Canais de Cálcio
Os canais de cálcio são proteínas de membrana que regulam o fluxo de íons de cálcio para dentro e fora das células, o que é essencial para várias funções celulares, incluindo a contração muscular, a liberação de neurotransmissores e a expressão gênica. A desregulação da atividade dos canais de cálcio está associada a condições como hipertensão, arritmias cardíacas e distúrbios neurológicos. Na CymitQuimica, oferecemos uma ampla seleção de moduladores de canais de cálcio para apoiar sua pesquisa em saúde cardiovascular, neurobiologia e transdução de sinais.
Foram encontrados 544 produtos de "Canais de Cálcio"
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KCa1.1 channel activator-1
A selective vascular KCa1.1 channel stimulator with CaV1.2 blocking ability and mild myorelaxant effects.Fórmula:C25H16O10Cor e Forma:SolidPeso molecular:476.39Nelutroctiv
CAS:Nelutroctiv is a potent activator of cardiac troponin.Fórmula:C24H22F5N3O4SCor e Forma:SolidPeso molecular:543.51Mioflazine
CAS:Mioflazine suppresses nucleoside uptake. Mioflazine is an orally active nucleoside transport inhibitor. It has the potential for sleep disorders treatment.Fórmula:C29H30Cl2F2N4O2Pureza:98%Cor e Forma:SolidPeso molecular:575.48LOE 908 hydrochloride
CAS:Broad spectrum cation channel blockerFórmula:C41H49ClN2O9Pureza:98%Cor e Forma:SolidPeso molecular:749.29Mioflazine hydrochloride
CAS:Mioflazine hydrochloride is a nucleoside transport inhibitor that acts on adenosine to improve sleep.Fórmula:C29H34Cl4F2N4O3Cor e Forma:SolidPeso molecular:666.41Cavα2δ1&NET-IN-3
CAS:Cavα2δ1&NET-IN-3 (example 216) is an inhibitor targeting both the α2δ subunit of voltage-gated calcium channels (VGCC) and the noradrenaline transporter (NET).Fórmula:C24H30N6O2SCor e Forma:SolidPeso molecular:466.6RO 23-6152
CAS:RO 23-6152, a new calcium antagonist, can inhibit platelet aggregation in vitro associated with occlusive coronary thrombus formation.Fórmula:C26H29ClN2O4SCor e Forma:SolidPeso molecular:501.04Reldesemtiv
CAS:<p>Reldesemtiv (CK-2127107) boosts exercise capacity, targeting fast muscle troponin, EC50 3.4 μM.</p>Fórmula:C19H18F2N6OPureza:97.27%Cor e Forma:SolidPeso molecular:384.38AY 77
CAS:<p>AY 77: Potent, selective PAR2 agonist, favors Ca2+ (ec50=40nM) & ERK1/2 (ec50=2μM), boosts breast cancer cell migration.</p>Fórmula:C21H32N4O4Pureza:99.7%Cor e Forma:SolidPeso molecular:404.5Cis-22a
CAS:Cis-22a: selective TRPV6 inhibitor (IC50=0.32μM), halts T47D breast cancer cell growth.Fórmula:C24H30F3N3O2Pureza:99.99%Cor e Forma:SolidPeso molecular:449.51Calcium channel-modulator-1
CAS:<p>Calcium channel-modulator-1 is a calcium channel-modulator (IC50:0.8 μM) with specialisation to block aortic constriction.</p>Fórmula:C26H24Cl2N2O7SPureza:99.95%Cor e Forma:SolidPeso molecular:579.45Bupivacaine hydrochloride monohydrate
CAS:Bupivacaine hydrochloride monohydrate is an NMDA receptor inhibitor that inhibits SCN5A channels and is commonly used in the study of chronic pain.Fórmula:C18H31ClN2O2Pureza:99.91%Cor e Forma:SolidPeso molecular:342.9EMD57033
CAS:EMD57033 activates cardiac troponin C, enhances Ca2+ sensitivity to boost heart contraction.Fórmula:C22H23N3O4SPureza:97.24% - 99.11%Cor e Forma:SolidPeso molecular:425.5Fluspirilene
CAS:Fluspirilene is a long-acting antipsychotic for schizophrenia, inhibiting L-type calcium channels (IC50: 0.03 μM).Fórmula:C29H31F2N3OPureza:99.59%Cor e Forma:SolidPeso molecular:475.57PDE1-IN-4
