P-gp
A P-glicoproteína é uma bomba de efluxo dependente de ATP que transporta uma ampla variedade de substratos, incluindo medicamentos, toxinas e lipídios, para fora das células. Ela desempenha um papel crítico na resistência a medicamentos, particularmente no câncer, ao reduzir a concentração intracelular de agentes quimioterápicos. A P-gp também está envolvida na barreira hematoencefálica, influenciando a exposição do sistema nervoso central a vários compostos. Na CymitQuimica, oferecemos uma variedade de moduladores de P-gp para apoiar sua pesquisa em resistência a medicamentos, farmacocinética e desenvolvimento terapêutico.
Foram encontrados 64 produtos para "P-gp".
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WS-917
WS-917 is an efficacious and orally active regulator of ABCB1. It enhances the ABCB1 ATPase activity and significantly boosts the antitumor efficacy of combined paclitaxel and anti-PD-1 antibody therapy. WS-917 also promotes the activation of CD8+ T cells.Fórmula:C16H13N5OS2Cor e Forma:SolidPeso molecular:355.44P-gp inhibitor 25
CAS:P-gp Inhibitor 25 (compound 16c) is a P-gp inhibitor that enhances the oral absorption of paclitaxel. It is utilized in cancer research to improve treatment efficacy.Fórmula:C41H36N4O8Cor e Forma:SolidPeso molecular:712.75Tariquidar methanesulfonate hydrate
CAS:m-PEG8-Ms is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC compounds.Fórmula:C40H58N4O18S2Pureza:98.13%Cor e Forma:Yellow SolidPeso molecular:947.04P-gp modulator-5
P-gp Modulator-5 (compound 25) serves as a modulator of P-gp, effectively inhibiting the proliferation of multidrug-resistant (MDR) tumors. This compound suppresses the function of drug efflux pumps in MDR cells, which results in significant accumulation of ROS and modifications in cell cycle profiles.Fórmula:C19H16N2O5Cor e Forma:SolidPeso molecular:352.34P-gp-IN-33
P-gp-IN-33 (Compound 17a) functions as a P-gp inhibitor. This compound binds to the Verapamil binding pocket of P-gp. P-gp-IN-33 exhibits higher cytotoxicity against resistant non-small cell lung cancer cells compared to non-resistant ones.Antitrypanosomal agent 24
Antitrypanosomal agent 24 is a benzothiazole amidoxime compound with potent and selective activity against trypanosomes (IC50 = 0.92 μM). It serves as a substrate for the P-glycoprotein efflux pump and exhibits high membrane permeability and good metabolic stability. Antitrypanosomal agent 24 binds to DNA/RNA via intercalation.Evodine
CAS:1. Evodine has antinociceptive activity.Fórmula:C18H19NO5Pureza:98%Cor e Forma:SolidPeso molecular:329.35YS-370
CAS:YS-370 orally blocks P-gp, moderately inhibits CYP3A4, reverses drug resistance, and enhances paclitaxel's anticancer effects.Fórmula:C37H35BrN4O3Pureza:98.05%Cor e Forma:SolidPeso molecular:663.6Laniquidar TFA
Laniquidar TFA (R101933), a non-competitive P-gp inhibitor, has an IC50 of 0.51 μM; used to study AML and MDS, but with limited bioavailability.Fórmula:C39H37F3N4O5Pureza:99.85%Cor e Forma:SoildPeso molecular:698.73Voacamine
CAS:Voacamine: an indole alkaloid, CB1 antagonist, inhibits P-gp, may affect rhythm.Fórmula:C43H52N4O5Pureza:98.54% - 99.97%Cor e Forma:White SolidPeso molecular:704.9Ceefourin 1
CAS:Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.Fórmula:C11H10N4S3Pureza:99.15%Cor e Forma:SolidPeso molecular:294.42Ref: TM-T8596
1mg40,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg113,00€25mg236,00€50mg369,00€100mg522,00€200mg743,00€Paris saponin VII
CAS:Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.Fórmula:C51H82O21Pureza:99.57% - 99.63%Cor e Forma:SolidPeso molecular:1031.18Polyoxyethylene stearate
CAS:Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.Fórmula:C20H40O3Pureza:n~9-10Cor e Forma:SolidPeso molecular:328.29775Isosinensetin
CAS:1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.Fórmula:C20H20O7Pureza:99.98% - ≥95%Cor e Forma:SolidPeso molecular:372.37Ref: TM-T2S0223
1mg63,00€5mg135,00€1mL*10mM (DMSO)147,00€10mg195,00€25mg326,00€50mg485,00€100mg700,00€Tariquidar
CAS:Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.Fórmula:C38H38N4O6Pureza:98.07% - 99.45%Cor e Forma:Yellow SolidPeso molecular:646.73Selamectin
CAS:Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening inFórmula:C43H63NO11Pureza:99.84%Cor e Forma:Yellow SolidPeso molecular:769.96Phellamurin
CAS:Phellamurin blocks intestinal P-glycoprotein dose-dependently and it seriously interacts with cyclosporin; coadministration should be avoided.Fórmula:C26H30O11Pureza:97.91%Cor e Forma:White SolidPeso molecular:518.51Ref: TM-TN4761
1mg155,00€5mg304,00€1mL*10mM (DMSO)389,00€10mg447,00€25mg713,00€50mg1.018,00€100mg1.369,00€Sinapine
CAS:Sinapine: an alkaloid with chemo-resistance, antioxidant, and radioprotective properties from cruciferous seeds.Fórmula:C16H24NO5Pureza:98% - 99.96%Cor e Forma:White Or Light-Tan SolidPeso molecular:310.37Convallatoxin
CAS:Convallatoxin is a natural product.Fórmula:C29H42O10Pureza:99.27% - 99.53%Cor e Forma:SolidPeso molecular:550.64Zosuquidar trihydrochloride
CAS:Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.Fórmula:C32H31F2N3O2·3HClPureza:99.49% - >99.99%Cor e Forma:Yellow SolidPeso molecular:636.99
