PDE
As fosfodiesterases (PDEs) são enzimas que hidrolisam nucleotídeos cíclicos, como AMPc e GMPc, em suas formas inativas, desempenhando um papel crucial na regulação das vias de sinalização intracelular. Inibidores de PDE são utilizados no tratamento de diversas condições, incluindo doenças cardiovasculares, disfunção erétil e distúrbios respiratórios, devido à sua capacidade de modular os níveis de nucleotídeos cíclicos. Na CymitQuimica, oferecemos uma variedade de inibidores de PDE para apoiar sua pesquisa em sinalização celular, farmacologia e desenvolvimento terapêutico.
Foram encontrados 169 produtos de "PDE"
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Deltarasin
CAS:Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.Fórmula:C40H37N5OPureza:99.4%Cor e Forma:SolidPeso molecular:603.75ent-Tadalafil
CAS:ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS).Fórmula:C22H19N3O4Pureza:98%Cor e Forma:SolidPeso molecular:389.4Deltasonamide 2
CAS:Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Fórmula:C30H39ClN6O4S2Pureza:98%Cor e Forma:SolidPeso molecular:647.25PDE7-IN-2
CAS:PDE7-IN-2 is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used in Parkinson's disease studies.Fórmula:C14H11ClN2O3SPureza:98%Cor e Forma:SolidPeso molecular:322.77Deltasonamide 2 (TFA)
CAS:Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Fórmula:C32H40ClF3N6O6S2Pureza:98%Cor e Forma:SolidPeso molecular:761.28Tilivapram
CAS:Tilivapram is a PDE4 (phosphodiesterase IV) inhibitor that can be used in the study of mental illness.Fórmula:C16H15Cl2N3O4Pureza:99.87%Cor e Forma:SolidPeso molecular:384.21PF-04822163
CAS:PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.Fórmula:C19H17ClN2O2Pureza:99.55%Cor e Forma:SolidPeso molecular:340.8Propentofylline
CAS:Propentofylline (Hextol) has neuroprotective, antiproliferative and anti-inflammatory activities and can be used in the study of Alzheimer's disease.Fórmula:C15H22N4O3Pureza:99.76% - 99.86%Cor e Forma:Off-White SolidPeso molecular:306.36Ref: TM-T19812
2mgA consultar1mg65,00€5mg69,00€1mL*10mM (DMSO)77,00€10mg105,00€25mg195,00€50mg359,00€100mg523,00€Imazodan
CAS:Imazodan is a compound with positive inotropic activity and is a type III phosphodiesterase inhibitor that can be used to study heart failure.Fórmula:C13H12N4OPureza:98% - 98.31%Cor e Forma:SolidPeso molecular:240.26ATX inhibitor 5
CAS:ATX inhibitor 5: potent, oral autotaxin blocker, IC50 15.3 nM, curbs CCl4 liver fibrosis.Fórmula:C22H18ClF3N6OPureza:99.73%Cor e Forma:SolidPeso molecular:474.87Ref: TM-T10409
1mg46,00€5mg94,00€1mL*10mM (DMSO)96,00€10mg149,00€25mg245,00€50mg338,00€100mg460,00€200mg622,00€K134
CAS:K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.Fórmula:C22H29N3O4Pureza:98%Cor e Forma:SolidPeso molecular:399.48Senazodan hydrochloride
CAS:Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.Fórmula:C15H15ClN4OPureza:99.93%Cor e Forma:SolidPeso molecular:302.76PDE9-IN-1
CAS:PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).Fórmula:C17H23FN6O2Pureza:99.86%Cor e Forma:SolidPeso molecular:362.4Ref: TM-T12395
1mg40,00€1mL*10mM (DMSO)88,00€5mg89,00€10mg130,00€25mg222,00€50mg324,00€100mg470,00€200mg665,00€Trequinsin hydrochloride
CAS:Azetirelin (YM 14673) is a new thyrotropin-releasing hormone (TRH) analog.Fórmula:C24H28ClN3O3Pureza:99.95%Cor e Forma:SolidPeso molecular:441.95Autotaxin-IN-1
CAS:Autotaxin-IN-1: strong inhibitor for osteoarthritis pain; IC50=2.2 nM; good PK and PK/PD.Fórmula:C21H23N7O2Pureza:98%Cor e Forma:SolidPeso molecular:405.45AN3199
CAS:AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.Fórmula:C17H18BNO5Pureza:99.45%Cor e Forma:SolidPeso molecular:327.14WAY127093B racemate
