P-gp
A P-glicoproteína é uma bomba de efluxo dependente de ATP que transporta uma ampla variedade de substratos, incluindo medicamentos, toxinas e lipídios, para fora das células. Ela desempenha um papel crítico na resistência a medicamentos, particularmente no câncer, ao reduzir a concentração intracelular de agentes quimioterápicos. A P-gp também está envolvida na barreira hematoencefálica, influenciando a exposição do sistema nervoso central a vários compostos. Na CymitQuimica, oferecemos uma variedade de moduladores de P-gp para apoiar sua pesquisa em resistência a medicamentos, farmacocinética e desenvolvimento terapêutico.
Foram encontrados 55 produtos de "P-gp"
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Laniquidar TFA
Laniquidar TFA (R101933), a non-competitive P-gp inhibitor, has an IC50 of 0.51 μM; used to study AML and MDS, but with limited bioavailability.Fórmula:C39H37F3N4O5Pureza:99.85%Cor e Forma:SoildPeso molecular:698.73WS-917
WS-917 is an efficacious and orally active regulator of ABCB1. It enhances the ABCB1 ATPase activity and significantly boosts the antitumor efficacy of combined paclitaxel and anti-PD-1 antibody therapy. WS-917 also promotes the activation of CD8+ T cells.Fórmula:C16H13N5OS2Cor e Forma:SolidPeso molecular:355.44Valspodar
CAS:Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.Fórmula:C63H111N11O12Pureza:95% - >99.99%Cor e Forma:SolidPeso molecular:1214.62P-gp inhibitor 25
CAS:P-gp Inhibitor 25 (compound 16c) is a P-gp inhibitor that enhances the oral absorption of paclitaxel. It is utilized in cancer research to improve treatment efficacy.Fórmula:C41H36N4O8Peso molecular:712.75Solamargine
CAS:Solamargine, a steroidal alkaloid from Solanum nigrum, inhibits cancer cell growth and induces apoptosis.Fórmula:C45H73NO15Pureza:99.17% - 99.96%Cor e Forma:SolidPeso molecular:868.06Ref: TM-T4034
1mg56,00€2mg78,00€5mg109,00€10mg165,00€25mg289,00€50mg434,00€100mg655,00€200mg883,00€1mL*10mM (DMSO)158,00€Ceefourin 1
CAS:Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.Fórmula:C11H10N4S3Pureza:99.15%Cor e Forma:SolidPeso molecular:294.42Ref: TM-T8596
1mg43,00€5mg88,00€10mg119,00€25mg250,00€50mg389,00€100mg550,00€200mg785,00€1mL*10mM (DMSO)87,00€Paris saponin VII
CAS:Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
Fórmula:C51H82O21Pureza:99.51% - 99.63%Cor e Forma:SolidPeso molecular:1031.18Polyoxyethylene stearate
CAS:Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.Fórmula:C20H40O3Pureza:n~9-10Cor e Forma:Light Amber SemisolidPeso molecular:328.29775Isosinensetin
CAS:1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.Fórmula:C20H20O7Pureza:99.98% - ≥95%Cor e Forma:SolidPeso molecular:372.37Ref: TM-T2S0223
1mg63,00€5mg135,00€10mg195,00€25mg326,00€50mg485,00€100mg700,00€1mL*10mM (DMSO)165,00€Voacamine
CAS:Voacamine: an indole alkaloid, CB1 antagonist, inhibits P-gp, may affect rhythm.
Fórmula:C43H52N4O5Pureza:98.54% - 99.82%Cor e Forma:SolidPeso molecular:704.9Tariquidar
CAS:Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.Fórmula:C38H38N4O6Pureza:98.07% - 99.45%Cor e Forma:SolidPeso molecular:646.73Selamectin
CAS:Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening inFórmula:C43H63NO11Pureza:99.84%Cor e Forma:SolidPeso molecular:769.96Phellamurin
CAS:Phellamurin blocks intestinal P-glycoprotein dose-dependently and it seriously interacts with cyclosporin; coadministration should be avoided.Fórmula:C26H30O11Pureza:97.91%Cor e Forma:SolidPeso molecular:518.51Ref: TM-TN4761
1mg155,00€5mg304,00€10mg447,00€25mg713,00€50mg1.018,00€100mg1.369,00€1mL*10mM (DMSO)389,00€Sinapine
CAS:Sinapine: an alkaloid with chemo-resistance, antioxidant, and radioprotective properties from cruciferous seeds.Fórmula:C16H24NO5Pureza:98% - 99.68%Cor e Forma:White Or Light-Tan SolidPeso molecular:310.37Convallatoxin
CAS:Convallatoxin is a natural product.Fórmula:C29H42O10Pureza:99.27% - 99.53%Cor e Forma:Prisms From Methanol + Ether SolidPeso molecular:550.64Zosuquidar trihydrochloride
CAS:Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.Fórmula:C32H31F2N3O2·3HClPureza:99.49% - >99.99%Cor e Forma:SolidPeso molecular:636.99Hypophyllanthin
CAS:Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.Fórmula:C24H30O7Pureza:98.39%Cor e Forma:SolidPeso molecular:430.49Zosuquidar
CAS:Zosuquidar (RS 33295-198) is a potent P-glycoprotein inhibitor with antitumor activity that inhibits tumor growth.Fórmula:C32H31F2N3O2Pureza:99.99%Cor e Forma:SolidPeso molecular:527.6Ref: TM-T6018L
1mg73,00€5mg152,00€10mg220,00€25mg358,00€50mg537,00€100mg782,00€200mg1.071,00€1mL*10mM (DMSO)170,00€HM-30181 mesylate monohydrate
CAS:HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.Fórmula:C39H42N6O11SPureza:99.37%Cor e Forma:SolidPeso molecular:802.85Ref: TM-T9173
1mg65,00€2mg94,00€5mg119,00€10mg185,00€25mg309,00€50mg442,00€100mg643,00€200mg835,00€500mg1.251,00€1mL*10mM (DMSO)177,00€Encequidar
CAS:Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.Fórmula:C38H36N6O7Pureza:99.93%Cor e Forma:SolidPeso molecular:688.73Ref: TM-T8426
1mg46,00€2mg62,00€5mg90,00€10mg137,00€25mg234,00€50mg360,00€100mg528,00€1mL*10mM (DMSO)127,00€
