N3O3Cor e Forma:SolidPeso molecular:383.49DIOA
CAS:DIOA acts as a potent antagonist of acid-sensitive outwardly rectifying (ASOR) anion channels [1].Fórmula:C20H24Cl2O4Cor e Forma:SolidPeso molecular:399.31OADS
CAS:OADS is an inhibitor of ClC-ec1 with low micromolar affinity. OADS has no specific effect on a CLC channel (ClC-1).Fórmula:C30H42N2O8S2Cor e Forma:SolidPeso molecular:622.79PAT1inh-B01
CAS:PAT1inh-B01, a selective SLC26A6 inhibitor, impedes PAT1 (a Cl-/HCO3- exchanger) activity, with an IC50 of 350 nM, effectively inhibiting anion exchange.Fórmula:C22H18BrF3N6O2Cor e Forma:SolidPeso molecular:535.32PAT1inh-A0030
CAS:PAT1inh-A0030 is a selective inhibitor of PAT1 (SLC26A6) with an IC 50 value of 1.0 μM. It inhibits fluid absorption in the ileum of wild-type and cystic fibrosis (CF) mice (CftrdelF508/delF508) in a closed-loop model of intestinal fluid absorption and can be used in the study of intestinal diseases related to CF [1].Fórmula:C17H18N4O3Cor e Forma:SolidPeso molecular:326.35