CAS:WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs.Fórmula:C23H28N4O4Pureza:99.67%Cor e Forma:SolidPeso molecular:424.49Ref: TM-T13331
1mg50,00€5mg105,00€1mL*10mM (DMSO)116,00€10mg155,00€25mg224,00€50mg315,00€100mg424,00€200mg560,00€KD-027
CAS:KD-027 is a novel and long-acting PDE5A(phosphodiesterase 5A) inhibitor with potential antihypertensive activity.Fórmula:C25H35N7O6SPureza:99.55%Cor e Forma:SolidPeso molecular:561.65Lirimilast
CAS:Lirimilast: oral PDE4 inhibitor (IC50: 49 nM), anti-inflammatory, treats asthma/COPD.Fórmula:C17H12Cl2N2O6SPureza:98%Cor e Forma:SolidPeso molecular:443.26(R)-DNMDP
CAS:(R)-DNMDP is a potent and selective cancer cytotoxic agent that directly binds PDE3A and has an EC50 500-fold lower than that of (S)-DNMDP against HeLa.Fórmula:C15H20N4O3Cor e Forma:SolidPeso molecular:304.34Imazodan hydrochloride
CAS:Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure.Fórmula:C13H13ClN4OPureza:98.97%Cor e Forma:SolidPeso molecular:276.72PAT-048
CAS:PAT-048 is an effective and selective autotaxin inhibitor.Fórmula:C22H18ClF2N3O2SPureza:98%Cor e Forma:SolidPeso molecular:461.91BAY 73-6691
CAS:BAY 73-6691 is an inhibitor of brain penetrant PDE9A.Fórmula:C15H12ClF3N4OCor e Forma:SolidPeso molecular:356.73Verofylline
CAS:Verofylline (Verofyllinum) is an orally available, long-acting, multiacting, methylxanthine-substituted bronchodilator with inhibitory effects on PDE4 for theFórmula:C12H18N4O2Pureza:98.4% - 99.8%Cor e Forma:SolidPeso molecular:250.3Nanterinone
CAS:Nanterinone: oral phosphodiesterase inhibitor, improves acute heart failure hemodynamics.Fórmula:C15H15N3OPureza:99.96%Cor e Forma:SolidPeso molecular:253.3PF-04447943
CAS:PF-04447943, a selective PDE9A inhibitor (IC50=12nM), may aid sickle cell anemia research with its anti-inflammatory properties.Fórmula:C20H25N7O2Pureza:97.01% - 99.36%Cor e Forma:SolidPeso molecular:395.46Isomazole
CAS:Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 and PDE4.
Fórmula:C14H13N3O2SPureza:98.66%Cor e Forma:SolidPeso molecular:287.34Dovramilast
CAS:Dovramilast (CC-11050) is a PDE4 inhibitor that reduces the production of pro-inflammatory mediators in lupus erythematosus.Fórmula:C24H28N2O6SPureza:98.75% - 99.62%Cor e Forma:SolidPeso molecular:472.55MK-0873
CAS:MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.Fórmula:C25H18N4O3Pureza:99.14%Cor e Forma:SolidPeso molecular:422.44Dasantafil
CAS:Dasantafil (SCH446132) is a small molecule phosphodiesterase-5A (PDE5A) inhibitor used to treat genitourinary disorders and study erectile dysfunction.Fórmula:C22H28BrN5O5Pureza:99.4% - 99.50%Cor e Forma:SolidPeso molecular:522.39PDE IV-IN-1
CAS:PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary diseaseFórmula:C20H23ClN4O2Pureza:99.79%Cor e Forma:SolidPeso molecular:386.88Ref: TM-T10201
1mg225,00€5mg480,00€1mL*10mM (DMSO)540,00€10mg642,00€25mg964,00€50mg1.288,00€100mg1.738,00€200mg2.332,00€Carbazeran
CAS:Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases.Fórmula:C18H24N4O4Pureza:99.3%Cor e Forma:SolidPeso molecular:360.41Ref: TM-T21457
1mL*10mM (DMSO)A consultar2mg42,00€5mg62,00€10mg96,00€25mg170,00€50mg256,00€100mg385,00€Autotaxin-IN-3
CAS:Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the increase in lysophosphatidic acid in ascites and plasma.Fórmula:C22H21N9O2Pureza:99.54% - 99.79%Cor e Forma:SolidPeso molecular:443.46Ref: TM-T10415
2mg43,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg96,00€25mg173,00€50mg269,00€100mg432,00€200mg592,00€Filaminast
CAS:Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.Fórmula:C15H20N2O4Pureza:98.93% - 99.99%Cor e Forma:SolidPeso molecular:292.33Ref: TM-T31792
1mg156,00€1mL*10mM (DMSO)333,00€5mg366,00€10mg487,00€25mg737,00€50mg982,00€100mg1.324,00€200mg1.791,00€uk-50001
