Canal de Sódio
Os canais de sódio são proteínas de membrana essenciais que permitem a passagem de íons de sódio (Na+) através da membrana celular, gerando e propagando sinais elétricos em neurônios, células musculares e outros tecidos excitáveis. Esses canais são vitais para a iniciação e condução de potenciais de ação, sendo cruciais em processos como a transmissão de impulsos nervosos, contração muscular e função cardíaca. A desregulação dos canais de sódio pode levar a distúrbios neurológicos, arritmias e condições de dor crônica. Na CymitQuimica, oferecemos uma variedade de moduladores de canais de sódio para apoiar sua pesquisa em neurobiologia, cardiologia e manejo da dor.
Foram encontrados 202 produtos de "Canal de Sódio"
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3-Deoxyyunaconitine
CAS:Produto Controlado<p>Applications 3-Deoxyyunaconitine is a metabolite of Aconitine (A189875), a neurotoxin that binds, activates tetrodotoxin-sensitive Na+ channels and prolongs the opening of the sodium-ion channel by suppressing conformational changes.<br>References Derbre, S., et al.: Anal. Bioanal. Chem., 398, 1747 (2010), Li, M., et al.: J. Pharm. Biomed. Anal., 53, 1063 (2010),<br></p>Fórmula:C35H49NO10Cor e Forma:NeatPeso molecular:643.761,2,4-Oxadiazol-3-amine
CAS:Produto Controlado<p>Applications 1,2,4-oxadiazol-3-amine (cas# 39512-64-6) is a useful research chemical.<br></p>Fórmula:C2H3N3OCor e Forma:NeatPeso molecular:85.066-(Propylamino)-2-hydroxy-N-(2,6-dimethylphenyl)hexanamide
Produto Controlado<p>Applications 6-(Propylamino)-2-hydroxy-N-(2,6-dimethylphenyl)-hexanamide is a derivative of Bupivacaine (B689560), a sodium channel blocker, local anesthetic.<br>References Wilson, T.D., et al.: Anal. Profiles Drug Subs., 19, 59 (1990), McClellan, K.J., et al.: Drugs, 56, 355 (1998),<br></p>Fórmula:C17H28N2O2Cor e Forma:NeatPeso molecular:292.416Halofuginone
CAS:<p>Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.</p>Fórmula:C16H17BrClN3O3Pureza:99.53%Cor e Forma:Off-White SolidPeso molecular:414.68Clopamide
CAS:<p>Clopamide (Brinaldix) is a piperidine and sulfamoylbenzamide-based diuretic with thiazide-like diuretic activity.</p>Fórmula:C14H20ClN3O3SPureza:99.71%Cor e Forma:White To Yellowish Crystalline PowderPeso molecular:345.84Nav1.7 inhibitor
CAS:<p>Nav1.7 inhibitor is a Nav1.7 inhibitor for research in the field of pain and anesthesia.</p>Fórmula:C15H11Cl3FNO4SPureza:97.52%Cor e Forma:SolidPeso molecular:426.68GX-585
CAS:<p>GX-585 is a novel potent inhibitor of NaV1.7 and highly selective against NaV1.5, having limited selectivity against NaV1.1 and NaV1.2.</p>Fórmula:C24H25Cl2FN4O3SPureza:99.02% - 99.03%Cor e Forma:SolidPeso molecular:539.45(5R)-BW-4030W92
CAS:<p>(5R)-BW-4030W92 is the R-type of BW-4030W92, the active enantiomer.</p>Fórmula:C11H9Cl2FN4Pureza:98.27%Cor e Forma:SolidPeso molecular:287.12Sodium Channel inhibitor 2
CAS:<p>Sodium Channel inhibitor 2 is a blocker of sodium channel.</p>Fórmula:C26H25Cl2N3OPureza:98%Cor e Forma:SolidPeso molecular:466.4GNE-0439
