PDE
As fosfodiesterases (PDEs) são enzimas que hidrolisam nucleotídeos cíclicos, como AMPc e GMPc, em suas formas inativas, desempenhando um papel crucial na regulação das vias de sinalização intracelular. Inibidores de PDE são utilizados no tratamento de diversas condições, incluindo doenças cardiovasculares, disfunção erétil e distúrbios respiratórios, devido à sua capacidade de modular os níveis de nucleotídeos cíclicos. Na CymitQuimica, oferecemos uma variedade de inibidores de PDE para apoiar sua pesquisa em sinalização celular, farmacologia e desenvolvimento terapêutico.
Foram encontrados 178 produtos para "PDE".
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Pimobendan
CAS:Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).Fórmula:C19H18N4O2Pureza:99.91%Cor e Forma:White SolidPeso molecular:334.37Pumafentrine
CAS:Pumafentrine（BY 343） is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.Fórmula:C29H39N3O3Pureza:99.85%Cor e Forma:White SolidPeso molecular:477.64MR-L2
CAS:MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).Fórmula:C19H16Cl3FN4OPureza:98.09% - 98.94%Cor e Forma:SolidPeso molecular:441.71Ref: TM-T12103
1mg138,00€2mg197,00€5mg334,00€1mL*10mM (DMSO)358,00€10mg500,00€25mg807,00€50mg1.099,00€100mg1.485,00€500mg2.962,00€Carbodenafil
CAS:Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).Fórmula:C24H32N6O3Pureza:98.96% - 99.89%Cor e Forma:White SolidPeso molecular:452.55Zatolmilast
CAS:Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).Fórmula:C21H15ClF3NO2Pureza:98.20%Cor e Forma:SolidPeso molecular:405.8Ref: TM-T10590
1mg66,00€5mg128,00€1mL*10mM (DMSO)141,00€10mg231,00€25mg388,00€50mg532,00€100mg740,00€200mg973,00€Milrinone
CAS:Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.Fórmula:C12H9N3OPureza:99.22% - 99.92%Cor e Forma:SolidPeso molecular:211.22Enpp-1-IN-14
CAS:Enpp-1-IN-14: potent ENPP1 inhibitor, IC50 = 32.38 nM, exhibits anti-tumor properties.Fórmula:C15H22ClN5O4SPureza:99.83%Cor e Forma:SoildPeso molecular:403.88Zomepirac sodium salt
CAS:Zomepirac sodium salt (McN-2783-21-98) is a prostaglandin synthetase inhibitor.Fórmula:C15H13ClNNaO3Pureza:98.65% - ≥95%Cor e Forma:Yellow SolidPeso molecular:313.71ITI-214
CAS:ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members, exhibits potent PDE1 inhibitory activity.Fórmula:C29H29FN7O5PPureza:98.21%Cor e Forma:SolidPeso molecular:605.56Ref: TM-T11689
1mg71,00€2mg92,00€5mg158,00€1mL*10mM (DMSO)207,00€10mg286,00€25mg505,00€50mg712,00€100mg1.009,00€Roflumilast
CAS:Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potentialFórmula:C17H14Cl2F2N2O3Pureza:99.76% - 99.86%Cor e Forma:SolidPeso molecular:403.21Amrinone
CAS:Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.Fórmula:C10H9N3OPureza:98.88% - 99.45%Cor e Forma:SolidPeso molecular:187.2EMD57439
CAS:EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).Fórmula:C22H23N3O4SPureza:99.35% - 99.57%Cor e Forma:SolidPeso molecular:425.5Trapidil
CAS:Trapidil (Avantrin) is a coronary vasodilator agent.Fórmula:C10H15N5Pureza:99.42%Cor e Forma:White SolidPeso molecular:205.26NSP-805
