PDE
As fosfodiesterases (PDEs) são enzimas que hidrolisam nucleotídeos cíclicos, como AMPc e GMPc, em suas formas inativas, desempenhando um papel crucial na regulação das vias de sinalização intracelular. Inibidores de PDE são utilizados no tratamento de diversas condições, incluindo doenças cardiovasculares, disfunção erétil e distúrbios respiratórios, devido à sua capacidade de modular os níveis de nucleotídeos cíclicos. Na CymitQuimica, oferecemos uma variedade de inibidores de PDE para apoiar sua pesquisa em sinalização celular, farmacologia e desenvolvimento terapêutico.
Foram encontrados 170 produtos de "PDE"
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(1R,2R)-MK-8189
CAS:(1R,2R)-MK-8189 is an isomer of MK-8189, a potent and selective pyrimidine PDE10A inhibitor.Fórmula:C19H22N6OSPureza:>99.99% - >99.99%Cor e Forma:SoildPeso molecular:382.48Dazonone
CAS:Dazonone (Imidazo[2,1-b]quinazolin-2(3H)-one, 6-chloro-1,5-dihydro-3-methyl-) is a specific PDE III inhibitors.Fórmula:C11H10ClN3OPureza:99.54% - 99.73%Cor e Forma:SolidPeso molecular:235.67Ref: TM-T9871
1mg73,00€1mL*10mM (DMSO)131,00€5mg149,00€10mg213,00€25mg319,00€50mg450,00€100mg605,00€200mg802,00€Arofylline
CAS:Arofylline (LAS 31025) is a PDE4 inhibitor and can be used for asthma studies.Fórmula:C14H13ClN4O2Pureza:98.19%Cor e Forma:SolidPeso molecular:304.73JNJ 42396302
CAS:JNJ 42396302 is an effective PDE10A inhibitor that enhances motility and viability in human sperm cells.Fórmula:C19H23N5O2Pureza:99.36%Cor e Forma:SolidPeso molecular:353.42PDE5-IN-9
CAS:WAY-639921 treats cardiovascular and respiratory conditions by inhibiting PDE1c.Fórmula:C18H14N4SPureza:99.98%Cor e Forma:SolidPeso molecular:318.4UK 227786
CAS:UK 227786 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.Fórmula:C22H22Cl2N4O4Pureza:99.9%Cor e Forma:SoildPeso molecular:477.34Ref: TM-T11220L
1mg109,00€2mg163,00€5mg243,00€1mL*10mM (DMSO)289,00€10mg355,00€25mg532,00€50mg750,00€100mg1.009,00€500mg2.035,00€BAY 2666605
CAS:BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 has anticancer effects.Fórmula:C17H12F4N2O2Pureza:99.81%Cor e Forma:SolidPeso molecular:352.28Ref: TM-T9805
1mg97,00€5mg235,00€1mL*10mM (DMSO)259,00€10mg376,00€25mg828,00€50mg1.320,00€100mg2.118,00€Acetildenafil
CAS:Acetildenafil is an analog of the phosphodiesterase inhibitor sildenafil.Fórmula:C25H34N6O3Cor e Forma:Off-White To Pale Yelow SolidPeso molecular:466.58OPC18750 HCl
CAS:OPC18750 HCl is a phosphodiesterase inhibitor with positive inotropic effects that can be used to study asthma, cancer, diabetes, and psychiatric disorders.Fórmula:C20H23ClN2O4Pureza:98.92%Cor e Forma:SoildPeso molecular:390.86Ref: TM-T83974
1mL*10mM (DMSO)47,00€1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.415,00€100mg1.872,00€Theodrenaline hydrochloride
CAS:Theodrenaline hydrochloride is an inhibitor targeting SARS-CoV-2 for the study of hypotension induced by spinal anesthesia.Fórmula:C17H22ClN5O5Pureza:97.05% - 98.18%Cor e Forma:SoildPeso molecular:411.84Enpp-1-IN-27
Enpp-1-IN-27 is a selective ENPP1 inhibitor with an IC50 of 14.68 nM, exhibiting approximately 410-fold selectivity over ENPP2 and roughly 10-fold selectivity over ENPP3. This compound stabilizes cGAMP levels and activates the STING pathway, leading to cytokine release and an enhanced innate immune response. In addition, Enpp-1-IN-27 activates ISRE and boosts cGAMP-mediated immune responses, demonstrating significant antitumor effects in 4T1 and CT26 syngeneic mouse models. It is applicable to breast cancer and colon cancer research.Cor e Forma:Odour SolidNerandomilast
CAS:Nerandomilast (BI 1015550) is an orally active PDE4B inhibitor with IC50 of 7.2 nM.Cost-effective and quality-assured.Fórmula:C20H25ClN6O2SPureza:98.06% - 99.96%Cor e Forma:SoildPeso molecular:448.97Oglemilast
CAS:Oglemilast (GRC 3886) suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo.Fórmula:C20H13Cl2F2N3O5SPureza:99.82%Cor e Forma:SolidPeso molecular:516.3Menabitan dihydrochloride
CAS:Menabitan dihydrochloride (SP-204 dihydrochloride), the dihydrochloride salt of Menabitan, serves as a non-opioid analgesic agent by inhibiting phosphodiesterase 9 (PDE 9). Additionally, it has been shown to reduce intraocular pressure in a rabbit model .Fórmula:C37H58Cl2N2O3Cor e Forma:SolidPeso molecular:649.77PDE10A-IN-5
PDE10A-IN-5 (Compound A30) is an orally active inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 value of 3.5 nM. By inhibiting PDE10A, it activates the cyclic adenosine monophosphate (cAMP)-related signaling pathway, exhibiting activity against pulmonary vascular remodeling. This compound is applicable to research in the field of pulmonary arterial hypertension.Cor e Forma:Odour Solidcis-Tadalafil
CAS:Tadalafil: a carboline-based PDE5 inhibitor, treats erectile dysfunction, prostatic hyperplasia, and pulmonary hypertension.
Fórmula:C22H19N3O4Pureza:99.89%Cor e Forma:SolidPeso molecular:389.4Anti-ALDH7A1 Antibody (5P692)
Anti-ALDH7A1 Antibody (5P692) is a Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (5P692) can be used in FCM,ICC/IF.Cor e Forma:Odour LiquidAnti-ALDH7A1 Antibody (3P955)
Anti-ALDH7A1 Antibody (3P955) is a Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (3P955) can be used in WB,ELISA,IP.Cor e Forma:Odour LiquidBAY 73-6691 racemate
CAS:BAY 73-6691 racemate (Rac-BAY 73-6691) is a phosphodiesterase 9A (PDE9A) inhibitor, useful for studying Parkinson’s disease.Fórmula:C15H12ClF3N4OCor e Forma:SolidPeso molecular:356.73N-Ethyl tadalafil
CAS:N-Ethyl tadalafil (NEthyl tadalafil) is a PDE inhibitor used in the study of cardiovascular disease.Fórmula:C23H21N3O4Pureza:99.58%Cor e Forma:SolidPeso molecular:403.43