CAS:<p>GNE-0439 is a Nav1.7-selective inhibitor (IC50 0.34 μM), also targeting Nav1.5 and mutant N1742K channels, valuable for ion channel research.</p>Fórmula:C21H31NO3Pureza:99.60%Cor e Forma:SolidPeso molecular:345.48E 0747
CAS:<p>E 0747 is an antiarrhythmic agent of class 1C type. E-0747 suppresses arrhythmia by inhibiting the Na channels of cardiac cells.</p>Fórmula:C21H28ClN3O4Pureza:95.17%Cor e Forma:SolidPeso molecular:421.92GX-674
CAS:<p>GX-674 is a highly potent and selective voltage-gated sodium channel 1.7 (Nav1.7) antagonist with an IC50 value of 0.1 nM measured at -40 mV for the study of</p>Fórmula:C21H13ClF2N6O3S2Pureza:98.60%Cor e Forma:SolidPeso molecular:534.95DPI 201-106
CAS:<p>DPI 201-106: cardioselective h1 Na channel inhibitor, enhances heart contraction, blocks potassium and calcium currents.</p>Fórmula:C29H30N4O2Pureza:99.94%Cor e Forma:SolidPeso molecular:466.57PF 05089771 tosylate
CAS:<p>PF-05089771 inhibits Nav1.7 channels (IC50: 11-33 nM), selective over Nav1.1-1.6/1.8, Ca+, K+ channels, TRPV1; 1000x affinity for half-inactivated state.</p>Fórmula:C18H12Cl2FN5O3S2·C7H8O3SPureza:98.55%Cor e Forma:SolidPeso molecular:672.56NHE3-IN-2
CAS:<p>NHE3-IN-2 is an inhibitor of NHE3 (Na+/H+ exchanger-3), applicable for treating hypertension, thrombosis, and ischaemic diseases.</p>Fórmula:C15H12ClN5Cor e Forma:SolidPeso molecular:297.74Halofuginone hydrobromide
CAS:<p>Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the suppression of angiogenesis and tumor cell growth.</p>Fórmula:C16H17BrClN3O3·HBrPureza:97.01% - 99.73%Cor e Forma:SolidPeso molecular:495.59Phenamil
CAS:<p>Phenamil is an inhibitor of epithelial sodium channels, activates the osteomorphin protein pathway to promote bone repair and induces significant fat formation.</p>Fórmula:C12H12ClN7OPureza:99.07%Cor e Forma:SolidPeso molecular:305.72GDC-0276
CAS:<p>GDC-0276 is an orally active, selective, and potent NaV1.7 inhibitor that can be used for the study of pain-related diseases.</p>Fórmula:C24H31FN2O4SPureza:99.77%Cor e Forma:SolidPeso molecular:462.58KR-32568
CAS:<p>KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM).</p>Fórmula:C13H12FN3O2Pureza:99.91%Cor e Forma:SolidPeso molecular:261.25Nisoxetine hydrochloride
CAS:<p>Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitor</p>Fórmula:C17H21NO2·HClPureza:99.21%Cor e Forma:White SolidPeso molecular:307.82Silperisone HCl
CAS:<p>Silperisone HCl is a muscle relaxant and vasodilator, treating myoclonus, hypertonia, dystonia, and myospasm by blocking Na+ and Ca2+ channels.</p>Fórmula:C15H25ClFNSiPureza:99.62%Cor e Forma:SolidPeso molecular:301.9Elpetrigine
CAS:<p>Elpetrigine (GW273293) is a potential sodium channel blocker with antiepileptic activity that can be used to study epilepsy.</p>Fórmula:C10H7Cl3N4Pureza:99.04% - 99.43%Cor e Forma:SolidPeso molecular:289.55NaV1.2/1.6 channel blocker-1
CAS:<p>NaV1.2/1.6 channel blocker-1 is a NaV1.2/1.6 channel blocker that inhibits rNaV1.6 and can be used to study generalised epilepsy and movement disorders.</p>Fórmula:C14H14N2OSPureza:99.54%Cor e Forma:SolidPeso molecular:258.34NHE3-IN-1
CAS:<p>NHE3-IN-1 是钠/质子交换剂 3 (NHE-3) 的抑制剂。</p>Fórmula:C12H10ClN3SPureza:99.93%Cor e Forma:SolidPeso molecular:263.75TC-N 1752