CAS:NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.Fórmula:C17H19N3O2Pureza:99.85%Cor e Forma:Yellow SolidPeso molecular:297.35Ref: TM-T12267
1mg38,00€5mg86,00€1mL*10mM (DMSO)94,00€10mg129,00€25mg216,00€50mg309,00€100mg427,00€200mg577,00€ATX inhibitor 1
CAS:ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP).Fórmula:C21H23Cl2N2O6PPureza:99.52%Cor e Forma:White SolidPeso molecular:501.3N-Methylbenzamide
CAS:N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.Fórmula:C8H9NOPureza:99.83%Cor e Forma:Physical Description Off-White Crystalline Solid (Ntp 1992)Peso molecular:135.16Menabitan dihydrochloride
CAS:Menabitan dihydrochloride (SP-204 dihydrochloride), the dihydrochloride salt of Menabitan, serves as a non-opioid analgesic agent by inhibiting phosphodiesterase 9 (PDE 9). Additionally, it has been shown to reduce intraocular pressure in a rabbit model .Fórmula:C37H58Cl2N2O3Cor e Forma:SolidPeso molecular:649.77PDE10A-IN-5
PDE10A-IN-5 (Compound A30) is an orally active inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 value of 3.5 nM. By inhibiting PDE10A, it activates the cyclic adenosine monophosphate (cAMP)-related signaling pathway, exhibiting activity against pulmonary vascular remodeling. This compound is applicable to research in the field of pulmonary arterial hypertension.Cor e Forma:Odour SolidBAY 2666605
CAS:BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 has anticancer effects.Fórmula:C17H12F4N2O2Pureza:99.81%Cor e Forma:SolidPeso molecular:352.28Ref: TM-T9805
1mg92,00€5mg222,00€1mL*10mM (DMSO)245,00€10mg356,00€25mg785,00€50mg1.251,00€100mg2.008,00€UK 227786
CAS:UK 227786 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.Fórmula:C22H22Cl2N4O4Pureza:99.9%Cor e Forma:White SolidPeso molecular:477.34Ref: TM-T11220L
1mg109,00€2mg163,00€5mg243,00€1mL*10mM (DMSO)289,00€10mg355,00€25mg532,00€50mg750,00€100mg1.009,00€500mg2.035,00€PDE4-IN-21
PDE4-IN-21 (Compound L19) is an effective PDE4 inhibitor with an IC50 of 0.48 μM. It demonstrates substantial inhibitory activity and notable metabolic stability in rat liver microsomes.Fórmula:C15H10Cl2N6SCor e Forma:SolidPeso molecular:377.25Dazonone
CAS:Dazonone (Imidazo[2,1-b]quinazolin-2(3H)-one, 6-chloro-1,5-dihydro-3-methyl-) is a specific PDE III inhibitors.Fórmula:C11H10ClN3OPureza:99.54% - 99.73%Cor e Forma:SolidPeso molecular:235.67Ref: TM-T9871
1mg73,00€1mL*10mM (DMSO)131,00€5mg149,00€10mg213,00€25mg319,00€50mg450,00€100mg605,00€200mg802,00€PDE4-IN-17
PDE4-IN-17 (compound 4e) is a potent PDE4 inhibitor. It effectively inhibits PDE4B and PDE4D with IC50 values of 10.0 nM and 15.2 nM, respectively. In SD rats, PDE4-IN-17 demonstrates good oral bioavailability (F=66%) and a relatively long half-life (t1/2=2.0 h).Fórmula:C17H16N2O3Cor e Forma:SolidPeso molecular:296.11609(1R,2R)-MK-8189
CAS:(1R,2R)-MK-8189 is an isomer of MK-8189, a potent and selective pyrimidine PDE10A inhibitor.Fórmula:C19H22N6OSPureza:>99.99% - >99.99%Cor e Forma:SoildPeso molecular:382.48JNJ 42396302