PDE1-IN-4: inhibits PDE1C/A/B with IC50s 10/145/354 nM, may help study idiopathic pulmonary fibrosis.Fórmula:C33H33N3O4Cor e Forma:SolidPeso molecular:535.63PD-217014
CAS:PD-217014 is an α2δ ligand that exhibits visceral analgesic activity and can suppress visceral hypersensitivity. Its antihyperalgesic effects are dose-dependent.Fórmula:C10H17NO2Cor e Forma:SolidPeso molecular:183.25NNC 55-0396
CAS:NNC 55-0396: Selective T-type calcium channel blocker, IC50 6.8 μM, inhibits human ovarian cancer cell growth.Fórmula:C30H40Cl2FN3O2Pureza:99.00%Cor e Forma:SolidPeso molecular:564.56Ref: TM-T12238
1mg66,00€5mg126,00€10mg202,00€25mg354,00€50mg550,00€100mg787,00€1mL*10mM (DMSO)160,00€MP-010
CAS:MP-010 is an FKBP12 ligand that regulates cytosolic calcium by stabilizing RyR channel activity. It facilitates functional improvement in SOD1G93A mice with amyotrophic lateral sclerosis (ALS), evidenced by enhanced motor coordination, increased integrity of neuromuscular junctions, and significantly higher spinal motor neuron survival rates. MP-010 is applicable for research in the field of neurological disorders.Fórmula:C14H20N4O2SCor e Forma:SolidPeso molecular:308.399Leualacin
CAS:Leualacin is a novel calcium blocker from Hapsidospora irregularis.Fórmula:C31H47N3O7Pureza:98%Cor e Forma:SolidPeso molecular:573.72Calpain Inhibitor-2
CAS:Calpain Inhibitor-2: Lipophilic, moderates growth of A-375, B-16F1, PC-3 cancers, and hinders 80% DU-145 cell invasion.Fórmula:C26H33N3O5SCor e Forma:SolidPeso molecular:499.62BER-5
CAS:BER-5 is a potent MrgX2 antagonist, demonstrating broad-spectrum antagonistic activity against various MrgX2 agonists. It can inhibit Substance P(SP)-induced degranulation in LAD2 cells and alleviate SP-induced allergic reactions in mice. BER-5 is useful for researching mechanisms related to allergic reactions.Fórmula:C20H16O4Cor e Forma:SolidPeso molecular:320.34AZD 2066 hydrate
AZD 2066 hydrate is a selective, orally active, and brain-penetrant antagonist of mGluR5. It exhibits antinociceptive effects [1].Fórmula:C19H18ClN5O3Cor e Forma:SolidPeso molecular:386.33Mibefradil dihydrochloride hydrate
CAS:Mibefradil dihydrochloride hydrate is a long-acting antihypertensive blocking high-voltage L calcium channels.Fórmula:C29H42Cl2FN3O4Cor e Forma:SolidPeso molecular:586.57Cav 3.2 inhibitor 3
Cav 3.2 inhibitor 3 is a potent inhibitor of the Cav3.2 T-type Ca2+channel (IC50: 0.1534 μM) and has a low binding affinity for D2 receptors.Fórmula:C32H37N3O2Cor e Forma:SolidPeso molecular:495.66Cav 3.1 blocker 1
CAS:Cav 3.1 blocker 1 (compound 12) is a T-type calcium channel inhibitor with an IC50 value of 160 nM for Cav3.1. It exhibits weaker inhibition on Cav 3.2 with an IC50 of 5000 nM and shows no inhibitory effect on Cav 3.3 and Cav 1.2 (IC50 > 10000 nM).Fórmula:C26H19F6N3O2Cor e Forma:SolidPeso molecular:519.438Emopamil
CAS:Emopamil, a calcium channel inhibitor, reduces neuronal damage caused by ischemia.Fórmula:C23H30N2Cor e Forma:SolidPeso molecular:334.5SR 33805 oxalate
CAS:Ca2+ channel antagonistFórmula:C34H42N2O9SPureza:98%Cor e Forma:SolidPeso molecular:654.77CAD204520
CAS:CAD204520 functions as an inhibitor of SERCA (IC50 = 0.34 μM), specifically targeting mutations in the wild-type NOTCH1 protein associated with T-cell acute lymphoblastic leukemia (T-ALL) and mantle cell lymphoma (MCL).Fórmula:C23H32F3N3O2Cor e Forma:SolidPeso molecular:439.51Cav 3.2 inhibitor 1