CAS:UK-50001 is a PDE4 inhibitor for treating inflammation, allergies, respiratory issues, and wounds.Fórmula:C26H24F3N3O4Pureza:99.90%Cor e Forma:SolidPeso molecular:499.48Ref: TM-T67815
1mg150,00€5mg360,00€1mL*10mM (DMSO)445,00€10mg540,00€25mg863,00€50mg1.153,00€100mg1.575,00€500mg3.142,00€Mopidamol
CAS:Mopidamol (RA 233) is a phosphodiesterase inhibitor, a dipyridamole derivative, with anticancer activity that prevents retinal vascular defects in experimentalFórmula:C19H31N7O4Pureza:99.31% - 99.78%Cor e Forma:SolidPeso molecular:421.49PDE4B-IN-2
CAS:PDE4B-IN-2 (A 33), an oral PDE4B inhibitor, IC50: 15 nM; less potent on PDE4D (IC50: 1.7 µM), has anti-inflammatory properties.Fórmula:C19H18ClN3O2SPureza:99.32%Cor e Forma:SolidPeso molecular:387.88Ref: TM-T36832
1mg37,00€5mg79,00€1mL*10mM (DMSO)87,00€10mg111,00€25mg216,00€50mg354,00€100mg567,00€500mg1.198,00€AWD 12-281
CAS:AWD 12-281 is a PDE4 inhibitor with anti-inflammatory activity and bronchodilator activity for the study of chronic obstructive pulmonary disease (COPD).Fórmula:C22H14Cl2FN3O3Pureza:99.25% - 99.85%Cor e Forma:SolidPeso molecular:458.27Tofimilast
CAS:Tofimilast (CP-325366), a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic obstructive pulmonary disease.Fórmula:C18H21N5SPureza:99.55%Cor e Forma:SolidPeso molecular:339.46Adibendan
CAS:Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.Fórmula:C16H14N4OPureza:99.52% - >99.99%Cor e Forma:SolidPeso molecular:278.31Autotaxin-IN-5
CAS:Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Fórmula:C30H29N9O2Pureza:98%Cor e Forma:SolidPeso molecular:547.61GSK356278
CAS:GSK356278: selective PDE4A/B/D inhibitor, pIC50~8.7, anti-inflammatory, anxiolytic, cognition-enhancing.Fórmula:C21H25N7O2SPureza:99.90% - 99.97%Cor e Forma:SolidPeso molecular:439.53Gisadenafil
CAS:Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.Fórmula:C23H33N7O5SPureza:98.82% - 99.50%Cor e Forma:SolidPeso molecular:519.62Ref: TM-T15381
1mg175,00€5mg394,00€1mL*10mM (DMSO)492,00€10mg582,00€25mg888,00€50mg1.243,00€100mg1.674,00€PDE5-IN-2
CAS:PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)Fórmula:C25H21N3O6SPureza:98%Cor e Forma:SolidPeso molecular:491.52Autotaxin-IN-4
CAS:Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Fórmula:C22H21N9O2Pureza:98%Cor e Forma:SolidPeso molecular:443.46MK-8189
CAS:MK-8189 is a potent and selective pyrimidine PDE10A inhibitor, with excellent PDE (phosphodiesterase) selectivity for the treatment of schizophrenia.Fórmula:C19H22N6OSPureza:99.38% - 99.67%Cor e Forma:SolidPeso molecular:382.48Gisadenafil besylate
CAS:Gisadenafil besylate (UK 369003-26) is a potent and orally active PDE5 inhibitor, for lower urinary tract symptoms associated with benign prostatic hyperplasia.Fórmula:C29H39N7O8S2Cor e Forma:SolidPeso molecular:677.79BIO-32546
CAS:BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM.Fórmula:C28H31F6NO3Pureza:98.4%Cor e Forma:SolidPeso molecular:543.54CI-1044
CAS:CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).Fórmula:C23H19N5O2Cor e Forma:SolidPeso molecular:397.43Difamilast
CAS:Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).Fórmula:C23H24F2N2O5Pureza:99.47% - 99.64%Cor e Forma:SolidPeso molecular:446.44PF-04957325
CAS:PF-04957325 is an inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A.PF-04957325 can be used for the study of autoimmune encephalomyelitis.Fórmula:C14H15F3N8OSPureza:99.02%Cor e Forma:SolidPeso molecular:400.38Ref: TM-T12422
1mg130,00€1mL*10mM (DMSO)195,00€5mg222,00€10mg334,00€25mg578,00€50mg838,00€100mg1.251,00€Siguazodan
CAS:Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM.Fórmula:C14H16N6OPureza:99.62% - 99.87%Cor e Forma:SolidPeso molecular:284.32Ref: TM-T12913
