P-gp
A P-glicoproteína é uma bomba de efluxo dependente de ATP que transporta uma ampla variedade de substratos, incluindo medicamentos, toxinas e lipídios, para fora das células. Ela desempenha um papel crítico na resistência a medicamentos, particularmente no câncer, ao reduzir a concentração intracelular de agentes quimioterápicos. A P-gp também está envolvida na barreira hematoencefálica, influenciando a exposição do sistema nervoso central a vários compostos. Na CymitQuimica, oferecemos uma variedade de moduladores de P-gp para apoiar sua pesquisa em resistência a medicamentos, farmacocinética e desenvolvimento terapêutico.
Foram encontrados 56 produtos para "P-gp".
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Laniquidar TFA
Laniquidar TFA (R101933), a non-competitive P-gp inhibitor, has an IC50 of 0.51 μM; used to study AML and MDS, but with limited bioavailability.Fórmula:C39H37F3N4O5Pureza:99.85%Cor e Forma:SoildPeso molecular:698.73P-gp inhibitor 14
CAS:Compound 8a, also known as P-gp inhibitor 14, demonstrates high affinity as a P-gp inhibitor and effectively reverses P-gp-mediated multidrug resistance (EC 50 = 48.74 nM). Additionally, this compound exhibits a weak inhibitory effect on CYP3A4 activity [1].Fórmula:C37H38N2O8Cor e Forma:SolidPeso molecular:638.71CPI1
CPI1 is an effective and highly specific inhibitor of multidrug resistance protein 1 (MRP1). It exhibits inhibitory activity against MRP1 at the nanomolar level (Ki: 100 nM) and has minimal effect on P-glycoprotein (Pgp). CPI1 competes with LTC4 for binding to the same site on MRP1, inhibiting ATP hydrolysis and substrate transport. It is useful in research related to drug delivery and addressing cancer chemotherapy resistance.Fórmula:C111H131N23O30SCor e Forma:SolidPeso molecular:2299.43YS-370
CAS:YS-370 orally blocks P-gp, moderately inhibits CYP3A4, reverses drug resistance, and enhances paclitaxel's anticancer effects.Fórmula:C37H35BrN4O3Pureza:98.05%Cor e Forma:SolidPeso molecular:663.6Sinapine
CAS:Sinapine: an alkaloid with chemo-resistance, antioxidant, and radioprotective properties from cruciferous seeds.Fórmula:C16H24NO5Pureza:98% - 99.96%Cor e Forma:White Or Light-Tan SolidPeso molecular:310.37Ceefourin 1
CAS:Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.Fórmula:C11H10N4S3Pureza:99.15%Cor e Forma:SolidPeso molecular:294.42Ref: TM-T8596
1mg40,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg113,00€25mg236,00€50mg369,00€100mg522,00€200mg743,00€Paris saponin VII
CAS:Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.Fórmula:C51H82O21Pureza:99.57% - 99.63%Cor e Forma:SolidPeso molecular:1031.18Polyoxyethylene stearate
CAS:Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.Fórmula:C20H40O3Pureza:n~9-10Cor e Forma:SolidPeso molecular:328.29775Isosinensetin
CAS:1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.Fórmula:C20H20O7Pureza:99.98% - ≥95%Cor e Forma:SolidPeso molecular:372.37Ref: TM-T2S0223
1mg63,00€5mg135,00€1mL*10mM (DMSO)147,00€10mg195,00€25mg326,00€50mg485,00€100mg700,00€Voacamine
CAS:Voacamine: an indole alkaloid, CB1 antagonist, inhibits P-gp, may affect rhythm.Fórmula:C43H52N4O5Pureza:98.54% - 99.97%Cor e Forma:White SolidPeso molecular:704.9Tariquidar
CAS:Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.Fórmula:C38H38N4O6Pureza:98.07% - 99.45%Cor e Forma:Yellow SolidPeso molecular:646.73Selamectin
CAS:Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening inFórmula:C43H63NO11Pureza:99.84%Cor e Forma:Yellow SolidPeso molecular:769.96Phellamurin
CAS:Phellamurin blocks intestinal P-glycoprotein dose-dependently and it seriously interacts with cyclosporin; coadministration should be avoided.Fórmula:C26H30O11Pureza:97.91%Cor e Forma:White SolidPeso molecular:518.51Ref: TM-TN4761
1mg155,00€5mg304,00€1mL*10mM (DMSO)389,00€10mg447,00€25mg713,00€50mg1.018,00€100mg1.369,00€Convallatoxin
CAS:Convallatoxin is a natural product.Fórmula:C29H42O10Pureza:99.27% - 99.53%Cor e Forma:SolidPeso molecular:550.64Zosuquidar trihydrochloride
CAS:Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.Fórmula:C32H31F2N3O2·3HClPureza:99.49% - >99.99%Cor e Forma:Yellow SolidPeso molecular:636.99Hypophyllanthin
CAS:Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.Fórmula:C24H30O7Pureza:98.39%Cor e Forma:SolidPeso molecular:430.49Zosuquidar
CAS:Zosuquidar (RS 33295-198) is a potent P-glycoprotein inhibitor with antitumor activity that inhibits tumor growth.Fórmula:C32H31F2N3O2Pureza:99.99%Cor e Forma:White SolidPeso molecular:527.6Ref: TM-T6018L
1mg73,00€5mg152,00€1mL*10mM (DMSO)170,00€10mg220,00€25mg358,00€50mg537,00€100mg782,00€200mg1.071,00€HM-30181 mesylate monohydrate
CAS:HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.Fórmula:C39H42N6O11SPureza:99.37%Cor e Forma:SolidPeso molecular:802.85Ref: TM-T9173
1mg65,00€2mg94,00€5mg119,00€1mL*10mM (DMSO)177,00€10mg185,00€25mg309,00€50mg442,00€100mg643,00€200mg835,00€500mg1.251,00€Encequidar
CAS:Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.Fórmula:C38H36N6O7Pureza:98.72% - 99.93%Cor e Forma:SolidPeso molecular:688.73Ref: TM-T8426
1mg46,00€2mg62,00€5mg90,00€1mL*10mM (DMSO)127,00€10mg137,00€25mg234,00€50mg360,00€100mg528,00€Trifluoperazine
CAS:Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.Fórmula:C21H24F3N3SPureza:98.3% - 99.46%Cor e Forma:SolidPeso molecular:407.5