Cav 3.2 inhibitor 1 targets T-type calcium channels, weakly binds D2 receptors, and aids physical and visceral pain research.Fórmula:C32H39N3OCor e Forma:SolidPeso molecular:481.67Sesamodil
CAS:Sesamodil (SD 3211) is a novel calcium antagonist that can be used to study hypertension.Fórmula:C29H32N2O6SPureza:98.87% - 99.87%Cor e Forma:SolidPeso molecular:536.64RWJ 22108
CAS:RWJ 22108 is a bronchial-selective calcium channel (calcium channel) blocker that exhibits an IC50 of 5.7 nM in dog bronchial smooth muscle calcium-dependent contractions.Fórmula:C27H30ClFN2O4SCor e Forma:SolidPeso molecular:533.06Cav 3.2 inhibitor 2
Cav 3.2 inhibitor 2 blocks T-type Ca2+ channels (IC50=0.09339 μM) and reduces mouse somatic/visceral pain. Used for intractable pain studies.Fórmula:C32H37F2N3OCor e Forma:SolidPeso molecular:517.65IAA65
CAS:IAA65 is a potent inhibitor of T-type calcium channels, exhibiting an IC50 value of 18.9 μM, and holds potential for use in epilepsy research [1].Fórmula:C16H13F6NO2Cor e Forma:SolidPeso molecular:365.27SB-423557
CAS:SB-423557 is an orally active antagonist of calcium-sensing receptor (CaR) with IC50 of 520 nMFórmula:C28H36N2O4Pureza:98%Cor e Forma:SolidPeso molecular:464.60IAB15
CAS:IAB15 is a potent inhibitor of T-type calcium channel that can be used in the research of epilepsy [1].Fórmula:C15H14F3NO2Cor e Forma:SolidPeso molecular:297.27Mibefradil
CAS:Mibefradil is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels (IC50s: 2.7 μM and 18.6 μM for T-type and L-type currents).Fórmula:C29H38FN3O3Pureza:98%Cor e Forma:SolidPeso molecular:495.63CCR4 antagonist 2
CAS:CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits TregFórmula:C26H28Cl2N6OPureza:98%Cor e Forma:SolidPeso molecular:511.45Cav 2.2/3.2 blocker 1
Compound 9e is a Cav 2.2/3.2 blocker; IC50: 1.22 μM & 80 μM, respectively; penetrates CNS.Fórmula:C28H30N2O3Cor e Forma:SolidPeso molecular:442.55T-Type calcium channel inhibitor 2
Compound 6g inhibits T-type Ca channels (IC50: Cav3.1-31μM, Cav3.2-83μM), cytotoxic to A549 (IC50: 5μM) & HCT-116 cells (IC50: 6.4μM).Fórmula:C36H39FN4OSCor e Forma:SolidPeso molecular:594.78(rel)-Mirogabalin
CAS:(rel)-Mirogabalin ((rel)-DS5565) is an inhibitor of voltage-dependent calcium channels, specifically targeting the α2δ-1 subunit.Fórmula:C12H19NO2Cor e Forma:SolidPeso molecular:209.28TTA-P1
CAS:TTA-P1: potent T-type calcium channel inhibitor; impacts neuron firing, hormone secretion, cell growth; potential in absence epilepsy research.Fórmula:C19H27Cl2FN2OCor e Forma:SolidPeso molecular:389.33Verapamil EP Impurity C hydrochloride
CAS:NSC-609249 hydrochloride, an impurity of Verapamil, is a calcium channel blocker with potent orally active properties. It also functions as a first-generation P-glycoprotein (P-gp) inhibitor.Fórmula:C12H20ClNO2Cor e Forma:SolidPeso molecular:245.75(Rac)-PD0299685
CAS:<p>(Rac)-PD0299685 is a potent voltage-dependent calcium channel inhibitor for the study of retina-related diseases.</p>Fórmula:C10H21NO2Pureza:97.20%Cor e Forma:SolidPeso molecular:187.28Fostedil
CAS:Fostedil enhances heart function, maintains blood flow during partial/total coronary occlusions, and lowers aortic pressure.Fórmula:C18H20NO3PSPureza:98%Cor e Forma:SolidPeso molecular:361.4