CAS:JNJ 42396302 is an effective PDE10A inhibitor that enhances motility and viability in human sperm cells.Fórmula:C19H23N5O2Pureza:99.36%Cor e Forma:Yellow SolidPeso molecular:353.42KR-40795
KR-40795 is an effective inhibitor of ATX (autotaxin) with an IC50 of 0.13 μM. This compound plays a crucial role in liver diseases.Fórmula:C26H20ClNO5Cor e Forma:SolidPeso molecular:461.89PDE5-IN-9
CAS:WAY-639921 treats cardiovascular and respiratory conditions by inhibiting PDE1c.Fórmula:C18H14N4SPureza:99.98%Cor e Forma:SolidPeso molecular:318.4Nerandomilast
CAS:Nerandomilast (BI 1015550) is an orally active PDE4B inhibitor with IC50 of 7.2 nM.Cost-effective and quality-assured.Fórmula:C20H25ClN6O2SPureza:98.06% - 99.96%Cor e Forma:SoildPeso molecular:448.97PDE3/4-IN-2
CAS:PDE3/4-IN-2 is a potent dual PDE3/PDE4 inhibitor with IC50 values of 0.13 nM for PDE3A and 50 nM for PDE4B1. It is used to investigate PDE-related diseases such as asthma, COPD, sepsis, and nephritis. the dual-target activity of PDE3/4-IN-2 provides a mechanistic basis for dissecting cAMP regulation and inflammatory signaling pathways.Fórmula:C28H33N5O4Pureza:99.99%Peso molecular:503.59Oglemilast
CAS:Oglemilast (GRC 3886) suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo.Fórmula:C20H13Cl2F2N3O5SPureza:99.82%Cor e Forma:Yellow SolidPeso molecular:516.3Enpp-1-IN-27
Enpp-1-IN-27 is a selective ENPP1 inhibitor with an IC50 of 14.68 nM, exhibiting approximately 410-fold selectivity over ENPP2 and roughly 10-fold selectivity over ENPP3. This compound stabilizes cGAMP levels and activates the STING pathway, leading to cytokine release and an enhanced innate immune response. In addition, Enpp-1-IN-27 activates ISRE and boosts cGAMP-mediated immune responses, demonstrating significant antitumor effects in 4T1 and CT26 syngeneic mouse models. It is applicable to breast cancer and colon cancer research.Cor e Forma:Odour SolidBC 11-38
CAS:BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM).Fórmula:C15H16N2OS2Pureza:98.95% - 99.28%Cor e Forma:SolidPeso molecular:304.43Ref: TM-T21865
1mg34,00€5mg66,00€1mL*10mM (DMSO)77,00€10mg92,00€25mg192,00€50mg313,00€100mg500,00€200mg708,00€Acetildenafil
CAS:Acetildenafil is an analog of the phosphodiesterase inhibitor sildenafil.Fórmula:C25H34N6O3Cor e Forma:Off-White To Pale Yelow SolidPeso molecular:466.58PDE4B-IN-6
PDE4B-IN-6 is a highly selective PDE4B inhibitor (IC50=7.42 nM) that exerts anti-inflammatory effects by elevating cAMP and inhibiting TNF-α, used in COPD research.Fórmula:C22H24F2N2O7Pureza:99.20%Peso molecular:466.43Theodrenaline hydrochloride
CAS:Theodrenaline hydrochloride is an inhibitor targeting SARS-CoV-2 for the study of hypotension induced by spinal anesthesia.Fórmula:C17H22ClN5O5Pureza:97.05% - 98.18%Cor e Forma:SolidPeso molecular:411.84OPC18750 HCl
CAS:OPC18750 HCl is a phosphodiesterase inhibitor with positive inotropic effects that can be used to study asthma, cancer, diabetes, and psychiatric disorders.Fórmula:C20H23ClN2O4Pureza:98.92%Cor e Forma:SolidPeso molecular:390.86Ref: TM-T83974
1mL*10mM (DMSO)33,00€1mg109,00€5mg261,00€10mg374,00€25mg583,00€50mg803,00€100mg1.063,00€PDE4B-IN-4