CAS:<p>TC-N 1752 is an orally active inhibitor of Nav1.7 channel with IC50 of 0.17 μM. TC-N 1752 shows analgesic activities.</p>Fórmula:C25H27F3N6O3Pureza:99.71%Cor e Forma:SolidPeso molecular:516.52Ralitoline
CAS:<p>Ralitoline (Ralitolinum) is an anticonvulsant with anticancer activity and sodium channel blocking activity.</p>Fórmula:C13H13ClN2O2SPureza:98.45%Cor e Forma:SolidPeso molecular:296.77(Rac)-AMG8379
CAS:<p>(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379 which is an orally active and selective sulfonamide NaV1.7 antagonist.</p>Fórmula:C25H16ClF2N3O5SPureza:99.6%Cor e Forma:SolidPeso molecular:543.93SLC13A5-IN-1
CAS:<p>SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5),completely blocks the uptake of 14C-citrate(IC50 : 0.022 μM in HepG2 cells).</p>Fórmula:C19H19Cl3N2O3SPureza:99.67%Cor e Forma:SolidPeso molecular:461.79PF 04531083
CAS:<p>PF 04531083 is a selective blocker of the NaV1.8 channel. PF 04531083 can be used for neuropathic and inflammatory pain studies.</p>Fórmula:C17H16ClN5O2Pureza:99.85%Cor e Forma:SolidPeso molecular:357.79Aneratrigine
CAS:<p>Aneratrigine is a blocker of the sodium channel protein type 9 subunit alpha, utilized in research on neuropathic pain diseases [1].</p>Fórmula:C19H20ClF2N5O2S2Pureza:98%Cor e Forma:SolidPeso molecular:487.97Sodium Channel inhibitor 4
CAS:<p>Sodium Channel Inhibitor 4 is a compound that functions as a sodium channel inhibitor [1].</p>Fórmula:C19H18ClN3O4S2Pureza:98%Cor e Forma:SolidPeso molecular:451.95Co 102862
CAS:<p>Co 102862 is a voltage-gated sodium channel blocker. Co 102862 can be used for anticonvulsant studies.</p>Fórmula:C14H12FN3O2Pureza:99.82%Cor e Forma:SolidPeso molecular:273.26GDC-0310
CAS:<p>GDC-0310 is a selective, orally available Nav1.7 inhibitor with an IC50 of 0.6 nM for human Nav1.7, suitable for pain research.</p>Fórmula:C25H29Cl2FN2O4SPureza:99.877%Cor e Forma:SolidPeso molecular:543.486-Iodoamiloride
CAS:<p>6-Iodoamiloride is a potent inhibitor of acid-sensing ion channel 1 (ASIC1), exhibiting an IC50 value of 88 nM.</p>Fórmula:C6H8IN7OPureza:98%Cor e Forma:SolidPeso molecular:321.08Aneratrigine hydrochloride
CAS:<p>Aneratrigine hydrochloride is a Nav 1.9 blocker that may be used to prevent or treat sodium channel blocker-related disorders.</p>Fórmula:C19H21Cl2F2N5O2S2Pureza:98.37% - 99.16%Cor e Forma:SolidPeso molecular:524.43VGSCs-IN-1
CAS:<p>VGSCs-IN-1, a VGSC inhibitor and Riluzole analog, exhibits good blocking activity on Nav1.4 and can be used to study cellular excitability disorders.</p>Fórmula:C12H12F3N3OSPureza:99.88%Cor e Forma:SolidPeso molecular:303.3Funapide
CAS:<p>Funapide (TV 45070) is a potent Nav1.7 inhibitor, potentially treating inflammation and various pains.</p>Fórmula:C22H14F3NO5Pureza:99.91%Cor e Forma:SolidPeso molecular:429.35PF-05661014
CAS:<p>PF-05661014, a demethylated analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing the inactivated state through interaction with the D4 VSD. This compound is utilized in research focused on sodium channel modulation.</p>Fórmula:C17H16N4O3S2Cor e Forma:SolidPeso molecular:388.46Olisutrigine bromide