2mg38,00€5mg59,00€1mL*10mM (DMSO)64,00€10mg94,00€25mg175,00€50mg280,00€100mg434,00€200mg612,00€TP-10
CAS:TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.Fórmula:C26H19F3N4OPureza:99.21%Cor e Forma:SolidPeso molecular:460.45Ref: TM-T13189
1mg87,00€2mg114,00€5mg177,00€1mL*10mM (DMSO)178,00€10mg264,00€25mg460,00€50mg668,00€100mg945,00€500mg1.783,00€Enpp-1-IN-16
CAS:Enpp-1-IN-16 is an ENPP1 inhibitor, yo anti-cancer activity.Enpp-1-IN-16 can be used to study insulin resistance and chondrocalcinosis.Fórmula:C23H32N4O4Pureza:99.87%Cor e Forma:SolidPeso molecular:428.52PDE9-IN-(S)-C33
CAS:PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.Fórmula:C18H20ClN5OPureza:98.75%Cor e Forma:SolidPeso molecular:357.84Ref: TM-T28352
1mg37,00€5mg70,00€1mL*10mM (DMSO)79,00€10mg88,00€25mg144,00€50mg207,00€100mg309,00€200mg440,00€AMG 579
CAS:AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).Fórmula:C25H23N5O3Pureza:99.87%Cor e Forma:SolidPeso molecular:441.48Ref: TM-T14217
25mgA consultar50mgA consultar1mg34,00€2mg44,00€5mg70,00€1mL*10mM (DMSO)78,00€10mg100,00€TPN171
CAS:TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary
Fórmula:C24H35N5O3Pureza:>99.99%Cor e Forma:SolidPeso molecular:441.57Cudetaxestat
CAS:Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.Fórmula:C21H15Cl2F2N3O2SPureza:99.9%Cor e Forma:SolidPeso molecular:482.33Ref: TM-T63190
1mg73,00€5mg161,00€1mL*10mM (DMSO)166,00€10mg235,00€25mg420,00€50mg627,00€100mg880,00€200mg1.161,00€NHTD
CAS:NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).Fórmula:C24H26N2O5Cor e Forma:SolidPeso molecular:422.47TAK-915
CAS:TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.Fórmula:C19H18F4N4O5Pureza:98%Cor e Forma:SolidPeso molecular:458.36Deltasonamide 2 hydrochloride
Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.Fórmula:C30H40Cl2N6O4S2Pureza:98%Cor e Forma:SolidPeso molecular:683.71Thioquinapiperifil dihydrochloride
CAS:Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.Fórmula:C24H29ClN6OSPureza:99.81%Cor e Forma:SolidPeso molecular:485.05Ref: TM-T9773
1mg55,00€5mg123,00€1mL*10mM (DMSO)140,00€10mg177,00€25mg289,00€50mg371,00€100mg522,00€200mg687,00€PF-00489791
CAS:PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.Fórmula:C20H28N8O4SPureza:99.97%Cor e Forma:SolidPeso molecular:476.55ASP9831
CAS:ASP9831 is an orally active PDE4 inhibitor. It suppresses LPS-induced TNF-α production and exhibits anti-inflammatory properties. ASP9831 is useful in the study of steatohepatitis.Fórmula:C20H23N3O3Cor e Forma:SolidPeso molecular:353.42Z21090
CAS:Z21090 (ZL40) is a highly effective inhibitor of PDE 4, exhibiting an IC 50 value of 37.4 nM, and possesses oral bioavailability. It is significant in the study of alcohol-related diseases [1].Fórmula:C12H14ClN3O3Cor e Forma:SolidPeso molecular:283.71Tovinontrine
CAS:Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.Fórmula:C21H26N6O2Pureza:98.8%Cor e Forma:SolidPeso molecular:394.47PDE1-IN-7
CAS:PDE1-IN-7 (Compound 13h), with an IC50 value of 10 nM, selectively inhibits bPDE1. This compound demonstrates significant anti-fibrotic effects in a BDL-induced liver fibrosis rat model and is useful for research purposes in studying liver fibrosis [1].Fórmula:C32H36F2N2O6SPeso molecular:614.7BMS-341400 mesylate
CAS:BMS-341400 mesylate (Compound 6) is an orally active selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM and is useful in the study of erectile dysfunction.Fórmula:C24H26ClN9O5SCor e Forma:SolidPeso molecular:588.039Roflupram
CAS:Roflupram, Selective PDE4 inhibitor (IC50=26.2 nM), oral/BBB permeable, reverses cognitive deficits, suppresses pro-inflammatory factors.Fórmula:C16H20F2O4Cor e Forma:SolidPeso molecular:314.32