PDE4B-IN-4 is an inhibitor of PDE4B (IC50: 2.82 nM) and TNF-α (IC50: 7.20 nM). It demonstrates anti-inflammatory properties by reducing neutrophilia in a mouse model of lipopolysaccharide (LPS)-induced sepsis.Fórmula:C26H27N5O5Cor e Forma:SolidPeso molecular:489.52ONO-8430506
CAS:ONO-8430506 is an orally available, potent autotaxin (ATX)/ENPP2 inhibitor (IC90: 100 nM) that inhibits ATX activity in mouse plasma.Fórmula:C27H28FN3O3Pureza:98.34%Cor e Forma:SolidPeso molecular:461.53Ref: TM-T38759
1mg103,00€5mg244,00€1mL*10mM (DMSO)271,00€10mg338,00€25mg510,00€50mg687,00€100mg919,00€Arofylline
CAS:Arofylline (LAS 31025) is a PDE4 inhibitor and can be used for asthma studies.Fórmula:C14H13ClN4O2Pureza:98.19%Cor e Forma:SolidPeso molecular:304.73FCPR03
CAS:FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively.Fórmula:C15H19F2NO3Pureza:99.94%Cor e Forma:White SolidPeso molecular:299.31Ref: TM-T39341
1mg38,00€5mg86,00€1mL*10mM (DMSO)94,00€10mg126,00€25mg207,00€50mg294,00€100mg400,00€200mg540,00€cis-Tadalafil
CAS:Tadalafil: a carboline-based PDE5 inhibitor, treats erectile dysfunction, prostatic hyperplasia, and pulmonary hypertension.Fórmula:C22H19N3O4Pureza:99.89%Cor e Forma:SolidPeso molecular:389.4Anti-ALDH7A1 Antibody (3P955)
Anti-ALDH7A1 Antibody (3P955) is a Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (3P955) can be used in WB,ELISA,IP.Cor e Forma:Odour LiquidN-Ethyl tadalafil
CAS:N-Ethyl tadalafil (NEthyl tadalafil) is a PDE inhibitor used in the study of cardiovascular disease.Fórmula:C23H21N3O4Pureza:99.58%Cor e Forma:SolidPeso molecular:403.43Anti-ALDH7A1 Antibody (5P692)
Anti-ALDH7A1 Antibody (5P692) is a Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (5P692) can be used in FCM,ICC/IF.Cor e Forma:Odour LiquidAnti-ALDH7A1 Antibody (6G475)
Anti-ALDH7A1 Antibody (6G475) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (6G475) can be used in IHC-P.Cor e Forma:Odour LiquidBay 60-7550
CAS:Bay 60-7550 is a PDE2 inhibitor that exerts positive inotropic effects in the rat heart by increasing PKA-mediated phosphorylation.Fórmula:C27H32N4O4Pureza:98.14%Cor e Forma:SolidPeso molecular:476.57BAY 73-6691 racemate
CAS:BAY 73-6691 racemate (Rac-BAY 73-6691) is a phosphodiesterase 9A (PDE9A) inhibitor, useful for studying Parkinson’s disease.Fórmula:C15H12ClF3N4OCor e Forma:White SolidPeso molecular:356.73BI-2545
CAS:BI-2545 is a potent and selective autotaxin (ATX) inhibitor with IC50 values of 2.2 nM and 3.4 nM for human and rat ATX, reduces plasma LPA levels.Fórmula:C23H19F6N5O3Pureza:98.85%Cor e Forma:White SolidPeso molecular:527.42ENPP1 Inhibitor C
CAS:ML-354 (VU0099704) is an antagonist with and PAR4 for the study of cardiovascular diseases.Fórmula:C15H18N6Pureza:99.28%Cor e Forma:Yellow ViscousPeso molecular:282.34Ref: TM-T37431
2mg105,00€1mL*10mM (DMSO)178,00€5mg222,00€10mg356,00€25mg715,00€50mg1.134,00€100mg1.521,00€200mg2.062,00€DNMDP
CAS:DNMDP is a potent and selective PDE3A inhibitor with anticancer activity. It binds to PDE3A, promoting its interaction with Schlafen 12 (SLFN12).Fórmula:C15H20N4O3Cor e Forma:Orange SolidPeso molecular:304.34