CAS:<p>Olisutrigine bromide is a sodium channel blocker used as an analgesic.</p>Fórmula:C25H35BrN2Cor e Forma:SolidPeso molecular:443.463N-Depropylpropafenone
CAS:<p>N-Depropylpropafenone, an active metabolite of Propafenone, is produced through the metabolism by the CYP450 enzyme system (primarily CYP2D6). It functions by blocking sodium ion channels, thereby delaying the depolarization process in myocardial cells and exhibiting antiarrhythmic properties.</p>Fórmula:C18H21NO3Cor e Forma:SolidPeso molecular:299.36Vormatrigine
CAS:<p>Vormatrigine effectively inhibits sodium channels (sodium channel).</p>Fórmula:C16H12F6N4O2Cor e Forma:SolidPeso molecular:406.28Tizolemide
CAS:<p>Tizolemide, a sulfonamide diuretic compound with alkaline properties, is cleared through the tubular transport system. It induces changes in the passive transport components across the basolateral membrane of isolated frog skin.</p>Fórmula:C11H14ClN3O3S2Cor e Forma:SolidPeso molecular:335.83Lubeluzole dihydrochloride
CAS:<p>Lubeluzole (dihydrochloride) acts as a neuroprotective agent by blocking neuronal voltage-gated sodium channels and also affects cardiac sodium channels, exhibiting both tonic and blocking effects. This compound is considered promising in the research of antiarrhythmic agents.</p>Fórmula:C22H27Cl2F2N3O2SCor e Forma:SolidPeso molecular:506.44Quinacainol dihydrochloride
CAS:<p>Quinacainol dihydrochloride (PK 10139 dihydrochloride) is the bis(2 hydrochloride) salt form of Quinacainol. It acts as an inhibitor of the sodium current, with an EC50 of 95 µM. This compound displays antiarrhythmic activity by modulating the electrophysiological properties of the heart.</p>Fórmula:C21H32Cl2N2OCor e Forma:SolidPeso molecular:399.398Zilvetrigine
CAS:<p>Zilvetrigine is a sodium channel (sodium channel) blocker. It can be used as an analgesic.</p>Fórmula:C20H20ClN3O2Cor e Forma:SolidPeso molecular:369.845(R)-Duloxetine
CAS:<p>(R)-Duloxetine, an isomer of Duloxetine, induces tonic and use-dependent blockade of neuronal Na+ channels. This compound is utilized in pain research.</p>Fórmula:C18H19NOSCor e Forma:SolidPeso molecular:297.42Olorigliflozin
CAS:<p>Olorigliflozin is a sodium glucose co-transporter (SGLT) inhibitor with antihyperglycemic properties.</p>Fórmula:C23H27ClO7Cor e Forma:SolidPeso molecular:450.909ErSO-TFPy
CAS:<p>ErSO-TFPy activates the sodium ion channel TRPM4, resulting in an imbalance of intracellular calcium and sodium ions. It exhibits low nanomolar-level cytotoxicity (IC50 = 5-25 nM) by inducing necrosis in ERα+ breast cancer cell lines. Additionally, ErSO-TFPy shows antitumor activity in mouse models.</p>Fórmula:C19H13F7N2O2Cor e Forma:SolidPeso molecular:434.307Suzetrigine
CAS:<p>Suzetrigine (VX-548) is an oral NaV1.8 inhibitor with analgesic properties for acute pain research.</p>Fórmula:C21H20F5N3O4Pureza:98.08% - 99.27%Cor e Forma:SolidPeso molecular:473.39SYM2206
CAS:<p>SYM2206 is a low affinity non-competitive AMPA receptor antagonist with an IC50 value of 1.6 μM.SYM2206 exhibits anticancer activity by blocking Nav1.6-mediated</p>Fórmula:C20H22N4O3Pureza:99.88%Cor e Forma:SolidPeso molecular:366.41
